Tuesday, September 8, 2009

Are We in for a Repeat of the Killer Flu Pandemic of 1918?

Loyola infectious disease physician, researcher says major differences in medicine exist between then and today

MAYWOOD, Ill. -- In 1918, the Spanish flu raced around the globe, ending the lives of an estimated 40 million people in less than a year. Epidemiologists believe one in four Americans became infected during that pandemic with 750,000 dying.

Fears are mounting that the H1N1 flu, which appeared in the spring of this year, will turn as virulent and deadly and mimic the course of the Spanish flu that initially struck in mild waves in the spring and summer of 1917 only to turn lethal in the fall and early winter of 1918.

It's understandable why so many people are fearful of H1N1 flu, which is also known as swine flu, said Dr. Jorge Parada, associate professor of medicine, infectious diseases, Loyola University Chicago Stritch School of Medicine, Maywood. The virus usually infects pigs and has rapidly spread around the world.

"The hysteria is primarily driven by two things: It's new and the data we have are not well established," said Parada, who is also medical director of the infection control program at Loyola University Health System in Maywood. "Another component of the fear is based on who is being most infected by H1N1 -- young people -- and the unexpected deaths among those young and otherwise healthy people."

Though there is some cause for concern about H1N1 flu, particularly during this time of the year with the regular seasonal flu season looming, there is little reason for panic, Parada said. Dramatic differences exist in medical knowledge and technology, epidemiology and clinical care between 1918 and today.

"Back then it was not quite as clear how diseases like the flu were transmitted and what could be done to decrease transmission," said Parada, who is also medical director of the infection control program at Loyola University Health System in Maywood.

In 1918, in the few cities where organized measures were instituted to limit infectious disease outbreaks, the spread of the Spanish flu was much lower, Parada said. Measures we take now include the frequent washing of hands, covering the nose and mouth after sneezing, avoiding touching the eyes, nose and mouth and using disinfectants on frequently touched surfaces where germs can linger.

"In most places that wasn't done. There was very little effort to block transmission and those people paid the price," Parada said.

Significantly, the Spanish flu pandemic occurred before the advent of antibiotics, which are effective in treating secondary infections caused by the flu, Parada said. A great many of the deaths that occurred during the 1918 pandemic were the results of secondary bacterial infections called post-influenza pneumonia.

"It was the pre-antibiotic age. If you had post-influenza pneumonia, the likelihood of doing poorly and dying were much higher," Parada said. "We're in the antibiotic age now and we do a much better job of treating and preventing post-influenza pneumonia."

In addition, in 1918 those infected with the Spanish flu didn't have access to the advanced care and technology standard in intensive care units across the country, Parada said. Without the aid of ventilators, for instance, victims of the 1918 pandemic who progressed to respiratory failure invariably died.

"They didn't have ventilators so they died," Parada said. "Instead of respiratory failure being a death sentence as it was in 1918, we can get you over the hump until you respond to treatment and are taken off the ventilator."

Also, unlike 1918, there are two prescription drug that are effective against the H1N1 flu strain -- Tamiflu (an oral medication) and Relenza (an inhaled medication). Millions of doses of both medications have been stockpiled by the federal and state governments for emergency use.

"The earlier treatment is started, the more effective it is," Parada said. "If treatment is started after 72 hours of symptoms, it has very limited effect. It has a greater effect if it's started after 48 hours and an even better effect if it's started within 24 hours of symptoms."

Better still, Tamiflu and Relenza can both be used to prevent infections, Parada said. This is called prophylaxis treatment.

"We try to limit the use of prophylaxis to special circumstances, especially in cases of persons weakened by cancer, transplant or HIV. The treatments can nip influenza infections in the bud,” Parada said. “These treatments are also used to treat health care workers who inadvertently become infected on the job. We can’t have all our workers getting sick, missing work or worse yet, coming to work ill and infecting our patients.”

However, the best treatment for the flu is prevention, Parada emphasized.

“I am a strong supporter of everyone receiving the yearly season flu shot, and once the H1N1 vaccine becomes available, I recommend that all high-risk patients get that vaccine as well,” Parada said.

Those patients include pregnant women, household contacts and caregivers for children younger than 6 months, healthcare and emergency medical services personnel, people from ages 6 months through 24 , people ages 25 through 64 years who have health conditions associated with higher risk of medical complications from influenza.

About Loyola University Health System

Loyola University Health System (LUHS) is part of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. Loyola University Medical Center’s campus is conveniently located in Maywood, 13 miles west of Chicago’s Loop and 8 miles east of Oak Brook, Ill. At the heart of the medical center campus is a 559-licensed-bed hospital that houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as Loyola University Chicago Stritch School of Medicine, Loyola University Chicago Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 255-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.

Trinity Health is a national Catholic health system with an enduring legacy and a steadfast mission to be a transforming and healing presence within the communities we serve. Trinity is committed to being a people-centered health care system that enables better health, better care and lower costs. Trinity Health has 88 hospitals and hundreds of continuing care facilities, home care agencies and outpatient centers in 21 states and 119,000 employees.