Preventing Early Menopause in Breast Cancer Patients | Loyola Medicine
Wednesday, March 4, 2015

Novel approach helps prevent early menopause in breast cancer patients, study finds

Drug also may protect fertility in women hoping to have children

MAYWOOD, Ill. – Early menopause can be prevented and fertility may be preserved in young women with early stage breast cancer, according to a study published today in The New England Journal of Medicine.

A major international clinical trial has found that the risk of sudden onset of menopause can be significantly reduced by adding a drug called goserelin to the chemotherapy regimen. Women who took goserelin and wanted to have children also were more likely to get pregnant and deliver a healthy baby.

“Some of the most distressing side effects of chemotherapy in young women with breast cancer are early and sudden onset of menopause and infertility,” said Kathy Albain, MD, senior author, medical oncologist and director of the Breast Cancer Clinical Research Program at Loyola University Chicago Cardinal Bernardin Cancer Center. “These findings provide hope for young women with breast cancer who would like to prevent early menopause or still have children.”

The overall purpose of goserelin is to temporarily put the ovaries “at rest” during chemotherapy. “We found that, in addition to reducing the risk of sudden, early menopause, and all of the symptoms that go along with menopause, goserelin was very safe and may even improve survival,” Dr. Albain said. “These findings are changing how we manage young women with breast cancer."

The Phase 3 multicenter trial included premenopausal women younger than 50 who had certain types of early-stage breast cancer (estrogen and progesterone-receptor negative). For this study, 257 patients were randomly assigned to receive standard chemotherapy or chemotherapy plus goserelin.

After two years, 22 percent of women receiving standard chemotherapy had stopped menstruating or had elevated levels of a hormone known as FSH, an indication of reduced estrogen production and egg supply. By comparison, only 8 percent of the women receiving goserelin had stopped menstruating or had elevated FSH. The pregnancy rate was nearly twice as high in the goserelin group (21 percent vs. 11 percent).

After four years, 78 percent of those receiving standard chemotherapy showed no signs or symptoms of cancer compared with 89 percent of patients who received goserelin. Overall survival at four years was 82 percent in the standard chemotherapy group and 92 percent in the goserelin group.

“Premenopausal women beginning chemotherapy for early breast cancer should consider this new option to prevent premature ovarian failure,” Dr. Albain and colleagues concluded.

Goserelin (trade name, Zoladex®) is similar to a natural hormone made by the body. It is FDA-approved for the treatment of prostate cancer, certain benign gynecological disorders and certain breast cancers.

Goserelin is administered by injection. In the clinical trial, women assigned to the goserelin group received one shot once every four weeks during the course of their chemotherapy regimen. Side effects of goserelin were uncommon and mostly included more symptoms related to reducing the activity of the ovaries during chemotherapy.

About 25 percent of breast cancers occur in women younger than 50. Breast cancer chemotherapy can trigger early menopause in women in their 20s, 30s and 40s. After completing chemotherapy, some women resume menstruating and are able to have children should they choose to do so. But for many women following chemotherapy, menopause is permanent.

Chemotherapy-induced menopause tends to come on suddenly, and consequently, symptoms are much more intense. These symptoms include irregular periods and then cessation of periods completely, vaginal dryness, hot flashes, night sweats, sleep problems, mood changes, weight gain, thinning hair, dry skin and loss of breast fullness.

“Early menopause in younger breast cancer patients can be very debilitating,” Dr. Albain said.

The clinical trial is named “Prevention of Early Menopause Study (POEMS) S0230.” It is sponsored by SWOG national cancer research cooperative along with SWOG’s collaborating groups, including the International Breast Cancer Study Group, Eastern Cooperative Oncology Group and the Alliance for Clinical Trials in Oncology. First author is Halle C.F. Moore, MD, of the Cleveland Clinic. The study was funded in part by the National Cancer Institute. Dr. Albain led the design, development and conduct of this study as its senior author.

About Loyola Medicine and Trinity Health

Loyola Medicine, a member of Trinity Health, is a quaternary care system based in the western suburbs of Chicago that includes Loyola University Medical Center (LUMC), Gottlieb Memorial Hospital, MacNeal Hospital and convenient locations offering primary and specialty care services from 1,877 physicians throughout Cook, Will and DuPage counties. LUMC is a 547-licensed-bed hospital in Maywood that includes the William G. and Mary A. Ryan Center for Heart & Vascular Medicine, the Cardinal Bernardin Cancer Center, a Level 1 trauma center, Illinois's largest burn center, a certified comprehensive stroke center and a children’s hospital. Having delivered compassionate care for over 50 years, Loyola also trains the next generation of caregivers through its teaching affiliation with Loyola University Chicago’s Stritch School of Medicine and Marcella Niehoff School of Nursing. Gottlieb is a 247-licensed-bed community hospital in Melrose Park with 150 physician offices, an adult day care program, the Gottlieb Center for Fitness, the Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park. MacNeal Hospital is a 374-bed teaching hospital in Berwyn with advanced inpatient and outpatient medical, surgical and psychiatric services, advanced diagnostics and treatments. MacNeal has a 12-bed acute rehabilitation unit, a 25-bed inpatient skilled nursing facility, and a 68-bed behavioral health program and community clinics. MacNeal has provided quality, patient-centered care to the near west suburbs since 1919.

Trinity Health is one of the largest multi-institutional Catholic healthcare systems in the nation, serving diverse communities that include more than 30 million people across 22 states. Trinity Health includes 92 hospitals, as well as 109 continuing care locations that include PACE programs, senior living facilities and home care and hospice services. Its continuing care programs provide nearly 2.5 million visits annually. Based in Livonia, Mich., and with annual operating revenues of $18.3 billion and assets of $26.2 billion, the organization returns $1.1 billion to its communities annually in the form of charity care and other community benefit programs. Trinity employs about 129,000 colleagues, including 7,800 employed physicians and clinicians. Committed to those who are poor and underserved in its communities, Trinity is known for its focus on the country's aging population. As a single, unified ministry, the organization is the innovator of Senior Emergency Departments, the largest not-for-profit provider of home health care services—ranked by number of visits—in the nation, as well as the nation’s leading provider of PACE (Program of All Inclusive Care for the Elderly) based on the number of available programs.