Susan C. Baker
  • Professor
  • Microbiology and Immunology

Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesisMielech,A. M.; Deng,X.; Chen,Y.; Kindler,E.; Wheeler,D. L.; Mesecar,A. D.; Thiel,V.; Perlman,S.; Baker,S. C.Journal of virology 2015 ; ( ):

Catalytic Function and Substrate Specificity of the PLpro Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)Baez-Santos,Y. M.; Mielech,A. M.; Deng,X.; Baker,S.; Mesecar,A. D.Journal of virology 2014 ; ( ):

A Study of Cardiovascular miRNA Biomarkers for Kawasaki DiseaseRowley,A. H.; Pink,A. J.; Reindel,R.; Innocentini,N.; Baker,S. C.; Shulman,S. T.; Kim,K. Y.The Pediatric infectious disease journal 2014 ; ( ):

A Chimeric Virus-Mouse Model System for Evaluating the Function and Inhibition of Papain-like Proteases of Emerging CoronavirusesDeng,X.; Agnihothram,S.; Mielech,A. M.; Nichols,D. B.; Wilson,M. W.; St John,S.; Larsen,S. D.; Mesecar,A. D.; Lenschow,D. J.; Baric,R. S.; Baker,S. C.Journal of virology 2014 ; ( ):

CD84 is Markedly Upregulated in Kawasaki Disease ArteriopathyReindel,R.; Bischof,J.; Kim,K. Y.; Orenstein,J. M.; Soares,M. B.; Baker,S. C.; Shulman,S. T.; Perlman,E. J.; Lingen,M. W.; Pink,A. J.; Trevenen,C.; Rowley,A. H.Clinical and experimental immunology 2014 ; ( ):

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like ProteaseRatia,K.; Kilianski,A.; Baez-Santos,Y. M.; Baker,S. C.; Mesecar,A.PLoS Pathogens 2014 ;10(5):e1004113

Coronaviruses Resistant to a 3C-like Protease Inhibitor Are Attenuated for Replication and Pathogenesis Revealing a Low Genetic Barrier but High Fitness Cost of ResistanceDeng,X.; St John,S. E.; Osswald,H. L.; O'Brien,A.; Banach,B. S.; Sleeman,K.; Ghosh,A. K.; Mesecar,A. D.; Baker,S. C.Journal of virology 2014 ; ( ):

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activitiesMielech,A. M.; Chen,Y.; Mesecar,A. D.; Baker,S. C.Virus research 2014 ; ( ):

Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitorsKilianski,A.; Baker,S. C.Antiviral Research 2013 ; ( ):

Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensorsKilianski,A.; Mielech,A. M.; Deng,X.; Baker,S. C.Journal of virology 2013 ;87(21):11955-11962

Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.Clementz,M. A.; Chen,Z.; Banach,B. S.; Wang,Y.; Sun,L.; Ratia,K.; Baez-Santos,Y. M.; Wang,J.; Takayama,J.; Ghosh,A. K.; Li,K.; Mesecar,A. D.; Baker,S. C.Journal of virology 2010 ;84(9):4619-4629

Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like ProteaseGhosh,A. K.; Takayama,J.; Aubin,Y.; Ratia,K.; Chaudhuri,R.; Baez,Y.; Sleeman,K.; Coughlin,M.; Nichols,D. B.; Mulhearn,D. C.; Prabhakar,B. S.; Baker,S. C.; Johnson,M. E.; Mesecar,A. D.Journal of medicinal chemistry 2009 ; ( ):

Detection of nonstructural protein 6 in murine coronavirus-infected cells and analysis of the transmembrane topology by using bioinformatics and molecular approaches.Baliji,S.; Cammer,S. A.; Sobral,B.; Baker,S. C.Journal of virology 2009 ;83(13):6957-6962

Human airway epithelial cell culture to identify new respiratory viruses: coronavirus NL63 as a model.Banach,B.; Orenstein,J. M.; Fox,L. M.; Randell,S. H.; Rowley,A. H.; Baker,S. C.Journal of virological methods 2009 ;156(1-2):19-26

Searching for the cause of Kawasaki disease--cytoplasmic inclusion bodies provide new insight.Rowley,A. H.; Baker,S. C.; Orenstein,J. M.; Shulman,S. T.Nature Reviews.Microbiology 2008 ;6(5):394-401

RNA-containing cytoplasmic inclusion bodies in ciliated bronchial epithelium months to years after acute Kawasaki disease.Rowley,A. H.; Baker,S. C.; Shulman,S. T.; Garcia,F. L.; Fox,L. M.; Kos,I. M.; Crawford,S. E.; Russo,P. A.; Hammadeh,R.; Takahashi,K.; Orenstein,J. M.PLoS ONE [Electronic Resource] 2008 ;3(2):e1582

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors.Ghosh,A. K.; Gong,G.; Grum-Tokars,V.; Mulhearn,D. C.; Baker,S. C.; Coughlin,M.; Prabhakar,B. S.; Sleeman,K.; Johnson,M. E.; Mesecar,A. D.Bioorganic & medicinal chemistry letters 2008 ;18(20):5684-5688

Morphogenesis of Coronavirus HCoV-NL63 in Cell Culture: A Transmission Electron Microscopic StudyOrenstein,J. M.; Banach,B.; Baker,S. C.The open infectious diseases journal 2008 ;2( ):52-58

Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles.Clementz,M. A.; Kanjanahaluethai,A.; O'Brien,T. E.; Baker,S. C.Virology 2008 ;375(1):118-129

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.Ratia,K.; Pegan,S.; Takayama,J.; Sleeman,K.; Coughlin,M.; Baliji,S.; Chaudhuri,R.; Fu,W.; Prabhakar,B. S.; Johnson,M. E.; Baker,S. C.; Ghosh,A. K.; Mesecar,A. D.Proceedings of the National Academy of Sciences of the United States of America 2008 ;105(42):16119-16124

Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression.Bechill,J.; Chen,Z.; Brewer,J. W.; Baker,S. C.Journal of virology 2008 ;82(9):4492-4501

Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery.Grum-Tokars,V.; Ratia,K.; Begaye,A.; Baker,S. C.; Mesecar,A. D.Virus research 2008 ;133(1):63-73

Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63.Chen,Z.; Wang,Y.; Ratia,K.; Mesecar,A. D.; Wilkinson,K. D.; Baker,S. C.Journal of virology 2007 ;81(11):6007-6018

Membrane topology of murine coronavirus replicase nonstructural protein 3.Kanjanahaluethai,A.; Chen,Z.; Jukneliene,D.; Baker,S. C.Virology 2007 ;361(2):391-401

The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation.Edwin,F.; Singh,R.; Endersby,R.; Baker,S. J.; Patel,T. B.Journal of Biological Chemistry 2006 ;281(8):4816-4822

Developing bioinformatic resources for coronavirusesBaker,S. C.; Jukneliene,D.; Purkayastha,A.; Snyder,E. E.; Crasta,O. R.; Czar,M. J.; Setubal,J. C.; Sobral,B. W.Advances in Experimental Medicine & Biology 2006 ;581( ):395-398

Human coronavirus-NL63 infection is not associated with acute Kawasaki disease.Baker,S. C.; Shimizu,C.; Shike,H.; Garcia,F.; van der Hoek,L.; Kuijper,T. W.; Reed,S. L.; Rowley,A. H.; Shulman,S. T.; Talbot,H. K.; Williams,J. V.; Burns,J. C.Advances in Experimental Medicine & Biology 2006 ;581( ):523-526

Deubiquitinating activity of the SARS-CoV papain-like protease.Barretto,N.; Jukneliene,D.; Ratia,K.; Chen,Z.; Mesecar,A. D.; Baker,S. C.Advances in Experimental Medicine & Biology 2006 ;581( ):37-41

Mouse hepatitis virus infection activates the Ire1/XBP1 pathway of the unfolded protein response.Bechill,J.; Chen,Z.; Brewer,J. W.; Baker,S. C.Advances in Experimental Medicine & Biology 2006 ;581( ):139-144

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity.Barretto,N.; Jukneliene,D.; Ratia,K.; Chen,Z.; Mesecar,A. D.; Baker,S. C.Journal of virology 2005 ;79(24):15189-15198

Coronaviruses: from common colds to severe acute respiratory syndromeBaker,S. C.Pediatric Infectious Disease Journal 2004 ;23(11):1049-1050

Identification of the murine coronavirus MP1 cleavage site recognized by papain-like proteinase 2.Kanjanahaluethai,A.; Jukneliene,D.; Baker,S. C.Journal of virology 2003 ;77(13):7376-7382