Monday, February 24, 2014

Niehoff study to determine if vitamin D supplements will improve mood in women with type 2 diabetes

Researchers enrolling women with diabetes and depression

MAYWOOD, Ill. – Loyola University Chicago Marcella Niehoff School of Nursing researchers are recruiting women for a study to determine whether raising blood levels of vitamin D can improve mood in women with diabetes. The study also will examine whether raising vitamin D levels can reduce blood pressure and affect how well women manage their diabetes. 

Principal investigator Sue M. Penckofer, PhD, RN, and colleagues hypothesize that women who have low levels of vitamin D and receive weekly doses of 50,000 IUs of vitamin D3 will report a better mood than those who receive weekly doses of 5,000 IUs. 

“Using a higher dose of vitamin D is potentially an easy and cost-effective way to improve mood,” Dr. Penckofer said. “Improving mood may make these women more likely to eat properly, take their medication, get enough exercise and better manage their disease overall.” 

Penckofer and her Loyola co-investigators received a $1.49 million grant (R01NR013906) for the study from the National Institute of Nursing Research at the National Institutes of Health. Women who are eligible are between the ages of 21 and 75 and have type 2 diabetes, low levels of vitamin D in their blood, are overweight and report symptoms of depression. Women will be randomly assigned to receive one of the two doses for six months. The study began enrolling women in November 2013 and will continue until 2017. 

Earlier studies have found that depressed people have elevated levels of inflammatory biomarkers, notably cytokines and C-reactive protein (CRP). The study will explore whether vitamin D supplementation decreases inflammation, thus providing evidence for a plausible mechanism for how the vitamin works as an antidepressant.

About 1 in 10 people in the United States has diabetes, and the incidence is projected to increase to 1 in 4 persons by 2050. Women with type 2 diabetes have worse outcomes than men. The reason may be due to depression, which affects more than 25 percent of women with diabetes. Depression impairs a patient’s ability to manage her disease.

Many Americans do not get enough vitamin D, and people with diabetes are prone to vitamin D insufficiency or deficiency. The exact mechanisms behind this are not known, but may include limited intake of foods high in vitamin D, obesity, lack of sun exposure, and genetic variations.

Penckofer is internationally known for her research on vitamin D, diabetes, and depression. Her co-investigators are Angelos Halaris, MD, PhD; Ramon Durazo, PhD; Pauline Camacho, MD,  Joanne Kouba, PhD, RD, Mary Ann Emanuele, MD, and Patricia Mumby, PhD.

For more information, call 708.216.9303.

About Loyola University Health System

Loyola University Health System (LUHS) is a member of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. Loyola University Medical Center’s campus is conveniently located in Maywood, 13 miles west of Chicago’s Loop and 8 miles east of Oak Brook, Ill. At the heart of the medical center campus is a 559-licensed-bed hospital that houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as Loyola University Chicago Stritch School of Medicine, Loyola University Chicago Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 255-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.

Trinity Health is one of the largest multi-institutional Catholic health care delivery systems in the nation. It serves people and communities in 22 states from coast to coast with 92 hospitals, and 120 continuing care locations — including home care, hospice, PACE and senior living facilities - that provide nearly 2.5 million visits annually.