Joseph Clark, MD, FACP

Medicine

Hematology/Oncology
Professor
Fellowship Program Director, Hematology/Oncology

Languages Spoken

English

Clinical Expertise

  • Head and Neck Cancer
  • Kidney Cancer
  • Melanoma

About Dr. Clark

Interests
Reading, Triathlon, Travel

Medical Education

Medical School
Loyola University Chicago Stritch School of Medicine
Residency
Loyola University Medical Center - Internal Medicine: General
Fellowship
Fox Chase Cancer Center/Temple University Hospital - Hematology & Medical Oncology

Board Certification

Medical Oncology
American Board of Internal Medicine Subspecialty

Research

  • Combination Trimodality Therapy Using Vismodegib for Basal Cell Carcinoma of the Face Block, A. M.; Alite, F.; Diaz, A. Z.; Borrowdale, R. W.; Clark, J. I.; Choi, M., Case reports in oncological medicine
  • Multidisciplinary treatment of olfactory neuroblastoma: Patterns of failure and management of recurrence Petruzzelli, G. J.; Howell, J. B.; Pederson, A.; Origitano, T. C.; Byrne, R. W.; Munoz, L.; Emami, B.; Clark, J. I., American Journal of Otolaryngology
  • Robust Differences in p16-Dependent Oropharyngeal Squamous Cell Carcinoma Distant Metastasis: Implications for Targeted Therapy Jaber, J. J.; Murrill, L.; Clark, J. I.; Johnson, J. T.; Feustel, P. J.; Mehta, V., Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
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  • The high-dose aldesleukin "select" trial: a trial to prospectively validate predictive models of response to treatment in patients with metastatic renal cell carcinoma McDermott, D. F.; Cheng, S. C.; Signoretti, S.; Margolin, K. A.; Clark, J. I.; Sosman, J. A.; Dutcher, J. P.; Logan, T. F.; Curti, B. D.; Ernstoff, M. S.; Appleman, L.; Wong, M. K.; Khushalani, N. I.; Oleksowicz, L.; Vaishampayan, U. N.; Mier, J. W.; Panka, D. J.; Bhatt, R. S.; Bailey, A. S.; Leibovich, B. C.; Kwon, E. D.; Kabbinavar, F. F.; Belldegrun, A. S.; Figlin, R. A.; Pantuck, A. J.; Regan, M. M.; Atkins, M. B., Clinical cancer research : an official journal of the American Association for Cancer Research
  • Axitinib versus sorafenib in advanced renal cell carcinoma: subanalyses by prior therapy from a randomised phase III trial Escudier, B.; Michaelson, M. D.; Motzer, R. J.; Hutson, T. E.; Clark, J. I.; Lim, H. Y.; Porfiri, E.; Zalewski, P.; Kannourakis, G.; Staehler, M.; Tarazi, J.; Rosbrook, B.; Cisar, L.; Hariharan, S.; Kim, S.; Rini, B. I., British journal of cancer
  • Phase I pilot study of oxaliplatin infusional 5-FU, and cetuximab in recurrent or metastatic head and neck cancer, Clark, J. I.; Greene, J. B.; Lau Clark, A.; Dalal, J. S.; Hofmeister, C. C., MEDICAL ONCOLOGY
  • Ipilimumab in patients with melanoma and brain metastases: an open-label phase 2 trial, Margolin, K.; Ernstoff, M. S.; Hamid, O.; Lawrence, D.; McDermott, D.; Puzanov, I.; Wolchok, J. D.; Clark, J. I.; Sznol, M.; Logan, T. F.; Richards, J.; Michener, T.; Balogh, A.; Heller, K. N.; Hodi, F. S., The lancet oncology
  • Evolving treatment strategies in thin cutaneous head and neck melanoma: 1 institution's experience. Jaber, J. J.; Clark, J. I.; Muzaffar, K.; Ruggiero, F. P.; Feustel, P. J.; Frett, M. J.; Zender, C. A., Head & neck
  • A phase II study of oxaliplatin docetaxel, and GM-CSF in patients with previously treated advanced melanoma, Locke, F.; Clark, J. I.; Gajewski, T. F., CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Cytokine working group study of lymphodepleting chemotherapy interleukin-2, and granulocyte-macrophage colony-stimulating factor in patients with metastatic melanoma: clinical outcomes and peripheral-blood cell recovery, Gunturu, K. S.; Meehan, K. R.; Mackenzie, T. A.; Crocenzi, T. S.; McDermott, D.; Usherwood, E. J.; Margolin, K. A.; Crosby, N. A.; Atkins, M. B.; Turk, M. J.; Ahonen, C.; Fuse, S.; Clark, J. I.; Fisher, J. L.; Noelle, R. J.; Ernstoff, M. S., Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • Improved survival with ipilimumab in patients with metastatic melanoma Hodi, F. S.; O'Day, S. J.; McDermott, D. F.; Weber, R. W.; Sosman, J. A.; Haanen, J. B.; Gonzalez, R.; Robert, C.; Schadendorf, D.; Hassel, J. C.; Akerley, W.; van den Eertwegh, A. J.; Lutzky, J.; Lorigan, P.; Vaubel, J. M.; Linette, G. P.; Hogg, D.; Ottensmeier, C. H.; Lebbe, C.; Peschel, C.; Quirt, I.; Clark, J. I.; Wolchok, J. D.; Weber, J. S.; Tian, J.; Yellin, M. J.; Nichol, G. M.; Hoos, A.; Urba, W. J., The New England journal of medicine
  • Phase 2 trial of combination thalidomide plus temozolomide in patients with metastatic malignant melanoma: Southwest Oncology Group S0508. Clark, J. I.; Moon, J.; Hutchins, L. F.; Sosman, J. A.; Kast, W. M.; Da Silva, D. M.; Liu, P. Y.; Thompson, J. A.; Flaherty, L. E.; Sondak, V. K., Cancer
  • A phase ii study of gemcitabine and capecitabine in patients with advanced renal cell cancer: Southwest Oncology Group Study S0312 Van Veldhuizen, P. J.; Hussey, M.; Lara, P. N., Jr; Mack, P. C.; Gandour-Edwards, R.; Clark, J. I.; Lange, M. K.; Crawford, D. E., American Journal of Clinical Oncology
  • Clinicopathological review: esthesioneuroblastoma Bragg, T. M.; Scianna, J.; Kassam, A.; Emami, B.; Brown, H. G.; Hacein-Bey, L.; Clark, J. I.; Muzaffar, K.; Boulis, N.; Prabhu, V. C., Neurosurgery
  • Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study Cohen, E. E.; Davis, D. W.; Karrison, T. G.; Seiwert, T. Y.; Wong, S. J.; Nattam, S.; Kozloff, M. F.; Clark, J. I.; Yan, D. H.; Liu, W.; Pierce, C.; Dancey, J. E.; Stenson, K.; Blair, E.; Dekker, A.; Vokes, E. E., The lancet oncology
  • Phase I adjuvant radiation with docetaxel in high-risk head and neck cancer. Clark, J. I.; Eisner, R. M.; Hofmeister, C.; Norton, J.; Thomas, S.; Choudhury, A.; Petruzzelli, G.; Lathers, D.; Young, M. R.; Lau, A.; Emami, B., American Journal of Clinical Oncology
  • Phase II study of erlotinib in patients with locally advanced or metastatic papillary histology renal cell cancer: SWOG S0317 Gordon, M. S.; Hussey, M.; Nagle, R. B.; Lara, P. N., Jr; Mack, P. C.; Dutcher, J.; Samlowski, W.; Clark, J. I.; Quinn, D. I.; Pan, C. X.; Crawford, D., Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • A University of Chicago consortium phase II trial of SB-715992 in advanced renal cell cancer Lee, R. T.; Beekman, K. E.; Hussain, M.; Davis, N. B.; Clark, J. I.; Thomas, S. P.; Nichols, K. F.; Stadler, W. M., CLINICAL GENITOURINARY CANCER
  • Temozolomide thalidomide, and whole brain radiation therapy for patients with brain metastasis from metastatic melanoma: a phase II Cytokine Working Group study, Atkins, M. B.; Sosman, J. A.; Agarwala, S.; Logan, T.; Clark, J. I.; Ernstoff, M. S.; Lawson, D.; Dutcher, J. P.; Weiss, G.; Curti, B.; Margolin, K. A., Cancer
  • Three phase II cytokine working group trials of gp100 (210M) peptide plus high-dose interleukin-2 in patients with HLA-A2-positive advanced melanoma Sosman, J. A.; Carrillo, C.; Urba, W. J.; Flaherty, L.; Atkins, M. B.; Clark, J. I.; Dutcher, J.; Margolin, K. A.; Mier, J.; Gollob, J.; Kirkwood, J. M.; Panka, D. J.; Crosby, N. A.; O'Boyle, K.; LaFleur, B.; Ernstoff, M. S., Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • Thrombotic microangiopathy associated with sunitinib a VEGF inhibitor, in a patient with factor V Leiden mutation., Levey, S. A.; Bajwa, R. S.; Picken, M. M.; Clark, J. I.; Barton, K.; Leehey, D. J., NDT Plus
  • Evaluation of interferon alpha-2B and thalidomide in patients with disseminated malignant melanoma phase 2, SWOG 0026., Hutchins, L. F.; Moon, J.; Clark, J. I.; Thompson, J. A.; Lange, M. K.; Flaherty, L. E.; Sondak, V. K., Cancer
  • Phase I trial of BAY 50-4798 an interleukin-2-specific agonist in advanced melanoma and renal cancer., Margolin, K.; Atkins, M. B.; Dutcher, J. P.; Ernstoff, M. S.; Smith, J. W., 2nd; Clark, J. I.; Baar, J.; Sosman, J.; Weber, J.; Lathia, C.; Brunetti, J.; Cihon, F.; Schwartz, B., Clinical Cancer Research
  • Phase I/II trial of outpatient PEG-interferon with interleukin-2 in advanced renal cell carcinoma: a cytokine working group study. Clark, J. I.; Mehrabi, J.; Sosman, J. A.; Logan, T. F.; Margolin, K. A.; Dutcher, J. P.; Urba, W. J.; Ernstoff, M. S.; McDermott, D. F.; Lau, A. M.; Atkins, M. B., Journal of Immunotherapy
  • Xp11.2 translocation renal cell carcinoma with very aggressive course in five adults. Meyer, P. N.; Clark, J. I.; Flanigan, R. C.; Picken, M. M., American Journal of Clinical Pathology
  • A phase II evaluation of a 3-hour infusion of paclitaxel cisplatin, and 5-fluorouracil in patients with advanced or recurrent squamous cell carcinoma of the head and neck: Southwest Oncology Group study 0007., Worden, F. P.; Moon, J.; Samlowski, W.; Clark, J. I.; Dakhil, S. R.; Williamson, S.; Urba, S. G.; Ensley, J.; Hussain, M. H., Cancer
  • Vaccine therapy of malignant melanoma. Farray, D.; Clark, J. I., Clinical and applied immunology reviews
  • Metastatic Melanoma to the Central Nervous System: Case Report and Review of the Literature Schneck, M. J.; Patel, A.; Rodriguez-Quinonez, A.; Brown, H. G.; Clark, J. I.; Prabhu, V.; Dafer, R. M.; Biller, J., Seminars in Cerebrovascular Diseases and Stroke
  • Neoadjuvant therapy: an emerging concept in oncology Tanvetyanon, T.; Clark, J. I.; Campbell, S. C.; Lo, S. S., Southern medical journal
  • Passive seeding in metanephric adenoma: a review of pseudometastatic lesions in perinephric lymph nodes. Paner, G. P.; Turk, T. M.; Clark, J. I.; Lindgren, V.; Picken, M. M., Archives of Pathology & Laboratory Medicine
  • Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma McDermott, D. F.; Regan, M. M.; Clark, J. I.; Flaherty, L. E.; Weiss, G. R.; Logan, T. F.; Kirkwood, J. M.; Gordon, M. S.; Sosman, J. A.; Ernstoff, M. S.; Tretter, C. P.; Urba, W. J.; Smith, J. W.; Margolin, K. A.; Mier, J. W.; Gollob, J. A.; Dutcher, J. P.; Atkins, M. B., Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • Review.[comment] Farray, D.; Clark, J. I., Clinical Advances in Hematology & Oncology
  • Case report and brief review: IL-2-induced myocarditis Eisner, R. M.; Husain, A.; Clark, J. I., Cancer investigation
  • Metastatic juxtaglomerular cell tumor in a 52-year-old man. Duan, X.; Bruneval, P.; Hammadeh, R.; Fresco, R.; Eble, J. N.; Clark, J. I.; Vigneswaran, W. T.; Flanigan, R. C.; Picken, M. M., American Journal of Surgical Pathology
  • Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3 Lathers, D. M.; Clark, J. I.; Achille, N. J.; Young, M. R., Cancer immunology, immunotherapy : CII
  • Randomized phase II trial of sequential chemotherapy in advanced non-small cell lung cancer (SWOG 9806): carboplatin/gemcitabine followed by paclitaxel or cisplatin/vinorelbine followed by docetaxel Edelman, M. J.; Clark, J. I.; Chansky, K.; Albain, K.; Bhoopalam, N.; Weiss, G. R.; Giguere, J. K.; Kelly, K.; Crowley, J.; Gandara, D. R., Clinical cancer research : an official journal of the American Association for Cancer Research
  • Renal tumor with overlapping distal nephron morphology and karyotype. Lindgren, V.; Paner, G. P.; Flanigan, R. C.; Clark, J. I.; Campbell, S. C.; Picken, M. M., Archives of Pathology & Laboratory Medicine
  • Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: a cytokine working group randomized trial. Clark, J. I.; Atkins, M. B.; Urba, W. J.; Creech, S.; Figlin, R. A.; Dutcher, J. P.; Flaherty, L.; Sosman, J. A.; Logan, T. F.; White, R.; Weiss, G. R.; Redman, B. G.; Tretter, C. P.; McDermott, D.; Smith, J. W.; Gordon, M. S.; Margolin, K. A., Journal of Clinical Oncology
  • Metastatic renal cell carcinoma Flanigan, R. C.; Campbell, S. C.; Clark, J. I.; Picken, M. M., Current Treatment Options in Oncology
  • Nephrectomy in metastatic renal cell carcinoma Campbell, S. C.; Flanigan, R. C.; Clark, J. I., Current Treatment Options in Oncology
  • Posterior marginal mandibulectomy in the management of cancer of the oral cavity and oropharynx. Petruzzelli, G. J.; Knight, F. K.; Vandevender, D.; Clark, J. I.; Emami, B., Otolaryngology - Head & Neck Surgery
  • A multi-institutional phase II trial of a novel inpatient schedule of continuous interleukin-2 with interferon alpha-2b in advanced renal cell carcinoma: major durable responses in a less highly selected patient population Clark, J. I.; Kuzel, T. M.; Lestingi, T. M.; Fisher, S. G.; Sorokin, P.; Martone, B.; Viola, M.; Sosman, J. A., Annals of Oncology : Official Journal of the European Society for Medical Oncology / ESMO
  • Analysis of c-kit protein expression in small-cell lung carcinoma and its implication for prognosis Naeem, M.; Dahiya, M.; Clark, J. I.; Creech, S. D.; Alkan, S., Human pathology
  • Concurrent cisplatin etoposide, and chest radiotherapy in pathologic stage IIIB non-small-cell lung cancer: a Southwest Oncology Group phase II study, SWOG 9019, Albain, K. S.; Crowley, J. J.; Turrisi, A. T., 3rd; Gandara, D. R.; Farrar, W. B.; Clark, J. I.; Beasley, K. R.; Livingston, R. B., Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • Response to paclitaxel and carboplatin in metastatic salivary gland cancer: a case report Ruzich, J. C.; Ciesla, M. C.; Clark, J. I., Head & neck
  • Combined modality therapy for early stage operable and locally advanced potentially resectable non-small cell lung carcinoma Clark, J. I.; Albain, K. S., Cancer treatment and research
  • Dendritic cells transduced with full-length wild-type p53 generate antitumor cytotoxic T lymphocytes from peripheral blood of cancer patients Nikitina, E. Y.; Clark, J. I.; Van Beynen, J.; Chada, S.; Virmani, A. K.; Carbone, D. P.; Gabrilovich, D. I., Clinical cancer research : an official journal of the American Association for Cancer Research
  • Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer Almand, B.; Clark, J. I.; Nikitina, E.; van Beynen, J.; English, N. R.; Knight, S. C.; Carbone, D. P.; Gabrilovich, D. I., Journal of immunology (Baltimore, Md.: 1950)
  • Metanephric adenosarcoma in a young adult: morphologic immunophenotypic, ultrastructural, and fluorescence in situ hybridization analyses: a case report and review of the literature, Picken, M. M.; Curry, J. L.; Lindgren, V.; Clark, J. I.; Eble, J. N., The American Journal of Surgical Pathology
  • Osteogenic sarcoma associated with Diamond-Blackfan anemia: a report from the Diamond-Blackfan Anemia Registry Lipton, J. M.; Federman, N.; Khabbaze, Y.; Schwartz, C. L.; Hilliard, L. M.; Clark, J. I.; Vlachos, A.; Diamond-Black Anemia Registry, Journal of pediatric hematology/oncology
  • Outpatient biochemotherapy with interleukin-2 and interferon alfa-2b in patients with metastatic malignant melanoma: results of two phase II cytokine working group trials Flaherty, L. E.; Atkins, M.; Sosman, J.; Weiss, G.; Clark, J. I.; Margolin, K.; Dutcher, J.; Gordon, M. S.; Lotze, M.; Mier, J.; Sorokin, P.; Fisher, R. I.; Appel, C.; Du, W., Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • Patterns of spread in recurrent head and neck squamous cell carcinoma Vaidya, A. M.; Petruzzelli, G. J.; Clark, J.; Emami, B., Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • Phase IB study of 25-hydroxyvitamin D(3) treatment to diminish suppressor cells in head and neck cancer patients Lathers, D. M.; Clark, J. I.; Achille, N. J.; Young, M. R., Human immunology
  • Phase II evaluation of paclitaxel in combination with carboplatin in advanced head and neck carcinoma. Clark, J. I.; Hofmeister, C.; Choudhury, A.; Matz, G.; Collins, S.; Bastian, R.; Melian, E.; Emami, B.; Petruzzelli, G., Cancer
  • Pilot study of sequential vinorelbine and cisplatin followed by docetaxel for selected IIIB and stage IV non-small cell lung cancer Clark, J. I.; Kancharla, K.; Qamar, R.; Fisher, S.; Hantel, A.; Panganiban, J.; Millbrandt, L.; Albain, K. S., Lung cancer (Amsterdam, Netherlands)
  • Clinical significance of defective dendritic cell differentiation in cancer Almand, B.; Resser, J. R.; Lindman, B.; Nadaf, S.; Clark, J. I.; Kwon, E. D.; Carbone, D. P.; Gabrilovich, D. I., Clinical cancer research : an official journal of the American Association for Cancer Research
  • New therapeutic strategies for the treatment and prevention of head and neck cancer Lingen, M. W.; Emami, B.; Clark, J. I., Expert opinion on investigational drugs