Tuesday, December 15, 2009

Stopping a Stroke in its Tracks

Catheter Device Restrores Blood Flow to Brain by Suctioning Blood Clots

MAYWOOD, Il. -- Bobbie Laird was suffering a life-threatening stroke triggered by a blood clot in her brain that was nearly half an inch long.

But Dr. John Whapham of Loyola University Health System was able to stop the stroke in its tracks by using a catheter device that busted up the clot and suctioned the debris.

Most strokes are caused by blood clots in brain vessels. Brain cells die when deprived of blood and oxygen. But if a patient gets to the hospital in time, fast treatment often can restore blood flow and minimize damage.

When Laird arrived by ambulance at Loyola's emergency room, she was paralyzed on the left side of her body. She was disoriented and losing consciousness. A clot had traveled from her heart and lodged in her right middle cerebral artery, which supplies blood to most of the right side of her brain. As blood backed up behind the clot and congealed, the clot grew to 10 to 12 millimeters long.

Fortunately, Laird arrived by ambulance within a three-hour time window when treatment is most effective. She was seen by Dr. Rima Dafer, a vascular neurologist (stroke specialist). Laird was treated with tPA, an intravenous clot-busting drug. The Food and Drug Administration has approved tPA for the treatment of stroke if given within three hours of the onset of symptoms.

There was a slight improvement -- Laird moved her arm a little bit -- but the improvement was temporary. So Laird was taken to the catheterization lab to determine if she could potentially benefit from a procedure to extract the blood clot from the clogged vessel.

Whapham inserted a catheter device called Penumbra® in an artery in the groin. Whapham guided the device up through the heart and carotid artery into the brain. He deployed a tiny agitator, which broke up the clot, then suctioned the debris through a thin tube. Blood flow was restored to the right side of the brain, which controls the left side of the body. Among those assisting in the procedure was clinical nurse Diane Broadley.


Whapham has done similar procedures on hundreds of stroke patients. He has to work fast, because each passing minute increases the chance of permanent damage. But he also has to be careful not to perforate a vessel in the brain, which could be fatal. "It is a very high stakes procedure," he said.

Laird said she is recovering well from her stroke. Her speech is good, and she can walk, although she still is a little wobbly. She is undergoing physical therapy and occupational therapy at Loyola.

"The procedure gave me another chance," Broadley said. "I have a lot to be thankful for."

The FDA has approved the catheter device for clot removal in carefully selected patients. Additional clinical trials are needed to define the role of this and similar devices in the emergency management of patients with acute strokes caused by blood clots, Dafer said.

Whapham said Laird's case illustrates the importance of calling 911 immediately at the first signs of a stroke. "Time is brain," Whapham said. "You have less time to waste with a stroke than you do with a heart attack."

Whapham is part of a new generation of neurologists who are using catheters to extract blood clots, repair aneurysms, open clogged arteries and repair blood vessel malformations in the brain. Catheter procedures are much less invasive and risky than traditional brain surgery, which involves cutting a large opening in the skull.

Catheter technology, originally developed for heart surgery, has been modified for narrower and more challenging blood vessels in the brain. "There has been a huge evolution in devices over the last five years," Whapham said. "Technology is getting better by the week."

Whapham is an assistant professor in the Departments of Neurology and Neurological Surgery, Loyola University Chicago Stritch School of Medicine. Dafer is an associate professor in the Department of Neurology.

About Loyola University Health System

Loyola University Health System (LUHS) is part of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. Loyola University Medical Center’s campus is conveniently located in Maywood, 13 miles west of Chicago’s Loop and 8 miles east of Oak Brook, Ill. At the heart of the medical center campus is a 559-licensed-bed hospital that houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as Loyola University Chicago Stritch School of Medicine, Loyola University Chicago Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 255-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.

Trinity Health is a national Catholic health system with an enduring legacy and a steadfast mission to be a transforming and healing presence within the communities we serve. Trinity is committed to being a people-centered health care system that enables better health, better care and lower costs. Trinity Health has 88 hospitals and hundreds of continuing care facilities, home care agencies and outpatient centers in 21 states and 119,000 employees.