Maurizio Bocchetta, PhD


Molecular Pharmacology and Therapeutics
Associate Professor

Languages Spoken


Medical Education

University of Illinois at Chicago Medical Center - Research


  • p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating with the Notch Transcriptional Complex via MAML1 Yun, J.; Espinoza, I.; Pannuti, A.; Romero, D.; Martinez, L.; Caskey, M.; Stanculescu, A.; Bocchetta, M.; Rizzo, P.; Band, V.; Band, H.; Kim, H. M.; Park, S. K.; Kang, K. W.; Avantaggiati, M. L.; Gomez, C. R.; Golde, T.; Osborne, B.; Miele, L., Journal of cellular physiology
  • Amyloid Precursor Protein (APP) Affects Global Protein Synthesis in Dividing Human Cells Sobol, A.; Galluzzo, P.; Liang, S.; Rambo, B.; Skucha, S.; Weber, M. J.; Alani, S.; Bocchetta, M., Journal of cellular physiology
  • Depletion of Amyloid Precursor Protein (APP) causes G0 arrest in nonsmall cell lung cancer (NSCLC) cells Sobol, A.; Galluzzo, P.; Weber, M. J.; Alani, S.; Bocchetta, M., Journal of cellular physiology
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  • Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzle Boccardi, M.; Bocchetta, M.; Aronen, H. J.; Repo-Tiihonen, E.; Vaurio, O.; Thompson, P. M.; Tiihonen, J.; Frisoni, G. B., International journal of law and psychiatry
  • Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment Clerx, L.; van Rossum, I. A.; Burns, L.; Knol, D. L.; Scheltens, P.; Verhey, F.; Aalten, P.; Lapuerta, P.; van de Pol, L.; van Schijndel, R.; de Jong, R.; Barkhof, F.; Wolz, R.; Rueckert, D.; Bocchetta, M.; Tsolaki, M.; Nobili, F.; Wahlund, L. O.; Minthon, L.; Frolich, L.; Hampel, H.; Soininen, H.; Visser, P. J., Neurobiology of aging
  • Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation Boccardi, M.; Bocchetta, M.; Ganzola, R.; Robitaille, N.; Redolfi, A.; Duchesne, S.; Jack, C. R., Jr; Frisoni, G. B.; EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative, Alzheimer's & dementia : the journal of the Alzheimer's Association
  • Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study Pievani, M.; Bocchetta, M.; Boccardi, M.; Cavedo, E.; Bonetti, M.; Thompson, P. M.; Frisoni, G. B., Neurobiology of aging
  • Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment Liang, S.; Galluzzo, P.; Sobol, A.; Skucha, S.; Rambo, B.; Bocchetta, M., Genes & cancer
  • Notch signaling in lung cancer Galluzzo, P.; Bocchetta, M., Expert Review of Anticancer Therapy
  • Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol Boccardi, M.; Ganzola, R.; Bocchetta, M.; Pievani, M.; Redolfi, A.; Bartzokis, G.; Camicioli, R.; Csernansky, J. G.; de Leon, M. J.; deToledo-Morrell, L.; Killiany, R. J.; Lehericy, S.; Pantel, J.; Pruessner, J. C.; Soininen, H.; Watson, C.; Duchesne, S.; Jack, C. R., Jr; Frisoni, G. B., Journal of Alzheimer's disease : JAD
  • Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Eliasz, S.; Liang, S.; Chen, Y.; De Marco, M. A.; Machek, O.; Skucha, S.; Miele, L.; Bocchetta, M., Oncogene
  • Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes Zhang, L.; Qi, F.; Gaudino, G.; Strianese, O.; Yang, H.; Morris, P.; Pass, H. I.; Nerurkar, V. R.; Bocchetta, M.; Carbone, M., Genes & cancer
  • A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells. Carbone, M.; Pannuti, A.; Zhang, L.; Testa, J. R.; Bocchetta, M., Cancer research
  • Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway. Graziani, I.; Eliasz, S.; De Marco, M. A.; Chen, Y.; Pass, H. I.; De May, R. M.; Strack, P. R.; Miele, L.; Bocchetta, M., Cancer research
  • SV40 Tag/p53 complexes actively promote malignant cell growth of human mesothelial cells. Bocchetta, M.; Carbone, M., Cellular Oncology
  • The SV40 large T antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth. Bocchetta, M.; Eliasz, S.; De Marco, M. A.; Rudzinski, J.; Zhang, L.; Carbone, M., Cancer research
  • Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung. Chen, Y.; De Marco, M. A.; Graziani, I.; Gazdar, A. F.; Strack, P. R.; Miele, L.; Bocchetta, M., Cancer research
  • Cellular and molecular parameters of mesothelioma Ramos-Nino, M. E.; Testa, J. R.; Altomare, D. A.; Pass, H. I.; Carbone, M.; Bocchetta, M.; Mossman, B. T., Journal of cellular biochemistry
  • Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters. Kroczynska, B.; Cutrone, R.; Bocchetta, M.; Yang, H.; Elmishad, A. G.; Vacek, P.; Ramos-Nino, M.; Mossman, B. T.; Pass, H. I.; Carbone, M., Proceedings of the National Academy of Sciences of the United States of America
  • Polio vaccines SV40 and human tumours, an update on false positive and false negative results., Elmishad, A. G.; Bocchetta, M.; Pass, H. I.; Carbone, M., Developments in biologicals
  • TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway a possible mechanism for asbestos-induced oncogenesis., Yang, H.; Bocchetta, M.; Kroczynska, B.; Elmishad, A. G.; Chen, Y.; Liu, Z.; Bubici, C.; Mossman, B. T.; Pass, H. I.; Testa, J. R.; Franzoso, G.; Carbone, M., Proceedings of the National Academy of Sciences of the United States of America
  • Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961. Cutrone, R.; Lednicky, J.; Dunn, G.; Rizzo, P.; Bocchetta, M.; Chumakov, K.; Minor, P.; Carbone, M., Cancer research
  • SV40 detection in human tumor specimens Carbone, M.; Rdzanek, M. A.; Rudzinski, J. J.; De Marco, M. A.; Bocchetta, M.; Ramos Nino, M.; Mossman, B.; Pass, H. I., Cancer research
  • Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformation Bocchetta, M.; Carbone, M., Oncogene
  • Evidence of an important role for SV40 in mesothelioma Pass, H. I.; Bocchetta, M.; Carbone, M., Thoracic Surgery Clinics
  • Genetically distant American Canine distemper virus lineages have recently caused epizootics with somewhat different characteristics in raccoons living around a large suburban zoo in the USA. Lednicky, J. A.; Dubach, J.; Kinsel, M. J.; Meehan, T. P.; Bocchetta, M.; Hungerford, L. L.; Sarich, N. A.; Witecki, K. E.; Braid, M. D.; Pedrak, C.; Houde, C. M., Virology Journal
  • SV40 and Notch-I: multi-functionality meets pleiotropy Carbone, M.; Bocchetta, M., Progress in Molecular & Subcellular Biology
  • Advances in prophylactic cancer vaccine research Le Poole, I. C.; Bommiasamy, H.; Bocchetta, M.; Kast, W. M., Expert Review of Anticancer Therapy
  • Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation. Carbone, M.; Burck, C.; Rdzanek, M.; Rudzinski, J.; Cutrone, R.; Bocchetta, M., Cancer research
  • High throughput testing of the SV40 Large T antigen binding to cellular p53 identifies putative drugs for the treatment of SV40-related cancers. Carbone, M.; Rudzinski, J.; Bocchetta, M., Virology
  • New developments about the association of SV40 with human mesothelioma Carbone, M.; Pass, H. I.; Miele, L.; Bocchetta, M., Oncogene
  • Notch-1 induction a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells., Bocchetta, M.; Miele, L.; Pass, H. I.; Carbone, M., Oncogene
  • SV40 and human brain tumors Carbone, M.; Bocchetta, M.; Cristaudo, A.; Emri, S.; Gazdar, A.; Jasani, B.; Lednicky, J.; Miele, L.; Mutti, L.; Pass, H. I.; Ramael, M.; Rizzo, P.; Testa, J. R.; Weggen, S.; Yeung, A., International journal of cancer.Journal international du cancer
  • Molecular analyses morphology and immunohistochemistry together differentiate pleural synovial sarcomas from mesotheliomas: clinical implications, Carbone, M.; Rizzo, P.; Powers, A.; Bocchetta, M.; Fresco, R.; Krausz, T., Anticancer Research
  • Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells Toyooka, S.; Carbone, M.; Toyooka, K. O.; Bocchetta, M.; Shivapurkar, N.; Minna, J. D.; Gazdar, A. F., Oncogene
  • SV40 infection induces telomerase activity in human mesothelial cells Foddis, R.; De Rienzo, A.; Broccoli, D.; Bocchetta, M.; Stekala, E.; Rizzo, P.; Tosolini, A.; Grobelny, J. V.; Jhanwar, S. C.; Pass, H. I.; Testa, J. R.; Carbone, M., Oncogene
  • Interactions between 23S rRNA and tRNA in the ribosomal E site Bocchetta, M.; Xiong, L.; Shah, S.; Mankin, A. S., RNA (New York, N.Y.)
  • SV40 and the pathogenesis of mesothelioma Rizzo, P.; Bocchetta, M.; Powers, A.; Foddis, R.; Stekala, E.; Pass, H. I.; Carbone, M., Seminars in cancer biology
  • Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity Bocchetta, M.; Di Resta, I.; Powers, A.; Fresco, R.; Tosolini, A.; Testa, J. R.; Pass, H. I.; Rizzo, P.; Carbone, M., Proceedings of the National Academy of Sciences of the United States of America
  • Phylogenetic depth of the bacterial genera Aquifex and Thermotoga inferred from analysis of ribosomal protein elongation factor, and RNA polymerase subunit sequences, Bocchetta, M.; Gribaldo, S.; Sanangelantoni, A.; Cammarano, P., Journal of Molecular Evolution

Our research is focused on studying and fighting hypoxic tumor microenvironment

Primary research interests involve the following: mechanisms of malignant transformation caused by oncogenic DNA viruses, interaction of the major Simian Virus 40 (SV40) oncogenes with cellular proteins, pathogenesis of mesothelioma.