Tuesday, April 12, 2011

Loyola Researchers Report Possible New Approach to Treating Deadly Leukemia in Babies

MAYWOOD, Ill. -- A Loyola University Health System study points to a promising new approach to treating an aggressive and usually fatal leukemia in babies. The study involved a type of leukemia called mixed lineage leukemia, or MLL leukemia. Only 25 to 50 percent of babies diagnosed with MLL leukemia survive the disease. The study demonstrated how it may be possible to kill cancerous MLL cells by targeting a protein called DOT1. Researchers showed that, without the DOT1 protein, cancerous MLL cells died, said Charles Hemenway, MD, PhD, senior author of the study. "We are focusing on the unique biology of MLL leukemia," Hemenway said. The study was presented at the 2011 meeting of the American Association for Cancer Research in Orlando, Fla. Between 5 and 10 percent of all leukemias are MLL positive. In children older than 1 who have MLL leukemia, the survival rate is about 75 percent. By comparison, the survival rate for most other childhood leukemias is about 90 percent. Adults who have MLL leukemia also have lower survival rates than those with other types of leukemia. MLL is a subtype of leukemia caused by a mutation in a gene called MLL. The mutated gene codes for an abnormal MLL protein, which turns a blood cell into a cancer cell. For reasons researchers don't understand, MLL leukemia is more resistant to chemotherapy than other forms of leukemia. In previous studies, Loyola researchers developed a small molecule, called PFWT, which binds to the MLL protein. This binding effectively disables the MLL protein, leading to the death of the cancer cell. Later this year Hemenway plans to begin testing PFWT molecules on mice that have MLL leukemia. The new study points to a second possible way to attack MLL cells, by targeting the DOT1 protein. DOT1 works in conjunction with the MLL protein. The study demonstrated that DOT1 is critical for keeping MLL cancer cells alive. Researchers cultured MLL cells from mice. From these cells, researchers removed the gene that codes for the DOT1 protein. Without the gene, the cell no longer produced the DOT1 protein, and without the DOT1 protein, the cancerous cells died. Loyola researchers are collaborating with researchers from Nemours/Alfred I. duPont Hospital for Children in Wilmington, Del., to identify molecules that could disable DOT1. Hemenway said a double-barrel approach -- targeting both the DOT1 and MLL proteins --potentially could be a more effective treatment than current chemotherapy, with fewer side effects. But it will take years of additional research and testing before such a treatment would be available for patients. Hemenway said several other Loyola researchers are studying MLL leukemia. "There are a lot of opportunities for collaboration," he said. Hemenway is the Ronald McDonald House Charities Endowed Professor in Pediatric Oncology and division director of Pediatric Hematology/Oncology at Loyola University Chicago Stritch School of Medicine. Other co-authors are first author Ming-Jin Chang, a visiting doctoral student at Stritch and Jeffrey Lynn, PhD, a postdoctoral researcher at Cleveland Clinic who previously studied in Hemenway's lab. The study was supported by the Leukemia & Lymphoma Society.

About Loyola University Health System

Loyola University Health System (LUHS) is part of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. Loyola University Medical Center’s campus is conveniently located in Maywood, 13 miles west of Chicago’s Loop and 8 miles east of Oak Brook, Ill. At the heart of the medical center campus is a 559-licensed-bed hospital that houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as Loyola University Chicago Stritch School of Medicine, Loyola University Chicago Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 255-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.

Trinity Health is a national Catholic health system with an enduring legacy and a steadfast mission to be a transforming and healing presence within the communities we serve. Trinity is committed to being a people-centered health care system that enables better health, better care and lower costs. Trinity Health has 88 hospitals and hundreds of continuing care facilities, home care agencies and outpatient centers in 21 states and 119,000 employees.