Karen Griffin, MD, FACP

Medicine

Nephrology
Professor
Fellowship Program Director, Nephrology, Medical Director, LUHS Comprehensive Hypertension Program

Languages Spoken

English

Clinical Expertise

  • Diabetic Kidney Disease
  • High Blood Pressure
  • Kidney Stones
  • Kidney Transplant
  • Polycystic Kidney Disease
  • Systemic Lupus Erythematosus
  • Chronic Kidney Disease

About Dr. Griffin

Interests
Bicycling, Exercise, Gardening, Fishing

Medical Education

Medical School
Rush Medical College of Rush University
Residency
Rush-Presbyterian-St. Luke's Medical Center - Internal Medicine: General
Fellowship
Rush-Presbyterian-St. Luke's Medical Center - Internal Medicine: Nephrology

Board Certification

Internal Medicine - General Cert: AM Board of Internal Medicine
Nephrology - Subspecialty Cert: AM Board of Internal Medicine

Research

  • Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy Polichnowski, A. J.; Licea-Vargas, H.; Picken, M. M.; Long, J.; Bisla, R.; Williamson, G. A.; Bidani, A. K.; Griffin, K. A., American journal of physiology.Renal physiology
  • Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension Polichnowski, A. J.; Griffin, K. A.; Picken, M. M.; Licea-Vargas, H.; Long, J.; Williamson, G. A.; Bidani, A. K., American journal of physiology.Renal physiology
  • Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model Griffin, K. A.; Polichnowski, A.; Litbarg, N.; Picken, M.; Venkatachalam, M. A.; Bidani, A. K., Hypertension
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  • Severe renal mass reduction impairs recovery and promotes fibrosis after AKI Polichnowski, A. J.; Lan, R.; Geng, H.; Griffin, K. A.; Venkatachalam, M. A.; Bidani, A. K., Journal of the American Society of Nephrology : JASN
  • Blood pressure-renal blood flow relationships in conscious angiotensin II- and phenylephrine-infused rats Polichnowski, A. J.; Griffin, K. A.; Long, J.; Williamson, G. A.; Bidani, A. K., American journal of physiology.Renal physiology
  • Renal microvascular dysfunction hypertension and CKD progression, Bidani, A. K.; Polichnowski, A. J.; Loutzenhiser, R.; Griffin, K. A., CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
  • Large BP-dependent and -independent differences in susceptibility to nephropathy after nitric oxide inhibition in Sprague-Dawley rats from two major suppliers. Griffin, K.; Polichnowski, A.; Licea-Vargas, H.; Picken, M.; Long, J.; Williamson, G.; Bidani, A., American Journal of Physiology - Renal Physiology
  • Large Bp-Dependent and -Independent Differences in Susceptibility to Nephropathy After Nitric Oxide Inhibition in Sprague-Dawley Rats from Two Major Suppliers Griffin, K. A.; Polichnowski, A. J.; Licea-Vargas, H.; Picken, M.; Long, J.; Williamson, G. A.; Bidani, A. K., American journal of physiology.Renal physiology
  • Solute and water excretion patterns in patients with nocturnal polyuria Herek, J. I.; FitzGerald, M. P.; Mohindra, M.; Wickman, C.; Leehey, D. J.; Bidani, A. K.; Griffin, K. A., International Journal of Nephrology & Urology
  • Angiotensin II type 2 receptor in chronic kidney disease: the good side of angiotensin II?. Griffin, K. A.; Bidani, A. K., Kidney international
  • Protective importance of the myogenic response in the renal circulation Bidani, A. K.; Griffin, K. A.; Williamson, G.; Wang, X.; Loutzenhiser, R., Hypertension
  • Adverse renal consequences of obesity Griffin, K. A.; Kramer, H.; Bidani, A. K., American Journal of Physiology - Renal Physiology
  • Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Pravenec, M.; Churchill, P. C.; Churchill, M. C.; Viklicky, O.; Kazdova, L.; Aitman, T. J.; Petretto, E.; Hubner, N.; Wallace, C. A.; Zimdahl, H.; Zidek, V.; Landa, V.; Dunbar, J.; Bidani, A. K.; Griffin, K.; Qi, N.; Maxova, M.; Kren, V.; Mlejnek, P.; Wang, J.; Kurtz, T. W., Nature genetics
  • Potential Risks of Calcium Channel Blockers in Chronic Kidney Disease. Griffin, K. A.; Bidani, A. K., Current Cardiology Reports
  • Systolic and mean blood pressures and afferent arteriolar myogenic response dynamics: a modeling approach. Williamson, G. A.; Loutzenhiser, R.; Wang, X.; Griffin, K. A.; Bidani, A. K., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology
  • Dynamic blood pressure load and nephropathy in the ZSF1 (fa/fa cp) model of type 2 diabetes. Griffin, K. A.; Abu-Naser, M.; Abu-Amarah, I.; Picken, M. M.; Williamson, G. A.; Bidani, A. K., American Journal of Physiology - Renal Physiology
  • Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance. Bidani, A. K.; Picken, M. M.; Hacioglu, R.; Williamson, G.; Griffin, K. A., American Journal of Physiology - Renal Physiology
  • Characterization of dynamics in renal autoregulation using volterra models. Hacioglu, R.; Williamson, G. A.; Abu-Amarah, I.; Griffin, K. A.; Bidani, A. K., IEEE Transactions on Biomedical Engineering
  • Hypertension and kidney damage. Griffin, K. A., Journal of clinical hypertension
  • Progression of renal disease: renoprotective specificity of renin-angiotensin system blockade Griffin, K. A.; Bidani, A. K., Clinical Journal of The American Society of Nephrology: CJASN
  • Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanisms Loutzenhiser, R.; Griffin, K.; Williamson, G.; Bidani, A. K., American Journal of Physiology - Regulatory Integrative & Comparative Physiology
  • Systolic blood pressure as the trigger for the renal myogenic response: protective or autoregulatory? Loutzenhiser, R.; Griffin, K. A.; Bidani, A. K., Current Opinion in Nephrology & Hypertension
  • The benefits of renin-angiotensin blockade in hypertension are dependent on blood-pressure lowering. Bidani, A. K.; Griffin, K. A., Nature Clinical Practice Nephrology
  • Differential effects of salt on renal hemodynamics and potential pressure transmission in stroke-prone and stroke-resistant spontaneously hypertensive rats. Abu-Amarah, I.; Bidani, A. K.; Hacioglu, R.; Williamson, G. A.; Griffin, K. A., American Journal of Physiology - Renal Physiology
  • Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research Professional and Public Education Subcommittee, Kurtz, T. W.; Griffin, K. A.; Bidani, A. K.; Davisson, R. L.; Hall, J. E., Arteriosclerosis, Thrombosis & Vascular Biology
  • Recommendations for blood pressure measurement in humans and experimental animals. Part 2: Blood pressure measurement in experimental animals: a statement for professionals from the subcommittee of professional and public education of the American Heart Association council on high blood pressure research Kurtz, T. W.; Griffin, K. A.; Bidani, A. K.; Davisson, R. L.; Hall, J. E., Hypertension
  • Blood pressure lability and glomerulosclerosis after normotensive 5/6 renal mass reduction in the rat. Griffin, K. A.; Picken, M. M.; Bidani, A. K., Kidney international
  • Effects of calcium channel blockers on "dynamic" and "steady-state step" renal autoregulation. Griffin, K. A.; Hacioglu, R.; Abu-Amarah, I.; Loutzenhiser, R.; Williamson, G. A.; Bidani, A. K., American Journal of Physiology - Renal Physiology
  • Hypertensive renal damage: insights from animal models and clinical relevance Griffin, K. A.; Bidani, A. K., Current hypertension reports
  • Pathophysiology of hypertensive renal damage: implications for therapy Bidani, A. K.; Griffin, K. A., Hypertension
  • "Step" vs. "dynamic" autoregulation: implications for susceptibility to hypertensive injury. Bidani, A. K.; Hacioglu, R.; Abu-Amarah, I.; Williamson, G. A.; Loutzenhiser, R.; Griffin, K. A., American Journal of Physiology - Renal Physiology
  • Long-term blood-pressure monitoring in unrestrained animals. Griffin, K. A.; Abu-Amarah, I.; Bidani, A. K., Methods in Molecular Medicine
  • Low protein diet mediated renoprotection in remnant kidneys: Renal autoregulatory versus hypertrophic mechanisms. Griffin, K. A.; Picken, M. M.; Giobbie-Hurder, A.; Bidani, A. K., Kidney international
  • Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent Griffin, K. A.; Abu-Amarah, I.; Picken, M. M.; Bidani, A. K., Hypertension
  • Increased genetic susceptibility to renal damage in the stroke-prone spontaneously hypertensive rat. Churchill, P. C.; Churchill, M. C.; Griffin, K. A.; Picken, M. M.; Webb, R. C.; Kurtz, T. W.; Bidani, A. K., Kidney international
  • Long-term renal consequences of hypertension for normal and diseased kidneys Bidani, A. K.; Griffin, K. A., Current Opinion in Nephrology & Hypertension
  • Comparative effects of selective T- and L-type calcium channel blockers in the remnant kidney model. Griffin, K. A.; Picken, M. M.; Bakris, G. L.; Bidani, A. K., Hypertension
  • Differential salt-sensitivity in the pathogenesis of renal damage in SHR and stroke prone SHR. Griffin, K. A.; Churchill, P. C.; Picken, M. M.; Webb, R. C.; Kurtz, T. W.; Bidani, A. K., American Journal of Hypertension
  • Genetic susceptibility to renal injury in hypertension Bidani, A. K.; Griffin, K. A.; Churchill, P. C.; Churchill, M. C.; St Lezin, E.; Kurtz, T. W., Experimental nephrology
  • Relative antihypertensive and glomeruloprotective efficacies of enalapril and candesartan cilexetil in the remnant kidney model. Griffin, K. A.; Picken, M. M.; Bakris, G.; Bidani, A. K., Journal of Renin-Angiotensin-Aldosterone System
  • Functional and structural correlates of glomerulosclerosis after renal mass reduction in the rat. Griffin, K. A.; Picken, M. M.; Churchill, M.; Churchill, P.; Bidani, A. K., Journal of the American Society of Nephrology
  • Lack of evidence of blood pressure-independent protection by renin-angiotensin system blockade after renal ablation Bidani, A. K.; Griffin, K. A.; Bakris, G.; Picken, M. M., Kidney international