Sakthivel Sadayappan
  • Associate Professor
  • Cell and Molecular Physiology
Research Keywords
  • Cardiovascular System
  • Heart

A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunctionKuster,D. W.; Govindan,S.; Springer,T. I.; Martin,J. L.; Finley,N. L.; Sadayappan,S.The Journal of biological chemistry 2015 ; ( ):

Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or beta1-Adrenergic StimulationTong,C. W.; Wu,X.; Liu,Y.; Rosas,P. C.; Sadayappan,S.; Hudmon,A.; Muthuchamy,M.; Powers,P. A.; Valdivia,H. H.; Moss,R. L.Circulation.Heart failure 2015 ; ( ):

Cardiac Myosin Binding Protein C Phosphorylation Affects Cross-Bridge Cycle's Elementary Steps in a Site-Specific MannerWang,L.; Sadayappan,S.; Kawai,M.PLoS ONE 2014 ;9(11):e113417

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathyBarefield,D.; Kumar,M.; de Tombe,P. P.; Sadayappan,S.American journal of physiology.Heart and circulatory physiology 2014 ;306(6):H807-15

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous miceBarefield,D.; Kumar,M.; Gorham,J.; Seidman,J. G.; Seidman,C. E.; de Tombe,P. P.; Sadayappan,S.Journal of Molecular and Cellular Cardiology 2014 ;79C( ):234-243

Orientation of Myosin Binding Protein C in the Cardiac Muscle Sarcomere Determined by Domain-Specific Immuno-EMLee,K.; Harris,S. P.; Sadayappan,S.; Craig,R.Journal of Molecular Biology 2014 ; ( ):

Transmural heterogeneity of cellular level power output is reduced in human heart failureHaynes,P.; Nava,K. E.; Lawson,B. A.; Chung,C. S.; Mitov,M. I.; Campbell,S. G.; Stromberg,A. J.; Sadayappan,S.; Bonnell,M. R.; Hoopes,C. W.; Campbell,K. S.Journal of Molecular and Cellular Cardiology 2014 ; ( ):

Myocardial infarction-induced N-terminal fragment of cMyBP-C impairs myofilament function in Human myocardiumWitayavanitkul,N.; Ait Mou,Y.; Kuster,D. W.; Khairallah,R. J.; Sarkey,J.; Govindan,S.; Chen,X.; Ge,Y.; Rajan,S.; Wieczorek,D. F.; Irving,T.; Westfall,M. V.; de Tombe,P. P.; Sadayappan,S.The Journal of biological chemistry 2014 ; ( ):

Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review seriesSadayappan,S.; de Tombe,P. P.Pflugers Archiv : European journal of physiology 2014 ;466(2):195-200

P679Ultrastructural and electron tomography analyses of cardiac muscle: normal muscle compared to presence and absence of myosin binding protein C-phosphorylationTorre,I.; Jeddi,M.; Amat-Roldan,I.; Hunter,S.; Sadayappan,S.; Robbins,J.; Moss,R.; Luther,P.Cardiovascular research 2014 ;103 Suppl 1( ):S124

Effects of a Myofilament Calcium Sensitizer on Left Ventricular Systolic and Diastolic Function in Rats with Volume Overload Heart FailureWilson,K.; Guggilam,A.; West,T. A.; Zhang,X.; Trask,A. J.; Cismowski,M. J.; de Tombe,P.; Sadayappan,S.; Lucchesi,P. A.American journal of physiology.Heart and circulatory physiology 2014 ; ( ):

Phosphorylation of cMyBP-C Affects Contractile Mechanisms in a Site-specific MannerWang,L.; Ji,X.; Barefield,D.; Sadayappan,S.; Kawai,M.Biophysical journal 2014 ;106(5):1112-1122

Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylationSimon,J. N.; Chowdhury,S. A.; Warren,C. M.; Sadayappan,S.; Wieczorek,D. F.; Solaro,R. J.; Wolska,B. M.Basic research in cardiology 2014 ;109(6):445-014-0445-6. Epub 2014 Oct 4

Sarcomere Mutation-Specific Expression Patterns in Human Hypertrophic CardiomyopathyHelms,A. S.; Davis,F.; Coleman,D.; Bartolone,S.; Glazier,A. A.; Pagani,F.; Yob,J. M.; Sadayappan,S.; Pedersen,E.; Lyons,R.; Westfall,M. V.; Jones,R.; Russell,M. W.; Day,S. M.Circulation.Cardiovascular Genetics 2014 ; ( ):

Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarctionGovindan,S.; Kuster,D. W.; Lin,B.; Kahn,D. J.; Jeske,W. P.; Walenga,J. M.; Leya,F.; Hoppensteadt,D.; Fareed,J.; Sadayappan,S.American journal of cardiovascular disease 2013 ;3(2):60-70

Cardiac Myosin binding protein-C plays no regulatory role in skeletal muscle structure and functionLin,B.; Govindan,S.; Lee,K.; Zhao,P.; Han,R.; Runte,K. E.; Craig,R.; Palmer,B. M.; Sadayappan,S.PLoS ONE 2013 ;8(7):e69671

Interactions between the Regulatory Subunit of Type I Protein Kinase A (PKARIalpha) and p90 Ribosomal S6 Kinase1 (RSK1) Regulate Cardiomyocyte ApoptosisGao,X.; Lin,B.; Sadayappan,S.; Patel,T. B.Molecular pharmacology 2013 ; ( ):

Finding the Missing Link: Disulfide-containing proteins via a high-throughput proteomics approachKhairallah,R. J.; Sadayappan,S.Proteomics 2013 ; ( ):

Release kinetics of circulating cardiac myosin binding protein-C following cardiac injuryKuster,D.; Cardenas-Ospina,A.; Miller,L.; Liebetrau,C.; Troidl,C.; Nef,H. M.; Mollmann,H.; Hamm,C. W.; Pieper,K. S.; Mahaffey,K. W.; Kleiman,N. S.; Stuyvers,B. D.; Marian,A. J.; Sadayappan,S.American journal of physiology.Heart and circulatory physiology 2013 ; ( ):

A sensitive and specific quantitation method for determination of serum cardiac Myosin binding protein-C by electrochemiluminescence immunoassayKuster,D. W.; Barefield,D.; Govindan,S.; Sadayappan,S.Journal of visualized experiments : JoVE 2013 ;78( ):

MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutationKuster,D. W.; Sadayappan,S.Pflugers Archiv : European journal of physiology 2013 ; ( ):

GSK3beta phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communicationKuster,D. W.; Sequeira,V.; Najafi,A.; Boontje,N. M.; Wijnker,P. J.; Witjas-Paalberends,E. R.; Marston,S. B.; Dos Remedios,C. G.; Carrier,L.; Demmers,J. A.; Redwood,C.; Sadayappan,S.; van der Velden,J.Circulation research 2013 ;112(4):633-639

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsSequeira,V.; Wijnker,P. J.; Nijenkamp,L. L.; Kuster,D. W.; Najafi,A.; Witjas-Paalberends,E. R.; Regan,J. A.; Boontje,N.; Ten Cate,F. J.; Germans,T.; Carrier,L.; Sadayappan,S.; van Slegtenhorst,M. A.; Zaremba,R.; Foster,D. B.; Murphy,A. M.; Poggesi,C.; Dos Remedios,C.; Stienen,G. J.; Ho,C. Y.; Michels,M.; van der Velden,J.Circulation research 2013 ;112(11):1491-1505

Cardiac myosin binding protein-C: redefining its structure and functionSadayappan,S.; de Tombe,P. P.Biophysical reviews 2012 ;4(2):93-106

Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.Govindan,S.; McElligott,A.; Muthusamy,S.; Nair,N.; Barefield,D.; Martin,J. L.; Gongora,E.; Greis,K. D.; Luther,P. K.; Winegrad,S.; Henderson,K. K.; Sadayappan,S.Journal of Molecular & Cellular Cardiology 2012 ;52(1):154-164

Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro.Govindan,S.; Sarkey,J.; Ji,X.; Sundaresan,N. R.; Gupta,M. P.; de Tombe,P. P.; Sadayappan,S.Journal of Muscle Research & Cell Motility 2012 ;33(1):17-30

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.Sadayappan,S.; Gulick,J.; Osinska,H.; Barefield,D.; Cuello,F.; Avkiran,M.; Lasko,V. M.; Lorenz,J. N.; Maillet,M.; Martin,J. L.; Brown,J. H.; Bers,D. M.; Molkentin,J. D.; James,J.; Robbins,J.Circulation research 2011 ;109(2):141-150

Phosphorylation and function of cardiac myosin binding protein-C in health and diseaseBarefield,D.; Sadayappan,S.Journal of Molecular & Cellular Cardiology 2010 ;48(5):866-875


Primary fields of interest:
Cardiac myosin binding protein-C: structure and function

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