CONTACT INFORMATION http://www.loyola.org
Ruben Mestril
Ph.D.
  • Professor
  • Cell and Molecular Physiology
  • Cardiology
Research Keywords
  • Apoptosis
  • Cardiovascular System
  • Gene Regulation
  • Gene Therapy
  • Hyperthermia
  • Muscle Disorders
  • Signal Transduction
  • Stress
  • Translational Research
Publications

HSP72 protects against obesity-induced insulin resistance.Chung,J.; Nguyen,A. K.; Henstridge,D. C.; Holmes,A. G.; Chan,M. H.; Mesa,J. L.; Lancaster,G. I.; Southgate,R. J.; Bruce,C. R.; Duffy,S. J.; Horvath,I.; Mestril,R.; Watt,M. J.; Hooper,P. L.; Kingwell,B. A.; Vigh,L.; Hevener,A.; Febbraio,M. A.Proceedings of the National Academy of Sciences of the United States of America 2008 ;105(5):1739-1744

CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.Kumar,P.; Ambasta,R. K.; Veereshwarayya,V.; Rosen,K. M.; Kosik,K. S.; Band,H.; Mestril,R.; Patterson,C.; Querfurth,H. W.Human molecular genetics 2007 ;16(7):848-864

Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor.Colston,J. T.; de la Rosa,S. D.; Koehler,M.; Gonzales,K.; Mestril,R.; Freeman,G. L.; Bailey,S. R.; Chandrasekar,B.American Journal of Physiology - Heart & Circulatory Physiology 2007 ;293(3):H1839-46

Influence of PKC-alpha overexpression on HSP70 and cardioprotection.Coaxum,S. D.; Griffin,T. M.; Martin,J. L.; Mestril,R.American Journal of Physiology - Heart & Circulatory Physiology 2007 ;292(5):H2220-6

Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection.Islamovic,E.; Duncan,A.; Bers,D. M.; Gerthoffer,W. T.; Mestril,R.Journal of Molecular & Cellular Cardiology 2007 ;42(4):862-869

Troponin I levels in patients with preeclampsia.Joyal,D.; Leya,F.; Koh,M.; Besinger,R.; Ramana,R.; Kahn,S.; Jeske,W.; Lewis,B.; Steen,L.; Mestril,R.; Arab,D.American Journal of Medicine 2007 ;120(9):819.e13-819.e14

Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity.Broome,C. S.; Kayani,A. C.; Palomero,J.; Dillmann,W. H.; Mestril,R.; Jackson,M. J.; McArdle,A.FASEB Journal 2006 ;20(9):1549-1551

Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning.Miyabara,E. H.; Martin,J. L.; Griffin,T. M.; Moriscot,A. S.; Mestril,R.American Journal of Physiology - Cell Physiology 2006 ;290(4):1128-1138

Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis.Veereshwarayya,V.; Kumar,P.; Rosen,K. M.; Mestril,R.; Querfurth,H. W.Journal of Biological Chemistry 2006 ;281(40):29468-29478

Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts.Liu,J.; Chen,Q.; Huang,W.; Horak,K. M.; Zheng,H.; Mestril,R.; Wang,X.FASEB Journal 2006 ;20(2):362-364

Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytesLiu,J.; Tang,M.; Mestril,R.; Wang,X.Journal of Molecular & Cellular Cardiology 2006 ;40(4):451-454

Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytesMaier,L. S.; Ziolo,M. T.; Bossuyt,J.; Persechini,A.; Mestril,R.; Bers,D. M.Journal of Molecular & Cellular Cardiology 2006 ;41(3):451-458

Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytesGuo,T.; Zhang,T.; Mestril,R.; Bers,D. M.Circulation research 2006 ;99(4):398-406

Downregulation of the constitutively expressed Hsc70 in diabetic myocardium is mediated by insulin deficiency.Chen,H. S.; Jia,J.; Su,H. F.; Lin,H. D.; Chen,J. W.; Lin,S. J.; Yang,J. Y.; Lai,H. C.; Mestril,R.; Wang,P. H.Journal of Endocrinology 2006 ;190(2):433-440

Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA.Blum,J. L.; Samarel,A. M.; Mestril,R.American Journal of Physiology - Heart & Circulatory Physiology 2005 ;289(6):H2543-50

The use of transgenic mice to study cytoprotection by the stress proteins.Mestril,R.Methods (Duluth) 2005 ;35(2):165-169

4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo.Kroll,T. M.; Bommiasamy,H.; Boissy,R. E.; Hernandez,C.; Nickoloff,B. J.; Mestril,R.; Le Poole,I. C.Journal of Investigative Dermatology 2005 ;124(4):798-806

Overexpression of heat shock proteins differentially modulates protein kinase C expression in rat neonatal cardiomyocytes.Coaxum,S. D.; Martin,J. L.; Mestril,R.Cell stress & chaperones 2003 ;8(4):297-302

Education
Fellowship
  • German Cancer Research Institute, Research
Biography

Primary field of interest:
Study of the roles of heat shock proteins play in cardiac and skeletal muscle.

Languages
  • Spanish
  • French
  • German
Interests
  • Movies
  • Chess
  • Soccer