Ruben Mestril, PhD

Cell and Molecular Physiology

Medicine, Cardiology

Languages Spoken

English, Spanish, French, German



Primary field of interest:
Study of the roles of heat shock proteins play in cardiac and skeletal muscle.

Movies, Chess, Soccer

Medical Education

German Cancer Research Institute, Germany - Research


  • HSP72 protects against obesity-induced insulin resistance. Chung, J.; Nguyen, A. K.; Henstridge, D. C.; Holmes, A. G.; Chan, M. H.; Mesa, J. L.; Lancaster, G. I.; Southgate, R. J.; Bruce, C. R.; Duffy, S. J.; Horvath, I.; Mestril, R.; Watt, M. J.; Hooper, P. L.; Kingwell, B. A.; Vigh, L.; Hevener, A.; Febbraio, M. A., Proceedings of the National Academy of Sciences of the United States of America
  • CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Kumar, P.; Ambasta, R. K.; Veereshwarayya, V.; Rosen, K. M.; Kosik, K. S.; Band, H.; Mestril, R.; Patterson, C.; Querfurth, H. W., Human molecular genetics
  • Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection. Islamovic, E.; Duncan, A.; Bers, D. M.; Gerthoffer, W. T.; Mestril, R., Journal of Molecular & Cellular Cardiology
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  • Influence of PKC-alpha overexpression on HSP70 and cardioprotection. Coaxum, S. D.; Griffin, T. M.; Martin, J. L.; Mestril, R., American Journal of Physiology - Heart & Circulatory Physiology
  • Troponin I levels in patients with preeclampsia. Joyal, D.; Leya, F.; Koh, M.; Besinger, R.; Ramana, R.; Kahn, S.; Jeske, W.; Lewis, B.; Steen, L.; Mestril, R.; Arab, D., American Journal of Medicine
  • Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Colston, J. T.; de la Rosa, S. D.; Koehler, M.; Gonzales, K.; Mestril, R.; Freeman, G. L.; Bailey, S. R.; Chandrasekar, B., American Journal of Physiology - Heart & Circulatory Physiology
  • Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes Liu, J.; Tang, M.; Mestril, R.; Wang, X., Journal of Molecular & Cellular Cardiology
  • Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes Guo, T.; Zhang, T.; Mestril, R.; Bers, D. M., Circulation research
  • Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis. Veereshwarayya, V.; Kumar, P.; Rosen, K. M.; Mestril, R.; Querfurth, H. W., Journal of Biological Chemistry
  • Downregulation of the constitutively expressed Hsc70 in diabetic myocardium is mediated by insulin deficiency. Chen, H. S.; Jia, J.; Su, H. F.; Lin, H. D.; Chen, J. W.; Lin, S. J.; Yang, J. Y.; Lai, H. C.; Mestril, R.; Wang, P. H., Journal of Endocrinology
  • Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes Maier, L. S.; Ziolo, M. T.; Bossuyt, J.; Persechini, A.; Mestril, R.; Bers, D. M., Journal of Molecular & Cellular Cardiology
  • Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity. Broome, C. S.; Kayani, A. C.; Palomero, J.; Dillmann, W. H.; Mestril, R.; Jackson, M. J.; McArdle, A., FASEB Journal
  • Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts. Liu, J.; Chen, Q.; Huang, W.; Horak, K. M.; Zheng, H.; Mestril, R.; Wang, X., FASEB Journal
  • Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning. Miyabara, E. H.; Martin, J. L.; Griffin, T. M.; Moriscot, A. S.; Mestril, R., American Journal of Physiology - Cell Physiology
  • 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo. Kroll, T. M.; Bommiasamy, H.; Boissy, R. E.; Hernandez, C.; Nickoloff, B. J.; Mestril, R.; Le Poole, I. C., Journal of Investigative Dermatology
  • Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA. Blum, J. L.; Samarel, A. M.; Mestril, R., American Journal of Physiology - Heart & Circulatory Physiology
  • The use of transgenic mice to study cytoprotection by the stress proteins. Mestril, R., Methods (Duluth)
  • Overexpression of heat shock proteins differentially modulates protein kinase C expression in rat neonatal cardiomyocytes. Coaxum, S. D.; Martin, J. L.; Mestril, R., Cell stress & chaperones