Allen Samarel, MD, FAHA

Medicine

Cardiology
Cell and Molecular Physiology
Professor Emeritus

Languages Spoken

English

Clinical Expertise

  • Cardiac Rehabilitation
  • Congestive Heart Failure

Medical Education

Medical School
Harvard Medical School
Residency
Mount Sinai Medical Center - Internal Medicine: General
Fellowship
Northwestern University McGaw Medical Center - Cardiology, Northwestern University McGaw Medical Center - Cardiology

Board Certification

Cardiovascular Disease - Subspecialty Cert: AM Board of Internal Medicine
Internal Medicine - General Cert: AM Board of Internal Medicine

Research

  • Myocardial infarction sensitizes medial prefrontal cortex to inhibitory effect of locus coeruleus stimulation in rats Glasgow, J.; Koshman, Y.; Samarel, A. M.; Tseng, K. Y.; Scrogin, K., Psychopharmacology
  • Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy Koshman, Y. E.; Sternlicht, M. D.; Kim, T.; O'Hara, C. P.; Koczor, C. A.; Lewis, W.; Seeley, T. W.; Lipson, K. E.; Samarel, A. M., Journal of Molecular and Cellular Cardiology
  • PKCepsilon-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis Mylroie, H.; Dumont, O.; Bauer, A.; Thornton, C. C.; Mackey, J.; Calay, D.; Hamdulay, S. S.; Choo, J. R.; Boyle, J. J.; Samarel, A. M.; Randi, A. M.; Evans, P. C.; Mason, J. C., Cardiovascular research
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  • Cardiomyocyte-specific expression of CRNK the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy, Koshman, Y. E.; Chu, M.; Kim, T.; Kalmanson, O.; Farjah, M.; Kumar, M.; Lewis, W.; Geenen, D. L.; de Tombe, P.; Goldspink, P. H.; Solaro, R. J.; Samarel, A. M., Journal of Molecular and Cellular Cardiology
  • Focal adhesion signaling in heart failure Samarel, A. M., Pflugers Archiv : European journal of physiology
  • Chronic fluoxetine reduces autonomic control of cardiac rhythms in rats with congestive heart failure Henze, M.; Tiniakov, R.; Samarel, A.; Holmes, E.; Scrogin, K., American journal of physiology.Heart and circulatory physiology
  • Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure Koshman, Y. E.; Patel, N.; Chu, M.; Iyengar, R.; Kim, T.; Ersahin, C.; Lewis, W.; Heroux, A.; Samarel, A. M., Journal of cardiac failure
  • Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting tyrosine 168 phosphorylation, and competition for p130(Cas) binding., Koshman, Y. E.; Chu, M.; Engman, S. J.; Kim, T.; Iyengar, R.; Robia, S. L.; Samarel, A. M., Arteriosclerosis, Thrombosis & Vascular Biology
  • Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange K+, and Ca2+ currents in cultured neonatal rat myocytes., Puglisi, J. L.; Yuan, W.; Timofeyev, V.; Myers, R. E.; Chiamvimonvat, N.; Samarel, A. M.; Bers, D. M., American Journal of Physiology - Heart & Circulatory Physiology
  • FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells. Koshman, Y. E.; Kim, T.; Chu, M.; Engman, S. J.; Iyengar, R.; Robia, S. L.; Samarel, A. M., Arteriosclerosis, Thrombosis & Vascular Biology
  • FRNK overexpression limits the depth and frequency of vascular smooth muscle cell invasion in a three-dimensional fibrin matrix. Brewster, L. P.; Ucuzian, A. A.; Brey, E. M.; Liwanag, M.; Samarel, A. M.; Greisler, H. P., Journal of cellular physiology
  • Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width Russell, B.; Curtis, M. W.; Koshman, Y. E.; Samarel, A. M., Journal of Molecular and Cellular Cardiology
  • Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration. Koshman, Y. E.; Engman, S. J.; Kim, T.; Iyengar, R.; Henderson, K. K.; Samarel, A. M., Cardiovascular research
  • CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms. Hartman, T. J.; Martin, J. L.; Solaro, R. J.; Samarel, A. M.; Russell, B., American Journal of Physiology - Cell Physiology
  • Laminin acts via focal adhesion kinase/phosphatidylinositol-3' kinase/protein kinase B to down-regulate beta1-adrenergic receptor signalling in cat atrial myocytes. Wang, Y. G.; Ji, X.; Pabbidi, M.; Samarel, A. M.; Lipsius, S. L., Journal of Physiology
  • Laminin enhances beta(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes. Pabbidi, M. R.; Ji, X.; Samarel, A. M.; Lipsius, S. L., Journal of Physiology
  • Physiological replacement of T3 improves left ventricular function in an animal model of myocardial infarction-induced congestive heart failure. Henderson, K. K.; Danzi, S.; Paul, J. T.; Leya, G.; Klein, I.; Samarel, A. M., Circulation: Heart Failure
  • CRNK gene transfer improves function and reverses the myosin heavy chain isoenzyme switch during post-myocardial infarction left ventricular remodeling. Hart, D. L.; Heidkamp, M. C.; Iyengar, R.; Vijayan, K.; Szotek, E. L.; Barakat, J. A.; Leya, M.; Henze, M.; Scrogin, K.; Henderson, K. K.; Samarel, A. M., Journal of Molecular & Cellular Cardiology
  • Persistent alterations in heart rate variability baroreflex sensitivity, and anxiety-like behaviors during development of heart failure in the rat, Henze, M.; Hart, D.; Samarel, A.; Barakat, J.; Eckert, L.; Scrogin, K., American Journal of Physiology - Heart & Circulatory Physiology
  • PICOT: a multidomain scaffolding inhibitor of hypertrophic signal transduction. Samarel, A. M., Circulation research
  • Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras p38, and CCAAT/enhancer-binding protein., Khare, S.; Mustafi, R.; Cerda, S.; Yuan, W.; Jagadeeswaran, S.; Dougherty, U.; Tretiakova, M.; Samarel, A.; Cohen, G.; Wang, J.; Moore, C.; Wali, R.; Holgren, C.; Joseph, L.; Fichera, A.; Li, Y. C.; Bissonnette, M., Nutrition & Cancer
  • A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. Steinberg, R.; Harari, O. A.; Lidington, E. A.; Boyle, J. J.; Nohadani, M.; Samarel, A. M.; Ohba, M.; Haskard, D. O.; Mason, J. C., Journal of Biological Chemistry
  • An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic. Fernandez, A.; Sanguino, A.; Peng, Z.; Ozturk, E.; Chen, J.; Crespo, A.; Wulf, S.; Shavrin, A.; Qin, C.; Ma, J.; Trent, J.; Lin, Y.; Han, H. D.; Mangala, L. S.; Bankson, J. A.; Gelovani, J.; Samarel, A.; Bornmann, W.; Sood, A. K.; Lopez-Berestein, G., Journal of Clinical Investigation
  • PKCepsilon induces astrocyte stellation by modulating multiple cytoskeletal proteins and interacting with Rho A signalling pathways: implications for neuroinflammation. Burgos, M.; Calvo, S.; Molina, F.; Vaquero, C. F.; Samarel, A.; Llopis, J.; Tranque, P., European Journal of Neuroscience
  • Protein kinase Cepsilon-dependent MARCKS phosphorylation in neonatal and adult rat ventricular myocytes. Heidkamp, M. C.; Iyengar, R.; Szotek, E. L.; Cribbs, L. L.; Samarel, A. M., Journal of Molecular & Cellular Cardiology
  • Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes. Dedkova, E. N.; Wang, Y. G.; Ji, X.; Blatter, L. A.; Samarel, A. M.; Lipsius, S. L., Journal of Physiology
  • Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2. Khare, S.; Holgren, C.; Samarel, A. M., American Journal of Physiology - Gastrointestinal & Liver Physiology
  • Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. Holinstat, M.; Knezevic, N.; Broman, M.; Samarel, A. M.; Malik, A. B.; Mehta, D., Journal of Biological Chemistry
  • Costameres focal adhesions, and cardiomyocyte mechanotransduction, Samarel, A. M., American Journal of Physiology - Heart & Circulatory Physiology
  • Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA. Blum, J. L.; Samarel, A. M.; Mestril, R., American Journal of Physiology - Heart & Circulatory Physiology
  • PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes. Heidkamp, M. C.; Scully, B. T.; Vijayan, K.; Engman, S. J.; Szotek, E. L.; Samarel, A. M., American Journal of Physiology - Cell Physiology
  • Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes. Vijayan, K.; Szotek, E. L.; Martin, J. L.; Samarel, A. M., American Journal of Physiology - Heart & Circulatory Physiology
  • Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes. Heidkamp, M. C.; Bayer, A. L.; Scully, B. T.; Eble, D. M.; Samarel, A. M., American Journal of Physiology - Heart & Circulatory Physiology
  • Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy. Bayer, A. L.; Heidkamp, M. C.; Patel, N.; Porter, M.; Engman, S.; Samarel, A. M., Molecular & Cellular Biochemistry
  • Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes Porter, M. J.; Heidkamp, M. C.; Scully, B. T.; Patel, N.; Martin, J. L.; Samarel, A. M., American Journal of Physiology - Cell Physiology
  • Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. Bayer, A. L.; Heidkamp, M. C.; Howes, A. L.; Heller Brown, J.; Byron, K. L.; Samarel, A. M., Journal of Molecular & Cellular Cardiology