Loyola one of main enrollers in JAMA study
MAYWOOD, Ill. – A new type of contrast MRI can predict which heart patients with atrial fibrillation are most likely to benefit from a treatment called catheter ablation, according to a landmark multicenter study published in The Journal of the American Medical Association.
Loyola University Medical Center had the second-highest enrollment in the international study, contributing 15 percent of the patients. David Wilber, MD, director of Loyola’s Division of Cardiology and medical director of Clinical Electrophysiology, is second author. First author is Nassir Marrouche, MD, of the University of Utah School of Medicine.
Atrial fibrillation, or A-fib, is the most common type of arrhythmia (irregular heartbeat). It’s caused by erratic electrical signals in the heart. When medications don’t work, A-fib often can be controlled with catheter ablation, in which a catheter burns away the heart tissue responsible for the erratic signals. Catheter ablation does not work for all patients, however, and there has not been a reliable way to predict which ones will benefit.
Researchers enrolled 329 patients from 15 centers in the United States, Europe and Australia. Each patient underwent a catheter ablation. Less than 30 days before their ablations, the patients also underwent a new type of imaging test called delayed enhancement-magnetic resonance imaging (DE-MRI) of the upper chamber of the heart (left atrium). The imaging shows scarring of the wall of the left atrium called atrial fibrosis.
Researchers excluded 69 patients because their DE-MRIs were of insufficient quality or because researchers lost track of them during follow-up. That left 260 patients. After 475 days of follow-up, patients with the least amount of scarring had significantly higher ablation success rates.
The pre-ablation DE-MRIs showed the amount of scarring in the left atrium, one of the heart’s two upper chambers. Scarring ranged from Stage 1 (covering less than 10 percent of the atrial wall) to Stage 4 (covering more than 30 percent of the atrial wall).
After 475 days of follow-up, 85 percent of patients with the least-severe Stage 1 scarring had experienced no recurrent arrhythmias. The success rate dropped to 64 percent for patients with Stage 2 scarring, 54 percent for patients with Stage 3 scarring and only 31 percent for patients with the most severe Stage 4 scarring.
“Catheter ablation is a very effective treatment for atrial fibrillation, but it can’t cure everyone,” Wilber said. “The findings from this study suggest there may be patients whose scarring is so advanced that ablation in its current form is much less likely to be effective as a single procedure. In such cases, patients, in consultation with their physicians, may decide to forgo ablation, or be prepared to have more than one procedure to control the arrhythmia."
Patients unlikely to benefit from ablation still could be treated with medications and in some circumstances with pacemakers, Wilber said.
Loyola is the only center in the Midwest that offers this new type of DE-MRI for A-fib patients. DE-MRI uses sophisticated imaging techniques to acquire and process images.
“DE-MRI enables us to look at not just the heart size and function but also structural changes in the heart, such as fibrosis, that can better inform treatment decisions,” said Mushabbar Syed, MD, Loyola’s director of Cardiovascular Imaging. These advanced imaging technologies, along with expert arrhythmia specialists, make Loyola a unique center for A-fib patients.
The study also suggests that earlier treatment may be beneficial, since the longer a patient experiences A-fib, the more scarring the patient is likely to have. But this would need to be confirmed by further studies, Wilber said.
Patients in the study also underwent DE-MRIs 90 days after their catheter ablations. These follow-up scans showed physicians how effective the ablations had been in burning troublesome scar tissue. Such findings could help guide physicians if and when additional ablations are necessary, Wilber said.
More than 2 million Americans have atrial fibrillation, and there are about 160,000 new cases each year. The number is increasing, due in part to the aging population and the obesity epidemic. A-fib is the most common form of irregular heartbeat. Electrical signals, which regulate the heartbeat, become erratic.
Instead of beating regularly, the upper chambers of the heart quiver. Not all the blood gets pumped out, so clots can form. A-fib can lead to strokes and heart failure. A-fib symptoms include heart palpitations, dizziness, chest pain, fatigue, shortness of breath, fainting and lightheadedness.
Wilber is the George M. Eisenberg Professor of Cardiovascular Sciences in the Department of Medicine of Loyola University Chicago Stritch School of Medicine. Syed is the Rolf and Merian Gunnar Professor of Medicine in the Department of Medicine