Monday, December 6, 2010

Loyola Surgeons Report Favorable Outcomes for "Vast Majority" of Patients with Acoustic Tumors

Award-winning study details results from 730 patients over 21 years

MAYWOOD, Ill. -- Surgery to remove tumors under the brain known as acoustic neuromas produces favorable outcomes in the "vast majority" of patients, according to one of the largest studies of its kind. Loyola University Hospital surgeons Dr. Douglas Anderson and Dr. John Leonetti followed 730 patients whom they had jointly operated on during a 21-year period. Patients ranged in age from 9 to 79, with a median age of 48. The average clinical follow-up was 32 months. Every patient survived the surgery, and the surgeons were able to completely remove the tumors in 95.1 percent of the patients. Ninety percent of patients experienced little or no facial paralysis. And among those who still retained hearing in the affected ear before surgery, 44 percent came out of the surgery with useful hearing in that ear, and 63 percent had at least some hearing. These results are as good as or better than any other series of acoustic neuromas reported in the medical literature. "With careful microsurgical technique, one can achieve gross total resection [removal] of the vast majority of acoustic tumors with minimal major morbidity or mortality and at the same time achieve a high percentage of normal to near-normal facial function," the study authors concluded. Anderson is first author of the study. He presented results at the 2010 Congress of Neurological Surgeons, which awarded him the prestigious Synthes Skull Base Surgery Award. An acoustic neuroma, also known as a vestibular schwannoma, is a slow-growing, usually benign, tumor, located behind the ear on the nerve that connects the ear to the brain. The tumor can cause hearing loss in one ear and paralysis on one side of the face. If the tumor grows large enough, it can be fatal. Treatment options include microsurgery (surgery with a microscope), radiation or simply keeping a watchful eye on the tumor. In the study, the average tumor diameter was 2.2 cm, and 89.5 percent of patients had experienced partial or complete loss of hearing in one ear. Other presurgery symptoms included tinnitus (43.7 percent of patients), dizziness/imbalance (26.8 percent), facial numbness (11.1 percent), headache (10.3 percent) and facial weakness (2.6 percent). Leonetti and Anderson work as a team, with Leonetti gaining access to the tumor and Anderson removing it. If the patient still retains hearing, Leonetti uses one of two surgical techniques, called the retrosigmoid approach or the middle fossa approach. If the patient has lost all hearing, Leonetti uses a technique called the translabyrinthine approach. Leonetti is a professor in the departments of Otolaryngology and Neurological Surgery and program director of Cranial Base Surgery, and Anderson is a professor in the Department of Neurological Surgery at Loyola University Chicago Stritch School of Medicine. In recent years, the adoption of techniques to monitor neural structures during surgery has enabled surgeons to frequently preserve hearing and facial nerves. "Before, the goal simply was to get the tumor out and be glad if the patient survived," Anderson said. Though Anderson and Leonetti have their own practices, they also collaborate to remove acoustic neuromas and other tumors. Over the last 23 years, they have performed about 1,250 surgeries together. "It's been a long and successful partnership," Anderson said. "We have had wonderful results. It's like a nice marriage." Anderson said Leonetti "is a very innovative surgeon, and extremely adept at the myriad of approaches to the skull base. He also has a wonderful attitude -- highly professional but also fun to work with." Leonetti also has high praise for Anderson. "He is the most technically gifted neurosurgeon I have ever seen," Leonetti said. "More importantly, he is a kind, compassionate and wonderful person, but he'll never beat me at golf." Other co-authors of the study are Dr. Edward Perry, a resident in neurological surgery and Marc Pisansky, a research assistant.

About Loyola University Health System

Loyola University Health System (LUHS) is part of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. Loyola University Medical Center’s campus is conveniently located in Maywood, 13 miles west of Chicago’s Loop and 8 miles east of Oak Brook, Ill. At the heart of the medical center campus is a 559-licensed-bed hospital that houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as Loyola University Chicago Stritch School of Medicine, Loyola University Chicago Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 255-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.

Trinity Health is a national Catholic health system with an enduring legacy and a steadfast mission to be a transforming and healing presence within the communities we serve. Trinity is committed to being a people-centered health care system that enables better health, better care and lower costs. Trinity Health has 88 hospitals and hundreds of continuing care facilities, home care agencies and outpatient centers in 21 states and 119,000 employees.