Jiwang Zhang, MD, PhD

Pathology

Associate Professor
Director, Stem Cell Program (Oncology Institute)

Languages Spoken

English, Chinese

Medical Education

Medical School
Lanzhou Medical College, China

Research

  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Breslin, P.; Kuo, P.; Ding, X.; Cotler, S.; Nishimura, M.; Zhang, J.; Qiu, W.; Arteaga, M.; Zaidi, A.; Shang, N., Gene expression
  • FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Na, S.; Arteaga, M.; Zaidi, A.; Colter, S.; Breslin, P.; Ding, X.; Kuo, P.; Nishimura, M.; Zhang, J.; Qiu, W., Gene expression
  • Hematopoietic Stem Cell Activity is Regulated by Pten Phosphorylation through a Niche-Dependent Mechanism Li, J.; Zhang, J.; Tang, M.; Xin, J.; Xu, Y.; Volk, A.; Hao, C.; Hu, C.; Sun, J.; Wei, W.; Cao, Q.; Breslin, P.; Zhang, J., Stem cells (Dayton, Ohio)
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  • Hematopoietic Stem Cell Activity is Regulated by Pten Phosphorylation through a Niche-Dependent Mechanism Li, J.; Zhang, J.; Tang, M.; Xin, J.; Xu, Y.; Volk, A.; Hao, C.; Hu, C.; Sun, J.; Wei, W.; Cao, Q.; Breslin, P.; Zhang, J., Stem cells (Dayton, Ohio)
  • miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia Jiang, X.; Hu, C.; Arnovitz, S.; Bugno, J.; Yu, M.; Zuo, Z.; Chen, P.; Huang, H.; Ulrich, B.; Gurbuxani, S.; Weng, H.; Strong, J.; Wang, Y.; Li, Y.; Salat, J.; Li, S.; Elkahloun, A. G.; Yang, Y.; Neilly, M. B.; Larson, R. A.; Le Beau, M. M.; Herold, T.; Bohlander, S. K.; Liu, P. P.; Zhang, J.; Li, Z.; He, C.; Jin, J.; Hong, S.; Chen, J., Nature communications
  • Osteopontin-A Master Regulator of Epithelial-Mesenchymal Transition Kothari, A. N.; Arffa, M. L.; Chang, V.; Blackwell, R. H.; Syn, W. K.; Zhang, J.; Mi, Z.; Kuo, P. C., Journal of clinical medicine
  • Alcohol inhibits osteopontin-dependent transforming growth factor-beta1 expression in human mesenchymal stem cells Driver, J.; Weber, C. E.; Callaci, J. J.; Kothari, A. N.; Zapf, M. A.; Roper, P. M.; Borys, D.; Franzen, C. A.; Gupta, G. N.; Wai, P. Y.; Zhang, J.; Denning, M. F.; Kuo, P. C.; Mi, Z., The Journal of biological chemistry
  • BP and Renal Outcomes in Diabetic Kidney Disease: The Veterans Affairs Nephropathy in Diabetes Trial Leehey, D. J.; Zhang, J. H.; Emanuele, N. V.; Whaley-Connell, A.; Palevsky, P. M.; Reilly, R. F.; Guarino, P.; Fried, L. F.; VA NEPHRON-D Study Group, Clinical journal of the American Society of Nephrology : CJASN
  • FAK is required for c-Met/beta-catenin-driven hepatocarcinogenesis Shang, N.; Arteaga, M.; Zaidi, A.; Stauffer, J.; Cotler, S. J.; Zeleznik-Le, N. J.; Zhang, J.; Qiu, W., Hepatology (Baltimore, Md.)
  • FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells You, D.; Xin, J.; Volk, A.; Wei, W.; Schmidt, R.; Scurti, G.; Nand, S.; Breuer, E. K.; Kuo, P. C.; Breslin, P.; Kini, A. R.; Nishimura, M. I.; Zeleznik-Le, N. J.; Zhang, J., Cell reports
  • Long-term persistence of zoster vaccine efficacy Morrison, V. A.; Johnson, G. R.; Schmader, K. E.; Levin, M. J.; Zhang, J. H.; Looney, D. J.; Betts, R.; Gelb, L.; Guatelli, J. C.; Harbecke, R.; Pachucki, C.; Keay, S.; Menzies, B.; Griffin, M. R.; Kauffman, C. A.; Marques, A.; Toney, J.; Boardman, K.; Su, S. C.; Li, X.; Chan, I. S.; Parrino, J.; Annunziato, P.; Oxman, M. N.; Shingles Prevention Study Group, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • Overexpression and knockout of miR-126 both promote leukemogenesis Li, Z.; Chen, P.; Su, R.; Li, Y.; Hu, C.; Wang, Y.; Arnovitz, S.; He, M.; Gurbuxani, S.; Zuo, Z.; Elkahloun, A. G.; Li, S.; Weng, H.; Huang, H.; Neilly, M. B.; Wang, S.; Olson, E. N.; Larson, R. A.; Le Beau, M. M.; Zhang, J.; Jiang, X.; Wei, M.; Jin, J.; Liu, P. P.; Chen, J., Blood
  • Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases Cannova, J.; Breslin, S. J. P.; Zhang, J., Frontiers of medicine
  • Co-inhibition of NF-kappaB and JNK is synergistic in TNF-expressing human AML Volk, A.; Li, J.; Xin, J.; You, D.; Zhang, J.; Liu, X.; Xiao, Y.; Breslin, P.; Li, Z.; Wei, W.; Schmidt, R.; Li, X.; Zhang, Z.; Kuo, P. C.; Nand, S.; Zhang, J.; Chen, J.; Zhang, J., The Journal of experimental medicine
  • Co-inhibition of NF-kappaB and JNK is synergistic in TNF-expressing human AML Volk, A.; Li, J.; Xin, J.; You, D.; Zhang, J.; Liu, X.; Xiao, Y.; Breslin, P.; Li, Z.; Wei, W.; Schmidt, R.; Li, X.; Zhang, Z.; Kuo, P. C.; Nand, S.; Zhang, J.; Chen, J.; Zhang, J., The Journal of experimental medicine
  • Co-inhibition of NF-kappaB and JNK is synergistic in TNF-expressing human AML Volk, A.; Li, J.; Xin, J.; You, D.; Zhang, J.; Liu, X.; Xiao, Y.; Breslin, P.; Li, Z.; Wei, W.; Schmidt, R.; Li, X.; Zhang, Z.; Kuo, P. C.; Nand, S.; Zhang, J.; Chen, J.; Zhang, J., The Journal of experimental medicine
  • Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer Weber, C. E.; Kothari, A. N.; Wai, P. Y.; Li, N. Y.; Driver, J.; Zapf, M. A.; Franzen, C. A.; Gupta, G. N.; Osipo, C.; Zlobin, A.; Syn, W. K.; Zhang, J.; Kuo, P. C.; Mi, Z., Oncogene
  • Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor Christensen, C. L.; Kwiatkowski, N.; Abraham, B. J.; Carretero, J.; Al-Shahrour, F.; Zhang, T.; Chipumuro, E.; Herter-Sprie, G. S.; Akbay, E. A.; Altabef, A.; Zhang, J.; Shimamura, T.; Capelletti, M.; Reibel, J. B.; Cavanaugh, J. D.; Gao, P.; Liu, Y.; Michaelsen, S. R.; Poulsen, H. S.; Aref, A. R.; Barbie, D. A.; Bradner, J. E.; George, R. E.; Gray, N. S.; Young, R. A.; Wong, K. K., CANCER CELL
  • TGF-beta-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation Kim, S. I.; Lee, S. Y.; Wang, Z.; Ding, Y.; Haque, N.; Zhang, J.; Zhou, J.; Choi, M. E., Journal of the American Society of Nephrology : JASN
  • The Synergistic Repressive Effect of NF-kappaB and JNK Inhibitor on the Clonogenic Capacity of Jurkat Leukemia Cells Liu, X.; Zhang, J.; Li, J.; Volk, A.; Breslin, P.; Zhang, J.; Zhang, Z., PLoS ONE
  • The Synergistic Repressive Effect of NF-kappaB and JNK Inhibitor on the Clonogenic Capacity of Jurkat Leukemia Cells Liu, X.; Zhang, J.; Li, J.; Volk, A.; Breslin, P.; Zhang, J.; Zhang, Z., PLoS ONE
  • An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines Li, N. Y.; Weber, C. E.; Wai, P. Y.; Cuevas, B. D.; Zhang, J.; Kuo, P. C.; Mi, Z., Surgery
  • Increases in systemic and local stress: a probable mechanism of visceral fat accumulation and insulin resistance in adult catch-up growth rats? Hu, X.; Chen, L. L.; Zheng, J.; Kong, W.; Zhang, H. H.; Zeng, T. S.; Zhang, J. Y.; Li, H. Q.; Hu, D.; Liao, Y. F., Experimental biology and medicine (Maywood, N.J.)
  • Modeling the acute and chronic phases of Theiler murine encephalomyelitis virus infection Zhang, J.; Lipton, H. L.; Perelson, A. S.; Dahari, H., Journal of virology
  • p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia Zhang, J.; Seet, C. S.; Sun, C.; Li, J.; You, D.; Volk, A.; Breslin, P.; Li, X.; Wei, W.; Qian, Z.; Zeleznik-Le, N. J.; Zhang, Z.; Zhang, J., Molecular oncology
  • p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia Zhang, J.; Seet, C. S.; Sun, C.; Li, J.; You, D.; Volk, A.; Breslin, P.; Li, X.; Wei, W.; Qian, Z.; Zeleznik-Le, N. J.; Zhang, Z.; Zhang, J., Molecular oncology
  • Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia Jiang, X.; Huang, H.; Li, Z.; Li, Y.; Wang, X.; Gurbuxani, S.; Chen, P.; He, C.; You, D.; Zhang, S.; Wang, J.; Arnovitz, S.; Elkahloun, A.; Price, C.; Hong, G. M.; Ren, H.; Kunjamma, R. B.; Neilly, M. B.; Matthews, J. M.; Xu, M.; Larson, R. A.; Le Beau, M. M.; Slany, R. K.; Liu, P. P.; Lu, J.; Zhang, J.; He, C.; Chen, J., CANCER CELL
  • Differentially expressed genes and pathways induced by organophosphates in human neuroblastoma cells Li, T.; Zhao, H.; Hung, G. C.; Han, J.; Tsai, S.; Li, B.; Zhang, J.; Puri, R. K.; Lo, S. C., Experimental biology and medicine (Maywood, N.J.)
  • Food restriction alters villi morphology in obese rats: gut mechanism for weight regain? Zhang, J. G.; Sun, X. W.; Gao, P.; Xie, L.; Liu, W. Q.; Xiao, H. T.; Ai, H., Experimental biology and medicine (Maywood, N.J.)
  • Insulin resistance induces medial artery calcification in fructose-fed rats Zhou, Y. B.; Zhang, J.; Cai, Y.; Teng, X.; Duan, X. H.; Song, J. Q.; Du, J.; Tang, C. S.; Qi, Y. F., Experimental biology and medicine (Maywood, N.J.)
  • miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia Li, Z.; Huang, H.; Chen, P.; He, M.; Li, Y.; Arnovitz, S.; Jiang, X.; He, C.; Hyjek, E.; Zhang, J.; Zhang, Z.; Elkahloun, A.; Cao, D.; Shen, C.; Wunderlich, M.; Wang, Y.; Neilly, M. B.; Jin, J.; Wei, M.; Lu, J.; Valk, P. J.; Delwel, R.; Lowenberg, B.; Le Beau, M. M.; Vardiman, J.; Mulloy, J. C.; Zeleznik-Le, N. J.; Liu, P. P.; Zhang, J.; Chen, J., Nature communications
  • miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia Li, Z.; Huang, H.; Chen, P.; He, M.; Li, Y.; Arnovitz, S.; Jiang, X.; He, C.; Hyjek, E.; Zhang, J.; Zhang, Z.; Elkahloun, A.; Cao, D.; Shen, C.; Wunderlich, M.; Wang, Y.; Neilly, M. B.; Jin, J.; Wei, M.; Lu, J.; Valk, P. J.; Delwel, R.; Lowenberg, B.; Le Beau, M. M.; Vardiman, J.; Mulloy, J. C.; Zeleznik-Le, N. J.; Liu, P. P.; Zhang, J.; Chen, J., Nature communications
  • Congenital anomalies and rhabdoid tumor associated with 22q11 germline deletion and somatic inactivation of the SMARCB1 tumor suppressor. Toth, G.; Zraly, C. B.; Thomson, T. L.; Jones, C.; Lapetino, S.; Muraskas, J.; Zhang, J.; Dingwall, A. K., Genes, chromosomes & cancer
  • Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice Zhang, J.; Xiao, Y.; Guo, Y.; Breslin, P.; Zhang, S.; Wei, W.; Zhang, Z.; Zhang, J., Leukemia
  • Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice Zhang, J.; Xiao, Y.; Guo, Y.; Breslin, P.; Zhang, S.; Wei, W.; Zhang, Z.; Zhang, J., Leukemia
  • TNF-alpha/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations. Xiao, Y.; Li, H.; Zhang, J.; Volk, A.; Zhang, S.; Wei, W.; Zhang, S.; Breslin, P.; Zhang, J., Blood
  • TNF-alpha/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations. Xiao, Y.; Li, H.; Zhang, J.; Volk, A.; Zhang, S.; Wei, W.; Zhang, S.; Breslin, P.; Zhang, J., Blood
  • Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production Rajasekaran, K.; Chu, H.; Kumar, P.; Xiao, Y.; Tinguely, M.; Samarakoon, A.; Kim, T. W.; Li, X.; Thakar, M. S.; Zhang, J.; Malarkannan, S., The Journal of biological chemistry
  • An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation Fu, C. T.; Zhu, K. Y.; Mi, J. Q.; Liu, Y. F.; Murray, S. T.; Fu, Y. F.; Ren, C. G.; Dong, Z. W.; Liu, Y. J.; Dong, M.; Jin, Y.; Chen, Y.; Deng, M.; Zhang, W.; Chen, B.; Breslin, P.; Chen, S. J.; Chen, Z.; Becker, M. W.; Zhu, J.; Zhang, J. W.; Liu, T. X., Blood
  • c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development. Niu, C.; Zhang, J.; Breslin, P.; Onciu, M.; Ma, Z.; Morris, S. W., Blood
  • c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Guo, Y.; Niu, C.; Breslin, P.; Tang, M.; Zhang, S.; Wei, W.; Kini, A. R.; Paner, G. P.; Alkan, S.; Morris, S. W.; Diaz, M.; Stiff, P. J.; Zhang, J., Blood
  • Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Popovic, R.; Riesbeck, L. E.; Velu, C. S.; Chaubey, A.; Zhang, J.; Achille, N. J.; Erfurth, F. E.; Eaton, K.; Lu, J.; Grimes, H. L.; Chen, J.; Rowley, J. D.; Zeleznik-Le, N. J., Blood
  • Stem cell niche: microenvironment and beyond Zhang, J.; Li, L., The Journal of biological chemistry
  • TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. Tang, M.; Wei, X.; Guo, Y.; Breslin, P.; Zhang, S.; Zhang, S.; Wei, W.; Xia, Z.; Diaz, M.; Akira, S.; Zhang, J., Journal of Experimental Medicine
  • Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche Hofmeister, C. C.; Zhang, J.; Knight, K. L.; Le, P.; Stiff, P. J., Bone marrow transplantation
  • Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Zhang, J.; He, X. C.; Tong, W. G.; Johnson, T.; Wiedemann, L. M.; Mishina, Y.; Feng, J. Q.; Li, L., Stem cells
  • PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Zhang, J.; Grindley, J. C.; Yin, T.; Jayasinghe, S.; He, X. C.; Ross, J. T.; Haug, J. S.; Rupp, D.; Porter-Westpfahl, K. S.; Wiedemann, L. M.; Wu, H.; Li, L., Nature
  • Sterile and disposable fluidic subsystem suitable for clinical high speed fluorescence-activated cell sorting. Jayasinghe, S. M.; Wunderlich, J.; McKee, A.; Newkirk, H.; Pope, S.; Zhang, J.; Staehling-Hampton, K.; Li, L.; Haug, J. S., Cytometry Part B, Clinical Cytometry
  • BMP signaling and stem cell regulation Zhang, J.; Li, L., Developmental biology
  • Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior He, X. C.; Zhang, J.; Li, L., Annals of the New York Academy of Sciences
  • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. He, X. C.; Zhang, J.; Tong, W. G.; Tawfik, O.; Ross, J.; Scoville, D. H.; Tian, Q.; Zeng, X.; He, X.; Wiedemann, L. M.; Mishina, Y.; Li, L., Nature genetics
  • 25-year mystery unveiled: Hematopoietic stem cell niche is found Zhang, J.; Li, L., Discovery Medicine
  • Identification of the haematopoietic stem cell niche and control of the niche size. Zhang, J.; Niu, C.; Ye, L.; Huang, H.; He, X.; Tong, W. G.; Ross, J.; Haug, J.; Johnson, T.; Feng, J. Q.; Harris, S.; Wiedemann, L. M.; Mishina, Y.; Li, L., Nature
  • Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Akashi, K.; He, X.; Chen, J.; Iwasaki, H.; Niu, C.; Steenhard, B.; Zhang, J.; Haug, J.; Li, L., Blood
  • Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. Zhu, Q.; Zhang, J. W.; Zhu, H. Q.; Shen, Y. L.; Flexor, M.; Jia, P. M.; Yu, Y.; Cai, X.; Waxman, S.; Lanotte, M.; Chen, S. J.; Chen, Z.; Tong, J. H., Blood
  • Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Cai, X.; Shen, Y. L.; Zhu, Q.; Jia, P. M.; Yu, Y.; Zhou, L.; Huang, Y.; Zhang, J. W.; Xiong, S. M.; Chen, S. J.; Wang, Z. Y.; Chen, Z.; Chen, G. Q., Leukemia
  • Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang, Q. H.; Ye, M.; Wu, X. Y.; Ren, S. X.; Zhao, M.; Zhao, C. J.; Fu, G.; Shen, Y.; Fan, H. Y.; Lu, G.; Zhong, M.; Xu, X. R.; Han, Z. G.; Zhang, J. W.; Tao, J.; Huang, Q. H.; Zhou, J.; Hu, G. X.; Gu, J.; Chen, S. J.; Chen, Z., Genome research
  • Gene expression networks underlying retinoic acid-induced differentiation of acute promyelocytic leukemia cells. Liu, T. X.; Zhang, J. W.; Tao, J.; Zhang, R. B.; Zhang, Q. H.; Zhao, C. J.; Tong, J. H.; Lanotte, M.; Waxman, S.; Chen, S. J.; Mao, M.; Hu, G. X.; Zhu, L.; Chen, Z., Blood
  • Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells Zhang, J. W.; Wang, J. Y.; Chen, S. J.; Chen, Z., Journal of Biosciences