Ruben Mestril, PhD | Loyola Medicine

COVID-19 (Coronavirus) Update

Loyola Medicine is resuming select health care services. Learn more about resumption of services.

Ruben Mestril, PhD

Cell and Molecular Physiology

Professor

Languages Spoken

English, Spanish,French,German

Clinical Expertise

Biography

Biography

Primary field of interest:
Study of the roles of heat shock proteins play in cardiac and skeletal muscle.

Interests
Movies;Chess;Soccer

Medical Education

Medical School
Residency
Fellowship
  • German Cancer Research Institute, Germany - Research

Board Certification

Research

  • Protein kinase C-a interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells. Nowak, G; Soundararajan, S; Mestril, R, American journal of physiology. Renal physiology
  • Hyperthermia: from diagnostic and treatments to new discoveries Romero-Suarez, S.; Mo, C.; Touchberry, C.; Lara, N.; Baker, K.; Craig, R.; Brotto, L.; Andresen, J.; Wacker, M.; Kaja, S.; Abreu, E.; Dillmann, W.; Mestril, R.; Brotto, M.; Nosek, T., Recent patents on biotechnology
  • HSP72 protects against obesity-induced insulin resistance. Chung, J.; Nguyen, A. K.; Henstridge, D. C.; Holmes, A. G.; Chan, M. H.; Mesa, J. L.; Lancaster, G. I.; Southgate, R. J.; Bruce, C. R.; Duffy, S. J.; Horvath, I.; Mestril, R.; Watt, M. J.; Hooper, P. L.; Kingwell, B. A.; Vigh, L.; Hevener, A.; Febbraio, M. A., Proceedings of the National Academy of Sciences of the United States of America
View All ResearchShow Less
  • CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Kumar, P.; Ambasta, R. K.; Veereshwarayya, V.; Rosen, K. M.; Kosik, K. S.; Band, H.; Mestril, R.; Patterson, C.; Querfurth, H. W., Human molecular genetics
  • Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection. Islamovic, E.; Duncan, A.; Bers, D. M.; Gerthoffer, W. T.; Mestril, R., Journal of Molecular & Cellular Cardiology
  • Influence of PKC-alpha overexpression on HSP70 and cardioprotection. Coaxum, S. D.; Griffin, T. M.; Martin, J. L.; Mestril, R., American Journal of Physiology - Heart & Circulatory Physiology
  • Troponin I levels in patients with preeclampsia. Joyal, D.; Leya, F.; Koh, M.; Besinger, R.; Ramana, R.; Kahn, S.; Jeske, W.; Lewis, B.; Steen, L.; Mestril, R.; Arab, D., American Journal of Medicine
  • Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Colston, J. T.; de la Rosa, S. D.; Koehler, M.; Gonzales, K.; Mestril, R.; Freeman, G. L.; Bailey, S. R.; Chandrasekar, B., American Journal of Physiology - Heart & Circulatory Physiology
  • Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes Liu, J.; Tang, M.; Mestril, R.; Wang, X., Journal of Molecular & Cellular Cardiology
  • Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes Guo, T.; Zhang, T.; Mestril, R.; Bers, D. M., Circulation research
  • Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis. Veereshwarayya, V.; Kumar, P.; Rosen, K. M.; Mestril, R.; Querfurth, H. W., Journal of Biological Chemistry
  • Downregulation of the constitutively expressed Hsc70 in diabetic myocardium is mediated by insulin deficiency. Chen, H. S.; Jia, J.; Su, H. F.; Lin, H. D.; Chen, J. W.; Lin, S. J.; Yang, J. Y.; Lai, H. C.; Mestril, R.; Wang, P. H., Journal of Endocrinology
  • Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes Maier, L. S.; Ziolo, M. T.; Bossuyt, J.; Persechini, A.; Mestril, R.; Bers, D. M., Journal of Molecular & Cellular Cardiology
  • Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity. Broome, C. S.; Kayani, A. C.; Palomero, J.; Dillmann, W. H.; Mestril, R.; Jackson, M. J.; McArdle, A., FASEB Journal
  • Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts. Liu, J.; Chen, Q.; Huang, W.; Horak, K. M.; Zheng, H.; Mestril, R.; Wang, X., FASEB Journal
  • Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning. Miyabara, E. H.; Martin, J. L.; Griffin, T. M.; Moriscot, A. S.; Mestril, R., American Journal of Physiology - Cell Physiology
  • 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo. Kroll, T. M.; Bommiasamy, H.; Boissy, R. E.; Hernandez, C.; Nickoloff, B. J.; Mestril, R.; Le Poole, I. C., Journal of Investigative Dermatology
  • Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA. Blum, J. L.; Samarel, A. M.; Mestril, R., American Journal of Physiology - Heart & Circulatory Physiology
  • The use of transgenic mice to study cytoprotection by the stress proteins. Mestril, R., Methods (Duluth)
  • Overexpression of heat shock proteins differentially modulates protein kinase C expression in rat neonatal cardiomyocytes. Coaxum, S. D.; Martin, J. L.; Mestril, R., Cell stress & chaperones