Wednesday, April 3, 2013

Loyola Researchers to Determine if Certain Bacteria Cause Overactive Bladder Symptoms

Nationally renowned researchers looking for women to enroll in study

MAYWOOD, Ill. – Thousands of women suffer from overactive bladder (OAB) or the sudden need to urinate, yet many don’t get relief from medication. Researchers at Loyola University Health System believe certain bacteria may be to blame.

Loyola has launched a clinical trial to determine if the bacteria present in the urine of women who respond to treatment for overactive bladder is different than those who do not respond.

“Overactive bladder can be caused by a number of issues, which may explain why medication works for some and not others,” said Linda Brubaker, MD, a urogynecologist at Loyola University Health System and dean of Loyola University Chicago Stritch School of Medicine. “If we can identify differences in the bacteria in women who respond to treatment and those who do not, we can better manage these patients and improve their quality of life."

OAB is a socially debilitating disease that may result from various issues, including cancer or neurological diseases. Urinary tract infections also lead to symptoms of OAB with the difference being bacteria.

“Certain bacteria in the urine may contribute to urinary symptoms,” Dr. Brubaker said. “While further research is needed, women with these bacteria may benefit from antibiotics rather than traditional treatments for OAB."

Loyola researchers are looking to recruit women for this study. Study participants will complete a questionnaire and will undergo a series of screening procedures.

Women involved in the study also will provide urine samples, which researchers will evaluate with traditional cultures and DNA-based detection measures to identify the bacteria present. Women can call (708) 216-2067 to determine if they are eligible to participate in the study.

About Loyola University Health System

Loyola University Health System (LUHS) is a member of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system that includes Loyola University Medical Center (LUMC), located on a 61-acre campus in Maywood, Gottlieb Memorial Hospital (GMH), on a 36-acre campus in Melrose Park, and convenient locations offering primary and specialty care services throughout Cook, Will and DuPage counties. At the heart of LUMC is a 547-licensed-bed hospital that houses the Center for Heart & Vascular Medicine, the Cardinal Bernardin Cancer Center, a Level 1 trauma center, a burn center, a children's hospital, Loyola Outpatient Center, and Loyola Oral Health Center. The campus also is home to Loyola University Chicago Stritch School of Medicine, Loyola University Chicago Marcella Niehoff School of Nursing and the Loyola Center for Fitness. The GMH campus includes a 254-licensed-bed community hospital, a Professional Office Building with 150 private practice clinics, an adult day care program, the Gottlieb Center for Fitness, the Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.

Trinity Health is one of the largest multi-institutional Catholic health care delivery systems in the nation. It serves people and communities in 22 states from coast to coast with 93 hospitals, and 120 continuing care locations — including home care, hospice, PACE and senior living facilities — that provide nearly 2.5 million visits annually.