Maurizio Bocchetta, PhD | Loyola Medicine

COVID-19 (Coronavirus) Update

Loyola Medicine is resuming select health care services. Learn more about resumption of services.

Maurizio Bocchetta, PhD

Cancer Biology

Associate Professor

Languages Spoken

English

Clinical Expertise

Biography

Interests

Medical Education

Medical School
Residency
Fellowship
  • University of Illinois at Chicago Medical Center - Research

Board Certification

Research

  • Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival. Baker, A; Wyatt, D; Bocchetta, M; Li, J; Filipovic, A; Green, A; Peiffer, DS; Fuqua, S; Miele, L; Albain, KS; Osipo, C, Oncogene
  • Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation Sobol, A.; Askonas, C.; Alani, S.; Weber, M. J.; Ananthanarayanan, V.; Osipo, C.; Bocchetta, M., Molecular cancer research : MCR
  • Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells Sobol, A.; Galluzzo, P.; Liang, S.; Rambo, B.; Skucha, S.; Weber, M. J.; Alani, S.; Bocchetta, M., Journal of cellular physiology
View All ResearchShow Less
  • Depletion of Amyloid Precursor Protein (APP) causes G0 arrest in non-small cell lung cancer (NSCLC) cells Sobol, A.; Galluzzo, P.; Weber, M. J.; Alani, S.; Bocchetta, M., Journal of cellular physiology
  • Non-small-cell lung carcinoma: role of the Notch signaling pathway. Barse, L; Bocchetta, M, Lung Cancer (Auckland, N.Z.)
  • Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentation Boccardi, M.; Bocchetta, M.; Ganzola, R.; Robitaille, N.; Redolfi, A.; Duchesne, S.; Jack, C. R., Jr; Frisoni, G. B.; EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Segmentation and for the Alzheimer's Disease Neuroimaging Initiative, Alzheimer's & dementia : the journal of the Alzheimer's Association
  • p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating with the Notch Transcriptional Complex via MAML1 Yun, J.; Espinoza, I.; Pannuti, A.; Romero, D.; Martinez, L.; Caskey, M.; Stanculescu, A.; Bocchetta, M.; Rizzo, P.; Band, V.; Band, H.; Kim, H. M.; Park, S. K.; Kang, K. W.; Avantaggiati, M. L.; Gomez, C. R.; Golde, T.; Osborne, B.; Miele, L., Journal of cellular physiology
  • Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzle Boccardi, M.; Bocchetta, M.; Aronen, H. J.; Repo-Tiihonen, E.; Vaurio, O.; Thompson, P. M.; Tiihonen, J.; Frisoni, G. B., International journal of law and psychiatry
  • Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment Clerx, L.; van Rossum, I. A.; Burns, L.; Knol, D. L.; Scheltens, P.; Verhey, F.; Aalten, P.; Lapuerta, P.; van de Pol, L.; van Schijndel, R.; de Jong, R.; Barkhof, F.; Wolz, R.; Rueckert, D.; Bocchetta, M.; Tsolaki, M.; Nobili, F.; Wahlund, L. O.; Minthon, L.; Frolich, L.; Hampel, H.; Soininen, H.; Visser, P. J., Neurobiology of aging
  • Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study Pievani, M.; Bocchetta, M.; Boccardi, M.; Cavedo, E.; Bonetti, M.; Thompson, P. M.; Frisoni, G. B., Neurobiology of aging
  • Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment Liang, S.; Galluzzo, P.; Sobol, A.; Skucha, S.; Rambo, B.; Bocchetta, M., Genes & cancer
  • Notch signaling in lung cancer Galluzzo, P.; Bocchetta, M., Expert Review of Anticancer Therapy
  • Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol Boccardi, M.; Ganzola, R.; Bocchetta, M.; Pievani, M.; Redolfi, A.; Bartzokis, G.; Camicioli, R.; Csernansky, J. G.; de Leon, M. J.; deToledo-Morrell, L.; Killiany, R. J.; Lehericy, S.; Pantel, J.; Pruessner, J. C.; Soininen, H.; Watson, C.; Duchesne, S.; Jack, C. R., Jr; Frisoni, G. B., Journal of Alzheimer's disease : JAD
  • Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Eliasz, S.; Liang, S.; Chen, Y.; De Marco, M. A.; Machek, O.; Skucha, S.; Miele, L.; Bocchetta, M., Oncogene
  • Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes Zhang, L.; Qi, F.; Gaudino, G.; Strianese, O.; Yang, H.; Morris, P.; Pass, H. I.; Nerurkar, V. R.; Bocchetta, M.; Carbone, M., Genes & cancer
  • A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells. Carbone, M.; Pannuti, A.; Zhang, L.; Testa, J. R.; Bocchetta, M., Cancer research
  • Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway. Graziani, I.; Eliasz, S.; De Marco, M. A.; Chen, Y.; Pass, H. I.; De May, R. M.; Strack, P. R.; Miele, L.; Bocchetta, M., Cancer research
  • SV40 Tag/p53 complexes actively promote malignant cell growth of human mesothelial cells. Bocchetta, M.; Carbone, M., Cellular Oncology
  • The SV40 large T antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth. Bocchetta, M.; Eliasz, S.; De Marco, M. A.; Rudzinski, J.; Zhang, L.; Carbone, M., Cancer research
  • Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung. Chen, Y.; De Marco, M. A.; Graziani, I.; Gazdar, A. F.; Strack, P. R.; Miele, L.; Bocchetta, M., Cancer research
  • Cellular and molecular parameters of mesothelioma Ramos-Nino, M. E.; Testa, J. R.; Altomare, D. A.; Pass, H. I.; Carbone, M.; Bocchetta, M.; Mossman, B. T., Journal of cellular biochemistry
  • Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters. Kroczynska, B.; Cutrone, R.; Bocchetta, M.; Yang, H.; Elmishad, A. G.; Vacek, P.; Ramos-Nino, M.; Mossman, B. T.; Pass, H. I.; Carbone, M., Proceedings of the National Academy of Sciences of the United States of America
  • Polio vaccines SV40 and human tumours, an update on false positive and false negative results., Elmishad, A. G.; Bocchetta, M.; Pass, H. I.; Carbone, M., Developments in biologicals
  • TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway a possible mechanism for asbestos-induced oncogenesis., Yang, H.; Bocchetta, M.; Kroczynska, B.; Elmishad, A. G.; Chen, Y.; Liu, Z.; Bubici, C.; Mossman, B. T.; Pass, H. I.; Testa, J. R.; Franzoso, G.; Carbone, M., Proceedings of the National Academy of Sciences of the United States of America
  • Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961. Cutrone, R.; Lednicky, J.; Dunn, G.; Rizzo, P.; Bocchetta, M.; Chumakov, K.; Minor, P.; Carbone, M., Cancer research
  • SV40 detection in human tumor specimens Carbone, M.; Rdzanek, M. A.; Rudzinski, J. J.; De Marco, M. A.; Bocchetta, M.; Ramos Nino, M.; Mossman, B.; Pass, H. I., Cancer research
  • Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformation Bocchetta, M.; Carbone, M., Oncogene
  • Evidence of an important role for SV40 in mesothelioma Pass, H. I.; Bocchetta, M.; Carbone, M., Thoracic Surgery Clinics
  • Genetically distant American Canine distemper virus lineages have recently caused epizootics with somewhat different characteristics in raccoons living around a large suburban zoo in the USA. Lednicky, J. A.; Dubach, J.; Kinsel, M. J.; Meehan, T. P.; Bocchetta, M.; Hungerford, L. L.; Sarich, N. A.; Witecki, K. E.; Braid, M. D.; Pedrak, C.; Houde, C. M., Virology Journal
  • SV40 and Notch-I: multi-functionality meets pleiotropy Carbone, M.; Bocchetta, M., Progress in Molecular & Subcellular Biology
  • Advances in prophylactic cancer vaccine research Le Poole, I. C.; Bommiasamy, H.; Bocchetta, M.; Kast, W. M., Expert Review of Anticancer Therapy
  • Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation. Carbone, M.; Burck, C.; Rdzanek, M.; Rudzinski, J.; Cutrone, R.; Bocchetta, M., Cancer research
  • High throughput testing of the SV40 Large T antigen binding to cellular p53 identifies putative drugs for the treatment of SV40-related cancers. Carbone, M.; Rudzinski, J.; Bocchetta, M., Virology
  • New developments about the association of SV40 with human mesothelioma Carbone, M.; Pass, H. I.; Miele, L.; Bocchetta, M., Oncogene
  • Notch-1 induction a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells., Bocchetta, M.; Miele, L.; Pass, H. I.; Carbone, M., Oncogene
  • SV40 and human brain tumors Carbone, M.; Bocchetta, M.; Cristaudo, A.; Emri, S.; Gazdar, A.; Jasani, B.; Lednicky, J.; Miele, L.; Mutti, L.; Pass, H. I.; Ramael, M.; Rizzo, P.; Testa, J. R.; Weggen, S.; Yeung, A., International journal of cancer.Journal international du cancer
  • Molecular analyses morphology and immunohistochemistry together differentiate pleural synovial sarcomas from mesotheliomas: clinical implications, Carbone, M.; Rizzo, P.; Powers, A.; Bocchetta, M.; Fresco, R.; Krausz, T., Anticancer Research
  • Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells Toyooka, S.; Carbone, M.; Toyooka, K. O.; Bocchetta, M.; Shivapurkar, N.; Minna, J. D.; Gazdar, A. F., Oncogene
  • SV40 infection induces telomerase activity in human mesothelial cells Foddis, R.; De Rienzo, A.; Broccoli, D.; Bocchetta, M.; Stekala, E.; Rizzo, P.; Tosolini, A.; Grobelny, J. V.; Jhanwar, S. C.; Pass, H. I.; Testa, J. R.; Carbone, M., Oncogene
  • Interactions between 23S rRNA and tRNA in the ribosomal E site Bocchetta, M.; Xiong, L.; Shah, S.; Mankin, A. S., RNA (New York, N.Y.)
  • SV40 and the pathogenesis of mesothelioma Rizzo, P.; Bocchetta, M.; Powers, A.; Foddis, R.; Stekala, E.; Pass, H. I.; Carbone, M., Seminars in cancer biology
  • Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity Bocchetta, M.; Di Resta, I.; Powers, A.; Fresco, R.; Tosolini, A.; Testa, J. R.; Pass, H. I.; Rizzo, P.; Carbone, M., Proceedings of the National Academy of Sciences of the United States of America
  • Phylogenetic depth of the bacterial genera Aquifex and Thermotoga inferred from analysis of ribosomal protein elongation factor, and RNA polymerase subunit sequences, Bocchetta, M.; Gribaldo, S.; Sanangelantoni, A.; Cammarano, P., Journal of Molecular Evolution

Our research is focused on studying and fighting hypoxic tumor microenvironment

Primary research interests involve the following: deubiquitinase OTUD6B regulation of growth and proliferation of lung cancer cells.