Pieter de Tombe, PhD

Cell and Molecular Physiology

Professor
Department Chairperson, Cell and Molecular Physiology

Languages Spoken

English, Dutch, German

Biography

Interests
Photography, Travel

Board Certification

American Nurses Credentialing Center
Anesthesiology
American Board of

Research

  • Myosin light chain phosphorylation novel targets to repair a broken heart?, Szczesna-Cordary, D.; de Tombe, P. P., Cardiovascular research
  • Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure Paudyal, A.; Dewan, S.; Ikie, C.; Whalley, B. J.; de Tombe, P. P.; Boateng, S. Y., The Journal of physiology
  • R-CEPIA1er as a new tool to directly measure sarcoplasmic reticulum [Ca] in ventricular myocytes Bovo, E.; Martin, J. L.; Tyryfter, J.; de Tombe, P. P.; Zima, A. V., American journal of physiology.Heart and circulatory physiology
View All ResearchShow Less
  • A Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy Associated Mutation in Human Cardiac Troponin I (K206I) Warren, C. M.; Karam, C. N.; Wolska, B. M.; Kobayashi, T.; de Tombe, P. P.; Arteaga, G. M.; Bos, J. M.; Ackerman, M. J.; Solaro, R. J., Circulation.Cardiovascular Genetics
  • Acute Inotropic and Lusitropic Effects of Cardiomyopathic R9C Mutation of Phospholamban Abrol, N.; de Tombe, P. P.; Robia, S. L., The Journal of biological chemistry
  • Cardiac muscle mechanics: Sarcomere length matters de Tombe, P. P.; Ter Keurs, H. E., Journal of Molecular and Cellular Cardiology
  • Cardiac myosin binding protein C and Troponin-I phosphorylation independently modulate myofilament length dependent activation Kumar, M.; Govindan, S.; Zhang, M.; Khairallah, R.; Martin, J. L.; Sadayappan, S.; de Tombe, P. P., The Journal of biological chemistry
  • Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin I (K206I) Warren, C. M.; Karam, C. N.; Wolska, B. M.; Kobayashi, T.; de Tombe, P. P.; Arteaga, G. M.; Bos, J. M.; Ackerman, M. J.; Solaro, R. J., Circulation.Cardiovascular Genetics
  • Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation Bovo, E.; Mazurek, S. R.; de Tombe, P. P.; Zima, A. V., Biophysical journal
  • Myosin light chain phosphorylation to the rescue Granzier, H. L.; de Tombe, P. P., Proceedings of the National Academy of Sciences of the United States of America
  • Pacemaker-induced transient asynchrony suppresses heart failure progression Kirk, J. A.; Chakir, K.; Lee, K. H.; Karst, E.; Holewinski, R. J.; Pironti, G.; Tunin, R. S.; Pozios, I.; Abraham, T. P.; de Tombe, P.; Rockman, H. A.; Van Eyk, J. E.; Craig, R.; Farazi, T. G.; Kass, D. A., Science translational medicine
  • Rapid large-scale purification of myofilament proteins using a cleavable His6-tag Zhang, M.; Martin, J. L.; Kumar, M.; Khairallah, R. J.; de Tombe, P. P., American journal of physiology.Heart and circulatory physiology
  • Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series Sadayappan, S.; de Tombe, P. P., Pflugers Archiv : European journal of physiology
  • Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3beta Kirk, J. A.; Holewinski, R. J.; Kooij, V.; Agnetti, G.; Tunin, R. S.; Witayavanitkul, N.; de Tombe, P. P.; Gao, W. D.; Van Eyk, J.; Kass, D. A., The Journal of clinical investigation
  • Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca sensitivity and accelerates deactivation Salhi, H. E.; Walton, S. D.; Hassel, N. C.; Brundage, E. A.; de Tombe, P. P.; Janssen, P. M.; Davis, J. P.; Biesiadecki, B. J., Journal of Molecular and Cellular Cardiology
  • Cardiomyocyte-specific expression of CRNK the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy, Koshman, Y. E.; Chu, M.; Kim, T.; Kalmanson, O.; Farjah, M.; Kumar, M.; Lewis, W.; Geenen, D. L.; de Tombe, P.; Goldspink, P. H.; Solaro, R. J.; Samarel, A. M., Journal of Molecular and Cellular Cardiology
  • Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy Barefield, D.; Kumar, M.; de Tombe, P. P.; Sadayappan, S., American journal of physiology.Heart and circulatory physiology
  • Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure Wilson, K.; Guggilam, A.; West, T. A.; Zhang, X.; Trask, A. J.; Cismowski, M. J.; de Tombe, P.; Sadayappan, S.; Lucchesi, P. A., American journal of physiology.Heart and circulatory physiology
  • Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice Barefield, D.; Kumar, M.; Gorham, J.; Seidman, J. G.; Seidman, C. E.; de Tombe, P. P.; Sadayappan, S., Journal of Molecular and Cellular Cardiology
  • Heart failure: a special issue van der Velden, J.; de Tombe, P. P., Pflugers Archiv : European journal of physiology
  • Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium Witayavanitkul, N.; Ait Mou, Y.; Kuster, D. W.; Khairallah, R. J.; Sarkey, J.; Govindan, S.; Chen, X.; Ge, Y.; Rajan, S.; Wieczorek, D. F.; Irving, T.; Westfall, M. V.; de Tombe, P. P.; Sadayappan, S., The Journal of biological chemistry
  • Novel approaches to determine contractile function of the isolated adult zebrafish ventricular cardiac myocyte Dvornikov, A. V.; Dewan, S.; Alekhina, O. V.; Pickett, F. B.; de Tombe, P. P., The Journal of physiology
  • The Role of Dyadic Organization in Regulation of Sarcoplasmic Reticulum Ca(2+) Handling during Rest in Rabbit Ventricular Myocytes Bovo, E.; de Tombe, P. P.; Zima, A. V., Biophysical journal
  • Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle Mateja, R. D.; Greaser, M. L.; de Tombe, P. P., Biochimica et biophysica acta
  • Mechanisms of Ca(2)+ handling in zebrafish ventricular myocytes Bovo, E.; Dvornikov, A. V.; Mazurek, S. R.; de Tombe, P. P.; Zima, A. V., Pflugers Archiv : European journal of physiology
  • New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I Henze, M.; Patrick, S. E.; Hinken, A.; Scruggs, S. B.; Goldspink, P.; de Tombe, P. P.; Kobayashi, M.; Ping, P.; Kobayashi, T.; Solaro, R. J., Biochimica et biophysica acta
  • Sex differences in health and disease: brain and heart connections--a special issue Wattanapermpool, J.; de Tombe, P. P.; Pak, T. R., Pflugers Archiv : European journal of physiology
  • Cardiac myosin binding protein-C: redefining its structure and function Sadayappan, S.; de Tombe, P. P., Biophysical reviews
  • Myofilament length-dependent activation develops within 5 ms in guinea-pig myocardium Mateja, R. D.; de Tombe, P. P., Biophysical journal
  • Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. Govindan, S.; Sarkey, J.; Ji, X.; Sundaresan, N. R.; Gupta, M. P.; de Tombe, P. P.; Sadayappan, S., Journal of Muscle Research & Cell Motility
  • The velocity of cardiac sarcomere shortening: mechanisms and implications de Tombe, P. P.; ter Keurs, H. E., JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
  • Equal force recovery in dysferlin-deficient and wild-type muscles following saponin exposure. Zhao, P.; Xu, L.; Ait-Mou, Y.; de Tombe, P. P.; Han, R., Journal of Biomedicine & Biotechnology
  • Myosin head orientation: a structural determinant for the Frank-Starling relationship. Farman, G. P.; Gore, D.; Allen, E.; Schoenfelt, K.; Irving, T. C.; de Tombe, P. P., American Journal of Physiology - Heart & Circulatory Physiology
  • Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes. Sarkey, J. P.; Chu, M.; McShane, M.; Bovo, E.; Mou, Y. A.; Zima, A. V.; de Tombe, P. P.; Kartje, G. L.; Martin, J. L., Journal of Molecular & Cellular Cardiology
  • Myofilament length dependent activation de Tombe, P. P.; Mateja, R. D.; Tachampa, K.; Mou, Y. A.; Farman, G. P.; Irving, T. C., Journal of Molecular & Cellular Cardiology
  • Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. Scruggs, S. B.; Hinken, A. C.; Thawornkaiwong, A.; Robbins, J.; Walker, L. A.; de Tombe, P. P.; Geenen, D. L.; Buttrick, P. M.; Solaro, R. J., Journal of Biological Chemistry
  • Glass microneedles for force measurements: a finite-element analysis model. Ayittey, P. N.; Walker, J. S.; Rice, J. J.; de Tombe, P. P., Pflugers Archiv - European Journal of Physiology
  • Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Rice, J. J.; Wang, F.; Bers, D. M.; de Tombe, P. P., Biophysical journal
  • Blebbistatin: use as inhibitor of muscle contraction. Farman, G. P.; Tachampa, K.; Mateja, R.; Cazorla, O.; Lacampagne, A.; de Tombe, P. P., Pflugers Archiv - European Journal of Physiology
  • Cardiac thin filament regulation Kobayashi, T.; Jin, L.; de Tombe, P. P., Pflugers Archiv - European Journal of Physiology
  • Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes. Koshman, Y. E.; Waters, S. B.; Walker, L. A.; Los, T.; de Tombe, P. P.; Goldspink, P. H.; Russell, B., Journal of Molecular & Cellular Cardiology
  • Differential contribution of cardiac sarcomeric proteins in the myofibrillar force response to stretch. Ait Mou, Y.; le Guennec, J. Y.; Mosca, E.; de Tombe, P. P.; Cazorla, O., Pflugers Archiv - European Journal of Physiology
  • Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle. Tachampa, K.; Kobayashi, T.; Wang, H.; Martin, A. F.; Biesiadecki, B. J.; Solaro, R. J.; de Tombe, P. P., Journal of Biological Chemistry
  • Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function. Solaro, R. J.; de Tombe, P. P., Cardiovascular research
  • Some rat: a very special rat with a rather special titin. Cazorla, O.; de Tombe, P. P., Journal of Molecular & Cellular Cardiology
  • Spatially-compressed cardiac myofilament models generate hysteresis that is not found in real muscle. Rice, J. J.; Tu, Y.; Poggesi, C.; De Tombe, P. P., Pacific Symposium on Biocomputing
  • Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?. Marston, S. B.; de Tombe, P. P., Journal of Molecular & Cellular Cardiology
  • Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure Belin, R. J.; Sumandea, M. P.; Allen, E. J.; Schoenfelt, K.; Wang, H.; Solaro, R. J.; de Tombe, P. P., Circulation research
  • Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein. Boateng, S. Y.; Belin, R. J.; Geenen, D. L.; Margulies, K. B.; Martin, J. L.; Hoshijima, M.; de Tombe, P. P.; Russell, B., American Journal of Physiology - Heart & Circulatory Physiology
  • Cardiac troponin I threonine 144: role in myofilament length dependent activation. Tachampa, K.; Wang, H.; Farman, G. P.; de Tombe, P. P., Circulation research
  • Development of contractile dysfunction in rat heart failure: hierarchy of cellular events. Daniels, M. C.; Naya, T.; Rundell, V. L.; de Tombe, P. P., American Journal of Physiology - Regulatory Integrative & Comparative Physiology
  • Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. Lamberts, R. R.; Hamdani, N.; Soekhoe, T. W.; Boontje, N. M.; Zaremba, R.; Walker, L. A.; de Tombe, P. P.; van der Velden, J.; Stienen, G. J., Journal of Physiology
  • Impact of temperature on cross-bridge cycling kinetics in rat myocardium. de Tombe, P. P.; Stienen, G. J., Journal of Physiology
  • Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae. Farman, G. P.; Allen, E. J.; Gore, D.; Irving, T. C.; de Tombe, P. P., Biophysical journal
  • Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics. de Tombe, P. P.; Belus, A.; Piroddi, N.; Scellini, B.; Walker, J. S.; Martin, A. F.; Tesi, C.; Poggesi, C., American Journal of Physiology - Regulatory Integrative & Comparative Physiology
  • p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. Vahebi, S.; Ota, A.; Li, M.; Warren, C. M.; de Tombe, P. P.; Wang, Y.; Solaro, R. J., Circulation research
  • The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Biesiadecki, B. J.; Kobayashi, T.; Walker, J. S.; John Solaro, R.; de Tombe, P. P., Circulation research