Michael Nishimura, PhD | Loyola Medicine

Michael Nishimura, PhD

Michael Nishimura, PhD

Surgery

Surgical Research
Professor
Program Director, Immunologic Therapeutics

Languages Spoken

English

Clinical Expertise

Biography

Interests

Medical Education

Medical School
Residency
Fellowship

Board Certification

Research

  • Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells Spear, T. T.; Wang, Y.; Smith TW, Jr; Simms, P. E.; Garrett-Mayer, E.; Hellman, L. M.; Baker, B. M.; Nishimura, M. I., Molecular therapy : the journal of the American Society of Gene Therapy
  • CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response Chatterjee, S.; Daenthanasanmak, A.; Chakraborty, P.; Wyatt, M. W.; Dhar, P.; Selvam, S. P.; Fu, J.; Zhang, J.; Nguyen, H.; Kang, I.; Toth, K.; Al-Homrani, M.; Husain, M.; Beeson, G.; Ball, L.; Helke, K.; Husain, S.; Garrett-Mayer, E.; Hardiman, G.; Mehrotra, M.; Nishimura, M. I.; Beeson, C. C.; Bupp, M. G.; Wu, J.; Ogretmen, B.; Paulos, C. M.; Rathmell, J.; Yu, X. Z.; Mehrotra, S., Cell metabolism
  • Cell intrinsic characteristics of human cord blood naive CD4T cells Jacks, R. D.; Keller, T. J.; Nelson, A.; Nishimura, M. I.; White, P.; Iwashima, M., Immunology letters
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  • Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells Moore, T.; Wagner, C. R.; Scurti, G. M.; Hutchens, K. A.; Godellas, C.; Clark, A. L.; Kolawole, E. M.; Hellman, L. M.; Singh, N. K.; Huyke, F. A.; Wang, S. Y.; Calabrese, K. M.; Embree, H. D.; Orentas, R.; Shirai, K.; Dellacecca, E.; Garrett-Mayer, E.; Li, M.; Eby, J. M.; Stiff, P. J.; Evavold, B. D.; Baker, B. M.; Le Poole, I. C.; Dropulic, B.; Clark, J. I.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • Combination immunotherapies implementing adoptive T-cell transfer for advanced-stage melanoma Foley, K. C.; Nishimura, M. I.; Moore, T. V., Melanoma research
  • Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells Moore, T.; Wagner, C. R.; Scurti, G. M.; Hutchens, K. A.; Godellas, C.; Clark, A. L.; Kolawole, E. M.; Hellman, L. M.; Singh, N. K.; Huyke, F. A.; Wang, S. Y.; Calabrese, K. M.; Embree, H. D.; Orentas, R.; Shirai, K.; Dellacecca, E.; Garrett-Mayer, E.; Li, M.; Eby, J. M.; Stiff, P. J.; Evavold, B. D.; Baker, B. M.; Le Poole, I. C.; Dropulic, B.; Clark, J. I.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner Scheffel, M. J.; Scurti, G.; Wyatt, M. M.; Garrett-Mayer, E.; Paulos, C. M.; Nishimura, M. I.; Voelkel-Johnson, C., Cancer immunology, immunotherapy : CII
  • TCR modifications that enhance chain pairing in gene-modified T cells can augment cross-reactivity and alleviate CD8 dependence Spear, T. T.; Foley, K. C.; Garrett-Mayer, E.; Nishimura, M. I., Journal of leukocyte biology
  • CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response Chatterjee, S.; Daenthanasanmak, A.; Chakraborty, P.; Wyatt, M. W.; Dhar, P.; Selvam, S. P.; Fu, J.; Zhang, J.; Nguyen, H.; Kang, I.; Toth, K.; Al-Homrani, M.; Husain, M.; Beeson, G.; Ball, L.; Helke, K.; Husain, S.; Garrett-Mayer, E.; Hardiman, G.; Mehrotra, M.; Nishimura, M. I.; Beeson, C. C.; Bupp, M. G.; Wu, J.; Ogretmen, B.; Paulos, C. M.; Rathmell, J.; Yu, X. Z.; Mehrotra, S., Cell metabolism
  • Comparative exploration of multidimensional flow cytometry software: a model approach evaluating T cell polyfunctional behavior Spear, T. T.; Nishimura, M. I.; Simms, P. E., Journal of leukocyte biology
  • Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells Spear, T. T.; Wang, Y.; Foley, K. C.; Murray, D. C.; Scurti, G. M.; Simms, P. E.; Garrett-Mayer, E.; Hellman, L. M.; Baker, B. M.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • Effective control of acute myeloid leukaemia and acute lymphoblastic leukaemia progression by telomerase specific adoptive T-cell therapy Sandri, S.; De Sanctis, F.; Lamolinara, A.; Boschi, F.; Poffe, O.; Trovato, R.; Fiore, A.; Sartori, S.; Sbarbati, A.; Bondanza, A.; Cesaro, S.; Krampera, M.; Scupoli, M. T.; Nishimura, M. I.; Iezzi, M.; Sartoris, S.; Bronte, V.; Ugel, S., Oncotarget
  • Enhanced stimulation of human tumor-specific T cells by dendritic cells matured in the presence of interferon-gamma and multiple toll-like receptor agonists Lovgren, T.; Sarhan, D.; Truxova, I.; Choudhary, B.; Maas, R.; Melief, J.; Nystrom, M.; Edback, U.; Vermeij, R.; Scurti, G.; Nishimura, M.; Masucci, G.; Karlsson-Parra, A.; Lundqvist, A.; Adamson, L.; Kiessling, R., Cancer immunology, immunotherapy : CII
  • HCV T Cell Receptor Chain Modifications to Enhance Expression Pairing, and Antigen Recognition in T Cells for Adoptive Transfer, Foley, K. C.; Spear, T. T.; Murray, D. C.; Nagato, K.; Garrett-Mayer, E.; Nishimura, M. I., Molecular therapy oncolytics
  • How an alloreactive T-cell receptor achieves peptide and MHC specificity Wang, Y.; Singh, N. K.; Spear, T. T.; Hellman, L. M.; Piepenbrink, K. H.; McMahan, R. H.; Rosen, H. R.; Vander Kooi, C. W.; Nishimura, M. I.; Baker, B. M., Proceedings of the National Academy of Sciences of the United States of America
  • Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms Muller, L.; Simms, P.; Hong, C. S.; Nishimura, M. I.; Jackson, E. K.; Watkins, S. C.; Whiteside, T. L., Oncoimmunology
  • Inducible Enhancement of T Cell Function and Anti-tumor Activity after Adoptive Transfer Wrangle, J.; Paulos, C. M.; Smith TW, Jr; Nishimura, M. I.; Rubinstein, M. P., Molecular therapy : the journal of the American Society of Gene Therapy
  • Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer Mehrotra, S.; Britten, C. D.; Chin, S.; Garrett-Mayer, E.; Cloud, C. A.; Li, M.; Scurti, G.; Salem, M. L.; Nelson, M. H.; Thomas, M. B.; Paulos, C. M.; Salazar, A. M.; Nishimura, M. I.; Rubinstein, M. P.; Li, Z.; Cole, D. J., Journal of hematology & oncology
  • Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control Kesarwani, P.; Chakraborty, P.; Gudi, R.; Chatterjee, S.; Scurti, G.; Toth, K.; Simms, P.; Husain, M.; Armeson, K.; Husain, S.; Garrett-Mayer, E.; Vasu, C.; Nishimura, M. I.; Mehrotra, S., Oncotarget
  • Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes Hellman, L. M.; Yin, L.; Wang, Y.; Blevins, S. J.; Riley, T. P.; Belden, O. S.; Spear, T. T.; Nishimura, M. I.; Stern, L. J.; Baker, B. M., Journal of immunological methods
  • Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine Which Limits Activation-Induced T-cell Death, Scheffel, M. J.; Scurti, G.; Simms, P.; Garrett-Mayer, E.; Mehrotra, S.; Nishimura, M. I.; Voelkel-Johnson, C., Cancer research
  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Na, S.; Arteaga, M.; Zaidi, A.; Colter, S.; Breslin, P.; Ding, X.; Kuo, P.; Nishimura, M.; Zhang, J.; Qiu, W., Gene expression
  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Breslin, P.; Kuo, P.; Ding, X.; Cotler, S.; Nishimura, M.; Zhang, J.; Qiu, W.; Arteaga, M.; Zaidi, A.; Shang, N., Gene expression
  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Shang, N.; Arteaga, M.; Zaidi, A.; Colter, S.; Breslin, P.; Ding, X.; Kuo, P.; Nishimura, M.; Zhang, J.; Qiu, W., Gene expression
  • Feasibility of Telomerase-Specific Adoptive T-cell Therapy for B-cell Chronic Lymphocytic Leukemia and Solid Malignancies Sandri, S.; Bobisse, S.; Moxley, K.; Lamolinara, A.; De Sanctis, F.; Boschi, F.; Sbarbati, A.; Fracasso, G.; Ferrarini, G.; Hendriks, R. W.; Cavallini, C.; Scupoli, M. T.; Sartoris, S.; Iezzi, M.; Nishimura, M. I.; Bronte, V.; Ugel, S., Cancer research
  • Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin Klarquist, J.; Eby, J. M.; Henning, S. W.; Li, M.; Wainwright, D. A.; Westerhof, W.; Luiten, R. M.; Nishimura, M. I.; Le Poole, I. C., Pigment Cell & Melanoma Research
  • Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability Spear, T. T.; Riley, T. P.; Lyons, G. E.; Callender, G. G.; Roszkowski, J. J.; Wang, Y.; Simms, P. E.; Scurti, G. M.; Foley, K. C.; Murray, D. C.; Hellman, L. M.; McMahan, R. H.; Iwashima, M.; Garrett-Mayer, E.; Rosen, H. R.; Baker, B. M.; Nishimura, M. I., Journal of leukocyte biology
  • How structural adaptability exists alongside HLA-A2 bias in the human alphabeta TCR repertoire Blevins, S. J.; Pierce, B. G.; Singh, N. K.; Riley, T. P.; Wang, Y.; Spear, T. T.; Nishimura, M. I.; Weng, Z.; Baker, B. M., Proceedings of the National Academy of Sciences of the United States of America
  • Lack of p53 Augments Anti-Tumor Functions In Cytolytic T Cells Banerjee, A.; Thyagarajan, K.; Chatterjee, S.; Chakraborty, P.; Kesarwani, P.; Soloshchenko, M.; Hommrani, M. A.; Andrijauskaite, K.; Moxley, K.; Janakiraman, H.; Scheffel, M. J.; Helke, K.; Armeson, K.; Palanisamy, V.; Rubinstein, M. P.; Garrett-Mayer, E.; Cole, D. J.; Paulos, C. M.; Voelkel-Johnson, C.; Nishimura, M. I.; Mehrotra, S., Cancer research
  • Strategies to genetically engineer T cells for cancer immunotherapy Spear, T. T.; Nagato, K.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors Spear, T. T.; Callender, G. G.; Roszkowski, J. J.; Moxley, K. M.; Simms, P. E.; Foley, K. C.; Murray, D. C.; Scurti, G. M.; Li, M.; Thomas, J. T.; Langerman, A.; Garrett-Mayer, E.; Zhang, Y.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells Takami, M.; Fujimaki, K.; Nishimura, M. I.; Iwashima, M., Journal of immunology (Baltimore, Md.: 1950)
  • FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells You, D.; Xin, J.; Volk, A.; Wei, W.; Schmidt, R.; Scurti, G.; Nand, S.; Breuer, E. K.; Kuo, P. C.; Breslin, P.; Kini, A. R.; Nishimura, M. I.; Zeleznik-Le, N. J.; Zhang, J., Cell reports
  • Mutant HSP70 reverses autoimmune depigmentation in vitiligo Mosenson, J. A.; Zloza, A.; Nieland, J. D.; Garrett-Mayer, E.; Eby, J. M.; Huelsmann, E. J.; Kumar, P.; Denman, C. J.; Lacek, A. T.; Kohlhapp, F. J.; Alamiri, A.; Hughes, T.; Bines, S. D.; Kaufman, H. L.; Overbeck, A.; Mehrotra, S.; Hernandez, C.; Nishimura, M. I.; Guevara-Patino, J. A.; Le Poole, I. C., Science translational medicine
  • A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice Mehrotra, S.; Al-Khami, A. A.; Klarquist, J.; Husain, S.; Naga, O.; Eby, J. M.; Murali, A. K.; Lyons, G. E.; Li, M.; Spivey, N. D.; Norell, H.; Martins da Palma, T.; Onicescu, G.; Diaz-Montero, C. M.; Garrett-Mayer, E.; Cole, D. J.; Le Poole, I. C.; Nishimura, M. I., Journal of immunology (Baltimore, Md.: 1950)
  • CD8 co-receptor promotes susceptibility of CD8+ T cells to transforming growth factor-beta (TGF-beta)-mediated suppression Zloza, A.; Jagoda, M. C.; Lyons, G. E.; Graves, M. C.; Kohlhapp, F. J.; O'Sullivan, J. A.; Lacek, A. T.; Nishimura, M. I.; Guevara-Patino, J. A., Cancer immunology, immunotherapy : CII
  • Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses Koya, R. C.; Mok, S.; Comin-Anduix, B.; Chodon, T.; Radu, C. G.; Nishimura, M. I.; Witte, O. N.; Ribas, A., Proceedings of the National Academy of Sciences of the United States of America
  • Reduced skin homing by functional Treg in vitiligo Klarquist, J.; Denman, C. J.; Hernandez, C.; Wainwright, D. A.; Strickland, F. M.; Overbeck, A.; Mehrotra, S.; Nishimura, M. I.; Le Poole, I. C., Pigment Cell & Melanoma Research
  • Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity Zhang, Y.; Liu, Y.; Moxley, K. M.; Golden-Mason, L.; Hughes, M. G.; Liu, T.; Heemskerk, M. H.; Rosen, H. R.; Nishimura, M. I., PLoS Pathogens
  • Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells. Klarquist, J.; Barfuss, A.; Kandala, S.; Reust, M. J.; Braun, R. K.; Hu, J.; Dilling, D. F.; McKee, M. D.; Boissy, R. E.; Love, R. B.; Nishimura, M. I.; Le Poole, I. C., American Journal of Pathology
  • Relationship between CD8-dependent antigen recognition T cell functional avidity, and tumor cell recognition, Moore, T. V.; Lyons, G. E.; Brasic, N.; Roszkowski, J. J.; Voelkl, S.; Mackensen, A.; Kast, W. M.; Le Poole, I. C.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • T cell immunotherapy McKee, M. D.; Fichera, A.; Nishimura, M. I., Frontiers in bioscience : a journal and virtual library
  • Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition Callender, G. G.; Rosen, H. R.; Roszkowski, J. J.; Lyons, G. E.; Li, M.; Moore, T.; Brasic, N.; McKee, M. D.; Nishimura, M. I., Hepatology (Baltimore, Md.)
  • Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells Lyons, G. E.; Moore, T.; Brasic, N.; Li, M.; Roszkowski, J. J.; Nishimura, M. I., Cancer research
  • Interferon-gamma renders tumors that express low levels of Her-2/neu sensitive to cytotoxic T cells Kaplan, B. L.; Norell, H.; Callender, G. G.; Ohlum, T.; Kiessling, R.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T-cell receptor transduced T cells Lyons, G. E.; Roszkowski, J. J.; Man, S.; Yee, C.; Kast, W. M.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • Therapeutic implications of autoimmune vitiligo T cells Oyarbide-Valencia, K.; van den Boorn, J. G.; Denman, C. J.; Li, M.; Carlson, J. M.; Hernandez, C.; Nishimura, M. I.; Das, P. K.; Luiten, R. M.; Le Poole, I. C., Autoimmunity Reviews
  • A new murine tumor model for studying HLA-A2-restricted anti-tumor immunity Kaplan, B. L.; Moore, T. V.; Schreiber, K.; Callender, G. G.; Schreiber, H.; Nishimura, M. I., Cancer letters
  • Antigen recognition and T-cell biology Nishimura, M. I.; Roszkowski, J. J.; Moore, T. V.; Brasic, N.; McKee, M. D.; Clay, T. M., Cancer treatment and research
  • Recognition of host immune activation by Pseudomonas aeruginosa Wu, L.; Estrada, O.; Zaborina, O.; Bains, M.; Shen, L.; Kohler, J. E.; Patel, N.; Musch, M. W.; Chang, E. B.; Fu, Y. X.; Jacobs, M. A.; Nishimura, M. I.; Hancock, R. E.; Turner, J. R.; Alverdy, J. C., Science (New York, N.Y.)
  • Regulatory balance between the immune response of tumor antigen-specific T-cell receptor gene-transduced CD8 T cells and the suppressive effects of tolerogenic dendritic cells Fujii, S.; Nishimura, M. I.; Lotze, M. T., Cancer science
  • Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor Roszkowski, J. J.; Lyons, G. E.; Kast, W. M.; Yee, C.; Van Besien, K.; Nishimura, M. I., Cancer research
  • T cell avidity and tumor recognition: implications and therapeutic strategies McKee, M. D.; Roszkowski, J. J.; Nishimura, M. I., JOURNAL OF TRANSLATIONAL MEDICINE
  • Retroviral transduction of peptide stimulated t cells can generate dual t cell receptor-expressing (bifunctional) t cells reactive with two defined antigens Langerman, A.; Callender, G. G.; Nishimura, M. I., JOURNAL OF TRANSLATIONAL MEDICINE
  • CD8-independent tumor cell recognition is a property of the T cell receptor and not the T cell Roszkowski, J. J.; Yu, D. C.; Rubinstein, M. P.; McKee, M. D.; Cole, D. J.; Nishimura, M. I., Journal of immunology (Baltimore, Md.: 1950)
  • Cervical cancer vaccines: recent advances in HPV research Eiben, G. L.; da Silva, D. M.; Fausch, S. C.; Le Poole, I. C.; Nishimura, M. I.; Kast, W. M., Viral immunology
  • Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells Lee, K. M.; Bhawan, S.; Majima, T.; Wei, H.; Nishimura, M. I.; Yagita, H.; Kumar, V., Journal of immunology (Baltimore, Md.: 1950)
  • Redirecting T lymphocyte specificity using T cell receptor genes Kaplan, B. L.; Yu, D. C.; Clay, T. M.; Nishimura, M. I., International reviews of immunology
  • Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells Spiotto, M. T.; Yu, P.; Rowley, D. A.; Nishimura, M. I.; Meredith, S. C.; Gajewski, T. F.; Fu, Y. X.; Schreiber, H., Immunity
  • Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma Dudley, M. E.; Wunderlich, J.; Nishimura, M. I.; Yu, D.; Yang, J. C.; Topalian, S. L.; Schwartzentruber, D. J.; Hwu, P.; Marincola, F. M.; Sherry, R.; Leitman, S. F.; Rosenberg, S. A., Journal of immunotherapy (Hagerstown, Md.: 1997)