MAYWOOD, Ill. -- An influential 2001 article by a Loyola researcher on how estrogen potentially can protect the brain against Alzheimer's disease and other neurological disorders has been cited 500 times. The milestone was recorded by Google Scholar, which tracks citations in scholarly literature, including articles, books, theses and abstracts, etc. Another citation index, Thomson Reuters' Web of Science, has counted 471 citations for the article. By comparison, the median number of citations for papers on neuroscience and behavior that were written that year is 34.5. The much-cited article, by senior author Lydia L. DonCarlos, PhD, and colleagues, was published in the January 2001 issue of Progress in Neurobiology. It is titled "Neuroprotection by Estradiol." (Estradiol is one of the estrogen hormones.) It was among the first comprehensive reviews of the potential protective effects of estrogen on the brain. The article detailed how estrogen "decreases the risk and delays the onset and progression of Alzheimer's disease and schizophrenia, and may also enhance recovery from traumatic neurological injury such as stroke." Since publication, further data from the Women's Health Initiative and other studies have refined scientists' understanding of the benefits and risks of estrogen exposure, DonCarlos said. The Loyola University Health System neuroendocrinologist has written subsequent review articles about estrogen and the brain. Estrogen can protect against dementia and other neurological disorders by decreasing inflammatory responses and by enhancing cells' ability to survive damage. "It's a natural way for the brain to protect itself, since the brain normally makes neuroprotective estradiol in response to injury," DonCarlos said. But there also are risks. The Women's Health Initiative found that taking estrogen plus progestin increased women's risks of heart disease, blood clots, stroke and breast cancer. DonCarlos and other researchers are studying agents called selective estrogen receptor modulators (SERMs) that potentially could provide the benefits of estrogen without the risks. One such agent is tamoxifen, which reduces the risk of breast cancer by blocking estrogen receptors in the breast. In the bones, tamoxifen has the opposite effect by acting like estrogen and thus reducing the risk of osteoporosis, DonCarlos said. "We are looking for other SERMs that potentially could help protect the brain, without increasing the risk of breast cancer or other negative effects," DonCarlos said. Most studies suggest that estrogen has beneficial effects on cognitive function, DonCarlos said. "But we still have a lot of research to do before recommending use of estrogens in the clinic for this purpose." DonCarlos is a professor in the Department of Cell and Molecular Physiology at Loyola University Chicago Stritch School of Medicine. Her co-authors on the 2001 paper are Luis Miguel Garcia-Segura (first author), a professor at the Instituto Cajal in Madrid and past president of the Spanish Society for Neuroscience, and IÃ±igo Azcoitia, associate professor of biology at the Universidad Complutense of Madrid.
Landmark Article on how Estrogen Can Protect the Brain Hits 500-Citation Milestone
About Loyola University Health System
Loyola University Health System (LUHS) is part of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. Loyola University Medical Center’s campus is conveniently located in Maywood, 13 miles west of Chicago’s Loop and 8 miles east of Oak Brook, Ill. At the heart of the medical center campus is a 559-licensed-bed hospital that houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as Loyola University Chicago Stritch School of Medicine, Loyola University Chicago Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 255-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.
Trinity Health is a national Catholic health system with an enduring legacy and a steadfast mission to be a transforming and healing presence within the communities we serve. Trinity is committed to being a people-centered health care system that enables better health, better care and lower costs. Trinity Health has 88 hospitals and hundreds of continuing care facilities, home care agencies and outpatient centers in 21 states and 119,000 employees.