Leanne Cribbs, PhD | Loyola Medicine

Leanne Cribbs, PhD

Cell and Molecular Physiology

Associate Professor

Languages Spoken

English, French Not fluent

Clinical Expertise

Biography

Interests
Bicycling;Knitting

Medical Education

Medical School
Residency
Fellowship

Board Certification

Research

  • Mechanisms of PKA-Dependent Potentiation of Kv7.5 Channel Activity in Human Airway Smooth Muscle Cells. Brueggemann, LI; Cribbs, LL; Schwartz, J; Wang, M; Kouta, A; Byron, KL, International journal of molecular sciences
  • PKC-dependent regulation of Kv7.5 channels by the bronchoconstrictor histamine in human airway smooth muscle cells Haick, J. M.; Brueggemann, L. I.; Cribbs, L. L.; Denning, M. F.; Schwartz, J.; Byron, K. L., American journal of physiology.Lung cellular and molecular physiology
  • Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents Mani, B. K.; Robakowski, C.; Brueggemann, L. I.; Cribbs, L. L.; Tripathi, A.; Majetschak, M.; Byron, K. L., Molecular pharmacology
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  • Differential activation of vascular smooth muscle Kv7.4 Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673, Brueggemann, L. I.; Haick, J. M.; Cribbs, L. L.; Byron, K. L., Molecular pharmacology
  • Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels Brueggemann, L. I.; Mackie, A. R.; Cribbs, L. L.; Freda, J.; Tripathi, A.; Majetschak, M.; Byron, K. L., The Journal of biological chemistry
  • Down-regulation of endogenous KLHL1 decreases voltage-gated calcium current density Perissinotti, P. P.; Ethington, E. G.; Cribbs, L.; Koob, M. D.; Martin, J.; Piedras-Renteria, E. S., Cell calcium
  • KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a beta2-adrenergic agonist enhances relaxation of rat airways Brueggemann, L. I.; Haick, J. M.; Neuburg, S.; Tate, S.; Randhawa, D.; Cribbs, L. L.; Byron, K. L., American journal of physiology.Lung cellular and molecular physiology
  • Elimination of the actin-binding domain in kelch-like 1 protein induces T-type calcium channel modulation only in the presence of action potential waveforms Aromolaran, K. A.; Benzow, K. A.; Cribbs, L. L.; Koob, M. D.; Piedras-Renteria, E. S., Journal of signal transduction
  • Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy. Brueggemann, L. I.; Kakad, P. P.; Love, R. B.; Solway, J.; Dowell, M. L.; Cribbs, L. L.; Byron, K. L., American Journal of Physiology - Lung Cellular & Molecular Physiology
  • Diclofenac distinguishes among homomeric and heteromeric potassium channels composed of KCNQ4 and KCNQ5 subunits. Brueggemann, L. I.; Mackie, A. R.; Martin, J. L.; Cribbs, L. L.; Byron, K. L., Molecular pharmacology
  • Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells. Pluteanu, F.; Cribbs, L. L., American Journal of Physiology - Cell Physiology
  • T-type current modulation by the actin-binding protein Kelch-like 1. Aromolaran, K. A.; Benzow, K. A.; Cribbs, L. L.; Koob, M. D.; Piedras-Renteria, E. S., American Journal of Physiology - Cell Physiology
  • Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles. Brueggemann, L. I.; Mackie, A. R.; Mani, B. K.; Cribbs, L. L.; Byron, K. L., Molecular pharmacology
  • Kelch-like 1 protein upregulates T-type currents by an actin-F dependent increase in alpha(1H) channels via the recycling endosome Aromolaran, K. A.; Benzow, K. A.; Cribbs, L. L.; Koob, M. D.; Piedras-Renteria, E. S., Channels (Austin, Tex.)
  • Non-L-type voltage-dependent calcium channels control vascular tone of the rat basilar artery. Navarro-Gonzalez, M. F.; Grayson, T. H.; Meaney, K. R.; Cribbs, L. L.; Hill, C. E., Clinical & Experimental Pharmacology & Physiology
  • Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells. Mani, B. K.; Brueggemann, L. I.; Cribbs, L. L.; Byron, K. L., Cell calcium
  • T-type calcium channels are regulated by hypoxia/reoxygenation in ventricular myocytes. Pluteanu, F.; Cribbs, L. L., American Journal of Physiology - Heart & Circulatory Physiology
  • The role of L- and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles. Braunstein, T. H.; Inoue, R.; Cribbs, L.; Oike, M.; Ito, Y.; Holstein-Rathlou, N. H.; Jensen, L. J., Journal of vascular research
  • Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Jaleel, N.; Nakayama, H.; Chen, X.; Kubo, H.; MacDonnell, S.; Zhang, H.; Berretta, R.; Robbins, J.; Cribbs, L.; Molkentin, J. D.; Houser, S. R., Circulation research
  • Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance., Mackie, A. R.; Brueggemann, L. I.; Henderson, K. K.; Shiels, A. J.; Cribbs, L. L.; Scrogin, K. E.; Byron, K. L., Journal of Pharmacology & Experimental Therapeutics
  • Adolescent feline heart contains a population of small proliferative ventricular myocytes with immature physiological properties., Chen, X.; Wilson, R. M.; Kubo, H.; Berretta, R. M.; Harris, D. M.; Zhang, X.; Jaleel, N.; MacDonnell, S. M.; Bearzi, C.; Tillmanns, J.; Trofimova, I.; Hosoda, T.; Mosna, F.; Cribbs, L.; Leri, A.; Kajstura, J.; Anversa, P.; Houser, S. R., Circulation research
  • Protein kinase Cepsilon-dependent MARCKS phosphorylation in neonatal and adult rat ventricular myocytes. Heidkamp, M. C.; Iyengar, R.; Szotek, E. L.; Cribbs, L. L.; Samarel, A. M., Journal of Molecular & Cellular Cardiology
  • Vasopressin stimulates action potential firing by protein kinase C-dependent inhibition of KCNQ5 in A7r5 rat aortic smooth muscle cells. Brueggemann, L. I.; Moran, C. J.; Barakat, J. A.; Yeh, J. Z.; Cribbs, L. L.; Byron, K. L., American Journal of Physiology - Heart & Circulatory Physiology
  • Pharmacological and electrophysiological characterization of store-operated currents and capacitative Ca(2+) entry in vascular smooth muscle cells. Brueggemann, L. I.; Markun, D. R.; Henderson, K. K.; Cribbs, L. L.; Byron, K. L., Journal of Pharmacology & Experimental Therapeutics
  • T-type Ca2+ channels in vascular smooth muscle: multiple functions Cribbs, L. L., Cell calcium
  • Low voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking. Brueggemann, L. I.; Martin, B. L.; Barakat, J.; Byron, K. L.; Cribbs, L. L., American Journal of Physiology - Heart & Circulatory Physiology