Monday, June 15, 2015

Loyola Study Documents Toll of Smoke Inhalation Injuries

MAYWOOD, Ill.  -- A study of burn patients has found that those who suffered the most severe smoke inhalation also had more inflammation and spent more time on ventilators and in intensive care.

The study, led by researchers at Loyola University Chicago Stritch School of Medicine, was published prior to the print version in the journal Critical Care Medicine. It is the first to show that the severity of smoke-inhalation injuries may play a role in the overall pulmonary inflammatory response.

Inflammation occurs in response to injury. It includes the release of proteins that can trigger wound healing. But too much inflammation can damage healthy tissue.

Researchers wrote that their findings could "serve the purpose of better understanding the biological mechanisms behind smoke inhalation injury."

In the United States, about 40,000 people are hospitalized for burn injuries each year. As many as 20 percent of fire victims also have smoke-inhalation injuries.

At Loyola, smoke inhalation is rated from 0 (no injury) to 4 (massive injury). Researchers conducted an observational study of 60 adult burn patients, including nine patients who had Grade 0 inflammation, 15 who had Grade 1, 15 with Grade 2, 18 who had Grade 3 and three with Grade 4.

The study included an examination of proteins called cytokines contained in fluid flushed out of patients' lungs. (Cytokines are the so-called hormones of the immune system.)  Researchers looked at 28 cytokines associated with inflammation and found that 21 were at their highest in patients with the most severe smoke inhalation injuries. (The inflammatory proteins included interferon-ÿ, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein-1 and several interleukins.)

Patients who had low smoke-inhalation injuries (Grades 1 or 2) spent a median of seven days on the ventilator, while patients with high-inhalation injuries (Grades 3 or 4) spent a median of 23 days on the ventilator. Low-inhalation-injury patients spent a median of 13 days in intensive care; high-inhalation-injury patients spent 24 days. Thirty-three percent of low-inhalation-injury patients required a tracheotomy, compared with 52 percent of high-inhalation-injury patients. However, the degree of inhalation injury did not have a significant effect on subsequent pneumonia, sepsis, hospital length of stay or mortality.

Senior author of the study is Elizabeth J. Kovacs, PhD, director of Loyola's Burn and Shock Trauma Institute. First author is Joslyn M. Albright, MD, a research fellow in the institute. "This study is an excellent example of clinicians and basic scientists working together," Kovacs said.

Other co-authors are Christopher S. Davis, MD, MPH; Melanie D. Bird, PhD; Luis Ramirez, BS; and Richard L. Gamelli, MD, FACS, of Loyola's Burn and Shock Trauma Institute; Hajwa Kim, MS, MA, of the University of Illinois at Chicago; and Ellen L. Burnham, MD, MS, of the University of Colorado Denver School of Medicine. Gamelli is director of the Burn and Shock Trauma Institute and Senior Vice President and Provost of the Health Sciences Division of Loyola University Chicago Stritch School of Medicine.

The study is supported in part by funding from the National Institutes of Health, the International Association of Fire Fighters and the Dr. Ralph and Marian C. Falk Medical Research Trust.

In their acknowledgements, authors thanked Jurgen Peters, MD of the Universitatsklinikum Essen in Essen, Germany, and the "dedicated assistance of nursing and support staff in the Burn Intensive Care Unit at Loyola University Medical Center."


About Loyola University Health System

Loyola University Health System (LUHS) is part of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. Loyola University Medical Center’s campus is conveniently located in Maywood, 13 miles west of Chicago’s Loop and 8 miles east of Oak Brook, Ill. At the heart of the medical center campus is a 559-licensed-bed hospital that houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as Loyola University Chicago Stritch School of Medicine, Loyola University Chicago Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 255-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.

Trinity Health is a national Catholic health system with an enduring legacy and a steadfast mission to be a transforming and healing presence within the communities we serve. Trinity is committed to being a people-centered health care system that enables better health, better care and lower costs. Trinity Health has 88 hospitals and hundreds of continuing care facilities, home care agencies and outpatient centers in 21 states and 119,000 employees.