Zhiyong Mi, PhD

Surgery

Surgical Research
Assistant Professor

Languages Spoken

English

Research

  • Alcohol inhibits osteopontin-dependent transforming growth factor-beta1 expression in human mesenchymal stem cells Driver, J.; Weber, C. E.; Callaci, J. J.; Kothari, A. N.; Zapf, M. A.; Roper, P. M.; Borys, D.; Franzen, C. A.; Gupta, G. N.; Wai, P. Y.; Zhang, J.; Denning, M. F.; Kuo, P. C.; Mi, Z., The Journal of biological chemistry
  • Components of Hospital Perioperative Infrastructure Can Overcome the Weekend Effect in Urgent General Surgery Procedures Kothari, A. N.; Zapf, M. A.; Blackwell, R. H.; Markossian, T.; Chang, V.; Mi, Z.; Gupta, G. N.; Kuo, P. C., Annals of Surgery
  • Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular carcinoma Zapf, M. A.; Kothari, A. N.; Weber, C. E.; Arffa, M. L.; Wai, P. Y.; Driver, J.; Gupta, G. N.; Kuo, P. C.; Mi, Z., Surgery
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  • Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis Coombes, J. D.; Choi, S. S.; Swiderska-Syn, M.; Manka, P. P.; Reid, D.; Palma, E.; Briones-Orta, M. A.; Xie, G.; Younis, R.; Kitamura, N.; Della Peruta, M.; Bitencourt, S.; Dolle, L.; Oo, Y. H.; Mi, Z.; Kuo, P. C.; Williams, R.; Chokshi, S.; Canbay, A.; Claridge, L. C.; Eksteen, B.; Diehl, A. M.; Syn, W. K., Biochimica et biophysica acta
  • Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice Coombes, J. D.; Swiderska-Syn, M.; Dolle, L.; Reid, D.; Eksteen, B.; Claridge, L.; Briones-Orta, M. A.; Shetty, S.; Oo, Y. H.; Riva, A.; Chokshi, S.; Papa, S.; Mi, Z.; Kuo, P. C.; Williams, R.; Canbay, A.; Adams, D. H.; Diehl, A. M.; van Grunsven, L. A.; Choi, S. S.; Syn, W. K., Gut
  • Novel clinical therapeutics targeting the epithelial to mesenchymal transition Kothari, A. N.; Mi, Z.; Zapf, M.; Kuo, P. C., Clinical and translational medicine
  • Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication Choi, S. S.; Claridge, L. C.; Jhaveri, R.; Swiderska-Syn, M.; Clark, P.; Suzuki, A.; Pereira, T. A.; Mi, Z.; Kuo, P. C.; Guy, C. D.; Pereira, F. E.; Diehl, A. M.; Patel, K.; Syn, W. K., Clinical science (London, England : 1979)
  • Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer Weber, C. E.; Kothari, A. N.; Wai, P. Y.; Li, N. Y.; Driver, J.; Zapf, M. A.; Franzen, C. A.; Gupta, G. N.; Osipo, C.; Zlobin, A.; Syn, W. K.; Zhang, J.; Kuo, P. C.; Mi, Z., Oncogene
  • Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activity Guo, H.; Gao, C.; Mi, Z.; Wai, P. Y.; Kuo, P. C., The Biochemical journal
  • An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines Li, N. Y.; Weber, C. E.; Wai, P. Y.; Cuevas, B. D.; Zhang, J.; Kuo, P. C.; Mi, Z., Surgery
  • Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype Li, N. Y.; Weber, C. E.; Mi, Z.; Wai, P. Y.; Cuevas, B. D.; Kuo, P. C., Journal of the American College of Surgeons
  • Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers Bhattacharya, S. D.; Mi, Z.; Talbot, L. J.; Guo, H.; Kuo, P. C., Surgery
  • Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model Bhattacharya, S. D.; Mi, Z.; Kim, V. M.; Guo, H.; Talbot, L. J.; Kuo, P. C., Annals of Surgery
  • EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells. Zhang, J.; Guo, H.; Mi, Z.; Gao, C.; Bhattacharya, S.; Li, J.; Kuo, P. C., Experimental cell research
  • Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancer Mi, Z.; Guo, H.; Kuo, P. C., BMC research notes
  • RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. Mi, Z.; Guo, H.; Russell, M. B.; Liu, Y.; Sullenger, B. A.; Kuo, P. C., Molecular Therapy: the Journal of the American Society of Gene Therapy
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. Guo, H.; Mi, Z.; Kuo, P. C., Journal of Biological Chemistry
  • Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. Guo, H.; Wai, P. Y.; Mi, Z.; Gao, C.; Zhang, J.; Kuo, P. C., Surgery
  • PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes Yang, Q.; Larsen, S. K.; Mi, Z.; Robbins, P. D.; Basse, P. H., The AAPS journal
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. Guo, H.; Gao, C.; Mi, Z.; Zhang, J.; Kuo, P. C., Journal of Biochemistry
  • Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. Gao, C.; Guo, H.; Mi, Z.; Grusby, M. J.; Kuo, P. C., Journal of Immunology
  • Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. Gao, C.; Mi, Z.; Guo, H.; Kuo, P. C., Neoplasia (New York)
  • Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells. Takami, Y.; Russell, M. B.; Gao, C.; Mi, Z.; Guo, H.; Mantyh, C. R.; Kuo, P. C., Surgery
  • Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages. Guo, L.; Guo, H.; Gao, C.; Mi, Z.; Russell, W. B.; Kuo, P. C., Surgery
  • Targeting of products of genes to tumor sites using adoptively transferred A-NK and T-LAK cells Goding, S.; Yang, Q.; Mi, Z.; Robbins, P. D.; Basse, P. H., CANCER GENE THERAPY
  • Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells. Mi, Z.; Oliver, T.; Guo, H.; Gao, C.; Kuo, P. C., Cancer research
  • Ets-1 and runx2 regulate transcription of a metastatic gene osteopontin, in murine colorectal cancer cells., Wai, P. Y.; Mi, Z.; Gao, C.; Guo, H.; Marroquin, C.; Kuo, P. C., Journal of Biological Chemistry
  • Human viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis, Keravala, A.; Lechman, E. R.; Nash, J.; Mi, Z.; Robbins, P. D., ARTHRITIS RESEARCH & THERAPY
  • Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Mi, Z.; Guo, H.; Wai, P. Y.; Gao, C.; Kuo, P. C., Carcinogenesis
  • Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis Yao, Q.; Seol, D. W.; Mi, Z.; Robbins, P. D., ARTHRITIS RESEARCH & THERAPY
  • Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. Wai, P. Y.; Guo, L.; Gao, C.; Mi, Z.; Guo, H.; Kuo, P. C., Surgery
  • Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Guo, H.; Gao, C.; Mi, Z.; Wai, P. Y.; Kuo, P. C., Biochemical Journal
  • Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. Gao, C.; Guo, H.; Wei, J.; Mi, Z.; Wai, P. Y.; Kuo, P. C., Nitric Oxide
  • Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis. Wai, P. Y.; Mi, Z.; Guo, H.; Sarraf-Yazdi, S.; Gao, C.; Wei, J.; Marroquin, C. E.; Clary, B.; Kuo, P. C., Carcinogenesis
  • Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin. Gao, C.; Guo, H.; Mi, Z.; Wai, P. Y.; Kuo, P. C., Journal of Immunology
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. Gao, C.; Mi, Z.; Guo, H.; Wei, J.; Wai, P. Y.; Kuo, P. C., Biochemical & Biophysical Research Communications
  • Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. Mi, Z.; Guo, H.; Wai, P. Y.; Gao, C.; Wei, J.; Kuo, P. C., Journal of Biological Chemistry
  • S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. Gao, C.; Guo, H.; Wei, J.; Mi, Z.; Wai, P.; Kuo, P. C., Journal of Biological Chemistry
  • Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide Rehman, K. K.; Bertera, S.; Bottino, R.; Balamurugan, A. N.; Mai, J. C.; Mi, Z.; Trucco, M.; Robbins, P. D., The Journal of biological chemistry
  • The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen Lechman, E. R.; Keravala, A.; Nash, J.; Kim, S. H.; Mi, Z.; Robbins, P. D., Gene therapy
  • Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I Giannoukakis, N.; Mi, Z.; Rudert, W. A.; Gambotto, A.; Trucco, M.; Robbins, P., Gene therapy