I. Caroline LePoole, PhD | Loyola Medicine

I. Caroline LePoole, PhD

Pathology

Affiliate Professor

Languages Spoken

English, Dutch

Clinical Expertise

Biography

Interests

Medical Education

Medical School
Residency
Fellowship

Board Certification

Research

  • Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells Moore, T.; Wagner, C. R.; Scurti, G. M.; Hutchens, K. A.; Godellas, C.; Clark, A. L.; Kolawole, E. M.; Hellman, L. M.; Singh, N. K.; Huyke, F. A.; Wang, S. Y.; Calabrese, K. M.; Embree, H. D.; Orentas, R.; Shirai, K.; Dellacecca, E.; Garrett-Mayer, E.; Li, M.; Eby, J. M.; Stiff, P. J.; Evavold, B. D.; Baker, B. M.; Le Poole, I. C.; Dropulic, B.; Clark, J. I.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells Moore, T.; Wagner, C. R.; Scurti, G. M.; Hutchens, K. A.; Godellas, C.; Clark, A. L.; Kolawole, E. M.; Hellman, L. M.; Singh, N. K.; Huyke, F. A.; Wang, S. Y.; Calabrese, K. M.; Embree, H. D.; Orentas, R.; Shirai, K.; Dellacecca, E.; Garrett-Mayer, E.; Li, M.; Eby, J. M.; Stiff, P. J.; Evavold, B. D.; Baker, B. M.; Le Poole, I. C.; Dropulic, B.; Clark, J. I.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • Alpha-N-acetyl-neuraminide alpha-2 8-sialyltransferase 1 can support immune responses toward tumors overexpressing ganglioside D3 in mice, Eby, J. M.; Barse, L.; Henning, S. W.; Rabelink, M. J.; Klarquist, J.; Gilbert, E. R.; Hammer, A. M.; Fernandez, M. F.; Yung, N.; Khan, S.; Miller, H. G.; Kessler, E. R.; Garrett-Mayer, E.; Dilling, D. F.; Hoeben, R. C.; Le Poole, I. C., Cancer immunology, immunotherapy : CII
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  • Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma Klarquist, J.; Tobin, K.; Farhangi Oskuei, P.; Henning, S. W.; Fernandez, M. F.; Dellacecca, E. R.; Navarro, F. C.; Eby, J. M.; Chatterjee, S.; Mehrotra, S.; Clark, J. I.; Le Poole, I. C., Cancer research
  • Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin Klarquist, J.; Eby, J. M.; Henning, S. W.; Li, M.; Wainwright, D. A.; Westerhof, W.; Luiten, R. M.; Nishimura, M. I.; Le Poole, I. C., Pigment Cell & Melanoma Research
  • TNF-alpha inhibition can stabilize disease in progressive vitiligo Webb, K. C.; Tung, R.; Winterfield, L. S.; Gottlieb, A. B.; Eby, J. M.; Henning, S. W.; Le Poole, I. C., The British journal of dermatology
  • Tumour necrosis factor-alpha inhibition can stabilize disease in progressive vitiligo Webb, K. C.; Tung, R.; Winterfield, L. S.; Gottlieb, A. B.; Eby, J. M.; Henning, S. W.; Le Poole, I. C., The British journal of dermatology
  • Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress Mosenson, J. A.; Flood, K.; Klarquist, J.; Eby, J. M.; Koshoffer, A.; Boissy, R. E.; Overbeck, A.; Tung, R. C.; Le Poole, I. C., Pigment Cell & Melanoma Research
  • Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin Bonchak, J. G.; Eby, J. M.; Willenborg, K. A.; Chrobak, D.; Henning, S. W.; Krzywiec, A.; Johnson, S. L.; Le Poole, I. C., ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
  • Vitiligo treatment demystified: a flowchart for stratified treatment approaches Tung, R.; Le Poole, I. C., Experimental dermatology
  • A central role for inducible heat-shock protein 70 in autoimmune vitiligo Mosenson, J. A.; Eby, J. M.; Hernandez, C.; Le Poole, I. C., Experimental dermatology
  • Mutant HSP70 reverses autoimmune depigmentation in vitiligo Mosenson, J. A.; Zloza, A.; Nieland, J. D.; Garrett-Mayer, E.; Eby, J. M.; Huelsmann, E. J.; Kumar, P.; Denman, C. J.; Lacek, A. T.; Kohlhapp, F. J.; Alamiri, A.; Hughes, T.; Bines, S. D.; Kaufman, H. L.; Overbeck, A.; Mehrotra, S.; Hernandez, C.; Nishimura, M. I.; Guevara-Patino, J. A.; Le Poole, I. C., Science translational medicine
  • Positioning ganglioside D3 as an immunotherapeutic target in lymphangioleiomyomatosis Gilbert, E. R.; Eby, J. M.; Hammer, A. M.; Klarquist, J.; Christensen, D. G.; Barfuss, A. J.; Boissy, R. E.; Picken, M. M.; Love, R. B.; Dilling, D. F.; Le Poole, I. C., The American journal of pathology
  • Renal angiomyolipoma fat-poor variant--a clinicopathologic mimicker of malignancy, Mehta, V.; Venkataraman, G.; Antic, T.; Rubinas, T. C.; Le Poole, I. C.; Picken, M. M., Virchows Archiv : an international journal of pathology
  • A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice Mehrotra, S.; Al-Khami, A. A.; Klarquist, J.; Husain, S.; Naga, O.; Eby, J. M.; Murali, A. K.; Lyons, G. E.; Li, M.; Spivey, N. D.; Norell, H.; Martins da Palma, T.; Onicescu, G.; Diaz-Montero, C. M.; Garrett-Mayer, E.; Cole, D. J.; Le Poole, I. C.; Nishimura, M. I., Journal of immunology (Baltimore, Md.: 1950)
  • A current viewpoint of lymphangioleiomyomatosis supporting immunotherapeutic treatment options Dilling, D. F.; Gilbert, E. R.; Picken, M. M.; Eby, J. M.; Love, R. B.; Le Poole, I. C., American Journal of Respiratory Cell & Molecular Biology
  • Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference Ezzedine, K.; Lim, H. W.; Suzuki, T.; Katayama, I.; Hamzavi, I.; Lan, C. C.; Goh, B. K.; Anbar, T.; Silva de Castro, C.; Lee, A. Y.; Parsad, D.; van Geel, N.; Le Poole, I. C.; Oiso, N.; Benzekri, L.; Spritz, R.; Gauthier, Y.; Hann, S. K.; Picardo, M.; Taieb, A.; Vitiligo Global Issue Consensus Conference Panelists, Pigment Cell & Melanoma Research
  • Heme oxygenase-1 expression protects melanocytes from stress-induced cell death: implications for vitiligo. Elassiuty, Y. E.; Klarquist, J.; Speiser, J.; Yousef, R. M.; El Refaee, A. A.; Hunter, N. S.; Shaker, O. G.; Gundeti, M.; Nieuweboer-Krobotova, L.; Le Poole, I. C., Experimental dermatology
  • Notch signaling regulates mouse and human Th17 differentiation. Keerthivasan, S.; Suleiman, R.; Lawlor, R.; Roderick, J.; Bates, T.; Minter, L.; Anguita, J.; Juncadella, I.; Nickoloff, B. J.; Le Poole, I. C.; Miele, L.; Osborne, B. A., Journal of Immunology
  • Topical application of bleaching phenols; in-vivo studies and mechanism of action relevant to melanoma treatment. Hariharan, V.; Toole, T.; Klarquist, J.; Mosenson, J.; Longley, B. J.; Le Poole, I. C., Melanoma research
  • Functional alterations in protein kinase C beta II expression in melanoma. Voris, J. P.; Sitailo, L. A.; Rahn, H. R.; Defnet, A.; Gerds, A. T.; Sprague, R.; Yadav, V.; Le Poole, I. C.; Denning, M. F., Pigment Cell & Melanoma Research
  • Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation. Hariharan, V.; Klarquist, J.; Reust, M. J.; Koshoffer, A.; McKee, M. D.; Boissy, R. E.; Le Poole, I. C., Journal of Investigative Dermatology
  • Reduced skin homing by functional Treg in vitiligo Klarquist, J.; Denman, C. J.; Hernandez, C.; Wainwright, D. A.; Strickland, F. M.; Overbeck, A.; Mehrotra, S.; Nishimura, M. I.; Le Poole, I. C., Pigment Cell & Melanoma Research
  • De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase plasminogen activator receptor signaling-dependent MMP-2 activation Liu, J. W.; Sun, P.; Yan, Q.; Paller, A. S.; Gerami, P.; Ho, N.; Vashi, N.; Le Poole, I. C.; Wang, X. Q., Cancer research
  • Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells. Klarquist, J.; Barfuss, A.; Kandala, S.; Reust, M. J.; Braun, R. K.; Hu, J.; Dilling, D. F.; McKee, M. D.; Boissy, R. E.; Love, R. B.; Nishimura, M. I.; Le Poole, I. C., American Journal of Pathology
  • Relationship between CD8-dependent antigen recognition T cell functional avidity, and tumor cell recognition, Moore, T. V.; Lyons, G. E.; Brasic, N.; Roszkowski, J. J.; Voelkl, S.; Mackensen, A.; Kast, W. M.; Le Poole, I. C.; Nishimura, M. I., Cancer immunology, immunotherapy : CII
  • Autoimmune etiology of generalized vitiligo Le Poole, I. C.; Luiten, R. M., Current directions in autoimmunity
  • HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo. Denman, C. J.; McCracken, J.; Hariharan, V.; Klarquist, J.; Oyarbide-Valencia, K.; Guevara-Patino, J. A.; Le Poole, I. C., Journal of Investigative Dermatology
  • Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMP Ivanova, K.; Lambers, B.; van den Wijngaard, R.; Le Poole, I. C.; Grigorieva, O.; Gerzer, R.; Das, P. K., In vitro cellular & developmental biology.Animal
  • Langerhans cells and dendritic cells are cytotoxic towards HPV16 E6 and E7 expressing target cells. Le Poole, I. C.; ElMasri, W. M.; Denman, C. J.; Kroll, T. M.; Bommiasamy, H.; Lyons Eiben, G.; Kast, W. M., Cancer Immunology, Immunotherapy
  • Vitiligo pathogenesis: autoimmune disease genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?, Schallreuter, K. U.; Bahadoran, P.; Picardo, M.; Slominski, A.; Elassiuty, Y. E.; Kemp, E. H.; Giachino, C.; Liu, J. B.; Luiten, R. M.; Lambe, T.; Le Poole, I. C.; Dammak, I.; Onay, H.; Zmijewski, M. A.; Dell'Anna, M. L.; Zeegers, M. P.; Cornall, R. J.; Paus, R.; Ortonne, J. P.; Westerhof, W., Experimental dermatology
  • T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity van den Boorn, J. G.; Le Poole, I. C.; Luiten, R. M., International reviews of immunology
  • Therapeutic implications of autoimmune vitiligo T cells Oyarbide-Valencia, K.; van den Boorn, J. G.; Denman, C. J.; Li, M.; Carlson, J. M.; Hernandez, C.; Nishimura, M. I.; Das, P. K.; Luiten, R. M.; Le Poole, I. C., Autoimmunity Reviews
  • 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo. Kroll, T. M.; Bommiasamy, H.; Boissy, R. E.; Hernandez, C.; Nickoloff, B. J.; Mestril, R.; Le Poole, I. C., Journal of Investigative Dermatology
  • Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes Cassetti, M. C.; McElhiney, S. P.; Shahabi, V.; Pullen, J. K.; Le Poole, I. C.; Eiben, G. L.; Smith, L. R.; Kast, W. M., Vaccine
  • Autoimmune aspects of depigmentation in vitiligo Le Poole, I. C.; Wankowicz-Kalinska, A.; van den Wijngaard, R. M.; Nickoloff, B. J.; Das, P. K., Journal of Investigative Dermatology.Symposium Proceedings
  • Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter region. Stennett, L. S.; Riker, A. I.; Kroll, T. M.; Chamberlin, J.; Miki, T.; Nickoloff, B. J.; Le Poole, I. C., Pigment Cell Research
  • Advances in prophylactic cancer vaccine research Le Poole, I. C.; Bommiasamy, H.; Bocchetta, M.; Kast, W. M., Expert Review of Anticancer Therapy
  • Cervical cancer vaccines: recent advances in HPV research Eiben, G. L.; da Silva, D. M.; Fausch, S. C.; Le Poole, I. C.; Nishimura, M. I.; Kast, W. M., Viral immunology
  • Expansion of vitiligo lesions is associated with reduced epidermal CDw60 expression and increased expression of HLA-DR in perilesional skin. Le Poole, I. C.; Stennett, L. S.; Bonish, B. K.; Dee, L.; Robinson, J. K.; Hernandez, C.; Hann, S. K.; Nickoloff, B. J., British Journal of Dermatology
  • HPV protein/peptide vaccines: from animal models to clinical trials Fausch, S. C.; Da Silva, D. M.; Eiben, G. L.; Le Poole, I. C.; Kast, W. M., Frontiers in bioscience : a journal and virtual library
  • Recent progress in tumour vaccine development Le Poole, I. C.; Bommiasamy, H.; Kast, W. M., Expert opinion on investigational drugs
  • Emerging strategies in tumor vaccines Le Poole, I. C.; Gerberi, M. A.; Kast, W. M., Current opinion in oncology
  • Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells Le Poole, I. C.; Riker, A. I.; Quevedo, M. E.; Stennett, L. S.; Wang, E.; Marincola, F. M.; Kast, W. M.; Robinson, J. K.; Nickoloff, B. J., The American journal of pathology
  • 'VIT1' a novel gene associated with vitiligo, Le Poole, I. C.; Sarangarajan, R.; Zhao, Y.; Stennett, L. S.; Brown, T. L.; Sheth, P.; Miki, T.; Boissy, R. E., Pigment Cell Research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society
  • A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo Das, P. K.; van den Wijngaard, R. M.; Wankowicz-Kalinska, A.; Le Poole, I. C., Trends in immunology
  • Inhibition of melanosome transfer from melanocytes to keratinocytes by lectins and neoglycoproteins in an in vitro model system Minwalla, L.; Zhao, Y.; Cornelius, J.; Babcock, G. F.; Wickett, R. R.; Le Poole, I. C.; Boissy, R. E., Pigment Cell Research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society
  • Keratinocytes play a role in regulating distribution patterns of recipient melanosomes in vitro Minwalla, L.; Zhao, Y.; Le Poole, I. C.; Wickett, R. R.; Boissy, R. E., The Journal of investigative dermatology
  • Expression and modulation of apoptosis regulatory molecules in human melanocytes: significance in vitiligo van den Wijngaard, R. M.; Aten, J.; Scheepmaker, A.; Le Poole, I. C.; Tigges, A. J.; Westerhof, W.; Das, P. K., The British journal of dermatology
  • Micro-anatomy related antigen expression in melanocytic lesions Meije, C. B.; Mooi, W. J.; Le Poole, I. C.; Van Muijen, G. N.; Das, P. K., The Journal of pathology
  • PIG3V an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum, Le Poole, I. C.; Boissy, R. E.; Sarangarajan, R.; Chen, J.; Forristal, J. J.; Sheth, P.; Westerhof, W.; Babcock, G.; Das, P. K.; Saelinger, C. B., In vitro cellular & developmental biology.Animal
  • The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity Yang, F.; Sarangarajan, R.; Le Poole, I. C.; Medrano, E. E.; Boissy, R. E., The Journal of investigative dermatology