Manuel Diaz, MD

Medicine

Hematology/Oncology
Microbiology and Immunology
Professor

Languages Spoken

English

Medical Education

Medical School
University of the Republic, Uruguay

Board Certification

American Nurses Credentialing Center
Anesthesiology
American Board of

Research

  • In relation to the article "Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases" by Bogerhausen et al Diaz, M. O., CLINICAL GENETICS
  • Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad a homolog of the N-terminal portion of mammalian MLL2 and MLL3., Chauhan, C.; Zraly, C. B.; Parilla, M.; Diaz, M. O.; Dingwall, A. K., Development
  • Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapy Shih, S. J.; Fass, J.; Buffalo, V.; Lin, D.; Singh, S. P.; Diaz, M. O.; Vaughan, A. T., British journal of haematology
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  • 11q21.1-11q23.3 Is a site of intrinsic genomic instability triggered by irradiation Du, N.; Baker, P. M.; Do, T. U.; Bien, C.; Bier-Laning, C. M.; Singh, S.; Shih, S. J.; Diaz, M. O.; Vaughan, A. T., Genes, chromosomes & cancer
  • Diffuse centromere and chromosome polymorphism in haplogyne spiders of the families Dysderidae and Segestriidae. Diaz, M. O.; Maynard, R.; Brum-Zorrilla, N., Cytogenetic & Genome Research
  • The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression Park, S.; Osmers, U.; Raman, G.; Schwantes, R. H.; Diaz, M. O.; Bushweller, J. H., Biochemistry
  • c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Guo, Y.; Niu, C.; Breslin, P.; Tang, M.; Zhang, S.; Wei, W.; Kini, A. R.; Paner, G. P.; Alkan, S.; Morris, S. W.; Diaz, M.; Stiff, P. J.; Zhang, J., Blood
  • CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing Tie, F.; Banerjee, R.; Stratton, C. A.; Prasad-Sinha, J.; Stepanik, V.; Zlobin, A.; Diaz, M. O.; Scacheri, P. C.; Harte, P. J., Development (Cambridge, England)
  • Rearrangements of the MLL gene are influenced by DNA secondary structure potentially mediated by topoisomerase II binding, Le, H.; Singh, S.; Shih, S. J.; Du, N.; Schnyder, S.; Loredo, G. A.; Bien, C.; Michaelis, L.; Toor, A.; Diaz, M. O.; Vaughan, A. T., Genes, chromosomes & cancer
  • Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Chen, J.; Santillan, D. A.; Koonce, M.; Wei, W.; Luo, R.; Thirman, M. J.; Zeleznik-Le, N. J.; Diaz, M. O., Cancer research
  • MLL protects CpG clusters from methylation within the Hoxa9 gene maintaining transcript expression., Erfurth, F. E.; Popovic, R.; Grembecka, J.; Cierpicki, T.; Theisler, C.; Xia, Z. B.; Stuart, T.; Diaz, M. O.; Bushweller, J. H.; Zeleznik-Le, N. J., Proceedings of the National Academy of Sciences of the United States of America
  • TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. Tang, M.; Wei, X.; Guo, Y.; Breslin, P.; Zhang, S.; Zhang, S.; Wei, W.; Xia, Z.; Diaz, M.; Akira, S.; Zhang, J., Journal of Experimental Medicine
  • Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity. Betti, C. J.; Villalobos, M. J.; Jiang, Q.; Cline, E.; Diaz, M. O.; Loredo, G.; Vaughan, A. T., Leukemia
  • Surviving apoptosis: a possible mechanism of benzene-induced leukemia Vaughan, A. T.; Betti, C. J.; Villalobos, M. J.; Premkumar, K.; Cline, E.; Jiang, Q.; Diaz, M. O., Chemico-biological interactions
  • The MLL fusion gene MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression., Xia, Z. B.; Popovic, R.; Chen, J.; Theisler, C.; Stuart, T.; Santillan, D. A.; Erfurth, F.; Diaz, M. O.; Zeleznik-Le, N. J., Proceedings of the National Academy of Sciences of the United States of America
  • Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division Betti, C. J.; Villalobos, M. J.; Diaz, M. O.; Vaughan, A. T., Cancer research
  • MLL repression domain interacts with histone deacetylases the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein., Xia, Z. B.; Anderson, M.; Diaz, M. O.; Zeleznik-Le, N. J., Proceedings of the National Academy of Sciences of the United States of America
  • Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma. Chaturvedi, V.; Bonish, B.; Bacon, P.; Qin, J. Z.; Denning, M. F.; Foreman, K. E.; Diaz, M. O.; Robinson, J.; Nickoloff, B. J., Experimental dermatology
  • Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes Chaturvedi, V.; Cesnjaj, M.; Bacon, P.; Panella, J.; Choubey, D.; Diaz, M. O.; Nickoloff, B. J., The American journal of pathology
  • A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells Anderson, M.; Fair, K.; Amero, S.; Nelson, S.; Harte, P. J.; Diaz, M. O., Development genes and evolution
  • Abnormal NF-kappaB signaling pathway with enhanced susceptibility to apoptosis in immortalized keratinocytes Chaturvedi, V.; Qin, J. Z.; Denning, M. F.; Choubey, D.; Diaz, M. O.; Nickoloff, B. J., Journal of dermatological science
  • Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system Betti, C. J.; Villalobos, M. J.; Diaz, M. O.; Vaughan, A. T., Cancer research
  • Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells Fair, K.; Anderson, M.; Bulanova, E.; Mi, H.; Tropschug, M.; Diaz, M. O., Molecular and cellular biology
  • Id-1 delays senescence but does not immortalize keratinocytes Nickoloff, B. J.; Chaturvedi, V.; Bacon, P.; Qin, J. Z.; Denning, M. F.; Diaz, M. O., The Journal of biological chemistry