Aleksey Zima, PhD | Loyola Medicine

Aleksey Zima, PhD

Cell and Molecular Physiology

Associate Professor

Languages Spoken

English, Ukrainian

Clinical Expertise

Biography

Interests
History;Sports

Medical Education

Medical School
Residency
Fellowship
  • University of Florida - Electrophysiology

Board Certification

Research

  • The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function. Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwanski PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollmann BC, Cell calcium
  • Oxidation of ryanodine receptor following ischemia/reperfusion increases propensity of Ca waves during ß-adrenergic receptor stimulation. Bovo, E; Mazurek, SR; Zima, AV, American journal of physiology. Heart and circulatory physiology
  • Redistribution of SERCA calcium pump conformers during intracellular calcium signaling. Raguimova, ON; Smolin, N; Bovo, E; Bhayani, S; Autry, JM; Zima, AV; Robia, SL, The Journal of biological chemistry
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  • Redox Dependent Modifications of Ryanodine Receptor: Basic Mechanisms and Implications in Heart Diseases. Nikolaienko R, Bovo E, Zima AV, Frontiers in physiology
  • The role of RyR2 oxidation in the blunted frequency-dependent facilitation of Ca(2+) transient amplitude in rabbit failing myocytes Bovo, E.; Mazurek, S. R.; Zima, A. V., Pflugers Archiv : European journal of physiology
  • The effect of PKA-mediated phosphorylation of ryanodine receptor on SR Ca2+ leak in ventricular myocytes Bovo, E.; Huke, S.; Blatter, L. A.; Zima, A. V., Journal of Molecular and Cellular Cardiology
  • Functional Impact of Ryanodine Receptor Oxidation on Intracellular Calcium Regulation in the Heart Zima, A. V.; Mazurek, S. R., Reviews of physiology, biochemistry and pharmacology
  • R-CEPIA1er as a new tool to directly measure sarcoplasmic reticulum [Ca] in ventricular myocytes Bovo, E.; Martin, J. L.; Tyryfter, J.; de Tombe, P. P.; Zima, A. V., American journal of physiology.Heart and circulatory physiology
  • Cytosolic Ca(2+) buffering determines the intra-SR Ca(2+) concentration at which cardiac Ca(2+) sparks terminate Bovo, E.; Mazurek, S. R.; Fill, M.; Zima, A. V., Cell calcium
  • Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation Bovo, E.; Mazurek, S. R.; de Tombe, P. P.; Zima, A. V., Biophysical journal
  • Ca handling during excitation-contraction coupling in heart failure Zima, A. V.; Bovo, E.; Mazurek, S. R.; Rochira, J. A.; Li, W.; Terentyev, D., Pflugers Archiv : European journal of physiology
  • Regulation of sarcoplasmic reticulum Ca(2+) release by cytosolic glutathione in rabbit ventricular myocytes Mazurek, S. R.; Bovo, E.; Zima, A. V., Free radical biology & medicine
  • The Role of Dyadic Organization in Regulation of Sarcoplasmic Reticulum Ca(2+) Handling during Rest in Rabbit Ventricular Myocytes Bovo, E.; de Tombe, P. P.; Zima, A. V., Biophysical journal
  • Effects of mitochondrial uncoupling on Ca(2+) signaling during excitation-contraction coupling in atrial myocytes Zima, A. V.; Pabbidi, M. R.; Lipsius, S. L.; Blatter, L. A., American journal of physiology.Heart and circulatory physiology
  • Mechanisms of Ca(2)+ handling in zebrafish ventricular myocytes Bovo, E.; Dvornikov, A. V.; Mazurek, S. R.; de Tombe, P. P.; Zima, A. V., Pflugers Archiv : European journal of physiology
  • Reactive oxygen species contribute to the development of arrhythmogenic Ca2 waves during -adrenergic receptor stimulation in rabbit cardiomyocytes. Bovo, E.; Lipsius, S. L.; Zima, A. V., Journal of Physiology
  • Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release Picht, E.; Zima, A. V.; Shannon, T. R.; Duncan, A. M.; Blatter, L. A.; Bers, D. M., Circulation research
  • Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes. Sarkey, J. P.; Chu, M.; McShane, M.; Bovo, E.; Mou, Y. A.; Zima, A. V.; de Tombe, P. P.; Kartje, G. L.; Martin, J. L., Journal of Molecular & Cellular Cardiology
  • Phospholamban binds with differential affinity to calcium pump conformers. Bidwell, P.; Blackwell, D. J.; Hou, Z.; Zima, A. V.; Robia, S. L., Journal of Biological Chemistry
  • Regulation of sarcoplasmic reticulum Ca(2)(+) leak by cytosolic Ca(2)(+) in rabbit ventricular myocytes Bovo, E.; Mazurek, S. R.; Blatter, L. A.; Zima, A. V., The Journal of physiology
  • Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks Porta, M.; Zima, A. V.; Nani, A.; Diaz-Sylvester, P. L.; Copello, J. A.; Ramos-Franco, J.; Blatter, L. A.; Fill, M., Biophysical journal
  • Ca(2)+ spark-dependent and -independent sarcoplasmic reticulum Ca(2)+ leak in normal and failing rabbit ventricular myocytes Zima, A. V.; Bovo, E.; Bers, D. M.; Blatter, L. A., The Journal of physiology
  • Changes in intra-luminal calcium during spontaneous calcium waves following sensitization of ryanodine receptor channels Domeier, T. L.; Blatter, L. A.; Zima, A. V., Channels (Austin, Tex.)
  • Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure Domeier, T. L.; Blatter, L. A.; Zima, A. V., The Journal of physiology
  • Trifluoperazine: a rynodine receptor agonist Qin, J.; Zima, A. V.; Porta, M.; Blatter, L. A.; Fill, M., Pflugers Archiv : European journal of physiology
  • Emerging roles of inositol 1 4, 5-trisphosphate signaling in cardiac myocytes, Kockskamper, J.; Zima, A. V.; Roderick, H. L.; Pieske, B.; Blatter, L. A.; Bootman, M. D., Journal of Molecular and Cellular Cardiology
  • Ginsenoside Re suppresses electromechanical alternans in cat and human cardiomyocytes. Wang, Y. G.; Zima, A. V.; Ji, X.; Pabbidi, R.; Blatter, L. A.; Lipsius, S. L., American Journal of Physiology - Heart & Circulatory Physiology
  • IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes Domeier, T. L.; Zima, A. V.; Maxwell, J. T.; Huke, S.; Mignery, G. A.; Blatter, L. A., American Journal of Physiology - Heart & Circulatory Physiology
  • Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Zima, A. V.; Picht, E.; Bers, D. M.; Blatter, L. A., Biophysical journal
  • Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+] release flux, and intra-SR Ca2+ diffusion, Zima, A. V.; Picht, E.; Bers, D. M.; Blatter, L. A., Circulation research
  • Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes Zima, A. V.; Qin, J.; Fill, M.; Blatter, L. A., American journal of physiology.Heart and circulatory physiology
  • Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes Copello, J. A.; Zima, A. V.; Diaz-Sylvester, P. L.; Fill, M.; Blatter, L. A., American journal of physiology.Cell physiology
  • Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes Jung, C.; Zima, A. V.; Szentesi, P.; Jona, I.; Blatter, L. A.; Niggli, E., Cell calcium
  • IP3-dependent nuclear Ca2+ signalling in the mammalian heart. Zima, A. V.; Bare, D. J.; Mignery, G. A.; Blatter, L. A., Journal of Physiology
  • Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. Aromolaran, A. S.; Zima, A. V.; Blatter, L. A., American Journal of Physiology - Cell Physiology
  • SparkMaster: automated calcium spark analysis with ImageJ. Picht, E.; Zima, A. V.; Blatter, L. A.; Bers, D. M., American Journal of Physiology - Cell Physiology
  • Biosensors to measure inositol 1 4, 5-trisphosphate concentration in living cells with spatiotemporal resolution., Remus, T. P.; Zima, A. V.; Bossuyt, J.; Bare, D. J.; Martin, J. L.; Blatter, L. A.; Bers, D. M.; Mignery, G. A., Journal of Biological Chemistry
  • Cytosolic energy reserves determine the effect of glycolytic sugar phosphates on sarcoplasmic reticulum Ca2+ release in cat ventricular myocytes Zima, A. V.; Kockskamper, J.; Blatter, L. A., The Journal of physiology
  • Redox regulation of cardiac calcium channels and transporters Zima, A. V.; Blatter, L. A., Cardiovascular research
  • Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytes. Sheehan, K. A.; Zima, A. V.; Blatter, L. A., Journal of Physiology
  • Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1 4, 5-trisphosphate(IP3)-receptor type 2-deficient mice, Li, X.; Zima, A. V.; Sheikh, F.; Blatter, L. A.; Chen, J., Circulation research
  • Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes Kockskamper, J.; Zima, A. V.; Blatter, L. A., The Journal of physiology
  • Effects of cytosolic NADH/NAD(+) levels on sarcoplasmic reticulum Ca(2+) release in permeabilized rat ventricular myocytes. Zima, A. V.; Copello, J. A.; Blatter, L. A., Journal of Physiology
  • Inositol-1 4, 5-trisphosphate-dependent Ca(2+) signalling in cat atrial excitation-contraction coupling and arrhythmias., Zima, A. V.; Blatter, L. A., Journal of Physiology
  • NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release Cherednichenko, G.; Zima, A. V.; Feng, W.; Schaefer, S.; Blatter, L. A.; Pessah, I. N., Circulation research
  • Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps. Kockskamper, J.; Ahmmed, G. U.; Zima, A. V.; Sheehan, K. A.; Glitsch, H. G.; Blatter, L. A., American Journal of Physiology - Cell Physiology
  • Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH. Zima, A. V.; Copello, J. A.; Blatter, L. A., FEBS letters
  • Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes Blatter, L. A.; Kockskamper, J.; Sheehan, K. A.; Zima, A. V.; Huser, J.; Lipsius, S. L., The Journal of physiology
  • Pyruvate modulates cardiac sarcoplasmic reticulum Ca2+ release in rats via mitochondria-dependent and -independent mechanisms. Zima, A. V.; Kockskamper, J.; Mejia-Alvarez, R.; Blatter, L. A., Journal of Physiology