Jose Guevara-Patino, MD, PhD

Surgery

Surgical Research
Associate Professor

Languages Spoken

English, Spanish

Medical Education

Medical School
Universidad Central de Venezuela, Venezuela

Research

  • Mutant HSP70 reverses autoimmune depigmentation in vitiligo Mosenson, J. A.; Zloza, A.; Nieland, J. D.; Garrett-Mayer, E.; Eby, J. M.; Huelsmann, E. J.; Kumar, P.; Denman, C. J.; Lacek, A. T.; Kohlhapp, F. J.; Alamiri, A.; Hughes, T.; Bines, S. D.; Kaufman, H. L.; Overbeck, A.; Mehrotra, S.; Hernandez, C.; Nishimura, M. I.; Guevara-Patino, J. A.; Le Poole, I. C., Science translational medicine
  • CD8(+) T cells sabotage their own memory potential through IFN-gamma-dependent modification of the IL-12/IL-15 receptor alpha axis on dendritic cells Kohlhapp, F. J.; Zloza, A.; O'Sullivan, J. A.; Moore, T. V.; Lacek, A. T.; Jagoda, M. C.; McCracken, J.; Cole, D. J.; Guevara-Patino, J. A., Journal of immunology (Baltimore, Md.: 1950)
  • HSP70i is a critical component of the immune response leading to vitiligo. Mosenson, J. A.; Zloza, A.; Klarquist, J.; Barfuss, A. J.; Guevara-Patino, J. A.; Poole, I. C., Pigment Cell & Melanoma Research
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  • NKG2D signaling on CD8(+) T cells represses T-bet and rescues CD4-unhelped CD8(+) T cell memory recall but not effector responses Zloza, A.; Kohlhapp, F. J.; Lyons, G. E.; Schenkel, J. M.; Moore, T. V.; Lacek, A. T.; O'Sullivan, J. A.; Varanasi, V.; Williams, J. W.; Jagoda, M. C.; Bellavance, E. C.; Marzo, A. L.; Thomas, P. G.; Zafirova, B.; Polic, B.; Al-Harthi, L.; Sperling, A. I.; Guevara-Patino, J. A., Nature medicine
  • CD8 co-receptor promotes susceptibility of CD8+ T cells to transforming growth factor-beta (TGF-beta)-mediated suppression Zloza, A.; Jagoda, M. C.; Lyons, G. E.; Graves, M. C.; Kohlhapp, F. J.; O'Sullivan, J. A.; Lacek, A. T.; Nishimura, M. I.; Guevara-Patino, J. A., Cancer immunology, immunotherapy : CII
  • Combination of epitope-optimized DNA vaccination and passive infusion of monoclonal antibody against HER2/neu leads to breast tumor regression in mice Orlandi, F.; Guevara-Patino, J. A.; Merghoub, T.; Wolchok, J. D.; Houghton, A. N.; Gregor, P. D., Vaccine
  • Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-beta blockade during the perioperative period of tumor resection Bellavance, E. C.; Kohlhapp, F. J.; Zloza, A.; O'Sullivan, J. A.; McCracken, J.; Jagoda, M. C.; Lacek, A. T.; Posner, M. C.; Guevara-Patino, J. A., Journal of immunology (Baltimore, Md.: 1950)
  • Engagement of NK receptor NKG2D but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo, Zloza, A.; Lyons, G. E.; Chlewicki, L. K.; Kohlhapp, F. J.; O'Sullivan, J. A.; Lacek, A. T.; Moore, T. V.; Jagoda, M. C.; Kumar, V.; Guevara-Patino, J. A., Autoimmunity
  • Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)beta-mediated suppression O'Sullivan, J. A.; Zloza, A.; Kohlhapp, F. J.; Moore, T. V.; Lacek, A. T.; Dulin, N. O.; Guevara-Patino, J. A., Cancer immunology, immunotherapy : CII
  • Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens Cote, A. L.; Zhang, P.; O'Sullivan, J. A.; Jacobs, V. L.; Clemis, C. R.; Sakaguchi, S.; Guevara-Patino, J. A.; Turk, M. J., Journal of immunology (Baltimore, Md.: 1950)
  • Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies Lazarou, M.; Guevara-Patino, J. A.; Jennings, R. M.; McIntosh, R. S.; Shi, J.; Howell, S.; Cullen, E.; Jones, T.; Adame-Gallegos, J. R.; Chappel, J. A.; McBride, J. S.; Blackman, M. J.; Holder, A. A.; Pleass, R. J., INFECTION AND IMMUNITY
  • HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo. Denman, C. J.; McCracken, J.; Hariharan, V.; Klarquist, J.; Oyarbide-Valencia, K.; Guevara-Patino, J. A.; Le Poole, I. C., Journal of Investigative Dermatology
  • Mechanisms of immunization against cancer using chimeric antigens Engelhorn, M. E.; Guevara-Patino, J. A.; Merghoub, T.; Liu, C.; Ferrone, C. R.; Rizzuto, G. A.; Cymerman, D. H.; Posnett, D. N.; Houghton, A. N.; Wolchok, J. D., Molecular therapy : the journal of the American Society of Gene Therapy
  • Immunological validation of the EpitOptimizer program for streamlined design of heteroclitic epitopes Houghton, C. S.; Engelhorn, M. E.; Liu, C.; Song, D.; Gregor, P.; Livingston, P. O.; Orlandi, F.; Wolchok, J. D.; McCracken, J.; Houghton, A. N.; Guevara-Patino, J. A., Vaccine
  • Autoimmunity and tumor immunity induced by immune responses to mutations in self Engelhorn, M. E.; Guevara-Patino, J. A.; Noffz, G.; Hooper, A. T.; Lou, O.; Gold, J. S.; Kappel, B. J.; Houghton, A. N., Nature medicine
  • DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic hemopoietic stem cell transplantation Perales, M. A.; Diab, A.; Cohen, A. D.; Huggins, D. W.; Guevara-Patino, J. A.; Hubbard, V. M.; Engelhorn, M. E.; Kochman, A. A.; Eng, J. M.; Mortazavi, F.; Alpdogan, O.; Terwey, T. H.; Heller, G.; Wolchok, J. D.; Houghton, A. N.; van den Brink, M. R., Journal of immunology (Baltimore, Md.: 1950)
  • Optimization of a self antigen for presentation of multiple epitopes in cancer immunity Guevara-Patino, J. A.; Engelhorn, M. E.; Turk, M. J.; Liu, C.; Duan, F.; Rizzuto, G.; Cohen, A. D.; Merghoub, T.; Wolchok, J. D.; Houghton, A. N., The Journal of clinical investigation
  • CD8+ T-cell-dependent immunity following xenogeneic DNA immunization against CD20 in a tumor challenge model of B-cell lymphoma Palomba, M. L.; Roberts, W. K.; Dao, T.; Manukian, G.; Guevara-Patino, J. A.; Wolchok, J. D.; Scheinberg, D. A.; Houghton, A. N., Clinical cancer research : an official journal of the American Association for Cancer Research
  • Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles Goldberg, S. M.; Bartido, S. M.; Gardner, J. P.; Guevara-Patino, J. A.; Montgomery, S. C.; Perales, M. A.; Maughan, M. F.; Dempsey, J.; Donovan, G. P.; Olson, W. C.; Houghton, A. N.; Wolchok, J. D., Clinical cancer research : an official journal of the American Association for Cancer Research
  • Identification of cancer-testis genes expressed by melanoma and soft tissue sarcoma using bioinformatics Segal, N. H.; Blachere, N. E.; Guevara-Patino, J. A.; Gallardo, H. F.; Shiu, H. Y.; Viale, A.; Antonescu, C. R.; Wolchok, J. D.; Houghton, A. N., Cancer Immunity
  • Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense Messaoudi, I.; Lemaoult, J.; Guevara-Patino, J. A.; Metzner, B. M.; Nikolich-Zugich, J., The Journal of experimental medicine
  • Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells Turk, M. J.; Guevara-Patino, J. A.; Rizzuto, G. A.; Engelhorn, M. E.; Sakaguchi, S.; Houghton, A. N., The Journal of experimental medicine
  • CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses tumor immunity and autoimmunity to self antigens in animal and cellular model systems, Gregor, P. D.; Wolchok, J. D.; Ferrone, C. R.; Buchinshky, H.; Guevara-Patino, J. A.; Perales, M. A.; Mortazavi, F.; Bacich, D.; Heston, W.; Latouche, J. B.; Sadelain, M.; Allison, J. P.; Scher, H. I.; Houghton, A. N., Vaccine
  • Immune recognition of self in immunity against cancer Houghton, A. N.; Guevara-Patino, J. A., The Journal of clinical investigation
  • A single heteroclitic epitope determines cancer immunity after xenogeneic DNA immunization against a tumor differentiation antigen Gold, J. S.; Ferrone, C. R.; Guevara-Patino, J. A.; Hawkins, W. G.; Dyall, R.; Engelhorn, M. E.; Wolchok, J. D.; Lewis, J. J.; Houghton, A. N., Journal of immunology (Baltimore, Md.: 1950)
  • Immunity to cancer through immune recognition of altered self: studies with melanoma Guevara-Patino, J. A.; Turk, M. J.; Wolchok, J. D.; Houghton, A. N., Advances in Cancer Research
  • Immunity to melanoma: unraveling the relation of tumor immunity and autoimmunity Ramirez-Montagut, T.; Turk, M. J.; Wolchok, J. D.; Guevara-Patino, J. A.; Houghton, A. N., Oncogene
  • Direct link between mhc polymorphism T cell avidity, and diversity in immune defense, Messaoudi, I.; Guevara-Patino, J. A.; Dyall, R.; LeMaoult, J.; Nikolich-Zugich, J., Science (New York, N.Y.)
  • Multiple pathways to tumor immunity and concomitant autoimmunity Turk, M. J.; Wolchok, J. D.; Guevara-Patino, J. A.; Goldberg, S. M.; Houghton, A. N., Immunological reviews
  • Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum Uthaipibull, C.; Aufiero, B.; Syed, S. E.; Hansen, B.; Guevara-Patino, J. A.; Angov, E.; Ling, I. T.; Fegeding, K.; Morgan, W. D.; Ockenhouse, C.; Birdsall, B.; Feeney, J.; Lyon, J. A.; Holder, A. A., Journal of Molecular Biology
  • Immunogenicity and efficacy in aotus monkeys of four recombinant Plasmodium falciparum vaccines in multiple adjuvant formulations based on the 19-kilodalton C terminus of merozoite surface protein 1 Kumar, S.; Collins, W.; Egan, A.; Yadava, A.; Garraud, O.; Blackman, M. J.; Guevara-Patino, J. A.; Diggs, C.; Kaslow, D. C., INFECTION AND IMMUNITY
  • Sex steroids induce apoptosis of CD8+CD4+ double-positive thymocytes via TNF-alpha Guevara-Patino, J. A.; Marino, M. W.; Ivanov, V. N.; Nikolich-Zugich, J., European journal of immunology
  • TNF-alpha is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes Guevara-Patino, J. A.; Ivanov, V. N.; Lacy, E.; Elkon, K. B.; Marino, M. W.; Nikolic-Zugic, J., Journal of immunology (Baltimore, Md.: 1950)