Mashkoor A. Choudhry, PhD

Surgery

Surgical Research
Microbiology and Immunology
Professor

Languages Spoken

English

Research

  • Alcohol and inflammatory responses: Summary of the 2013 Alcohol and Immunology Research Interest Group (AIRIG) meeting Morris, N. L.; Ippolito, J. A.; Curtis, B. J.; Chen, M. M.; Friedman, S. L.; Hines, I. N.; Haddad, G. E.; Chang, S. L.; Brown, L. A.; Waldschmidt, T. J.; Mandrekar, P.; Kovacs, E. J.; Choudhry, M. A., Alcohol (Fayetteville, N.Y.)
  • Alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin Chen, M. M.; O'Halloran, E. B.; Ippolito, J. A.; Choudhry, M. A.; Kovacs, E. J., Shock (Augusta, Ga.)
  • Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation Earley, Z. M.; Akhtar, S.; Green, S. J.; Naqib, A.; Khan, O.; Cannon, A. R.; Hammer, A. M.; Morris, N. L.; Li, X.; Eberhardt, J. M.; Gamelli, R. L.; Kennedy, R. H.; Choudhry, M. A., PLoS ONE
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  • Inflammatory Response to Traumatic Injury: Clinical and Animal Researches in Inflammation Yu, H. P.; Chaudry, I. H.; Choudhry, M. A.; Hsing, C. H.; Liu, F. C.; Xia, Z., Mediators of inflammation
  • Intestine Immune Homeostasis after Alcohol and Burn Injury Li, X.; Hammer, A. M.; Rendon, J. L.; Choudhry, M. A., Shock (Augusta, Ga.)
  • Regional variation in expression of pro-inflammatory mediators in the intestine following a combined insult of alcohol and burn injury Morris, N. L.; Li, X.; Earley, Z. M.; Choudhry, M. A., Alcohol (Fayetteville, N.Y.)
  • Summary of the 2014 Alcohol and Immunology Research Interest Group (AIRIG) meeting Hammer, A. M.; Morris, N. L.; Cannon, A. R.; Shults, J. A.; Curtis, B.; Casey, C. A.; Sueblinvong, V.; Persidsky, Y.; Nixon, K.; Brown, L. A.; Waldschmidt, T.; Mandrekar, P.; Kovacs, E. J.; Choudhry, M. A., Alcohol (Fayetteville, N.Y.)
  • The Effects of Alcohol Intoxication and Burn Injury on the Expression of Claudins and Mucins in the Small and Large Intestines Hammer, A. M.; Khan, O. M.; Morris, N. L.; Li, X.; Movtchan, N. V.; Cannon, A. R.; Choudhry, M. A., Shock (Augusta, Ga.)
  • The First Line of Defense: The Effects of Alcohol on Post-Burn Intestinal Barrier Immune Cells, and Microbiome, Hammer, A. M.; Morris, N. L.; Earley, Z. M.; Choudhry, M. A., Alcohol research : current reviews
  • An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice Chen, M. M.; Zahs, A.; Brown, M. M.; Ramirez, L.; Turner, J. R.; Choudhry, M. A.; Kovacs, E. J., American journal of physiology.Gastrointestinal and liver physiology
  • T Cell IFN-gamma Suppression Following Alcohol and Burn Injury Is Independent of miRNA155 Li, X.; Rendon, J. L.; Choudhry, M. A., PLoS ONE
  • The role of aryl hydrocarbon receptor in interleukin-23-dependent restoration of interleukin-22 following ethanol exposure and burn injury Rendon, J. L.; Li, X.; Brubaker, A. L.; Kovacs, E. J.; Gamelli, R. L.; Choudhry, M. A., Annals of Surgery
  • Alcohol and immunology: Summary of the 2012 Alcohol and Immunology Research Interest Group (AIRIG) meeting Ippolito, J. A.; Curtis, B. J.; Choudhry, M. A.; Kovacs, E. J., Alcohol (Fayetteville, N.Y.)
  • Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury Zahs, A.; Bird, M. D.; Ramirez, L.; Choudhry, M. A.; Kovacs, E. J., Shock
  • Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury Rendon, J. L.; Li, X.; Akhtar, S.; Choudhry, M. A., Shock (Augusta, Ga.)
  • Intoxication by intraperitoneal injection or oral gavage equally potentiates postburn organ damage and inflammation Chen, M. M.; Palmer, J. L.; Ippolito, J. A.; Curtis, B. J.; Choudhry, M. A.; Kovacs, E. J., Mediators of inflammation
  • Noninvasive measurement of intestinal inflammation after burn injury Sigman, M.; Conrad, P.; Rendon, J. L.; Akhtar, S.; Eberhardt, J.; Gamelli, R. L.; Choudhry, M. A., Journal of burn care & research : official publication of the American Burn Association
  • Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age Brubaker, A. L.; Rendon, J. L.; Ramirez, L.; Choudhry, M. A.; Kovacs, E. J., Journal of immunology (Baltimore, Md.: 1950)
  • Activation of toll-like receptor 2 prevents suppression of T-cell interferon gamma production by modulating p38/extracellular signal-regulated kinase pathways following alcohol and burn injury Li, X.; Rendon, J. L.; Akhtar, S.; Choudhry, M. A., Molecular medicine (Cambridge, Mass.)
  • Alcohol and epigenetic changes: summary of the 2011 Alcohol and Immunology Research Interest Group (AIRIG) meeting Zahs, A.; Curtis, B. J.; Waldschmidt, T. J.; Brown, L. A.; Gauthier, T. W.; Choudhry, M. A.; Kovacs, E. J.; Bird, M. D., Alcohol (Fayetteville, N.Y.)
  • Alcohol and inflammation and infection: clinical and experimental systems--summary of the 2010 Alcohol and Immunology Research Interest Group Meeting. Zahs, A.; Cook, R. T.; Waldschimdt, T. J.; Choudhry, M. A.; Kovacs, E. J.; Bird, M. D., Alcohol
  • Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Li, X.; Akhtar, S.; Choudhry, M. A., Biochimica et biophysica acta
  • Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Zahs, A.; Bird, M. D.; Ramirez, L.; Turner, J. R.; Choudhry, M. A.; Kovacs, E. J., American Journal of Physiology - Gastrointestinal & Liver Physiology
  • Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice Biju, P. G.; Garg, S.; Wang, W.; Choudhry, M. A.; Kovacs, E. J.; Fink, L. M.; Hauer-Jensen, M., Shock (Augusta, Ga.)
  • Th17 cells: critical mediators of host responses to burn injury and sepsis Rendon, J. L.; Choudhry, M. A., Journal of leukocyte biology
  • Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury. Li, X.; Akhtar, S.; Kovacs, E. J.; Gamelli, R. L.; Choudhry, M. A., Journal of Burn Care & Research
  • Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury. Akhtar, S.; Li, X.; Kovacs, E. J.; Gamelli, R. L.; Choudhry, M. A., Molecular Medicine
  • Role of PPARgamma in the salutary effects of 17beta-estradiol on Kupffer cell cytokine production following trauma-hemorrhage Suzuki, T.; Kawasaki, T.; Choudhry, M. A.; Chaudry, I. H., Journal of cellular physiology
  • Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling. Bird, M. D.; Zahs, A.; Deburghgraeve, C.; Ramirez, L.; Choudhry, M. A.; Kovacs, E. J., Alcoholism: Clinical & Experimental Research
  • Salutary effects of 17beta-estradiol on Peyer's patch T cell functions following trauma-hemorrhage Kawasaki, T.; Suzuki, T.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Cytokine
  • Alcohol and trauma: a summary of the Satellite Symposium at the 30th Annual Meeting of the Shock Society. Bird, M. D.; Choudhry, M. A.; Molina, P. E.; Kovacs, E. J., Alcohol
  • Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage Kawasaki, T.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Cell physiology
  • ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury. Li, X.; Chaudry, I. H.; Choudhry, M. A., Journal of Immunology
  • Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses Yang, S.; Hu, S.; Chen, J.; Choudhry, M. A.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., Journal of leukocyte biology
  • Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation Hsu, J. T.; Kan, W. H.; Hsieh, C. H.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Critical care medicine
  • Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation Hsieh, C. H.; Nickel, E. A.; Chen, J.; Schwacha, M. G.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Journal of immunology (Baltimore, Md.: 1950)
  • Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. Akhtar, S.; Li, X.; Chaudry, I. H.; Choudhry, M. A., American Journal of Physiology - Gastrointestinal & Liver Physiology
  • Role of extracellular signal-regulated protein kinase (ERK) in 17beta-estradiol-mediated attenuation of lung injury after trauma-hemorrhage Hsu, J. T.; Kan, W. H.; Hsieh, C. H.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Surgery
  • 17beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alpha Kawasaki, T.; Choudhry, M. A.; Suzuki, T.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Molecular immunology
  • 17beta-Estradiol: a novel hormone for improving immune and cardiovascular responses following trauma-hemorrhage Choudhry, M. A.; Chaudry, I. H., Journal of leukocyte biology
  • Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injury Li, X.; Schwacha, M. G.; Chaudry, I. H.; Choudhry, M. A., Shock (Augusta, Ga.)
  • Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice Lederer, J. A.; Brownstein, B. H.; Lopez, M. C.; Macmillan, S.; Delisle, A. J.; Macconmara, M. P.; Choudhry, M. A.; Xiao, W.; Lekousi, S.; Cobb, J. P.; Baker, H. V.; Mannick, J. A.; Chaudry, I. H.; Inflammation and the Host Response to Injury Collaborative Research Program Participants, Physiological Genomics
  • Estradiol's salutary effects on keratinocytes following trauma-hemorrhage are mediated by estrogen receptor (ER)-alpha and ER-beta Moeinpour, F.; Choudhry, M. A.; de Figueiredo, L. F.; Bland, K. I.; Chaudry, I. H., Molecular medicine (Cambridge, Mass.)
  • Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G Kan, W. H.; Hsu, J. T.; Schwacha, M. G.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Annals of Surgery
  • Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhage Suzuki, T.; Yu, H. P.; Hsieh, Y. C.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Journal of cellular physiology
  • Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response oxidative stress, and apopotosis, Kan, W. H.; Hsieh, C. H.; Schwacha, M. G.; Choudhry, M. A.; Raju, R.; Bland, K. I.; Chaudry, I. H., Journal of applied physiology (Bethesda, Md.: 1985)
  • Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2- production in a two-hit model of alcohol intoxication and burn injury Li, X.; Schwacha, M. G.; Chaudry, I. H.; Choudhry, M. A., Journal of immunology (Baltimore, Md.: 1950)
  • Inhibition of protein tyrosine phosphatases prevents mesenteric lymph node T-cell suppression following alcohol intoxication and burn injury Li, X.; Schwacha, M. G.; Chaudry, I. H.; Choudhry, M. A., Journal of burn care & research : official publication of the American Burn Association
  • Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels Hsu, J. T.; Kan, W. H.; Hsieh, Y. C.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Shock (Augusta, Ga.)
  • Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage Suzuki, T.; Yu, H. P.; Hsieh, Y. C.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Cytokine
  • p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage Kan, W. H.; Hsu, J. T.; Ba, Z. F.; Schwacha, M. G.; Chen, J.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Heart and circulatory physiology
  • Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury Kan, W. H.; Hsu, J. T.; Schwacha, M. G.; Choudhry, M. A.; Raju, R.; Bland, K. I.; Chaudry, I. H., Journal of applied physiology (Bethesda, Md.: 1985)
  • The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: direct modulation of CINC-1 production by Kupffer cells Shimizu, T.; Suzuki, T.; Yu, H. P.; Yokoyama, Y.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Cytokine
  • The role of MIP-1 alpha in the development of systemic inflammatory response and organ injury following trauma hemorrhage Hsieh, C. H.; Frink, M.; Hsieh, Y. C.; Kan, W. H.; Hsu, J. T.; Schwacha, M. G.; Choudhry, M. A.; Chaudry, I. H., Journal of immunology (Baltimore, Md.: 1950)
  • Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process Kawasaki, T.; Choudhry, M. A.; Schwacha, M. G.; Fujimi, S.; Lederer, J. A.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Cell physiology
  • 17 Beta-estradiol normalizes Toll receptor 4 mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage, Moeinpour, F.; Choudhry, M. A.; Kawasaki, T.; Timares, L.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Molecular immunology
  • 17Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage Hsieh, Y. C.; Frink, M.; Thobe, B. M.; Hsu, J. T.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Molecular immunology
  • 17beta-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage Frink, M.; Thobe, B. M.; Hsieh, Y. C.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Lung cellular and molecular physiology
  • Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats. Li, X.; Kovacs, E. J.; Schwacha, M. G.; Chaudry, I. H.; Choudhry, M. A., American Journal of Physiology - Lung Cellular & Molecular Physiology
  • Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage Yang, S.; Hu, S.; Choudhry, M. A.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., Journal of Molecular and Cellular Cardiology
  • Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage Hsieh, Y. C.; Frink, M.; Hsieh, C. H.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Lung cellular and molecular physiology
  • Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage Hsieh, Y. C.; Frink, M.; Kawasaki, T.; Thobe, B. M.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Journal of cellular physiology
  • Estrogen receptor-alpha predominantly mediates the salutary effects of 17beta-estradiol on splenic macrophages following trauma-hemorrhage Suzuki, T.; Shimizu, T.; Yu, H. P.; Hsieh, Y. C.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Cell physiology
  • Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway Shimizu, T.; Yu, H. P.; Hsieh, Y. C.; Choudhry, M. A.; Suzuki, T.; Bland, K. I.; Chaudry, I. H., Annals of Surgery
  • G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage Hsieh, Y. C.; Yu, H. P.; Frink, M.; Suzuki, T.; Choudhry, M. A.; Schwacha, M. G.; Chaudry, I. H., The American journal of pathology
  • Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage Frink, M.; Hsieh, Y. C.; Hsieh, C. H.; Pape, H. C.; Choudhry, M. A.; Schwacha, M. G.; Chaudry, I. H., Shock (Augusta, Ga.)
  • Liver cytokine production and ICAM-1 expression following bone fracture tissue trauma, and hemorrhage in middle-aged mice, Matsutani, T.; Kang, S. C.; Miyashita, M.; Sasajima, K.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Gastrointestinal and liver physiology
  • Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation Hsu, J. T.; Kan, W. H.; Hsieh, C. H.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Journal of leukocyte biology
  • Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: upregulation of estradiol synthesis Frink, M.; Hsieh, Y. C.; Hu, S.; Hsieh, C. H.; Pape, H. C.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Annals of Surgery
  • Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway Yu, H. P.; Hsieh, Y. C.; Suzuki, T.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Journal of leukocyte biology
  • Metabolic modulators following trauma sepsis: sex hormones Hsieh, Y. C.; Frink, M.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Critical care medicine
  • Mitochondria play an important role in 17beta-estradiol attenuation of H(2)O(2)-induced rat endothelial cell apoptosis Lu, A.; Frink, M.; Choudhry, M. A.; Schwacha, M. G.; Hubbard, W. J.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., American journal of physiology.Endocrinology and metabolism
  • Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production Frink, M.; Lu, A.; Thobe, B. M.; Hsieh, Y. C.; Choudhry, M. A.; Schwacha, M. G.; Kunkel, S. L.; Chaudry, I. H., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology
  • Regulation of the postburn wound inflammatory response by gammadelta T-cells Daniel, T.; Thobe, B. M.; Chaudry, I. H.; Choudhry, M. A.; Hubbard, W. J.; Schwacha, M. G., Shock (Augusta, Ga.)
  • Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage Hsu, J. T.; Hsieh, Y. C.; Kan, W. H.; Chen, J. G.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Heart and circulatory physiology
  • Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-alpha Suzuki, T.; Shimizu, T.; Yu, H. P.; Hsieh, Y. C.; Choudhry, M. A.; Chaudry, I. H., American journal of physiology.Cell physiology
  • The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage Yu, H. P.; Hsieh, Y. C.; Suzuki, T.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Annals of Surgery
  • The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage Shimizu, T.; Yu, H. P.; Suzuki, T.; Szalay, L.; Hsieh, Y. C.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Journal of Hepatology
  • The role of MAPK in Kupffer cell toll-like receptor (TLR) 2- TLR4-, and TLR9-mediated signaling following trauma-hemorrhage, Thobe, B. M.; Frink, M.; Hildebrand, F.; Schwacha, M. G.; Hubbard, W. J.; Choudhry, M. A.; Chaudry, I. H., Journal of cellular physiology
  • Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage Suzuki, T.; Shimizu, T.; Yu, H. P.; Hsieh, Y. C.; Choudhry, M. A.; Schwacha, M. G.; Chaudry, I. H., Journal of applied physiology (Bethesda, Md.: 1985)
  • TLR4 regulates Kupffer cell chemokine production systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage, Frink, M.; Hsieh, Y. C.; Thobe, B. M.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Molecular immunology
  • Trauma and immune response--effect of gender differences Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Injury
  • Young and middle-age associated differences in cytokeratin expression after bone fracture tissue trauma, and hemorrhage, Matsutani, T.; Kang, S. C.; Miyashita, M.; Sasajima, K.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., American Journal of Surgery
  • 17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha Suzuki, T.; Shimizu, T.; Yu, H. P.; Hsieh, Y. C.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Surgery
  • A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injury Li, X.; Rana, S. N.; Schwacha, M. G.; Chaudry, I. H.; Choudhry, M. A., Journal of leukocyte biology
  • A role for corticosterone in impaired intestinal immunity and barrier function in a rodent model of acute alcohol intoxication and burn injury Choudhry, M. A.; Li, X.; Chaudry, I. H., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
  • A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury Li, X.; Schwacha, M. G.; Chaudry, I. H.; Choudhry, M. A., Journal of leukocyte biology
  • A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage Shimizu, T.; Szalay, L.; Hsieh, Y. C.; Suzuki, T.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Annals of Surgery
  • Alcohol intoxication and post-burn complications Choudhry, M. A.; Chaudry, I. H., Frontiers in bioscience : a journal and virtual library
  • Androstenediol administration after trauma-hemorrhage attenuates inflammatory response reduces organ damage, and improves survival following sepsis, Szalay, L.; Shimizu, T.; Suzuki, T.; Hsieh, Y. C.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Gastrointestinal and liver physiology
  • Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis Suzuki, T.; Shimizu, T.; Szalay, L.; Choudhry, M. A.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., Cytokine
  • Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta? Hildebrand, F.; Hubbard, W. J.; Choudhry, M. A.; Thobe, B. M.; Pape, H. C.; Chaudry, I. H., Journal of leukocyte biology
  • Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females Hildebrand, F.; Hubbard, W. J.; Choudhry, M. A.; Thobe, B. M.; Pape, H. C.; Chaudry, I. H., Journal of leukocyte biology
  • Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage Hildebrand, F.; Thobe, B. M.; Hubbard, W. J.; Choudhry, M. A.; Pape, H. C.; Chaudry, I. H., Cytokine
  • Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression Szalay, L.; Shimizu, T.; Suzuki, T.; Yu, H. P.; Choudhry, M. A.; Schwacha, M. G.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology
  • Estrus cycle: influence on cardiac function following trauma-hemorrhage Yang, S.; Choudhry, M. A.; Hsieh, Y. C.; Hu, S.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., American journal of physiology.Heart and circulatory physiology
  • Gender and susceptibility to sepsis following trauma Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Endocrine, metabolic & immune disorders drug targets
  • Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage Hsieh, Y. C.; Choudhry, M. A.; Yu, H. P.; Shimizu, T.; Yang, S.; Suzuki, T.; Chen, J.; Bland, K. I.; Chaudry, I. H., FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice Kawasaki, T.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Cell physiology
  • Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: upregulation of heme oxygenase-1 Yu, H. P.; Yang, S.; Hsieh, Y. C.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Lung cellular and molecular physiology
  • Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteins Yu, H. P.; Shimizu, T.; Choudhry, M. A.; Hsieh, Y. C.; Suzuki, T.; Bland, K. I.; Chaudry, I. H., Journal of Molecular and Cellular Cardiology
  • Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage Yang, S.; Hu, S.; Hsieh, Y. C.; Choudhry, M. A.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., Journal of Molecular and Cellular Cardiology
  • Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1 Yu, H. P.; Choudhry, M. A.; Shimizu, T.; Hsieh, Y. C.; Schwacha, M. G.; Yang, S.; Chaudry, I. H., Journal of leukocyte biology
  • MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxia Zheng, R.; Pan, G.; Thobe, B. M.; Choudhry, M. A.; Matsutani, T.; Samy, T. S.; Kang, S. C.; Bland, K. I.; Chaudry, I. H., Molecular medicine (Cambridge, Mass.)
  • Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction Daniel, T.; Alexander, M.; Hubbard, W. J.; Chaudry, I. H.; Choudhry, M. A.; Schwacha, M. G., Journal of cellular physiology
  • Salutary effects of estrogen receptor-beta agonist on lung injury after trauma-hemorrhage Yu, H. P.; Hsieh, Y. C.; Suzuki, T.; Shimizu, T.; Choudhry, M. A.; Schwacha, M. G.; Chaudry, I. H., American journal of physiology.Lung cellular and molecular physiology
  • Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia Thobe, B. M.; Frink, M.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Cell physiology
  • T cells of the gammadelta T-cell receptor lineage play an important role in the postburn wound healing process Alexander, M.; Daniel, T.; Chaudry, I. H.; Choudhry, M. A.; Schwacha, M. G., Journal of burn care & research : official publication of the American Burn Association
  • The role of the general transcription factor IIF in androgen receptor-dependent transcription Choudhry, M. A.; Ball, A.; McEwan, I. J., Molecular endocrinology (Baltimore, Md.)
  • Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage Yu, H. P.; Shimizu, T.; Hsieh, Y. C.; Suzuki, T.; Choudhry, M. A.; Schwacha, M. G.; Chaudry, I. H., Journal of leukocyte biology
  • Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice Kawasaki, T.; Fujimi, S.; Lederer, J. A.; Hubbard, W. J.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Journal of immunology (Baltimore, Md.: 1950)
  • Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage Hsieh, Y. C.; Yu, H. P.; Suzuki, T.; Choudhry, M. A.; Schwacha, M. G.; Bland, K. I.; Chaudry, I. H., Journal of Molecular and Cellular Cardiology
  • Alcohol ingestion before burn injury decreases splanchnic blood flow and oxygen delivery Choudhry, M. A.; Ba, Z. F.; Rana, S. N.; Bland, K. I.; Chaudry, I. H., American journal of physiology.Heart and circulatory physiology
  • Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury. Li, X.; Rana, S. N.; Kovacs, E. J.; Gamelli, R. L.; Chaudry, I. H.; Choudhry, M. A., American Journal of Physiology - Regulatory Integrative & Comparative Physiology
  • Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Kavanaugh, M. J.; Clark, C.; Goto, M.; Kovacs, E. J.; Gamelli, R. L.; Sayeed, M. M.; Choudhry, M. A., Burns
  • Gender differences in acute response to trauma-hemorrhage Choudhry, M. A.; Schwacha, M. G.; Hubbard, W. J.; Kerby, J. D.; Rue, L. W.; Bland, K. I.; Chaudry, I. H., Shock (Augusta, Ga.)
  • Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injury Rana, S. N.; Li, X.; Chaudry, I. H.; Bland, K. I.; Choudhry, M. A., Journal of leukocyte biology
  • Inhibition of T cell MAPKs (Erk 1/2 p38) with thermal injury is related to down-regulation of Ca2+ signaling., Fazal, N.; Choudhry, M. A.; Sayeed, M. M., Biochimica et biophysica acta
  • Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase Shimizu, T.; Szalay, L.; Choudhry, M. A.; Schwacha, M. G.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., American journal of physiology.Gastrointestinal and liver physiology
  • Mechanism responsible for the salutary effects of flutamide on cardiac performance after trauma-hemorrhagic shock: Upregulation of cardiomyocyte estrogen receptors Yu, H. P.; Yang, S.; Choudhry, M. A.; Hsieh, Y. C.; Bland, K. I.; Chaudry, I. H., Surgery
  • Salutary effects of androstenediol on hepatic function after trauma-hemorrhage are mediated via peroxisome proliferators-activated receptor gamma Shimizu, T.; Szalay, L.; Hsieh, Y. C.; Choudhry, M. A.; Bland, K. I.; Chaudry, I. H., Surgery
  • Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. Goral, J.; Choudhry, M. A.; Kovacs, E. J., Journal of leukocyte biology
  • Are the immune responses different in middle-aged and young mice following bone fracture tissue trauma and hemorrhage?, Kang, S. C.; Matsutani, T.; Choudhry, M. A.; Schwacha, M. G.; Rue, L. W.; Bland, K. I.; Chaudry, I. H., Cytokine
  • Combined alcohol and burn injury differentially regulate P-38 and ERK activation in mesenteric lymph node T cell. Choudhry, M. A.; Ren, X.; Romero, A.; Kovacs, E. J.; Gamelli, R. L.; Sayeed, M. M., Journal of Surgical Research
  • Impaired intestinal immunity and barrier function: a cause for enhanced bacterial translocation in alcohol intoxication and burn injury Choudhry, M. A.; Rana, S. N.; Kavanaugh, M. J.; Kovacs, E. J.; Gamelli, R. L.; Sayeed, M. M., Alcohol
  • Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage Shimizu, T.; Choudhry, M. A.; Szalay, L.; Rue, L. W., 3rd; Bland, K. I.; Chaudry, I. H., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology
  • A role for CD1d-restricted NKT cells in injury-associated T cell suppression. Faunce, D. E.; Gamelli, R. L.; Choudhry, M. A.; Kovacs, E. J., Journal of leukocyte biology
  • Advanced age negatively influences mesenteric lymph node T cell responses after burn injury. Choudhry, M. A.; Plackett, T. P.; Schilling, E. M.; Faunce, D. E.; Gamelli, R. L.; Kovacs, E. J., Immunology letters
  • Aging enhances lymphocyte cytokine defects after injury. Plackett, T. P.; Schilling, E. M.; Faunce, D. E.; Choudhry, M. A.; Witte, P. L.; Kovacs, E. J., FASEB Journal
  • Effects of pentoxyfylline on mesenteric lymph node T-cells in a rat model of thermal injury. Kotadia, B. K.; Ravindranath, T. M.; Choudhry, M. A.; Haque, F.; Al-Ghoul, W.; Sayeed, M. M., Shock
  • Enteral nutritional supplementation prevents mesenteric lymph node T-cell suppression in burn injury. Choudhry, M. A.; Haque, F.; Khan, M.; Fazal, N.; Al-Ghoul, W.; Ravindranath, T.; Gamelli, R. L.; Sayeed, M. M., Critical care medicine
  • T-cell proliferative responses following sepsis in neonatal rats Dallal, O.; Ravindranath, T. M.; Choudhry, M. A.; Kohn, A.; Muraskas, J. K.; Namak, S. Y.; Alattar, M. H.; Sayeed, M. M., Biology of the neonate
  • Gut-associated lymphoid T cell suppression enhances bacterial translocation in alcohol and burn injury. Choudhry, M. A.; Fazal, N.; Goto, M.; Gamelli, R. L.; Sayeed, M. M., American Journal of Physiology - Gastrointestinal & Liver Physiology
  • Effects of burn with and without Escherichia coli infection in rats on intestinal vs. splenic T-cell responses Ravindranath, T.; Al-Ghoul, W.; Namak, S.; Fazal, N.; Durazo-Arvizu, R. A.; Choudhry, M. A.; Sayeed, M. M., Critical care medicine
  • Sepsis-induced alteration in T-cell Ca(2+) signaling in neonatal rats Alattar, M. H.; Ravindranath, T. M.; Choudhry, M. A.; Muraskas, J. K.; Namak, S. Y.; Dallal, O.; Sayeed, M. M., Biology of the neonate
  • Ethanol exacerbates T cell dysfunction after thermal injury. Choudhry, M. A.; Messingham, K. A.; Namak, S.; Colantoni, A.; Fontanilla, C. V.; Duffner, L. A.; Sayeed, M. M.; Kovacs, E. J., Alcohol
  • Neutrophil depletion prevents intestinal mucosal permeability alterations in burn-injured rats. Sir, O.; Fazal, N.; Choudhry, M. A.; Gamelli, R. L.; Sayeed, M. M., American Journal of Physiology - Regulatory Integrative & Comparative Physiology
  • Role of neutrophils in burn-induced microvascular injury in the intestine. Sir, O.; Fazal, N.; Choudhry, M. A.; Goris, R. J.; Gamelli, R. L.; Sayeed, M. M., Shock

Research Interest: Gut immunity and epithelial barrier in response to injury

Intestine is the major reservoir of bacteria within the body and it maintains an effective barrier against these bacteria under healthy conditions. However, this barrier is compromised following alcohol exposure, burn injury and other traumatic insults; a compromised intestinal barrier facilitates the entry of intestinal bacteria and their products to extra intestinal sites. These intestinal-derived bacteria or their products present a major clinical problem to burn/trauma victims as well as in patients with history of alcohol exposure and are implicated in the subsequent development of multiple organ failure. Dr. Choudhry’s laboratory is interested in learning the mechanisms of impaired gut barrier following alcohol exposure and major trauma such as burn.

The focus of his ongoing research is on:
1) T cell mediated immunity against gut-derived bacteria;
2) Neutrophils and their role in tissue damage and defense against bacteria;
3) Epithelial cells and their role in defense against gut bacteria.

Additionally, emerging evidence indicates that gut microflora plays critical roles in maintaining an effective gut barrier. So, another major aspect of ongoing studies in Dr. Choudhry’s laboratory is to determine whether alcohol exposure or traumatic injury influences the gut microflora and whether changes in gut microflora have any relationship with impaired gut mucosal immunity and epithelial barrier function under those conditions.

View a partial list of Dr. Choudhry's publications through the National Library of Medicine's PubMed online database.