CONTACT INFORMATION http://www.loyola.org
William Small, Jr.
M.D., FACR, FASTRO
  • Professor
  • Department Chairperson, Radiation Oncology
  • Radiation Oncology
Specialties
Breast Cancer, Gynecologic Cancer, Gastrointestinal Cancers, Breast Brachytherapy, HDR/LDR Brachytherapy
Board Certifications
  • Radiation Oncology - General Cert: AM Board of Radiology
Research Summary

Dr. Small HAs been an active researcher for over 20 years. His research has focused on translating basic research into the treatment of cancer patients. Specifically, he has been involved in innovative radiotherapy techniques, combining chemotherapy and molecularly target medications with radiation and attempts to ameliorate radiotherapy toxicities. He has been the principal or co-principal investigator on a number of region, national and international studies.

Publications

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Uterine Serous CarcinomaSagae,S.; Susumu,N.; Viswanathan,A. N.; Aoki,D.; Backes,F. J.; Provencher,D. M.; Vaughan,M.; Creutzberg,C. L.; Kurzeder,C.; Kristensen,G.; Lee,C.; Kurtz,J. E.; Glasspool,R. M.; Small,W.,JrInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2014 ;24(9 Suppl 3):S83-9

The tolerance of gastrointestinal organs to stereotactic body radiation therapy: what do we know so far?Thomas,T. O.; Hasan,S.; Small,W.,Jr; Herman,J. M.; Lock,M.; Kim,E. Y.; Mayr,N. A.; Teh,B. S.; Lo,S. S.Journal of gastrointestinal oncology 2014 ;5(3):236-246

The role of postoperative radiation therapy for endometrial cancer: Executive Summary of an American Society for Radiation Oncology evidence-based guidelineKlopp,A.; Smith,B. D.; Alektiar,K.; Cabrera,A.; Damato,A. L.; Erickson,B.; Fleming,G.; Gaffney,D.; Greven,K.; Lu,K.; Miller,D.; Moore,D.; Petereit,D.; Schefter,T.; Small,W.,Jr; Yashar,C.; Viswanathan,A. N.Practical radiation oncology 2014 ;4(3):137-144

Uterine neoplasms, version 1.2014Koh,W. J.; Greer,B. E.; Abu-Rustum,N. R.; Apte,S. M.; Campos,S. M.; Chan,J.; Cho,K. R.; Cohn,D.; Crispens,M. A.; Dupont,N.; Eifel,P. J.; Fader,A. N.; Fisher,C. M.; Gaffney,D. K.; George,S.; Han,E.; Huh,W. K.; Lurain,J. R.,3rd; Martin,L.; Mutch,D.; Remmenga,S. W.; Reynolds,R. K.; Small,W.,Jr; Teng,N.; Tillmanns,T.; Valea,F. A.; McMillian,N.; Hughes,M.Journal of the National Comprehensive Cancer Network : JNCCN 2014 ;12(2):248-280

Neoadjuvant radiotherapy use in locally advanced rectal cancer at NCCN member institutionsReyngold,M.; Niland,J.; ter Veer,A.; Milne,D.; Bekaii-Saab,T.; Cohen,S. J.; Lai,L.; Schrag,D.; Skibber,J. M.; Small,W.,Jr; Weiser,M.; Wilkinson,N.; Goodman,K. A.Journal of the National Comprehensive Cancer Network : JNCCN 2014 ;12(2):235-243

Patterns of recurrence and role of pelvic radiotherapy in ovarian clear cell adenocarcinomaMacrie,B. D.; Strauss,J. B.; Helenowski,I. B.; Rademaker,A.; Schink,J. C.; Lurain,J. R.; Small,W.,JrInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2014 ;24(9):1597-1602

ACR Appropriateness Criteria(R)-Anal CancerExpert Panel on Radiation Oncology-Rectal/Anal Cancer; Hong,T. S.; Pretz,J. L.; Herman,J. M.; Abdel-Wahab,M.; Azad,N.; Blackstock,A. W.; Das,P.; Goodman,K. A.; Jabbour,S. K.; Jones,W. E.,3rd; Konski,A. A.; Koong,A. C.; Rodriguez-Bigas,M.; Small,W.,Jr; Thomas,C. R.,Jr; Zook,J.; Suh,W. W.Gastrointestinal cancer research : GCR 2014 ;7(1):4-14

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Mullerian Adenosarcoma of the Female Genital TractFriedlander,M. L.; Covens,A.; Glasspool,R. M.; Hilpert,F.; Kristensen,G.; Kwon,S.; Selle,F.; Small,W.; Witteveen,E.; Russell,P.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2014 ;24(9 Suppl 3):S78-82

Radiation Therapy Oncology Group Gynecologic Oncology Working Group: Comprehensive ResultsGaffney,D. K.; Jhingran,A.; Portelance,L.; Viswanathan,A.; Schefter,T.; Weidhaas,J.; Small,W.,JrInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2014 ; ( ):

Intraoperative radiation therapy techniques and options for breast cancerKalakota,K.; Small,W.,JrExpert review of medical devices 2014 ;11(3):265-273

Comparison and Consensus Guidelines for Delineation of Clinical Target Volume for CT- and MR-Based Brachytherapy in Locally Advanced Cervical CancerViswanathan,A. N.; Erickson,B.; Gaffney,D. K.; Beriwal,S.; Bhatia,S. K.; Lee Burnett,O.,3rd; D'Souza,D. P.; Patil,N.; Haddock,M. G.; Jhingran,A.; Jones,E. L.; Kunos,C. A.; Lee,L. J.; Lin,L. L.; Mayr,N. A.; Petersen,I.; Petric,P.; Portelance,L.; Small,W.,Jr; Strauss,J. B.; Townamchai,K.; Wolfson,A. H.; Yashar,C. M.; Bosch,W.International journal of radiation oncology, biology, physics 2014 ;90(2):320-328

Low-Dose-Rate Brachytherapy Boosting Concurrent Chemoradiation as a Definitive Treatment Modality for Cervical Cancer: Long-term Clinical Results of Outcomes and Associated ToxicityRefaat,T.; Donnelly,E. D.; Gentile,M.; Novak,C.; Yuan,Y.; Khedr,G. A.; Helenowksi,I.; Lurain,J.; Schink,J.; Rademaker,A.; Sathiaseelan,V.; Strauss,J. B.; Small,W.,JrAmerican Journal of Clinical Oncology 2014 ; ( ):

Single Administration of p2TA (AB103), a CD28 Antagonist Peptide, Prevents Inflammatory and Thrombotic Reactions and Protects against Gastrointestinal Injury in Total-Body Irradiated MiceMirzoeva,S.; Paunesku,T.; Wanzer,M. B.; Shirvan,A.; Kaempfer,R.; Woloschak,G. E.; Small,W.,JrPLoS ONE 2014 ;9(7):e101161

Radical hysterectomy compared with primary radiation for treatment of stage IB1 cervix cancerDoll,K. M.; Donnelly,E.; Helenowski,I.; Rosenbloom,L.; Small,W.,Jr; Schink,J. C.; Lurain,J. R.American Journal of Clinical Oncology 2014 ;37(1):30-34

RTOG 0417: Efficacy of Bevacizumab in Combination With Definitive Radiation Therapy and Cisplatin Chemotherapy in Untreated Patients With Locally Advanced Cervical CarcinomaSchefter,T.; Winter,K.; Kwon,J. S.; Stuhr,K.; Balaraj,K.; Yaremko,B. P.; Small,W.,Jr; Sause,W.; Gaffney,D.; Radiation Therapy Oncology Group (RTOG)International journal of radiation oncology, biology, physics 2014 ;88(1):101-105

ACR Appropriateness Criteria(R) Advanced Stage Endometrial CancerElshaikh,M. A.; Yashar,C. M.; Wolfson,A. H.; Cardenes,H. R.; Erickson,B.; Jhingran,A.; Jolly,S.; Kidd,E.; Lee,L. J.; Mayr,N. A.; Moore,D.; Rao,G. G.; Small,W.,Jr; Varia,M. A.; Wahl,A. O.; Yuh,W.; Gaffney,D. K.; Expert Panel on Radiation Oncology-Gynecology:American Journal of Clinical Oncology 2014 ; ( ):

Evaluation of Outcomes in Patients With Carcinoma of the Cervix Treated With Concurrent Radiation and Cisplatin Versus Cisplatin/5-FU Compared With Radiation AloneDonnelly,E. D.; Refaat,T.; Gentile,M.; Herskovic,A.; Boyle,J.; Helenowski,I.; Rademaker,A.; Lurain,J.; Schink,J.; Singh,D.; Strauss,J. B.; Small,W.,JrAmerican Journal of Clinical Oncology 2013 ; ( ):

Ribonucleotide reductase expression in cervical cancer: a radiation therapy oncology group translational science analysisKunos,C. A.; Winter,K.; Dicker,A. P.; Small,W.,Jr; Abdul-Karim,F. W.; Dawson,D.; Jhingran,A.; Valicenti,R.; Weidhaas,J. B.; Gaffney,D. K.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2013 ;23(4):615-621

ACR Appropriateness Criteria(R) management of locoregionally advanced squamous cell carcinoma of the vulvaExpert Panel on Radiation Oncology-Gynecology; Kidd,E.; Moore,D.; Varia,M. A.; Gaffney,D. K.; Elshaikh,M. A.; Erickson,B.; Jhingran,A.; Lee,L. J.; Mayr,N. A.; Puthawala,A. A.; Rao,G. G.; Small,W.,Jr; Wahl,A. O.; Wolfson,A. H.; Yashar,C. M.; Yuh,W.; Cardenes,H. R.American Journal of Clinical Oncology 2013 ;36(4):415-422

Metastatic colon cancer, version 3.2013: featured updates to the NCCN GuidelinesBenson,A. B.,3rd; Bekaii-Saab,T.; Chan,E.; Chen,Y. J.; Choti,M. A.; Cooper,H. S.; Engstrom,P. F.; Enzinger,P. C.; Fakih,M. G.; Fenton,M. J.; Fuchs,C. S.; Grem,J. L.; Hunt,S.; Kamel,A.; Leong,L. A.; Lin,E.; May,K. S.; Mulcahy,M. F.; Murphy,K.; Rohren,E.; Ryan,D. P.; Saltz,L.; Sharma,S.; Shibata,D.; Skibber,J. M.; Small,W.,Jr; Sofocleous,C. T.; Venook,A. P.; Willett,C. G.; Gregory,K. M.; Freedman-Cass,D. A.Journal of the National Comprehensive Cancer Network : JNCCN 2013 ;11(2):141-52; quiz 152

Localized colon cancer, version 3.2013: featured updates to the NCCN GuidelinesBenson,A. B.,3rd; Bekaii-Saab,T.; Chan,E.; Chen,Y. J.; Choti,M. A.; Cooper,H. S.; Engstrom,P. F.; Enzinger,P. C.; Fakih,M. G.; Fenton,M. J.; Fuchs,C. S.; Grem,J. L.; Hunt,S.; Kamel,A.; Leong,L. A.; Lin,E.; May,K. S.; Mulcahy,M. F.; Murphy,K.; Rohren,E.; Ryan,D. P.; Saltz,L.; Sharma,S.; Shibata,D.; Skibber,J. M.; Small,W.,Jr; Sofocleous,C. T.; Venook,A. P.; Willett,C. G.; Gregory,K. M.; Freedman-Cass,D. A.; National Comprehensive Cancer NetworkJournal of the National Comprehensive Cancer Network : JNCCN 2013 ;11(5):519-528

Concomitant Chemoradiotherapy With Image-guided Pulsed Dose Rate Brachytherapy as a definitive Treatment Modality for Early-stage Cervical CancerRefaat,T.; Castelain,B.; Small,W.,Jr; Elsaid,A.; Lotfy,N.; Lartigau,E.; Nickers,P.American Journal of Clinical Oncology 2013 ; ( ):

Markov Model and Cost-Effectiveness Analysis of Bevacizumab in HER2-Negative Metastatic Breast CancerRefaat,T.; Choi,M.; Gaber,G.; Kiel,K.; Mehta,M.; Gradishar,W.; Small,W.,JrAmerican Journal of Clinical Oncology 2013 ; ( ):

Differences in breast aesthetic outcomes due to radiation: A validated, quantitative analysis of expander-implant reconstructionMioton,L. M.; Gaido,J.; Small,W.,Jr; Fine,N. A.; Kim,J. Y.The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique 2013 ;21(2):73-77

Hematologic toxicity in RTOG 0418: a phase 2 study of postoperative IMRT for gynecologic cancerKlopp,A. H.; Moughan,J.; Portelance,L.; Miller,B. E.; Salehpour,M. R.; Hildebrandt,E.; Nuanjing,J.; D'Souza,D.; Souhami,L.; Small,W.,Jr; Gaur,R.; Jhingran,A.International journal of radiation oncology, biology, physics 2013 ;86(1):83-90

Acr appropriateness Criteria management of vaginal cancerLee,L. J.; Jhingran,A.; Kidd,E.; Cardenes,H. R.; Elshaikh,M. A.; Erickson,B.; Mayr,N. A.; Moore,D.; Puthawala,A. A.; Rao,G. G.; Small,W.,Jr; Varia,M. A.; Wahl,A. O.; Wolfson,A. H.; Yashar,C. M.; Yuh,W.; Gaffney,D. K.Oncology (Williston Park, N.Y.) 2013 ;27(11):1166-1173

Cervical cancerKoh,W. J.; Greer,B. E.; Abu-Rustum,N. R.; Apte,S. M.; Campos,S. M.; Chan,J.; Cho,K. R.; Cohn,D.; Crispens,M. A.; DuPont,N.; Eifel,P. J.; Gaffney,D. K.; Giuntoli,R. L.,2nd; Han,E.; Huh,W. K.; Lurain,J. R.,3rd; Martin,L.; Morgan,M. A.; Mutch,D.; Remmenga,S. W.; Reynolds,R. K.; Small,W.,Jr; Teng,N.; Tillmanns,T.; Valea,F. A.; McMillian,N. R.; Hughes,M.; National Comprehensive Cancer NetworkJournal of the National Comprehensive Cancer Network : JNCCN 2013 ;11(3):320-343

Using intensity-modulated radiotherapy to spare the kidney in a patient with seminoma and a solitary kidney: a case reportChoi,M.; Hayes,J. P.; Mehta,M. P.; Swisher,A.; Small,W.,Jr; Mittal,B. B.; MacVicar,G. R.; Kalapurakal,J. A.; Sejpal,S. V.Tumori 2013 ;99(2):e38-42

American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part III: low-dose-rate and pulsed-dose-rate brachytherapyLee,L. J.; Das,I. J.; Higgins,S. A.; Jhingran,A.; Small,W.,Jr; Thomadsen,B.; Viswanathan,A. N.; Wolfson,A.; Eifel,P.; American Brachytherapy SocietyBrachytherapy 2012 ;11(1):53-57

ACR Appropriateness Criteria(R) pretreatment planning of invasive cancer of the cervixSiegel,C. L.; Andreotti,R. F.; Cardenes,H. R.; Brown,D. L.; Gaffney,D. K.; Horowitz,N. S.; Javitt,M. C.; Lee,S. I.; Mitchell,D. G.; Moore,D. H.; Rao,G. G.; Royal,H. D.; Small,W.,Jr; Varia,M. A.; Yashar,C. M.; American College of RadiologyJournal of the American College of Radiology : JACR 2012 ;9(6):395-402

ACR Appropriateness Criteria(R) role of adjuvant therapy in the management of early stage cervical cancerWolfson,A. H.; Varia,M. A.; Moore,D.; Rao,G. G.; Gaffney,D. K.; Erickson-Wittmann,B. A.; Jhingran,A.; Mayr,N. A.; Puthawala,A. A.; Small,W.,Jr; Yashar,C. M.; Yuh,W.; Cardenes,H. R.; American College of Radiology (ACR)Gynecologic oncology 2012 ;125(1):256-262

International brachytherapy practice patterns: a survey of the Gynecologic Cancer Intergroup (GCIG)Viswanathan,A. N.; Creutzberg,C. L.; Craighead,P.; McCormack,M.; Toita,T.; Narayan,K.; Reed,N.; Long,H.; Kim,H. J.; Marth,C.; Lindegaard,J. C.; Cerrotta,A.; Small,W.,Jr; Trimble,E.International journal of radiation oncology, biology, physics 2012 ;82(1):250-255

American Brachytherapy Society consensus guidelines for adjuvant vaginal cuff brachytherapy after hysterectomySmall,W.,Jr; Beriwal,S.; Demanes,D. J.; Dusenbery,K. E.; Eifel,P.; Erickson,B.; Jones,E.; Rownd,J. J.; De Los Santos,J. F.; Viswanathan,A. N.; Gaffney,D.; American Brachytherapy SocietyBrachytherapy 2012 ;11(1):58-67

ACR Appropriateness Criteria(R) definitive therapy for early-stage cervical cancerSmall,W.,Jr; Strauss,J. B.; Jhingran,A.; Yashar,C. M.; Cardenes,H. R.; Erickson-Wittmann,B. A.; Gullett,N.; Kidd,E.; Lee,L. J.; Mayr,N. A.; Moore,D.; Puthawala,A. A.; Rao,G. G.; Varia,M. A.; Wahl,A. O.; Wolfson,A. H.; Yuh,W.; Gaffney,D. K.American Journal of Clinical Oncology 2012 ;35(4):399-405

ACR Appropriateness Criteria(R)-Recurrent Rectal CancerKonski,A. A.; Suh,W. W.; Herman,J. M.; Blackstock,A. W.,Jr; Hong,T. S.; Poggi,M. M.; Rodriguez-Bigas,M.; Small,W.,Jr; Thomas,C. R.,Jr; Zook,J.Gastrointestinal cancer research : GCR 2012 ;5(1):3-12

ACR appropriateness criteria(R) resectable rectal cancerJones,W. E.,3rd; Thomas,C. R.,Jr; Herman,J. M.; Abdel-Wahab,M.; Azad,N.; Blackstock,W.; Das,P.; Goodman,K. A.; Hong,T. S.; Jabbour,S. K.; Konski,A. A.; Koong,A. C.; Rodriguez-Bigas,M.; Small,W.,Jr; Zook,J.; Suh,W. W.Radiation oncology (London, England) 2012 ;7( ):161-717X-7-161

A phase II study of intensity modulated radiation therapy to the pelvis for postoperative patients with endometrial carcinoma: radiation therapy oncology group trial 0418Jhingran,A.; Winter,K.; Portelance,L.; Miller,B.; Salehpour,M.; Gaur,R.; Souhami,L.; Small,W.,Jr; Berk,L.; Gaffney,D.International journal of radiation oncology, biology, physics 2012 ;84(1):e23-8

Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlasGay,H. A.; Barthold,H. J.; O'Meara,E.; Bosch,W. R.; El Naqa,I.; Al-Lozi,R.; Rosenthal,S. A.; Lawton,C.; Lee,W. R.; Sandler,H.; Zietman,A.; Myerson,R.; Dawson,L. A.; Willett,C.; Kachnic,L. A.; Jhingran,A.; Portelance,L.; Ryu,J.; Small,W.,Jr; Gaffney,D.; Viswanathan,A. N.; Michalski,J. M.International journal of radiation oncology, biology, physics 2012 ;83(3):e353-62

Anal Carcinoma, Version 2.2012: featured updates to the NCCN guidelinesBenson,A. B.,3rd; Arnoletti,J. P.; Bekaii-Saab,T.; Chan,E.; Chen,Y. J.; Choti,M. A.; Cooper,H. S.; Dilawari,R. A.; Engstrom,P. F.; Enzinger,P. C.; Fakih,M. G.; Fleshman,J. W.,Jr; Fuchs,C. S.; Grem,J. L.; Leong,L. A.; Lin,E.; May,K. S.; Mulcahy,M. F.; Murphy,K.; Rohren,E.; Ryan,D. P.; Saltz,L.; Sharma,S.; Shibata,D.; Skibber,J. M.; Small,W.,Jr; Sofocleous,C. T.; Venook,A. P.; Willett,C.; Freedman-Cass,D. A.; National Comprehensive Cancer NetworkJournal of the National Comprehensive Cancer Network : JNCCN 2012 ;10(4):449-454

The quality of cervical cancer brachytherapy implantation and the impact on local recurrence and disease-free survival in radiation therapy oncology group prospective trials 0116 and 0128Viswanathan,A. N.; Moughan,J.; Small,W.,Jr; Levenback,C.; Iyer,R.; Hymes,S.; Dicker,A. P.; Miller,B.; Erickson,B.; Gaffney,D. K.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2012 ;22(1):123-131

Rectal cancerBenson,A. B.,3rd; Bekaii-Saab,T.; Chan,E.; Chen,Y. J.; Choti,M. A.; Cooper,H. S.; Engstrom,P. F.; Enzinger,P. C.; Fakih,M. G.; Fuchs,C. S.; Grem,J. L.; Hunt,S.; Leong,L. A.; Lin,E.; Martin,M. G.; May,K. S.; Mulcahy,M. F.; Murphy,K.; Rohren,E.; Ryan,D. P.; Saltz,L.; Sharma,S.; Shibata,D.; Skibber,J. M.; Small,W.,Jr; Sofocleous,C. T.; Venook,A. P.; Willett,C. G.; Freedman-Cass,D. A.; Gregory,K. M.Journal of the National Comprehensive Cancer Network : JNCCN 2012 ;10(12):1528-1564

Clinical outcomes in international federation of gynecology and obstetrics stage IA endometrial cancer with myometrial invasion treated with or without postoperative vaginal brachytherapyDiavolitsis,V.; Rademaker,A.; Lurain,J.; Hoekstra,A.; Strauss,J.; Small,W.,JrInternational journal of radiation oncology, biology, physics 2012 ;84(2):415-419

A phase II study of bevacizumab in combination with definitive radiotherapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma: preliminary results of RTOG 0417Schefter,T. E.; Winter,K.; Kwon,J. S.; Stuhr,K.; Balaraj,K.; Yaremko,B. P.; Small,W.,Jr; Gaffney,D. K.International journal of radiation oncology, biology, physics 2012 ;83(4):1179-1184

Brain metastasis in gestational trophoblastic neoplasia: an updateNeubauer,N. L.; Latif,N.; Kalakota,K.; Marymont,M.; Small,W.,Jr; Schink,J. C.; Lurain,J. R.The Journal of reproductive medicine 2012 ;57(7-8):288-292

Dosimetry and toxicity outcomes in postoperative high-dose-rate intracavitary brachytherapy for endometrial carcinomaDonnelly,E. D.; Rakhra,S.; Helenowski,I.; Gopalkrishnan,M.; Lurain,J.; Schink,J.; Singh,D.; Strauss,J.; Small,W.,JrJournal of contemporary brachytherapy 2012 ;4(3):135-140

Computed tomographic colonography (virtual colonoscopy): a multicenter comparison with standard colonoscopy for detection of colorectal neoplasiaCotton,P. B.; Durkalski,V. L.; Pineau,B. C.; Palesch,Y. Y.; Mauldin,P. D.; Hoffman,B.; Vining,D. J.; Small,W. C.; Affronti,J.; Rex,D.; Kopecky,K. K.; Ackerman,S.; Burdick,J. S.; Brewington,C.; Turner,M. A.; Zfass,A.; Wright,A. R.; Iyer,R. B.; Lynch,P.; Sivak,M. V.; Butler,H.JAMA 2004 ;291(14):1713-1719

Education
Medical School
  • Northwestern University Feinberg School of Medicine
Residency
  • Northwestern University Feinberg School of Medicine, Radiation Oncology
Interests
  • Golf
  • College Football- Traveling
  • Baseball
  • Blackhawks Hockey