Scott Cotler, MD


FCO Division Director, Hepatology

Languages Spoken


Clinical Expertise

  • Cirrhosis
  • Hepatitis B
  • Hepatitis C
  • Liver cancer

Medical Education

Medical School
University of Chicago Pritzker School of Medicine
University of Chicago Medical Center - Internal Medicine: General
Rush-Presbyterian-St. Luke's Medical Center - Internal Medicine: Gastroenterology, University of Washington Medical Center - Internal Medicine: Hepatology

Board Certification

American Board of Internal Medicine
American Board of Internal Medicine Subspecialty Transplant Hepatology


  • Adverse Effect of Post-Discharge Care Fragmentation on Outcomes after Readmissions after Liver Transplantation Kothari, A. N.; Loy, V. M.; Brownlee, S. A.; Ezure, Y.; Schaidle-Blackburn, C.; Cotler, S. J.; di Sabato, D.; Kuo, P. C.; Lu, A. D., Journal of the American College of Surgeons
  • An assessment of racial differences in the upper limits of normal ALT levels in children and the effect of obesity on elevated values Kliethermes, S.; Ma, M.; Purtell, C.; Balasubramanian, N.; Gonzalez, B.; Layden, T. J.; Cotler, S. J., Pediatric obesity
  • Cure prevents more than transmission of HCV Dahari, H.; Cotler, S. J.; Feld, J. J., Hepatology (Baltimore, Md.)
View All ResearchShow Less
  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Breslin, P.; Kuo, P.; Ding, X.; Cotler, S.; Nishimura, M.; Zhang, J.; Qiu, W.; Arteaga, M.; Zaidi, A.; Shang, N., Gene expression
  • HCV kinetic and modeling analyses indicate similar time to cure among sofosbuvir combination regimens with daclatasvir simeprevir or ledipasvir, Dahari, H.; Canini, L.; Graw, F.; Uprichard, S. L.; Araujo, E. S.; Penaranda, G.; Coquet, E.; Chiche, L.; Riso, A.; Renou, C.; Bourliere, M.; Cotler, S. J.; Halfon, P., Journal of Hepatology
  • Inhibition of SIRT2 suppresses hepatic fibrosis Arteaga, M.; Shang, N.; Ding, X.; Yong, S.; Cotler, S. J.; Denning, M. F.; Shimamura, T.; Breslin, P.; Luscher, B.; Qiu, W., American journal of physiology.Gastrointestinal and liver physiology
  • Resurrection of response-guided therapy for sofosbuvir combination therapies Dahari, H.; Halfon, P.; Cotler, S. J., Journal of Hepatology
  • Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer Kataria, Y.; Deaton, R. J.; Enk, E.; Jin, M.; Petrauskaite, M.; Dong, L.; Goldenberg, J. R.; Cotler, S. J.; Jensen, D. M.; van Breemen, R. B.; Gann, P. H., BMC GASTROENTEROLOGY
  • The time and cost investment required to obtain and initiate direct-acting antiviral therapy Loy, V.; Benyashvili, T.; Adams, W.; Pavkov, D.; O'Mahoney, M.; Cotler, S. J., ANTIVIRAL THERAPY
  • FAK is required for c-Met/beta-catenin-driven hepatocarcinogenesis Shang, N.; Arteaga, M.; Zaidi, A.; Stauffer, J.; Cotler, S. J.; Zeleznik-Le, N. J.; Zhang, J.; Qiu, W., Hepatology (Baltimore, Md.)
  • Mathematical Modeling of Hepatitis C Prevalence Reduction with Antiviral Treatment Scale-Up in Persons Who Inject Drugs in Metropolitan Chicago Echevarria, D.; Gutfraind, A.; Boodram, B.; Major, M.; Del Valle, S.; Cotler, S. J.; Dahari, H., PLoS ONE
  • Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised double-blind, placebo-controlled phase 2A trial, Koh, C.; Canini, L.; Dahari, H.; Zhao, X.; Uprichard, S. L.; Haynes-Williams, V.; Winters, M. A.; Subramanya, G.; Cooper, S. L.; Pinto, P.; Wolff, E. F.; Bishop, R.; Ai Thanda Han, M.; Cotler, S. J.; Kleiner, D. E.; Keskin, O.; Idilman, R.; Yurdaydin, C.; Glenn, J. S.; Heller, T., The Lancet.Infectious diseases
  • Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children Malespin, M.; Sleesman, B.; Lau, A.; Wong, S. S.; Cotler, S. J., Journal of clinical gastroenterology
  • Prevalence of suspected nonalcoholic fatty liver disease in Hispanic/Latino individuals differs by heritage Kallwitz, E. R.; Daviglus, M. L.; Allison, M. A.; Emory, K. T.; Zhao, L.; Kuniholm, M. H.; Chen, J.; Gouskova, N.; Pirzada, A.; Talavera, G. A.; Youngblood, M. E.; Cotler, S. J., Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics Dahari, H.; Shteingart, S.; Gafanovich, I.; Cotler, S. J.; D'Amato, M.; Pohl, R. T.; Weiss, G.; Ashkenazi, Y. J.; Tichler, T.; Goldin, E.; Lurie, Y., Liver international : official journal of the International Association for the Study of the Liver
  • The distribution of Hepatitis B virus exposure and infection in a population-based sample of US Hispanic adults Jung, M.; Kuniholm, M. H.; Ho, G. Y.; Cotler, S.; Strickler, H. D.; Thyagarajan, B.; Youngblood, M.; Kaplan, R. C.; Del Amo, J., Hepatology (Baltimore, Md.)
  • Association of genetic variants with rapid fibrosis: progression after liver transplantation for hepatitis C Layden, J. E.; Tayo, B. O.; Cotler, S. J.; Clark, N. M.; Baraoidan, K.; Friedman, S. L.; Cooper, R. S., Transplantation
  • Individualized treatment for patients with low HCV load (genotype 1): a viral kinetic approach Dahari, H.; Cotler, S. J., Hepatology (Baltimore, Md.)
  • Presurgical transarterial chemoembolization does not increase biliary stricture incidence in orthotopic liver transplant patients Casadaban, L.; Malespin, M.; Cheung, A.; McGuffey, R. A.; Boulay, B. R.; Halline, A. G.; Brown, R. D.; Cotler, S. J.; Jeon, H.; Bui, J. T.; Gaba, R. C., Transplantation proceedings
  • Understanding early serum hepatitis D virus and hepatitis B surface antigen kinetics during pegylated interferon-alpha therapy via mathematical modeling Guedj, J.; Rotman, Y.; Cotler, S. J.; Koh, C.; Schmid, P.; Albrecht, J.; Haynes-Williams, V.; Liang, T. J.; Hoofnagle, J. H.; Heller, T.; Dahari, H., Hepatology (Baltimore, Md.)
  • Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life Guedj, J.; Dahari, H.; Rong, L.; Sansone, N. D.; Nettles, R. E.; Cotler, S. J.; Layden, T. J.; Uprichard, S. L.; Perelson, A. S., Proceedings of the National Academy of Sciences of the United States of America
  • Physical activity and metabolic syndrome in liver transplant recipients Kallwitz, E. R.; Loy, V.; Mettu, P.; Von Roenn, N.; Berkes, J.; Cotler, S. J., Liver Transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • Prognostic capability of different liver disease scoring systems for prediction of early mortality after transjugular intrahepatic portosystemic shunt creation Gaba, R. C.; Couture, P. M.; Bui, J. T.; Knuttinen, M. G.; Walzer, N. M.; Kallwitz, E. R.; Berkes, J. L.; Cotler, S. J., Journal of vascular and interventional radiology : JVIR
  • Quantitative morphometric analysis of hepatocellular carcinoma: development of a programmed algorithm and preliminary application Yap, F. Y.; Bui, J. T.; Knuttinen, M. G.; Walzer, N. M.; Cotler, S. J.; Owens, C. A.; Berkes, J. L.; Gaba, R. C., Diagnostic and interventional radiology (Ankara, Turkey)
  • Understanding triphasic HCV decline during treatment in the era of IL28B polymorphisms and direct acting antiviral agents via mathematical modeling Dahari, H.; Cotler, S. J.; Layden, T. J.; Perelson, A. S., Journal of Hepatology
  • Barriers to treatment of hepatitis B in an urban Chinatown community Malespin, M.; Wong, S.; Siqueira, F.; Luc, B.; Ravaee, B.; Vainder, C.; Cotler, S. J., Journal of clinical gastroenterology
  • Characterizing hepatitis B stigma in Chinese immigrants Cotler, S. J.; Cotler, S.; Xie, H.; Luc, B. J.; Layden, T. J.; Wong, S. S., Journal of viral hepatitis
  • Characterizing hepatitis B stigma in Chinese immigrants Cotler, S. J.; Cotler, S.; Xie, H.; Luc, B. J.; Layden, T. J.; Wong, S. S., Journal of viral hepatitis
  • Impact of donor and recipient race on survival after hepatitis C-related liver transplantation Layden, J. E.; Cotler, S. J.; Grim, S. A.; Fischer, M. J.; Lucey, M. R.; Clark, N. M., Transplantation
  • Racial differences in fibrosis progression after HCV-related liver transplantation Layden, J. E.; Cotler, S.; Brown, K. A.; Lucey, M. R.; Te, H. S.; Eswaran, S.; Fimmel, C.; Layden, T. J.; Clark, N. M., Transplantation
  • TIPS for treatment of variceal hemorrhage: clinical outcomes in 128 patients at a single institution over a 12-year period Gaba, R. C.; Omene, B. O.; Podczerwinski, E. S.; Knuttinen, M. G.; Cotler, S. J.; Kallwitz, E. R.; Berkes, J. L.; Walzer, N. M.; Bui, J. T.; Owens, C. A., Journal of vascular and interventional radiology : JVIR
  • Potential treatment options and future research to increase hepatitis C virus treatment response rate Tencate, V.; Sainz, B., Jr; Cotler, S. J.; Uprichard, S. L., Hepatic medicine : evidence and research
  • Laboratory diagnosis and nonoperative management of biliary complications in living donor liver transplant patients Venu, M.; Brown, R. D.; Lepe, R.; Berkes, J.; Cotler, S. J.; Benedetti, E.; Testa, G.; Venu, R. P., Journal of clinical gastroenterology
  • Hepatic ischemia/reperfusion injury can be modulated with thymoglobulin induction therapy. Bogetti, D.; Jarzembowski, T. M.; Sankary, H. N.; Manzelli, A.; Knight, P. S.; Chejfec, G.; Cotler, S.; Oberholzer, J.; Testa, G.; Benedetti, E., Transplantation proceedings
  • Thymoglobulin induction protects liver allografts from ischemia/reperfusion injury. Bogetti, D.; Sankary, H. N.; Jarzembowski, T. M.; Manzelli, A.; Knight, P. S.; Thielke, J.; Chejfec, G.; Cotler, S.; Oberholzer, J.; Testa, G.; Benedetti, E., Clinical transplantation