Paul C. Kuo, MD, MBA, FACS

Surgery

Surgical Oncology
Public Health Sciences
Professor
Department Chairperson, Surgery, Director, Oncology Institute

Languages Spoken

English

Clinical Expertise

  • Bile Duct Cancer
  • Bile Duct Disorders
  • Gallbladder Disorders
  • Gastroesophageal Reflux (GERD)
  • Gastrointestinal Surgery
  • Hernia
  • Liver Cancer
  • Liver Disorders

Medical Education

Medical School
Johns Hopkins University School of Medicine
Residency
Brigham and Women's Hospital - General Surgery
Fellowship
Beth Israel Deaconess Medical Center/Harvard University Medical School - Transplant/Hepatobiliary Surgery

Board Certification

American Board of Surgery Subspecialty Surgical Critical Care

Research

  • "Take the Volume Pledge" may result in disparity in access to care Blanco, B. A.; Kothari, A. N.; Blackwell, R. H.; Brownlee, S. A.; Yau, R. M.; Attisha, J. P.; Ezure, Y.; Pappas, S.; Kuo, P. C.; Abood, G. J., Surgery
  • Adverse Effect of Post-Discharge Care Fragmentation on Outcomes after Readmissions after Liver Transplantation Kothari, A. N.; Loy, V. M.; Brownlee, S. A.; Ezure, Y.; Schaidle-Blackburn, C.; Cotler, S. J.; di Sabato, D.; Kuo, P. C.; Lu, A. D., Journal of the American College of Surgeons
  • Association Between Elements of Electronic Health Record Systems and the Weekend Effect in Urgent General Surgery Kothari, A. N.; Brownlee, S. A.; Blackwell, R. H.; Zapf, M. A.; Markossian, T.; Gupta, G. N.; Kuo, P. C., JAMA surgery
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  • Discordance between surgical care improvement project adherence and postoperative outcomes: implications for new Joint Commission standards Chang, V.; Blackwell, R. H.; Markossian, T.; Yau, R. M.; Blanco, B. A.; Zapf, M. A. C.; Abood, G. J.; Gupta, G. N.; Kuo, P. C.; Kothari, A. N., The Journal of surgical research
  • Impact of hospital transfer on surgical outcomes of intestinal atresia Erickson, T.; Vana, P. G.; Blanco, B. A.; Brownlee, S. A.; Paddock, H. N.; Kuo, P. C.; Kothari, A. N., American Journal of Surgery
  • Perioperative support not volume, is necessary to optimize outcomes in surgical management of necrotizing enterocolitis, Cobb, A. N.; Wong, Y. M.; Brownlee, S. A.; Blanco, B. A.; Ezure, Y.; Paddock, H. N.; Kuo, P. C.; Kothari, A. N., American Journal of Surgery
  • Postoperative Urinary Retention is an Independent Predictor of Short- and Long-Term Future Bladder Outlet Procedure in Men Blackwell, R. H.; Vedachalam, S.; Shah, A. S.; Kothari, A. N.; Kuo, P. C.; Gupta, G. N.; Turk, T. M. T., The Journal of urology
  • Rates and Risk Factors for Opioid Dependence and Overdose After Urologic Surgery Shah, A. S.; Blackwell, R. H.; Kuo, P. C.; Gupta, G. N., The Journal of urology
  • Transient atrial fibrillation after open abdominal aortic revascularization surgery is associated with increased length of stay mortality, and readmission rates, Blanco, B. A.; Kothari, A. N.; Halandras, P. M.; Blackwell, R. H.; Graunke, D. M.; Kuo, P. C.; Cho, J. S., Journal of Vascular Surgery
  • Acute Kidney Injury in Burn Patients: Clinically Significant Over the Initial Hospitalization and 1 Year After Injury: An Original Retrospective Cohort Study Thalji, S. Z.; Kothari, A. N.; Kuo, P. C.; Mosier, M. J., Annals of Surgery
  • Characterizing the role of a high-volume cancer resection ecosystem on low-volume high-quality surgical care, Kothari, A. N.; Blanco, B. A.; Brownlee, S. A.; Evans, A. E.; Chang, V. A.; Abood, G. J.; Settimi, R.; Raicu, D. S.; Kuo, P. C., Surgery
  • Early Intervention during Acute Stone Admissions: Revealing "The Weekend Effect" in Urological Practice Blackwell, R. H.; Barton, G. J.; Kothari, A. N.; Zapf, M. A.; Flanigan, R. C.; Kuo, P. C.; Gupta, G. N., The Journal of urology
  • Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis Arffa, M. L.; Zapf, M. A.; Kothari, A. N.; Chang, V.; Gupta, G. N.; Ding, X.; Al-Gayyar, M. M.; Syn, W.; Elsherbiny, N. M.; Kuo, P. C.; Mi, Z., PLoS ONE
  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Shang, N.; Arteaga, M.; Zaidi, A.; Colter, S.; Breslin, P.; Ding, X.; Kuo, P.; Nishimura, M.; Zhang, J.; Qiu, W., Gene expression
  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Na, S.; Arteaga, M.; Zaidi, A.; Colter, S.; Breslin, P.; Ding, X.; Kuo, P.; Nishimura, M.; Zhang, J.; Qiu, W., Gene expression
  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Breslin, P.; Kuo, P.; Ding, X.; Cotler, S.; Nishimura, M.; Zhang, J.; Qiu, W.; Arteaga, M.; Zaidi, A.; Shang, N., Gene expression
  • Impact of Post-Hospital Syndrome on Outcomes Following Elective Ambulatory Surgery, Brownlee, S. A.; Blackwell, R. H.; Blanco, B. A.; Zapf, M. A.; Kliethermes, S.; Gupta, G. N.; Kuo, P. C.; Kothari, A. N., Annals of Surgery
  • Inpatient Rehabilitation after Liver Transplantation Decreases Risk and Severity of 30-Day Readmissions Kothari, A. N.; Yau, R. M.; Blackwell, R. H.; Schaidle-Blackburn, C.; Markossian, T.; Zapf, M. A.; Lu, A. D.; Kuo, P. C., Journal of the American College of Surgeons
  • Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice Xin, J.; Breslin, P.; Wei, W.; Li, J.; Gutierrez, R.; Cannova, J.; Ni, A.; Ng, G.; Schmidt, R.; Chen, H.; Parini, V.; Kuo, P. C.; Kini, A. R.; Stiff, P.; Zhu, J.; Zhang, J., Haematologica
  • New onset postoperative atrial fibrillation predicts long-term cardiovascular events after gastrectomy Nassoiy, S. P.; Blackwell, R. H.; Kothari, A. N.; Besser, S.; Gupta, G. N.; Kuo, P. C.; Abood, G. J., American Journal of Surgery
  • Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis Coombes, J. D.; Choi, S. S.; Swiderska-Syn, M.; Manka, P.; Reid, D. T.; Palma, E.; Briones-Orta, M. A.; Xie, G.; Younis, R.; Kitamura, N.; Della Peruta, M.; Bitencourt, S.; Dolle, L.; Oo, Y. H.; Mi, Z.; Kuo, P. C.; Williams, R.; Chokshi, S.; Canbay, A.; Claridge, L. C.; Eksteen, B.; Diehl, A. M.; Syn, W. K., Biochimica et biophysica acta
  • Osteopontin-A Master Regulator of Epithelial-Mesenchymal Transition Kothari, A. N.; Arffa, M. L.; Chang, V.; Blackwell, R. H.; Syn, W. K.; Zhang, J.; Mi, Z.; Kuo, P. C., Journal of clinical medicine
  • Outcomes of percutaneous nephrolithotomy in spinal cord injury patients as compared to a matched cohort Baldea, K. G.; Blackwell, R. H.; Vedachalam, S.; Kothari, A. N.; Kuo, P. C.; Gupta, G. N.; Turk, T. M., Urolithiasis
  • Pancreatic Cancer and Osteopontin: The Relationship Remains Unclear Weber, C. E.; Ersahin, C. H.; Kuo, P. C.; Mi, Z., Pancreas
  • PLK-1 Silencing in Bladder Cancer by siRNA Delivered With Exosomes Greco, K. A.; Franzen, C. A.; Foreman, K. E.; Flanigan, R. C.; Kuo, P. C.; Gupta, G. N., Urology
  • Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway Xin, J.; You, D.; Breslin, P.; Li, J.; Zhang, J.; Wei, W.; Cannova, J.; Volk, A.; Gutierrez, R.; Xiao, Y.; Ni, A.; Ng, G.; Schmidt, R.; Xia, Z.; Pan, J.; Chen, H.; Patel, M. M.; Kuo, P. C.; Nand, S.; Kini, A. R.; Zhang, J.; Chen, J.; Zhu, J.; Zhang, J., Leukemia
  • Transient postoperative atrial fibrillation after abdominal aortic aneurysm repair increases mortality risk Kothari, A. N.; Halandras, P. M.; Drescher, M.; Blackwell, R. H.; Graunke, D. M.; Kliethermes, S.; Kuo, P. C.; Cho, J. S., Journal of Vascular Surgery
  • Variable surgical outcomes after hospital consolidation: Implications for local health care delivery Chang, V.; Blackwell, R. H.; Yau, R. M.; Besser, S.; Albright, J. M.; Gupta, G. N.; Kuo, P. C.; Kothari, A. N., Surgery
  • "Right place at the right time" impacts outcomes for acute intestinal obstruction Kothari, A. N.; Liles, J. L.; Holmes, C. J.; Zapf, M. A.; Blackwell, R. H.; Kliethermes, S.; Kuo, P. C.; Luchette, F. A., Surgery
  • Alcohol inhibits osteopontin-dependent transforming growth factor-beta1 expression in human mesenchymal stem cells Driver, J.; Weber, C. E.; Callaci, J. J.; Kothari, A. N.; Zapf, M. A.; Roper, P. M.; Borys, D.; Franzen, C. A.; Gupta, G. N.; Wai, P. Y.; Zhang, J.; Denning, M. F.; Kuo, P. C.; Mi, Z., The Journal of biological chemistry
  • Components of Hospital Perioperative Infrastructure Can Overcome the Weekend Effect in Urgent General Surgery Procedures Kothari, A. N.; Zapf, M. A.; Blackwell, R. H.; Markossian, T.; Chang, V.; Mi, Z.; Gupta, G. N.; Kuo, P. C., Annals of Surgery
  • FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells You, D.; Xin, J.; Volk, A.; Wei, W.; Schmidt, R.; Scurti, G.; Nand, S.; Breuer, E. K.; Kuo, P. C.; Breslin, P.; Kini, A. R.; Nishimura, M. I.; Zeleznik-Le, N. J.; Zhang, J., Cell reports
  • Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular carcinoma Zapf, M. A.; Kothari, A. N.; Weber, C. E.; Arffa, M. L.; Wai, P. Y.; Driver, J.; Gupta, G. N.; Kuo, P. C.; Mi, Z., Surgery
  • Intra-operative acoustic enhancement Cobb, A.; Ngo, J.; Kuo, P. C., The American Surgeon
  • New Onset Postoperative Atrial Fibrillation Predicts Long-Term Cardiovascular Events Following Radical Cystectomy Blackwell, R. H.; Ellimoottil, C.; Bajic, P.; Kothari, A.; Zapf, M.; Kliethermes, S.; Flanigan, R. C.; Quek, M. L.; Kuo, P. C.; Gupta, G. N., The Journal of urology
  • Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice Coombes, J. D.; Swiderska-Syn, M.; Dolle, L.; Reid, D.; Eksteen, B.; Claridge, L.; Briones-Orta, M. A.; Shetty, S.; Oo, Y. H.; Riva, A.; Chokshi, S.; Papa, S.; Mi, Z.; Kuo, P. C.; Williams, R.; Canbay, A.; Adams, D. H.; Diehl, A. M.; van Grunsven, L. A.; Choi, S. S.; Syn, W. K., Gut
  • Renal response following perioperative ketorolac analgesia in living kidney donation Li, N. Y.; Tong, L.; Barbas, A. S.; Bhattacharya, S. D.; Wai, P. Y.; Kuo, P. C., Transplantation
  • The "weekend effect" in urgent general operative procedures Zapf, M. A.; Kothari, A. N.; Markossian, T.; Gupta, G. N.; Blackwell, R. H.; Wai, P. Y.; Weber, C. E.; Driver, J.; Kuo, P. C., Surgery
  • Urinary Exosomes: The Potential for Biomarker Utility Intercellular Signaling and Therapeutics in Urological Malignancy, Franzen, C. A.; Blackwell, R. H.; Foreman, K. E.; Kuo, P. C.; Flanigan, R. C.; Gupta, G. N., The Journal of urology
  • Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes Franzen, C. A.; Blackwell, R. H.; Todorovic, V.; Greco, K. A.; Foreman, K. E.; Flanigan, R. C.; Kuo, P. C.; Gupta, G. N., Oncogenesis
  • Characterization of uptake and internalization of exosomes by bladder cancer cells Franzen, C. A.; Simms, P. E.; Van Huis, A. F.; Foreman, K. E.; Kuo, P. C.; Gupta, G. N., BioMed research international
  • Co-inhibition of NF-kappaB and JNK is synergistic in TNF-expressing human AML Volk, A.; Li, J.; Xin, J.; You, D.; Zhang, J.; Liu, X.; Xiao, Y.; Breslin, P.; Li, Z.; Wei, W.; Schmidt, R.; Li, X.; Zhang, Z.; Kuo, P. C.; Nand, S.; Zhang, J.; Chen, J.; Zhang, J., The Journal of experimental medicine
  • Doing well by doing good: linking access with quality Chang, V.; Kuo, P. C.; Wai, P. Y., American Journal of Surgery
  • Emetine dihydrochloride: a novel therapy for bladder cancer Foreman, K. E.; Jesse, J. N., 3rd; Kuo, P. C.; Gupta, G. N., The Journal of urology
  • Engagement workplace satisfaction, and retention of surgical specialists in academic medicine in the United States, Wai, P. Y.; Dandar, V.; Radosevich, D. M.; Brubaker, L.; Kuo, P. C., Journal of the American College of Surgeons
  • Novel clinical therapeutics targeting the epithelial to mesenchymal transition Kothari, A. N.; Mi, Z.; Zapf, M.; Kuo, P. C., Clinical and translational medicine
  • Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication Choi, S. S.; Claridge, L. C.; Jhaveri, R.; Swiderska-Syn, M.; Clark, P.; Suzuki, A.; Pereira, T. A.; Mi, Z.; Kuo, P. C.; Guy, C. D.; Pereira, F. E.; Diehl, A. M.; Patel, K.; Syn, W. K., Clinical science (London, England : 1979)
  • Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer Weber, C. E.; Kothari, A. N.; Wai, P. Y.; Li, N. Y.; Driver, J.; Zapf, M. A.; Franzen, C. A.; Gupta, G. N.; Osipo, C.; Zlobin, A.; Syn, W. K.; Zhang, J.; Kuo, P. C.; Mi, Z., Oncogene
  • Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activity Guo, H.; Gao, C.; Mi, Z.; Wai, P. Y.; Kuo, P. C., The Biochemical journal
  • Acute graft dysfunction after living-related renal transplant Ellimoottil, C.; Brandt, W.; Bernardi, K.; Evans, A.; Mehta, V.; Picken, M. M.; Phelan, K.; Heinrich, L.; Milner, J.; Wai, P. Y.; Asolati, M.; Kuo, P. C.; Lu, A. D., Urology
  • An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines Li, N. Y.; Weber, C. E.; Wai, P. Y.; Cuevas, B. D.; Zhang, J.; Kuo, P. C.; Mi, Z., Surgery
  • Comparing 20 years of national general surgery malpractice claims data: obesity versus morbid obesity Weber, C. E.; Talbot, L. J.; Geller, J. M.; Kuo, M. C.; Wai, P. Y.; Kuo, P. C., American Journal of Surgery
  • Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol Jing, Y. H.; Chen, K. H.; Kuo, P. C.; Pao, C. C.; Chen, J. K., Neuroendocrinology
  • Obesity and trends in malpractice claims for physicians and surgeons Weber, C. E.; Talbot, L. J.; Geller, J. M.; Kuo, M. C.; Wai, P. Y.; Kuo, P. C., Surgery
  • Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype Li, N. Y.; Weber, C. E.; Mi, Z.; Wai, P. Y.; Cuevas, B. D.; Kuo, P. C., Journal of the American College of Surgeons
  • Transcriptional regulators of the DeltaNp63: their role in limbal epithelial cell proliferation Hsueh, Y. J.; Kuo, P. C.; Chen, J. K., Journal of cellular physiology
  • Biplanar flap reconstruction for pressure ulcers: experience in patients with immobility from chronic spinal cord injuries Mehta, A.; Baker, T. A.; Shoup, M.; Brownson, K.; Amde, S.; Doren, E.; Shah, S.; Kuo, P.; Angelats, J., American Journal of Surgery
  • Epithelial-mesenchymal transition TGF-beta, and osteopontin in wound healing and tissue remodeling after injury, Weber, C. E.; Li, N. Y.; Wai, P. Y.; Kuo, P. C., Journal of Burn Care & Research
  • Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers Bhattacharya, S. D.; Mi, Z.; Talbot, L. J.; Guo, H.; Kuo, P. C., Surgery
  • Impact of business infrastructure on financial metrics in departments of surgery. Wai, P. Y.; O'Hern, T.; Andersen, D. O.; Kuo, M. C.; Weber, C. E.; Talbot, L. J.; Kuo, P. C., Surgery
  • Intersecting pathways in inflammation and cancer: Hepatocellular carcinoma as a paradigm Wai, P. Y.; Kuo, P. C., World journal of clinical oncology
  • Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model Bhattacharya, S. D.; Mi, Z.; Kim, V. M.; Guo, H.; Talbot, L. J.; Kuo, P. C., Annals of Surgery
  • The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity Hunter, C.; Bond, J.; Kuo, P. C.; Selim, M. A.; Levinson, H., The Journal of surgical research
  • The tumor microenvironment Weber, C. E.; Kuo, P. C., Surgical oncology
  • Laparoscopic Treatment of Epiphrenic Diverticula: Preoperative Evaluation and Surgical Technique. How I Do It Fisichella, P. M.; Pittman, M.; Kuo, P. C., Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Fisichella, P. M.; Davis, C. S.; Lundberg, P. W.; Lowery, E.; Burnham, E. L.; Alex, C. G.; Ramirez, L.; Pelletiere, K.; Love, R. B.; Kuo, P. C.; Kovacs, E. J., Surgery
  • EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells. Zhang, J.; Guo, H.; Mi, Z.; Gao, C.; Bhattacharya, S.; Li, J.; Kuo, P. C., Experimental cell research
  • Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancer Mi, Z.; Guo, H.; Kuo, P. C., BMC research notes
  • RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. Mi, Z.; Guo, H.; Russell, M. B.; Liu, Y.; Sullenger, B. A.; Kuo, P. C., Molecular Therapy: the Journal of the American Society of Gene Therapy
  • Streptococcus equi primary bacteremia in a hepatitis-C cirrhotic patient. Aggarwal, H.; Smith, A. D.; Kuo, P. C.; Vikraman, D. S., Transplantation
  • Will the clinicians support the researchers and teachers? Results of a salary satisfaction survey of 947 academic surgeons. Scarborough, J. E.; Bennett, K. M.; Schroeder, R. A.; Swedish, T. B.; Jacobs, D. O.; Kuo, P. C., Annals of Surgery
  • "Ghost" publications among applicants to a general surgery residency program. Kuo, P. C.; Schroeder, R. A.; Shah, A.; Shah, J.; Jacobs, D. O.; Pietrobon, R., Journal of the American College of Surgeons
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. Guo, H.; Mi, Z.; Kuo, P. C., Journal of Biological Chemistry
  • Functional analysis of tumor metastasis: modeling colon cancer Wai, P. Y.; Reddy, S. K.; Kuo, P. C., Oncology Reviews
  • Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant. Alexander, J. W.; Goodman, H. R.; Succop, P.; Light, J. A.; Kuo, P. C.; Moser, A. B.; James, J. H.; Woodle, E. S., Experimental & Clinical Transplantation: Official Journal of the Middle East Society for Organ Transplantation
  • Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. Guo, H.; Wai, P. Y.; Mi, Z.; Gao, C.; Zhang, J.; Kuo, P. C., Surgery
  • Osteopontin: regulation in tumor metastasis Wai, P. Y.; Kuo, P. C., Cancer & Metastasis Reviews
  • Pro: low central venous pressure during liver transplantation--not too low Schroeder, R. A.; Kuo, P. C., Journal of Cardiothoracic & Vascular Anesthesia
  • Regionalization of hepatic resections is associated with increasing disparities among some patient populations in use of high-volume providers. Scarborough, J. E.; Pietrobon, R.; Clary, B. M.; Marroquin, C. E.; Bennett, K. M.; Kuo, P. C.; Pappas, T. N., Journal of the American College of Surgeons
  • Relationship between provider volume and outcomes for orthotopic liver transplantation. Scarborough, J. E.; Pietrobon, R.; Tuttle-Newhall, J. E.; Marroquin, C. E.; Collins, B. H.; Desai, D. M.; Kuo, P. C.; Pappas, T. N., Journal of Gastrointestinal Surgery
  • RNA stability regulates differential expression of the metastasis protein osteopontin, in hepatocellular cancer., Emani, S.; Zhang, J.; Guo, L.; Guo, H.; Kuo, P. C., Surgery
  • Supply and demand for liver transplant surgery: are we training enough surgeons?. Scarborough, J. E.; Tuttle-Newhall, J. E.; Pietrobon, R.; Marroquin, C. E.; Collins, B. H.; Desai, D. M.; Kuo, P. C.; Pappas, T. N., HPB
  • The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Takami, Y.; Higashi, M.; Kumagai, S.; Kuo, P. C.; Kawana, H.; Koda, K.; Miyazaki, M.; Harigaya, K., Digestive Diseases & Sciences
  • Workforce projections for hepato-pancreato-biliary surgery. Scarborough, J. E.; Pietrobon, R.; Bennett, K. M.; Clary, B. M.; Kuo, P. C.; Tyler, D. S.; Pappas, T. N., Journal of the American College of Surgeons
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. Guo, H.; Gao, C.; Mi, Z.; Zhang, J.; Kuo, P. C., Journal of Biochemistry
  • Extended hepatic resection for gallbladder cancer. Reddy, S. K.; Marroquin, C. E.; Kuo, P. C.; Pappas, T. N.; Clary, B. M., American Journal of Surgery
  • Little science big science: strategies for research portfolio selection in academic surgery departments., Shah, A.; Pietrobon, R.; Cook, C.; Sheth, N. P.; Nguyen, L.; Guo, L.; Jacobs, D. O.; Kuo, P. C., Annals of Surgery
  • One-year results with extended-release tacrolimus/MMF tacrolimus/MMF and cyclosporine/MMF in de novo kidney transplant recipients, Silva, H. T., Jr; Yang, H. C.; Abouljoud, M.; Kuo, P. C.; Wisemandle, K.; Bhattacharya, P.; Dhadda, S.; Holman, J.; Fitzsimmons, W.; First, M. R., American Journal of Transplantation
  • Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. Gao, C.; Guo, H.; Mi, Z.; Grusby, M. J.; Kuo, P. C., Journal of Immunology
  • Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. Gao, C.; Mi, Z.; Guo, H.; Kuo, P. C., Neoplasia (New York)
  • Renal function with cyclosporine C2 monitoring enteric-coated mycophenolate sodium and basiliximab: a 12-month randomized trial in renal transplant recipients., Cibrik, D.; Meier-Kriesche, H. U.; Bresnahan, B.; Wu, Y. M.; Klintmalm, G.; Kew, C. E.; Kuo, P. C.; Whelchel, J.; Cohen, D.; Baliga, P.; Akalin, E.; Benedetti, E.; Wright, F.; Lieberman, B.; Ulbricht, B.; Jensik, S.; Myfortic-US01 Renal Transplant Study, Group, Clinical transplantation
  • Resection of noncolorectal nonneuroendocrine liver metastases: a comparative analysis. Reddy, S. K.; Barbas, A. S.; Marroquin, C. E.; Morse, M. A.; Kuo, P. C.; Clary, B. M., Journal of the American College of Surgeons
  • Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells. Takami, Y.; Russell, M. B.; Gao, C.; Mi, Z.; Guo, H.; Mantyh, C. R.; Kuo, P. C., Surgery
  • Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages. Guo, L.; Guo, H.; Gao, C.; Mi, Z.; Russell, W. B.; Kuo, P. C., Surgery
  • Temporal trends in early clinical outcomes and health care resource utilization for liver transplantation in the United States. Scarborough, J. E.; Pietrobon, R.; Marroquin, C. E.; Tuttle-Newhall, J. E.; Kuo, P. C.; Collins, B. H.; Desai, D. M.; Pappas, T. N., Journal of Gastrointestinal Surgery
  • Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells. Mi, Z.; Oliver, T.; Guo, H.; Gao, C.; Kuo, P. C., Cancer research
  • Clinical performance feedback is necessary but not sufficient for longterm success of the academic department of surgery. Kuo, P. C., Journal of the American College of Surgeons
  • Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. Palmer, S. M.; Burch, L. H.; Mir, S.; Smith, S. R.; Kuo, P. C.; Herczyk, W. F.; Reinsmoen, N. L.; Schwartz, D. A., Clinical transplantation
  • Ets-1 and runx2 regulate transcription of a metastatic gene osteopontin, in murine colorectal cancer cells., Wai, P. Y.; Mi, Z.; Gao, C.; Guo, H.; Marroquin, C.; Kuo, P. C., Journal of Biological Chemistry
  • Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Mi, Z.; Guo, H.; Wai, P. Y.; Gao, C.; Kuo, P. C., Carcinogenesis
  • Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. Wai, P. Y.; Guo, L.; Gao, C.; Mi, Z.; Guo, H.; Kuo, P. C., Surgery
  • Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Guo, H.; Gao, C.; Mi, Z.; Wai, P. Y.; Kuo, P. C., Biochemical Journal
  • Predictive indices of morbidity and mortality after liver resection. Schroeder, R. A.; Marroquin, C. E.; Bute, B. P.; Khuri, S.; Henderson, W. G.; Kuo, P. C., Annals of Surgery
  • Productivity measures associated with a patient access initiative. Gable, W. H.; Pappas, T. N.; Jacobs, D. O.; Cutler, D. A.; Kuo, P. C., Annals of Surgery
  • Scheduling the resident 80-hour work week: an operations research algorithm. Day, T. E.; Napoli, J. T.; Kuo, P. C., Current surgery
  • Who should perform liver transplantation? Should that be the transplant surgeon the hepatobilary surgeon, or the general surgeon? Part I: the transplant surgeon., Desai, D. M.; Kuo, P. C., Journal of Hepatology
  • Acute kidney transplant failure following transurethral bladder polyp fulguration. Collins, B. H.; Marroquin, C. E.; Tuttle-Newhall, J. E.; Kuo, P. C.; Preminger, G. M.; Butterly, D. W., Journal of the National Medical Association
  • Case 23-2005: a man with a mass in the liver. Smith, A. D.; Morse, M. A.; Kuo, P. C., New England Journal of Medicine
  • Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus. Smith, A. D.; Bai, D.; Marroquin, C. E.; Tuttle-Newhall, J. E.; Desai, D. M.; Collins, B. H.; Muir, A.; Kuo, P. C.; McHutchison, J.; Rockey, D. C., Clinical transplantation
  • Half-life analysis of pancreas and kidney transplants. Marroquin, C. E.; Edwards, E. B.; Collins, B. H.; Desai, D. M.; Tuttle-Newhall, J. E.; Kuo, P. C., Transplantation
  • Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. Gao, C.; Guo, H.; Wei, J.; Mi, Z.; Wai, P. Y.; Kuo, P. C., Nitric Oxide
  • Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. Guo, H.; Marroquin, C. E.; Wai, P. Y.; Kuo, P. C., Digestive Diseases & Sciences
  • Obesity predicts increased overall complications following pancreas transplantation. Hanish, S. I.; Petersen, R. P.; Collins, B. H.; Tuttle-Newhall, J.; Marroquin, C. E.; Kuo, P. C.; Butterly, D. W.; Smith, S. R.; Desai, D. M., Transplantation proceedings
  • Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis. Wai, P. Y.; Mi, Z.; Guo, H.; Sarraf-Yazdi, S.; Gao, C.; Wei, J.; Marroquin, C. E.; Clary, B.; Kuo, P. C., Carcinogenesis
  • Perioperative management of special populations: immunocompromised host (cancer HIV, transplantation), Desai, D. M.; Kuo, P. C., Surgical Clinics of North America
  • Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. Marroquin, C. E.; Wai, P. Y.; Kuo, P. C.; Guo, H., Surgery
  • The current status of living donor liver transplantation Tuttle-Newhall, J. E.; Collins, B. H.; Desai, D. M.; Kuo, P. C.; Heneghan, M. A., Current problems in surgery
  • Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin. Gao, C.; Guo, H.; Mi, Z.; Wai, P. Y.; Kuo, P. C., Journal of Immunology
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. Gao, C.; Mi, Z.; Guo, H.; Wei, J.; Wai, P. Y.; Kuo, P. C., Biochemical & Biophysical Research Communications
  • An overview of genomic data analysis. Huang, E. S.; Nevins, J. R.; West, M.; Kuo, P. C., Surgery
  • Determining benchmarks for evaluation and management coding in an academic division of general surgery. Kuo, P. C.; Douglas, A. R.; Oleski, D.; Jacobs, D. O.; Schroeder, R. A., Journal of the American College of Surgeons
  • Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. Mi, Z.; Guo, H.; Wai, P. Y.; Gao, C.; Wei, J.; Kuo, P. C., Journal of Biological Chemistry
  • Intraoperative fluid management during orthotopic liver transplantation. Schroeder, R. A.; Collins, B. H.; Tuttle-Newhall, E.; Robertson, K.; Plotkin, J.; Johnson, L. B.; Kuo, P. C., Journal of Cardiothoracic & Vascular Anesthesia
  • Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells. Marroquin, C. E.; Downey, L.; Guo, H.; Kuo, P. C., Immunology letters
  • Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter. Wei, J.; Guo, H.; Gao, C.; Kuo, P. C., Biochemical Journal
  • S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. Gao, C.; Guo, H.; Wei, J.; Mi, Z.; Wai, P.; Kuo, P. C., Journal of Biological Chemistry
  • The role of Osteopontin in tumor metastasis Wai, P. Y.; Kuo, P. C., Journal of Surgical Research
  • Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection. Rocha, P. N.; Butterly, D. W.; Greenberg, A.; Reddan, D. N.; Tuttle-Newhall, J.; Collins, B. H.; Kuo, P. C.; Reinsmoen, N.; Fields, T.; Howell, D. N.; Smith, S. R., Transplantation
  • De-novo cholangiocarcinoma in the setting of recurrent primary sclerosing cholangitis following liver transplant. Heneghan, M. A.; Tuttle-Newhall, J. E.; Suhocki, P. V.; Muir, A. J.; Morse, M.; Bornstein, J. D.; Sylvestre, P. B.; Collins, B.; Kuo, P. C.; Rockey, D. C., American Journal of Transplantation
  • Emergencies after liver transplantation. Marroquin, C. E.; Tuttle-Newhall, J. E.; Collins, B. H.; Kuo, P. C.; Schroeder, R. A., Seminars in gastrointestinal disease
  • Liver transplantation from a cadaver donor with ethylene-glycol-induced brain death. Dy-Liacco, M. S.; Tuttle-Newhall, E. J.; Collins, B. H.; Kuo, P. C., Transplantation
  • Optimization of operating room allocation using linear programming techniques. Kuo, P. C.; Schroeder, R. A.; Mahaffey, S.; Bollinger, R. R., Journal of the American College of Surgeons
  • Organ donation and treatment of the multi-organ donor Tuttle-Newhall, J. E.; Collins, B. H.; Kuo, P. C.; Schoeder, R., Current problems in surgery
  • Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. Gao, C.; Guo, H.; Wei, J.; Kuo, P. C., Biochemical & Biophysical Research Communications
  • Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. Gao, C.; Guo, H.; Downey, L.; Marroquin, C.; Wei, J.; Kuo, P. C., Carcinogenesis
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. Guo, H.; Wei, J.; Inoue, Y.; Gonzalez, F. J.; Kuo, P. C., American Journal of Physiology - Cell Physiology
  • Tolerance and the "Holy Grail" of transplantation Schroeder, R. A.; Marroquin, C. E.; Kuo, P. C., Journal of Surgical Research
  • An examination of factors predicting prioritization for liver transplantation. Muir, A. J.; Sanders, L. L.; Heneghan, M. A.; Kuo, P. C.; Wilkinson, W. E.; Provenzale, D., Liver Transplantation
  • Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. Wei, J.; Guo, H.; Kuo, P. C., Journal of Immunology
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. Guo, H.; Cai, C. Q.; Kuo, P. C., Journal of Biological Chemistry
  • MR angiography and preoperative evaluation for laparoscopic donor nephrectomy. Jha, R. C.; Korangy, S. J.; Ascher, S. M.; Takahama, J.; Kuo, P. C.; Johnson, L. B., AJR.American Journal of Roentgenology
  • Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. Guo, H. T.; Cai, C. Q.; Schroeder, R. A.; Kuo, P. C., Immunology letters
  • Pharmacokinetics and biochemical effects of hepapoietin in patients with chronic liver disease. Marino, G.; Rustgi, V. K.; Salzberg, G.; Johnson, L. B.; Kuo, P. C.; Plotkin, J. S.; Flockhart, D. A., Alimentary Pharmacology & Therapeutics
  • Surgical techniques in right laparoscopic donor nephrectomy. Buell, J. F.; Hanaway, M. J.; Potter, S. R.; Koffron, A.; Kuo, P. C.; Leventhal, J.; Cho, E.; Johnson, M.; Edye, M.; Woodle, E. S., Journal of the American College of Surgeons
  • Are concerns over right laparoscopic donor nephrectomy unwarranted?. Buell, J. F.; Edye, M.; Johnson, M.; Li, C.; Koffron, A.; Cho, E.; Kuo, P.; Johnson, L.; Hanaway, M.; Potter, S. R.; Bruce, D. S.; Cronin, D. C.; Newell, K. A.; Leventhal, J.; Jacobs, S.; Woodle, E. S.; Bartlett, S. T.; Flowers, J. L., Annals of Surgery
  • Candida fasciitis following renal transplantation Wai, P. H.; Ewing, C. A.; Johnson, L. B.; Lu, A. D.; Attinger, C.; Kuo, P. C., Transplantation
  • Dobutamine stress echocardiography for orthotopic liver transplant evaluation. Plotkin, J. S.; Johnson, L. B.; Rustgi, V. K.; Kuo, P. C.; Lu, A. D., Transplantation
  • Expanded criteria donors/high risk recipients is not always cheaper than hemodialysis. Kuo, P. C.; Lu, A. D.; Johnson, L. B., Transplantation
  • Nitric oxide inhibits expression of cytochrome B in endotoxin-stimulated murine macrophages. Guo, H.; Wei, J.; Kuo, P. C., Biochemical & Biophysical Research Communications
  • Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. Guo, H.; Cai, C. Q.; Schroeder, R. A.; Kuo, P. C., Journal of Immunology
  • Outcome of extra-anatomic vascular reconstruction in orthotopic liver transplantation. Cappadonna, C. R.; Johnson, L. B.; Lu, A. D.; Kuo, P. C., American Journal of Surgery
  • Reconsideration of HIV as a contraindication to transplantation. Kuo, P. C., Transplantation
  • Transplantation in the HIV+ patient Kuo, P. C.; Stock, P. G., American Journal of Transplantation
  • Transplantation of hepatitis C-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C-negative livers. Marroquin, C. E.; Marino, G.; Kuo, P. C.; Plotkin, J. S.; Rustgi, V. K.; Lu, A. D.; Edwards, E.; Taranto, S.; Johnson, L. B., Liver Transplantation
  • Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages. Guo, H. T.; Cai, C. Q.; Kuo, P. C., Biochemical & Biophysical Research Communications
  • Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene Kuo, P. C.; Abe, K.; Schroeder, R. A., Gastroenterology