Stephanie Watkins
  • Assistant Professor
  • Program Coordinator, Oncology Institute Education
  • Surgical Research
  • Microbiology and Immunology
Research Keywords
  • Immunotherapy
  • Immunosuppression

High-avidity T cells are preferentially tolerized in the tumor microenvironmentZhu,Z.; Singh,V.; Watkins,S. K.; Bronte,V.; Shoe,J. L.; Feigenbaum,L.; Hurwitz,A. A.Cancer research 2013 ;73(2):595-604

MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancerHudson,R. S.; Yi,M.; Esposito,D.; Glynn,S. A.; Starks,A. M.; Yang,Y.; Schetter,A. J.; Watkins,S. K.; Hurwitz,A. A.; Dorsey,T. H.; Stephens,R. M.; Croce,C. M.; Ambs,S.Oncogene 2013 ;32(35):4139-4147

Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cellsHurwitz,A. A.; Watkins,S. K.Cancer immunology, immunotherapy : CII 2012 ;61(2):289-293

MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancerHudson,R. S.; Yi,M.; Esposito,D.; Watkins,S. K.; Hurwitz,A. A.; Yfantis,H. G.; Lee,D. H.; Borin,J. F.; Naslund,M. J.; Alexander,R. B.; Dorsey,T. H.; Stephens,R. M.; Croce,C. M.; Ambs,S.Nucleic acids research 2012 ;40(8):3689-3703

FOXO3: A master switch for regulating tolerance and immunity in dendritic cellsWatkins,S. K.; Hurwitz,A. A.Oncoimmunology 2012 ;1(2):252-254

Isolation of immune cells from primary tumorsWatkins,S. K.; Zhu,Z.; Watkins,K. E.; Hurwitz,A. A.Journal of visualized experiments : JoVE 2012 ;(64):e3952. doi(64):e3952

FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancerWatkins,S. K.; Zhu,Z.; Riboldi,E.; Shafer-Weaver,K. A.; Stagliano,K. E.; Sklavos,M. M.; Ambs,S.; Yagita,H.; Hurwitz,A. A.The Journal of clinical investigation 2011 ;121(4):1361-1372

Immunity to murine prostatic tumors: continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cellsShafer-Weaver,K. A.; Watkins,S. K.; Anderson,M. J.; Draper,L. J.; Malyguine,A.; Alvord,W. G.; Greenberg,N. M.; Hurwitz,A. A.Cancer research 2009 ;69(15):6256-6264

Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regressionWatkins,S. K.; Li,B.; Richardson,K. S.; Head,K.; Egilmez,N. K.; Zeng,Q.; Suttles,J.; Stout,R. D.European journal of immunology 2009 ;39(8):2126-2135

Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophagesStout,R. D.; Watkins,S. K.; Suttles,J.Journal of leukocyte biology 2009 ;86(5):1105-1109

IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivoWatkins,S. K.; Egilmez,N. K.; Suttles,J.; Stout,R. D.Journal of immunology (Baltimore, Md.: 1950) 2007 ;178(3):1357-1362

The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shockRaman,K. G.; Sappington,P. L.; Yang,R.; Levy,R. M.; Prince,J. M.; Liu,S.; Watkins,S. K.; Schmidt,A. M.; Billiar,T. R.; Fink,M. P.American journal of physiology.Gastrointestinal and liver physiology 2006 ;291(4):G556-65

Prospective, randomized trial comparing shock wave lithotripsy and ureteroscopy for lower pole caliceal calculi 1 cm or lessPearle,M. S.; Lingeman,J. E.; Leveillee,R.; Kuo,R.; Preminger,G. M.; Nadler,R. B.; Macaluso,J.; Monga,M.; Kumar,U.; Dushinski,J.; Albala,D. M.; Wolf,J. S.,Jr; Assimos,D.; Fabrizio,M.; Munch,L. C.; Nakada,S. Y.; Auge,B.; Honey,J.; Ogan,K.; Pattaras,J.; McDougall,E. M.; Averch,T. D.; Turk,T. M.; Pietrow,P.; Watkins,S.Journal of Urology 2005 ;173(6):2005-2009

Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influencesStout,R. D.; Jiang,C.; Matta,B.; Tietzel,I.; Watkins,S. K.; Suttles,J.Journal of immunology (Baltimore, Md.: 1950) 2005 ;175(1):342-349

Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritisKim,S. H.; Lechman,E. R.; Bianco,N.; Menon,R.; Keravala,A.; Nash,J.; Mi,Z.; Watkins,S. C.; Gambotto,A.; Robbins,P. D.Journal of immunology (Baltimore, Md.: 1950) 2005 ;174(10):6440-6448

Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitisYang,R.; Uchiyama,T.; Alber,S. M.; Han,X.; Watkins,S. K.; Delude,R. L.; Fink,M. P.Critical care medicine 2004 ;32(7):1453-1459

Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularityWang,Z.; Cook,T.; Alber,S.; Liu,K.; Kovesdi,I.; Watkins,S. K.; Vodovotz,Y.; Billiar,T. R.; Blumberg,D.Cancer research 2004 ;64(4):1386-1395

Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasisYang,R.; Uchiyama,T.; Watkins,S. K.; Han,X.; Fink,M. P.Shock (Augusta, Ga.) 2004 ;22(4):369-375

IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in miceYang,R.; Han,X.; Uchiyama,T.; Watkins,S. K.; Yaguchi,A.; Delude,R. L.; Fink,M. P.American journal of physiology.Gastrointestinal and liver physiology 2003 ;285(3):G621-9

Effect of hemorrhagic shock on gut barrier function and expression of stress-related genes in normal and gnotobiotic miceYang,R.; Gallo,D. J.; Baust,J. J.; Watkins,S. K.; Delude,R. L.; Fink,M. P.American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 2002 ;283(5):R1263-74

Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shockYang,R.; Gallo,D. J.; Baust,J. J.; Uchiyama,T.; Watkins,S. K.; Delude,R. L.; Fink,M. P.American journal of physiology.Gastrointestinal and liver physiology 2002 ;283(1):G212-21