Elizabeth Kovacs, PhD

Surgery

Surgical Research
Microbiology and Immunology
Professor
Co-Director, Burn and Shock Trauma Research Institute, Division Director, Surgical Research, Program Director, Alcohol Research

Languages Spoken

English

Medical Education

Fellowship
National Cancer Institute (NCI) - Biological Response Modifiers Program

Research

  • Acute immunomodulatory effects of binge alcohol ingestion Afshar, M.; Richards, S.; Mann, D.; Cross, A.; Smith, G. B.; Netzer, G.; Kovacs, E.; Hasday, J., Alcohol (Fayetteville, N.Y.)
  • Alcohol and inflammatory responses: Summary of the 2013 Alcohol and Immunology Research Interest Group (AIRIG) meeting Morris, N. L.; Ippolito, J. A.; Curtis, B. J.; Chen, M. M.; Friedman, S. L.; Hines, I. N.; Haddad, G. E.; Chang, S. L.; Brown, L. A.; Waldschmidt, T. J.; Mandrekar, P.; Kovacs, E. J.; Choudhry, M. A., Alcohol (Fayetteville, N.Y.)
  • Alcohol Modulation of the Postburn Hepatic Response Chen, M. M.; Carter, S. R.; Curtis, B. J.; O'Halloran, E. B.; Gamelli, R. L.; Kovacs, E. J., Journal of burn care & research : official publication of the American Burn Association
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  • Alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin Chen, M. M.; O'Halloran, E. B.; Ippolito, J. A.; Choudhry, M. A.; Kovacs, E. J., Shock (Augusta, Ga.)
  • Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders O'Halloran, E. B.; Curtis, B. J.; Afshar, M.; Chen, M. M.; Kovacs, E. J.; Burnham, E. L., Alcohol (Fayetteville, N.Y.)
  • Chronic wound repair and healing in older adults: current status and future research Gould, L.; Abadir, P.; Brem, H.; Carter, M.; Conner-Kerr, T.; Davidson, J.; DiPietro, L.; Falanga, V.; Fife, C.; Gardner, S.; Grice, E.; Harmon, J.; Hazzard, W. R.; High, K. P.; Houghton, P.; Jacobson, N.; Kirsner, R. S.; Kovacs, E. J.; Margolis, D.; McFarland Horne, F.; Reed, M. J.; Sullivan, D. H.; Thom, S.; Tomic-Canic, M.; Walston, J.; Whitney, J.; Williams, J.; Zieman, S.; Schmader, K., WOUND REPAIR AND REGENERATION
  • Chronic wound repair and healing in older adults: current status and future research Gould, L.; Abadir, P.; Brem, H.; Carter, M.; Conner-Kerr, T.; Davidson, J.; DiPietro, L.; Falanga, V.; Fife, C.; Gardner, S.; Grice, E.; Harmon, J.; Hazzard, W. R.; High, K. P.; Houghton, P.; Jacobson, N.; Kirsner, R. S.; Kovacs, E. J.; Margolis, D.; McFarland Horne, F.; Reed, M. J.; Sullivan, D. H.; Thom, S.; Tomic-Canic, M.; Walston, J.; Whitney, J. A.; Williams, J.; Zieman, S.; Schmader, K., Journal of the American Geriatrics Society
  • Effects of High Estrogen Levels on Monocyte Chemoattractant Protein-1 and Wound Healing Plackett, T. P.; Gregory, M. S.; Kovacs, E. J., Advances in wound care
  • Experimental Approaches to Tissue Injury and Repair in Advanced Age Brubaker, A. L.; Carter, S. R.; Kovacs, E. J., Methods in molecular biology (Clifton, N.J.)
  • Extracellular traps and macrophages: new roles for the versatile phagocyte Boe, D. M.; Curtis, B. J.; Chen, M. M.; Ippolito, J. A.; Kovacs, E. J., Journal of leukocyte biology
  • Impaired respiratory function and heightened pulmonary inflammation in episodic binge ethanol intoxication and burn injury Shults, J. A.; Curtis, B. J.; Chen, M. M.; O'Halloran, E. B.; Ramirez, L.; Kovacs, E. J., Alcohol (Fayetteville, N.Y.)
  • Remote Burn Injury Increases Pulmonary Histone Deacetylase 1 and Reduces Histone Acetylation Curtis, B. J.; Shults, J. A.; Ramirez, L.; Kovacs, E. J., Journal of burn care & research : official publication of the American Burn Association
  • Screening for at-risk drinking behavior in trauma patients Plackett, T. P.; Ton-That, H. H.; Mueller, J.; Grimley, K. M.; Kovacs, E. J.; Esposito, T. J., The Journal of the American Osteopathic Association
  • Summary of the 2014 Alcohol and Immunology Research Interest Group (AIRIG) meeting Hammer, A. M.; Morris, N. L.; Cannon, A. R.; Shults, J. A.; Curtis, B.; Casey, C. A.; Sueblinvong, V.; Persidsky, Y.; Nixon, K.; Brown, L. A.; Waldschmidt, T.; Mandrekar, P.; Kovacs, E. J.; Choudhry, M. A., Alcohol (Fayetteville, N.Y.)
  • Adipose inflammation and macrophage infiltration after binge ethanol and burn injury Qin, Y.; Hamilton, J. L.; Bird, M. D.; Chen, M. M.; Ramirez, L.; Zahs, A.; Kovacs, E. J.; Makowski, L., Alcoholism, Clinical and Experimental Research
  • Age-related differences in the neutrophil response to pulmonary pseudomonas infection Chen, M. M.; Palmer, J. L.; Plackett, T. P.; Deburghgraeve, C. R.; Kovacs, E. J., Experimental gerontology
  • An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice Chen, M. M.; Zahs, A.; Brown, M. M.; Ramirez, L.; Turner, J. R.; Choudhry, M. A.; Kovacs, E. J., American journal of physiology.Gastrointestinal and liver physiology
  • Episodic binge ethanol exposure impairs murine macrophage infiltration and delays wound closure by promoting defects in early innate immune responses Curtis, B. J.; Hlavin, S.; Brubaker, A. L.; Kovacs, E. J.; Radek, K. A., Alcoholism, Clinical and Experimental Research
  • Heavy alcohol use in lung donors increases the risk for primary graft dysfunction Lowery, E. M.; Kuhlmann, E. A.; Mahoney, E. L.; Dilling, D. F.; Kliethermes, S. A.; Kovacs, E. J., Alcoholism, Clinical and Experimental Research
  • Modulation of inflammation by alcohol exposure Lehnert, M.; Kovacs, E. J.; Molina, P. E.; Relja, B., Mediators of inflammation
  • Neutrophil Accumulation in the Small Intestine Contributes to Local Tissue Destruction After Combined Radiation and Burn Injury Carter, S. R.; Chen, M. M.; Palmer, J. L.; Wang, L.; Ramirez, L.; Plackett, T. P.; Gamelli, R. L.; Kovacs, E. J., Journal of burn care & research : official publication of the American Burn Association
  • Street smarts of science for students Chen, M. M.; Zahs, A.; Chang, S. L.; Kovacs, E. J., Nature immunology
  • The diagnostic value of gastroesophageal reflux disease (GERD) symptoms and detection of pepsin and bile acids in bronchoalveolar lavage fluid and exhaled breath condensate for identifying lung transplantation patients with GERD-induced aspiration Reder, N. P.; Davis, C. S.; Kovacs, E. J.; Fisichella, P. M., Surgical endoscopy
  • The role of aryl hydrocarbon receptor in interleukin-23-dependent restoration of interleukin-22 following ethanol exposure and burn injury Rendon, J. L.; Li, X.; Brubaker, A. L.; Kovacs, E. J.; Gamelli, R. L.; Choudhry, M. A., Annals of Surgery
  • The systemic immune response to trauma: an overview of pathophysiology and treatment Lord, J. M.; Midwinter, M. J.; Chen, Y. F.; Belli, A.; Brohi, K.; Kovacs, E. J.; Koenderman, L.; Kubes, P.; Lilford, R. J., Lancet
  • Usefulness of pH monitoring in predicting the survival status of patients with scleroderma awaiting lung transplantation Fisichella, P. M.; Reder, N. P.; Gagermeier, J.; Kovacs, E. J., The Journal of surgical research
  • Alcohol and immunology: Summary of the 2012 Alcohol and Immunology Research Interest Group (AIRIG) meeting Ippolito, J. A.; Curtis, B. J.; Choudhry, M. A.; Kovacs, E. J., Alcohol (Fayetteville, N.Y.)
  • Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury Zahs, A.; Bird, M. D.; Ramirez, L.; Choudhry, M. A.; Kovacs, E. J., Shock
  • Aspiration Localized Pulmonary Inflammation, and Predictors of Early-Onset Bronchiolitis Obliterans Syndrome after Lung Transplantation, Fisichella, P. M.; Davis, C. S.; Lowery, E.; Ramirez, L.; Gamelli, R. L.; Kovacs, E. J., Journal of the American College of Surgeons
  • Combined radiation and burn injury results in exaggerated early pulmonary inflammation Palmer, J. L.; Deburghgraeve, C. R.; Bird, M. D.; Hauer-Jensen, M.; Chen, M. M.; Yong, S.; Kovacs, E. J., Radiation research
  • Epigenetic targets for reversing immune defects caused by alcohol exposure Curtis, B. J.; Zahs, A.; Kovacs, E. J., Alcohol research : current reviews
  • G-CSF enhances resolution of Staphylococcus aureus wound infection in an age-dependent manner Brubaker, A. L.; Kovacs, E. J., Shock (Augusta, Ga.)
  • Implications of alcohol intoxication at the time of burn and smoke inhalation injury: an epidemiologic and clinical analysis Davis, C. S.; Esposito, T. J.; Palladino-Davis, A. G.; Rychlik, K.; Schermer, C. R.; Gamelli, R. L.; Kovacs, E. J., Journal of Burn Care & Research
  • Inhalation injury severity and systemic immune perturbations in burned adults Davis, C. S.; Janus, S. E.; Mosier, M. J.; Carter, S. R.; Gibbs, J. T.; Ramirez, L.; Gamelli, R. L.; Kovacs, E. J., Annals of Surgery
  • Intestinal barrier disruption as a cause of mortality in combined radiation and burn injury Carter, S. R.; Zahs, A.; Palmer, J. L.; Wang, L.; Ramirez, L.; Gamelli, R. L.; Kovacs, E. J., Shock (Augusta, Ga.)
  • Intoxication by intraperitoneal injection or oral gavage equally potentiates postburn organ damage and inflammation Chen, M. M.; Palmer, J. L.; Ippolito, J. A.; Curtis, B. J.; Choudhry, M. A.; Kovacs, E. J., Mediators of inflammation
  • Pepsin concentrations are elevated in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis after lung transplantation Davis, C. S.; Mendez, B. M.; Flint, D. V.; Pelletiere, K.; Lowery, E.; Ramirez, L.; Love, R. B.; Kovacs, E. J.; Fisichella, P. M., The Journal of surgical research
  • Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking. Burnham, E. L.; Kovacs, E. J.; Davis, C. S., American journal of physiology.Lung cellular and molecular physiology
  • Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6 Chen, M. M.; Bird, M. D.; Zahs, A.; Deburghgraeve, C.; Posnik, B.; Davis, C. S.; Kovacs, E. J., Alcohol (Fayetteville, N.Y.)
  • Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age Brubaker, A. L.; Rendon, J. L.; Ramirez, L.; Choudhry, M. A.; Kovacs, E. J., Journal of immunology (Baltimore, Md.: 1950)
  • The aging lung Lowery, E. M.; Brubaker, A. L.; Kuhlmann, E.; Kovacs, E. J., Clinical interventions in aging
  • A review of the role of GERD-induced aspiration after lung transplantation Fisichella, P. M.; Davis, C. S.; Kovacs, E. J., Surgical endoscopy
  • Advanced age impairs macrophage polarization. Mahbub, S.; Deburghgraeve, C. R.; Kovacs, E. J., Journal of Interferon & Cytokine Research
  • Alcohol and epigenetic changes: summary of the 2011 Alcohol and Immunology Research Interest Group (AIRIG) meeting Zahs, A.; Curtis, B. J.; Waldschmidt, T. J.; Brown, L. A.; Gauthier, T. W.; Choudhry, M. A.; Kovacs, E. J.; Bird, M. D., Alcohol (Fayetteville, N.Y.)
  • Alcohol and inflammation and infection: clinical and experimental systems--summary of the 2010 Alcohol and Immunology Research Interest Group Meeting. Zahs, A.; Cook, R. T.; Waldschimdt, T. J.; Choudhry, M. A.; Kovacs, E. J.; Bird, M. D., Alcohol
  • Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation Nomellini, V.; Brubaker, A. L.; Mahbub, S.; Palmer, J. L.; Gomez, C. R.; Kovacs, E. J., Aging and disease
  • Early pulmonary immune hyporesponsiveness is associated with mortality after burn and smoke inhalation injury. Davis, C. S.; Albright, J. M.; Carter, S. R.; Ramirez, L.; Kim, H.; Gamelli, R. L.; Kovacs, E. J., Journal of Burn Care & Research
  • Ethanol suppresses phagosomal adhesion maturation Rac activation, and subsequent actin polymerization during FcgammaR-mediated phagocytosis., Karavitis, J.; Murdoch, E. L.; Deburghgraeve, C.; Ramirez, L.; Kovacs, E. J., Cellular immunology
  • Exhaled breath condensate collection in the mechanically ventilated patient Carter, S. R.; Davis, C. S.; Kovacs, E. J., Respiratory medicine
  • Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Zahs, A.; Bird, M. D.; Ramirez, L.; Turner, J. R.; Choudhry, M. A.; Kovacs, E. J., American Journal of Physiology - Gastrointestinal & Liver Physiology
  • Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice Biju, P. G.; Garg, S.; Wang, W.; Choudhry, M. A.; Kovacs, E. J.; Fink, L. M.; Hauer-Jensen, M., Shock (Augusta, Ga.)
  • Pulmonary immune changes early after laparoscopic antireflux surgery in lung transplant patients with gastroesophageal reflux disease. Fisichella, P. M.; Davis, C. S.; Lowery, E.; Pittman, M.; Gagermeier, J.; Love, R. B.; Kovacs, E. J., Journal of Surgical Research
  • The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury. Albright, J. M.; Davis, C. S.; Bird, M. D.; Ramirez, L.; Kim, H.; Burnham, E. L.; Gamelli, R. L.; Kovacs, E. J., Critical care medicine
  • The prevalence and extent of gastroesophageal reflux disease correlates to the type of lung transplantation. Fisichella, P. M.; Davis, C. S.; Shankaran, V.; Gagermeier, J.; Dilling, D.; Alex, C. G.; Kovacs, E. J.; Joehl, R. J.; Love, R. B., Surgical laparoscopy, endoscopy & percutaneous techniques
  • Ubiquitin and stromal cell-derived factor-1alpha in bronchoalveolar lavage fluid after burn and inhalation injury. Baker, T. A.; Davis, C. S.; Bach, H. H., 4th; Romero, J.; Burnham, E. L.; Kovacs, E. J.; Gamelli, R. L.; Majetschak, M., Journal of Burn Care & Research
  • Writing a first grant proposal Gomez-Cambronero, J.; Allen, L. A.; Cathcart, M. K.; Justement, L. B.; Kovacs, E. J.; McLeish, K. R.; Nauseef, W. M., Nature immunology
  • A novel role for NKT cells in cutaneous wound repair Schneider, D. F.; Palmer, J. L.; Tulley, J. M.; Speicher, J. T.; Kovacs, E. J.; Gamelli, R. L.; Faunce, D. E., The Journal of surgical research
  • Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models Brubaker, A. L.; Palmer, J. L.; Kovacs, E. J., Aging and disease
  • Aging of the Innate Immune System: An Update Mahbub, S.; Brubaker, A. L.; Kovacs, E. J., Current immunology reviews
  • Alcohol exposure and mechanisms of tissue injury and repair Jung, M. K.; Callaci, J. J.; Lauing, K. L.; Otis, J. S.; Radek, K. A.; Jones, M. K.; Kovacs, E. J., Alcoholism, Clinical and Experimental Research
  • An improved cell isolation method for flow cytometric and functional analyses of cutaneous wound leukocytes. Brubaker, A. L.; Schneider, D. F.; Palmer, J. L.; Faunce, D. E.; Kovacs, E. J., Journal of immunological methods
  • Development of a combined radiation and burn injury model Palmer, J. L.; Deburghgraeve, C. R.; Bird, M. D.; Hauer-Jensen, M.; Kovacs, E. J., Journal of Burn Care & Research
  • Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury. Li, X.; Akhtar, S.; Kovacs, E. J.; Gamelli, R. L.; Choudhry, M. A., Journal of Burn Care & Research
  • Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury. Akhtar, S.; Li, X.; Kovacs, E. J.; Gamelli, R. L.; Choudhry, M. A., Molecular Medicine
  • Laparoscopic antireflux surgery for gastroesophageal reflux disease after lung transplantation. Fisichella, P. M.; Davis, C. S.; Gagermeier, J.; Dilling, D.; Alex, C. G.; Dorfmeister, J. A.; Kovacs, E. J.; Love, R. B.; Gamelli, R. L., Journal of Surgical Research
  • Macrophage phagocytosis: effects of environmental pollutants alcohol, cigarette smoke, and other external factors, Karavitis, J.; Kovacs, E. J., Journal of leukocyte biology
  • Neutrophils and natural killer T cells as negative regulators of wound healing Brubaker, A. L.; Schneider, D. F.; Kovacs, E. J., Expert review of dermatology
  • Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals. Schneider, D. F.; Palmer, J. L.; Tulley, J. M.; Kovacs, E. J.; Gamelli, R. L.; Faunce, D. E., Journal of Surgical Research
  • Prolonged chemokine expression and excessive neutrophil infiltration in the lungs of burn-injured mice exposed to ethanol and pulmonary infection. Murdoch, E. L.; Karavitis, J.; Deburghgraeve, C.; Ramirez, L.; Kovacs, E. J., Shock
  • The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Fisichella, P. M.; Davis, C. S.; Lundberg, P. W.; Lowery, E.; Burnham, E. L.; Alex, C. G.; Ramirez, L.; Pelletiere, K.; Love, R. B.; Kuo, P. C.; Kovacs, E. J., Surgery
  • A review of the potential applications and controversies of non-invasive testing for biomarkers of aspiration in the lung transplant population Davis, C. S.; Gagermeier, J.; Dilling, D.; Alex, C.; Lowery, E.; Kovacs, E. J.; Love, R. B.; Fisichella, P. M., Clinical transplantation
  • Circulating proteasomes after burn injury. Majetschak, M.; Zedler, S.; Romero, J.; Albright, J. M.; Kraft, R.; Kovacs, E. J.; Faist, E.; Gamelli, R. L., Journal of Burn Care & Research
  • Decreased pulmonary inflammation after ethanol exposure and burn injury in intercellular adhesion molecule-1 knockout mice. Bird, M. D.; Morgan, M. O.; Ramirez, L.; Yong, S.; Kovacs, E. J., Journal of Burn Care & Research
  • Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling. Bird, M. D.; Zahs, A.; Deburghgraeve, C.; Ramirez, L.; Choudhry, M. A.; Kovacs, E. J., Alcoholism: Clinical & Experimental Research
  • Gastroesophageal reflux disease after lung transplantation: pathophysiology and implications for treatment. Davis, C. S.; Shankaran, V.; Kovacs, E. J.; Gagermeier, J.; Dilling, D.; Alex, C. G.; Love, R. B.; Sinacore, J.; Fisichella, P. M., Surgery
  • Gender-based differences in cytokine production after burn injury: a role of interleukin-6. Plackett, T. P.; Gamelli, R. L.; Kovacs, E. J., Journal of the American College of Surgeons
  • Interleukin-6 contributes to age-related alteration of cytokine production by macrophages. Gomez, C. R.; Karavitis, J.; Palmer, J. L.; Faunce, D. E.; Ramirez, L.; Nomellini, V.; Kovacs, E. J., Mediators of inflammation
  • Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model. D'Souza El-Guindy, N. B.; Kovacs, E. J.; De Witte, P.; Spies, C.; Littleton, J. M.; de Villiers, W. J.; Lott, A. J.; Plackett, T. P.; Lanzke, N.; Meadows, G. G., Alcoholism: Clinical & Experimental Research
  • Aging and animal models of systemic insult: trauma burn, and sepsis, Nomellini, V.; Gomez, C. R.; Gamelli, R. L.; Kovacs, E. J., Shock
  • Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors Kovacs, E. J.; Palmer, J. L.; Fortin, C. F.; Fulop, T., Jr; Goldstein, D. R.; Linton, P. J., Trends in immunology
  • Alcohol and trauma: a summary of the Satellite Symposium at the 30th Annual Meeting of the Shock Society. Bird, M. D.; Choudhry, M. A.; Molina, P. E.; Kovacs, E. J., Alcohol
  • Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration. Gomez, C. R.; Nomellini, V.; Baila, H.; Oshima, K.; Kovacs, E. J., Shock
  • Ethanol potentiates the acute fatty infiltration of liver caused by burn injury: prevention by insulin treatment. Emanuele, N. V.; Emanuele, M. A.; Morgan, M. O.; Sulo, D.; Yong, S.; Kovacs, E. J.; Himes, R. D.; Callaci, J. J., Journal of Burn Care & Research
  • Implications of formal alcohol screening in burn patients. Albright, J. M.; Kovacs, E. J.; Gamelli, R. L.; Schermer, C. R., Journal of Burn Care & Research
  • Proteasomes in human bronchoalveolar lavage fluid after burn and inhalation injury Albright, J. M.; Romero, J.; Saini, V.; Sixt, S. U.; Bird, M. D.; Kovacs, E. J.; Gamelli, R. L.; Peters, J.; Majetschak, M., Journal of Burn Care & Research
  • Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functions. Karavitis, J.; Murdoch, E. L.; Gomez, C. R.; Ramirez, L.; Kovacs, E. J., Journal of Interferon & Cytokine Research
  • Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Radek, K. A.; Kovacs, E. J.; Gallo, R. L.; DiPietro, L. A., American Journal of Physiology - Heart & Circulatory Physiology
  • Acute models of ethanol exposure to mice. Plackett, T. P.; Kovacs, E. J., Methods in Molecular Biology
  • Adverse clinical outcomes associated with elevated blood alcohol levels at the time of burn injury Silver, G. M.; Albright, J. M.; Schermer, C. R.; Halerz, M.; Conrad, P.; Ackerman, P. D.; Lau, L.; Emanuele, M. A.; Kovacs, E. J.; Gamelli, R. L., Journal of Burn Care & Research
  • Aging and impairment of innate immunity Nomellini, V.; Gomez, C. R.; Kovacs, E. J., Contributions to microbiology
  • Alcohol and inflammation and immune responses: summary of the 2006 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Waldschmidt, T. J.; Cook, R. T.; Kovacs, E. J., Alcohol
  • An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition. Nomellini, V.; Faunce, D. E.; Gomez, C. R.; Kovacs, E. J., Journal of leukocyte biology
  • Effects of ethanol on pulmonary inflammation in postburn intratracheal infection. Murdoch, E. L.; Brown, H. G.; Gamelli, R. L.; Kovacs, E. J., Journal of Burn Care & Research
  • Exposure-dependent effects of ethanol on the innate immune system Goral, J.; Karavitis, J.; Kovacs, E. J., Alcohol
  • Innate immunity and aging Gomez, C. R.; Nomellini, V.; Faunce, D. E.; Kovacs, E. J., Experimental gerontology
  • Organ-specific inflammation following acute ethanol and burn injury Bird, M. D.; Kovacs, E. J., Journal of leukocyte biology
  • Profound Effects of Burn and Ethanol on Proinflammatory Cytokines of the Reproductive Axis in the Male Mouse Emanuele, N. V.; LaPaglia, N.; Kovacs, E. J.; Gamelli, R. L.; Emanuele, M. A., Journal of Burn Care & Research
  • Sex differences and estrogen modulation of the cellular immune response after injury Bird, M. D.; Karavitis, J.; Kovacs, E. J., Cellular immunology
  • Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats. Li, X.; Kovacs, E. J.; Schwacha, M. G.; Chaudry, I. H.; Choudhry, M. A., American Journal of Physiology - Lung Cellular & Molecular Physiology
  • Acute ethanol exposure combined with burn injury enhances IL-6 levels in the murine ileum. Scalfani, M. T.; Chan, D. M.; Murdoch, E. L.; Kovacs, E. J.; White, F. A., Alcoholism: Clinical & Experimental Research
  • Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure. Gomez, C. R.; Hirano, S.; Cutro, B. T.; Birjandi, S.; Baila, H.; Nomellini, V.; Kovacs, E. J., Critical care medicine
  • Aging and estrogen: modulation of inflammatory responses after injury. Gomez, C. R.; Plackett, T. P.; Kovacs, E. J., Experimental gerontology
  • Effects of acute ethanol exposure on the early inflammatory response after excisional injury. Fitzgerald, D. J.; Radek, K. A.; Chaar, M.; Faunce, D. E.; DiPietro, L. A.; Kovacs, E. J., Alcoholism: Clinical & Experimental Research
  • Effects of insulin on hepatic inflammation induced by ethanol and burn injury in a murine model of critical illness. Emanuele, M. A.; Emanuele, N. V.; Gamelli, R. L.; Kovacs, E. J.; LaPaglia, N., Journal of Burn Care & Research
  • Matrix proteolytic activity during wound healing: modulation by acute ethanol exposure. Radek, K. A.; Kovacs, E. J.; DiPietro, L. A., Alcoholism: Clinical & Experimental Research
  • Signal transduction in the aging innate immune system Gomez, C. R.; Boehmer, E. D.; Nomellini, V.; Kovacs, E. J., Current immunology reviews
  • The early acute phase response after burn injury in mice. Plackett, T. P.; Colantoni, A.; Heinrich, S. A.; Messingham, K. A.; Gamelli, R. L.; Kovacs, E. J., Journal of Burn Care & Research
  • Vitamin E prevents ethanol-induced inflammatory hormonal, and cytotoxic changes in reproductive tissues., Zhu, Q.; Emanuele, M. A.; LaPaglia, N.; Kovacs, E. J.; Emanuele, N. V., Endocrine
  • Aberrant acute-phase response in aged interleukin-6 knockout mice. Gomez, C. R.; Goral, J.; Ramirez, L.; Kopf, M.; Kovacs, E. J., Shock
  • Acute and chronic alcohol abuse modulate immunity. Brown, L. A.; Cook, R. T.; Jerrells, T. R.; Kolls, J. K.; Nagy, L. E.; Szabo, G.; Wands, J. R.; Kovacs, E. J., Alcoholism: Clinical & Experimental Research
  • Alcohol and inflammation and immune responses: summary of the 2005 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Waldschmidt, T. J.; Cook, R. T.; Kovacs, E. J., Alcohol
  • Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells. Palmer, J. L.; Tulley, J. M.; Kovacs, E. J.; Gamelli, R. L.; Taniguchi, M.; Faunce, D. E., Journal of Immunology
  • Lack of aromatase improves cell-mediated immune response after burn. Plackett, T. P.; Oz, O. K.; Simpson, E. R.; Kovacs, E. J., Burns
  • A low blood ethanol level is associated with improved cytokine production in aged mice after traumatic injury. Plackett, T. P.; Jarrett, J.; Gamelli, R. L.; Kovacs, E. J., Journal of Trauma-Injury Infection & Critical Care
  • Acute ethanol exposure impairs angiogenesis and the proliferative phase of wound healing. Radek, K. A.; Matthies, A. M.; Burns, A. L.; Heinrich, S. A.; Kovacs, E. J.; Dipietro, L. A., American Journal of Physiology - Heart & Circulatory Physiology
  • Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Boehmer, E. D.; Meehan, M. J.; Cutro, B. T.; Kovacs, E. J., Mechanisms of Ageing & Development
  • Aging traumatic injury, and estrogen treatment, Kovacs, E. J., Experimental gerontology
  • CD1d-restricted NKT cells contribute to the age-associated decline of T cell immunity. Faunce, D. E.; Palmer, J. L.; Paskowicz, K. K.; Witte, P. L.; Kovacs, E. J., Journal of Immunology
  • Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury. Li, X.; Rana, S. N.; Kovacs, E. J.; Gamelli, R. L.; Chaudry, I. H.; Choudhry, M. A., American Journal of Physiology - Regulatory Integrative & Comparative Physiology
  • Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Kavanaugh, M. J.; Clark, C.; Goto, M.; Kovacs, E. J.; Gamelli, R. L.; Sayeed, M. M.; Choudhry, M. A., Burns
  • Effects of chronic ethanol (EtOH) administration on pro-inflammatory cytokines of the hypothalamic-pituitary-gonadal (HPG) axis in female rats. Emanuele, N.; LaPaglia, N.; Kovacs, E. J.; Emanuele, M. A., Endocrine research
  • In vivo ethanol exposure down-regulates TLR2- TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation., Goral, J.; Kovacs, E. J., Journal of Immunology
  • RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol cellular and organ damage, Hoek, J.; Thiele, G. M.; Klassen, L. W.; Mandrekar, P.; Zakhari, S.; Cook, R. T.; Ray, N. B.; Happel, K. I.; Kolls, J. K.; Kovacs, E. J.; Szab, G., Alcoholism: Clinical & Experimental Research
  • The aging innate immune system Gomez, C. R.; Boehmer, E. D.; Kovacs, E. J., Current opinion in immunology
  • The impact of burn injury and ethanol on the cytokine network of the mouse hypothalamus: reproductive implications. Emanuele, N. V.; LaPaglia, N.; Kovacs, E. J.; Emanuele, M. A., Cytokine
  • Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. Goral, J.; Choudhry, M. A.; Kovacs, E. J., Journal of leukocyte biology
  • Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. Boehmer, E. D.; Goral, J.; Faunce, D. E.; Kovacs, E. J., Journal of leukocyte biology
  • Aging and innate immune cells Plackett, T. P.; Boehmer, E. D.; Faunce, D. E.; Kovacs, E. J., Journal of leukocyte biology
  • Alcohol and immunology: introduction to and summary of the 2003 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Kovacs, E. J.; Jerrells, T. R., Alcohol
  • Combined alcohol and burn injury differentially regulate P-38 and ERK activation in mesenteric lymph node T cell. Choudhry, M. A.; Ren, X.; Romero, A.; Kovacs, E. J.; Gamelli, R. L.; Sayeed, M. M., Journal of Surgical Research
  • Estrogen replacement aging, and cell-mediated immunity after injury., Kovacs, E. J.; Plackett, T. P.; Witte, P. L., Journal of leukocyte biology
  • Ethanol and burn injury: estrogen modulation of immunity Kovacs, E. J.; Faunce, D. E.; Messingham, K. A., Alcohol
  • Immunosuppression after injury in aged mice is associated with a TH1-TH2 shift which can be restored by estrogen treatment., Kovacs, E. J.; Duffner, L. A.; Plackett, T. P., Mechanisms of Ageing & Development
  • Impaired intestinal immunity and barrier function: a cause for enhanced bacterial translocation in alcohol intoxication and burn injury Choudhry, M. A.; Rana, S. N.; Kavanaugh, M. J.; Kovacs, E. J.; Gamelli, R. L.; Sayeed, M. M., Alcohol
  • A role for CD1d-restricted NKT cells in injury-associated T cell suppression. Faunce, D. E.; Gamelli, R. L.; Choudhry, M. A.; Kovacs, E. J., Journal of leukocyte biology
  • Advanced age negatively influences mesenteric lymph node T cell responses after burn injury. Choudhry, M. A.; Plackett, T. P.; Schilling, E. M.; Faunce, D. E.; Gamelli, R. L.; Kovacs, E. J., Immunology letters
  • Aging enhances lymphocyte cytokine defects after injury. Plackett, T. P.; Schilling, E. M.; Faunce, D. E.; Choudhry, M. A.; Witte, P. L.; Kovacs, E. J., FASEB Journal
  • Effect of acute ethanol exposure on the dermal inflammatory response after burn injury. Faunce, D. E.; Garner, J. L.; Llanas, J. N.; Patel, P. J.; Gregory, M. S.; Duffner, L. A.; Gamelli, R. L.; Kovacs, E. J., Alcoholism: Clinical & Experimental Research
  • Elevated monocyte chemoattractant protein-1 levels following thermal injury precede monocyte recruitment to the wound site and are controlled in part, by tumor necrosis factor-alpha., Heinrich, S. A.; Messingham, K. A.; Gregory, M. S.; Colantoni, A.; Ferreira, A. M.; Dipietro, L. A.; Kovacs, E. J., Wound Repair & Regeneration
  • Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines. Colantoni, A.; Idilman, R.; De Maria, N.; La Paglia, N.; Belmonte, J.; Wezeman, F.; Emanuele, N.; Van Thiel, D. H.; Kovacs, E. J.; Emanuele, M. A., Alcoholism: Clinical & Experimental Research
  • Monocyte chemoattractant protein-1 (MCP-1) and macrophage infiltration into the skin after burn injury in aged mice. Shallo, H.; Plackett, T. P.; Heinrich, S. A.; Kovacs, E. J., Burns
  • Murine model of peritoneal adhesion formation. Jahoda, A. E.; Olson, M. K.; Kovacs, E. J., Methods in Molecular Medicine
  • Alcohol injury, and cellular immunity, Messingham, K. A.; Faunce, D. E.; Kovacs, E. J., Alcohol
  • Estrogen regulation of immune responses after injury Kovacs, E. J.; Messingham, K. A.; Gregory, M. S., Molecular & Cellular Endocrinology
  • Hepatic estrogen receptors and alcohol intake. Colantoni, A.; Emanuele, M. A.; Kovacs, E. J.; Villa, E.; Van Thiel, D. H., Molecular & Cellular Endocrinology
  • Influence of alcohol and gender on immune response Kovacs, E. J.; Messingham, K. A., Alcohol Research & Health: the Journal of the National Institute on Alcohol Abuse & Alcoholism
  • Interleukin-4 treatment restores cellular immunity after ethanol exposure and burn injury. Messingham, K. A.; Heinrich, S. A.; Schilling, E. M.; Kovacs, E. J., Alcoholism: Clinical & Experimental Research
  • Modulation of immunity and viral-host interactions by alcohol. Thiele, G. M.; Szabo, G.; Kovacs, E. J.; Bautista, A. P.; Sosa, L.; Jerrells, T. R., Alcoholism: Clinical & Experimental Research
  • Survival and cell-mediated immunity after brun injury in aged mice. Kovacs, E. J.; Grabowski, K. A.; Duffner, L. A.; Plackett, T. P.; Gregory, M. S., Age
  • Differential neutrophil traffic in gut and lung after scald injury. Dries, D. J.; Lorenz, K.; Kovacs, E. J., Journal of Burn Care & Rehabilitation
  • Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production. Messingham, K. A.; Heinrich, S. A.; Kovacs, E. J., Journal of leukocyte biology
  • Evidence of oxidative injury during aging of the liver in a mouse model Colantoni, A.; Idilman, R.; de Maria, N.; Duffner, L. A.; Van Thiel, D. H.; Witte, P. L.; Kovacs, E. J., Journal of the American Aging Association
  • Testosterone receptor blockade restores cellular immunity in male mice after burn injury. Messingham, K. A.; Shirazi, M.; Duffner, L. A.; Emanuele, M. A.; Kovacs, E. J., Journal of Endocrinology
  • Wound healing in MIP-1alpha(-/-) and MCP-1(-/-) mice. Low, Q. E.; Drugea, I. A.; Duffner, L. A.; Quinn, D. G.; Cook, D. N.; Rollins, B. J.; Kovacs, E. J.; DiPietro, L. A., American Journal of Pathology
  • Anti-interleukin-6 antibody treatment restores cell-mediated immune function in mice with acute ethanol exposure before burn trauma. Fontanilla, C. V.; Faunce, D. E.; Gregory, M. S.; Messingham, K. A.; Durbin, E. A.; Duffner, L. A.; Kovacs, E. J., Alcoholism: Clinical & Experimental Research
  • Cellular immunity after ethanol exposure and burn injury: dose and time dependence. Messingham, K. A.; Fontanilla, C. V.; Colantoni, A.; Duffner, L. A.; Kovacs, E. J., Alcohol
  • Differential production of prostaglandin E(2) in male and female mice subjected to thermal injury contributes to the gender difference in immune function: possible role for 15-hydroxyprostaglandin dehydrogenase. Gregory, M. S.; Duffner, L. A.; Hahn, E. L.; Tai, H. H.; Faunce, D. E.; Kovacs, E. J., Cellular immunology
  • Dose-dependent effect of ethanol on hepatic oxidative stress and interleukin-6 production after burn injury in the mouse. Colantoni, A.; Duffner, L. A.; De Maria, N.; Fontanilla, C. V.; Messingham, K. A.; Van Thiel, D. H.; Kovacs, E. J., Alcoholism: Clinical & Experimental Research
  • Estrogen mediates the sex difference in post-burn immunosuppression. Gregory, M. S.; Duffner, L. A.; Faunce, D. E.; Kovacs, E. J., Journal of Endocrinology
  • Ethanol exacerbates T cell dysfunction after thermal injury. Choudhry, M. A.; Messingham, K. A.; Namak, S.; Colantoni, A.; Fontanilla, C. V.; Duffner, L. A.; Sayeed, M. M.; Kovacs, E. J., Alcohol
  • Gender difference in cell-mediated immunity after thermal injury is mediated in part, by elevated levels of interleukin-6., Gregory, M. S.; Faunce, D. E.; Duffner, L. A.; Kovacs, E. J., Journal of leukocyte biology
  • The role of interleukin 6 in interferon-gamma production in thermally injured mice. Durbin, E. A.; Gregory, M. S.; Messingham, K. A.; Fontanilla, C. V.; Duffner, L. A.; Kovacs, E. J., Cytokine

Overall focus: The effects of advanced age, radiation, and alcohol exposure on inflammatory responses after traumatic injury.

  1. Binge alcohol exposure and inflammatory/immune responses after injury and/or infection. Systemic and organ-specific inflammatory response after burn injury with or without pulmonary infection. Effects of ethanol on macrophage and neutrophil recruitment, activation and function, including Toll-like receptor (TLR) mediated signal transduction, cytokine and chemokine production, receptor expression, phagocytosis and bacterial killing, apoptosis and chemotaxis.
  2. Inflamm-aging, “macroph-aging” and immunosenescence: Age-dependent effects on pulmonary response after remote injury or infection. Inflammatory and cutaneous wound infection in young vs. aged subjects. Role of TLR activation and mitogen activated protein (MAP) kinases in macrophages. Sex differences and hormone replacement alter inflammatory and immunity after burn injury in the aged.
  3. Combined radiation injury (CRI): Effects of total body irradiation (TBI) combined with scald burn injury on systemic, pulmonary and intestinal inflammation and barrier function. Development of pneumonitis and pulmonary fibrosis. Mitigating agents.
  4. Pulmonary response to smoke inhalation and infection after burn injury. Effect of smoke inhalation on acute lung injury and acute respiratory distress syndrome and systemic complications.
  5. Development of bronchiolitis obliterans in lung transplant recipients. Effects of donor and recipient alcohol exposure on pro-inflammatory and fibrogenic responses after lung transplantation.

View a partial list of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?dispmax=20&db=PubMed&pmfilter_EDatLimit=No+Limit&cmd_current=Limits&orig_db=PubMed&cmd=Search&term=Kovacs+EJ%5BAuthor+Name%5D&doptcmdl=DocSum target=_blank>Dr. Kovacs's publications through the National Library of Medicine's PubMed online database.