Aleksey Zima, PhD

Cell and Molecular Physiology

Associate Professor

Languages Spoken

English, Ukrainian

Biography

Interests
History, Sports

Medical Education

Fellowship
University of Florida - Electrophysiology

Board Certification

American Nurses Credentialing Center
Anesthesiology
American Board of

Research

  • Functional Impact of Ryanodine Receptor Oxidation on Intracellular Calcium Regulation in the Heart Zima, A. V.; Mazurek, S. R., Reviews of physiology, biochemistry and pharmacology
  • R-CEPIA1er as a new tool to directly measure sarcoplasmic reticulum [Ca] in ventricular myocytes Bovo, E.; Martin, J. L.; Tyryfter, J.; de Tombe, P. P.; Zima, A. V., American journal of physiology.Heart and circulatory physiology
  • Cytosolic Ca(2+) buffering determines the intra-SR Ca(2+) concentration at which cardiac Ca(2+) sparks terminate Bovo, E.; Mazurek, S. R.; Fill, M.; Zima, A. V., Cell calcium
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  • Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation Bovo, E.; Mazurek, S. R.; de Tombe, P. P.; Zima, A. V., Biophysical journal
  • Ca handling during excitation-contraction coupling in heart failure Zima, A. V.; Bovo, E.; Mazurek, S. R.; Rochira, J. A.; Li, W.; Terentyev, D., Pflugers Archiv : European journal of physiology
  • Regulation of sarcoplasmic reticulum Ca(2+) release by cytosolic glutathione in rabbit ventricular myocytes Mazurek, S. R.; Bovo, E.; Zima, A. V., Free radical biology & medicine
  • The Role of Dyadic Organization in Regulation of Sarcoplasmic Reticulum Ca(2+) Handling during Rest in Rabbit Ventricular Myocytes Bovo, E.; de Tombe, P. P.; Zima, A. V., Biophysical journal
  • Effects of mitochondrial uncoupling on Ca(2+) signaling during excitation-contraction coupling in atrial myocytes Zima, A. V.; Pabbidi, M. R.; Lipsius, S. L.; Blatter, L. A., American journal of physiology.Heart and circulatory physiology
  • Mechanisms of Ca(2)+ handling in zebrafish ventricular myocytes Bovo, E.; Dvornikov, A. V.; Mazurek, S. R.; de Tombe, P. P.; Zima, A. V., Pflugers Archiv : European journal of physiology
  • Reactive oxygen species contribute to the development of arrhythmogenic Ca2 waves during -adrenergic receptor stimulation in rabbit cardiomyocytes. Bovo, E.; Lipsius, S. L.; Zima, A. V., Journal of Physiology
  • Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes. Sarkey, J. P.; Chu, M.; McShane, M.; Bovo, E.; Mou, Y. A.; Zima, A. V.; de Tombe, P. P.; Kartje, G. L.; Martin, J. L., Journal of Molecular & Cellular Cardiology
  • Phospholamban binds with differential affinity to calcium pump conformers. Bidwell, P.; Blackwell, D. J.; Hou, Z.; Zima, A. V.; Robia, S. L., Journal of Biological Chemistry
  • Ginsenoside Re suppresses electromechanical alternans in cat and human cardiomyocytes. Wang, Y. G.; Zima, A. V.; Ji, X.; Pabbidi, R.; Blatter, L. A.; Lipsius, S. L., American Journal of Physiology - Heart & Circulatory Physiology
  • IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes Domeier, T. L.; Zima, A. V.; Maxwell, J. T.; Huke, S.; Mignery, G. A.; Blatter, L. A., American Journal of Physiology - Heart & Circulatory Physiology
  • Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Zima, A. V.; Picht, E.; Bers, D. M.; Blatter, L. A., Biophysical journal
  • IP3-dependent nuclear Ca2+ signalling in the mammalian heart. Zima, A. V.; Bare, D. J.; Mignery, G. A.; Blatter, L. A., Journal of Physiology
  • Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. Aromolaran, A. S.; Zima, A. V.; Blatter, L. A., American Journal of Physiology - Cell Physiology
  • SparkMaster: automated calcium spark analysis with ImageJ. Picht, E.; Zima, A. V.; Blatter, L. A.; Bers, D. M., American Journal of Physiology - Cell Physiology
  • Biosensors to measure inositol 1 4, 5-trisphosphate concentration in living cells with spatiotemporal resolution., Remus, T. P.; Zima, A. V.; Bossuyt, J.; Bare, D. J.; Martin, J. L.; Blatter, L. A.; Bers, D. M.; Mignery, G. A., Journal of Biological Chemistry
  • Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytes. Sheehan, K. A.; Zima, A. V.; Blatter, L. A., Journal of Physiology
  • Effects of cytosolic NADH/NAD(+) levels on sarcoplasmic reticulum Ca(2+) release in permeabilized rat ventricular myocytes. Zima, A. V.; Copello, J. A.; Blatter, L. A., Journal of Physiology
  • Inositol-1 4, 5-trisphosphate-dependent Ca(2+) signalling in cat atrial excitation-contraction coupling and arrhythmias., Zima, A. V.; Blatter, L. A., Journal of Physiology
  • Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps. Kockskamper, J.; Ahmmed, G. U.; Zima, A. V.; Sheehan, K. A.; Glitsch, H. G.; Blatter, L. A., American Journal of Physiology - Cell Physiology
  • Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH. Zima, A. V.; Copello, J. A.; Blatter, L. A., FEBS letters
  • Pyruvate modulates cardiac sarcoplasmic reticulum Ca2+ release in rats via mitochondria-dependent and -independent mechanisms. Zima, A. V.; Kockskamper, J.; Mejia-Alvarez, R.; Blatter, L. A., Journal of Physiology