CONTACT INFORMATION http://www.loyola.org
Pieter de Tombe
Ph.D.
  • James R. DePauw Professor of Cell and Molecular Physiology
  • Co-Director, Cardiovascular Research Institute
  • Department Chairperson, Cell and Molecular Physiology
  • Cell and Molecular Physiology
Research Keywords
  • Bioengineering
  • Biophysics
  • Calcium Signaling
  • Cardiovascular System
  • Excitation-Contraction coupling
  • Extracellular Matrix
  • Heart
  • Muscle Disorders
  • Translational Research
  • Signal Transduction
Publications

Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathyKoshman,Y. E.; Chu,M.; Kim,T.; Kalmanson,O.; Farjah,M.; Kumar,M.; Lewis,W.; Geenen,D. L.; de Tombe,P.; Goldspink,P. H.; Solaro,R. J.; Samarel,A. M.Journal of Molecular and Cellular Cardiology 2014 ;72C( ):281-291

Novel approaches to determine contractile function of the isolated adult zebrafish ventricular cardiac myocyteDvornikov,A. V.; Dewan,S.; Alekhina,O. V.; Pickett,F. B.; de Tombe,P. P.The Journal of physiology 2014 ; ( ):

Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3betaKirk,J. A.; Holewinski,R. J.; Kooij,V.; Agnetti,G.; Tunin,R. S.; Witayavanitkul,N.; de Tombe,P. P.; Gao,W. D.; Van Eyk,J.; Kass,D. A.The Journal of clinical investigation 2014 ;124(1):129-138

Heart failure: a special issuevan der Velden,J.; de Tombe,P. P.Pflugers Archiv : European journal of physiology 2014 ;466(6):1023-014-1531-1. Epub 2014 May 14

The Role of Dyadic Organization in Regulation of Sarcoplasmic Reticulum Ca(2+) Handling during Rest in Rabbit Ventricular MyocytesBovo,E.; de Tombe,P. P.; Zima,A. V.Biophysical journal 2014 ;106(9):1902-1909

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathyBarefield,D.; Kumar,M.; de Tombe,P. P.; Sadayappan,S.American journal of physiology.Heart and circulatory physiology 2014 ;306(6):H807-15

Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review seriesSadayappan,S.; de Tombe,P. P.Pflugers Archiv : European journal of physiology 2014 ;466(2):195-200

Myocardial infarction-induced N-terminal fragment of cMyBP-C impairs myofilament function in Human myocardiumWitayavanitkul,N.; Ait Mou,Y.; Kuster,D. W.; Khairallah,R. J.; Sarkey,J.; Govindan,S.; Chen,X.; Ge,Y.; Rajan,S.; Wieczorek,D. F.; Irving,T.; Westfall,M. V.; de Tombe,P. P.; Sadayappan,S.The Journal of biological chemistry 2014 ; ( ):

New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin IHenze,M.; Patrick,S. E.; Hinken,A.; Scruggs,S. B.; Goldspink,P.; de Tombe,P. P.; Kobayashi,M.; Ping,P.; Kobayashi,T.; Solaro,R. J.Biochimica et biophysica acta 2013 ;1833(4):823-832

Mechanisms of Ca(2)+ handling in zebrafish ventricular myocytesBovo,E.; Dvornikov,A. V.; Mazurek,S. R.; de Tombe,P. P.; Zima,A. V.Pflugers Archiv : European journal of physiology 2013 ;465(12):1775-1784

Sex differences in health and disease: brain and heart connections--a special issueWattanapermpool,J.; de Tombe,P. P.; Pak,T. R.Pflugers Archiv : European journal of physiology 2013 ;465(5):555-556

Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscleMateja,R. D.; Greaser,M. L.; de Tombe,P. P.Biochimica et biophysica acta 2013 ;1833(4):804-811

Myofilament length-dependent activation develops within 5 ms in guinea-pig myocardiumMateja,R. D.; de Tombe,P. P.Biophysical journal 2012 ;103(1):L13-5

The velocity of cardiac sarcomere shortening: mechanisms and implicationsde Tombe,P. P.; ter Keurs,H. E.JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 2012 ;33(6):431-437

Cardiac myosin binding protein-C: redefining its structure and functionSadayappan,S.; de Tombe,P. P.Biophysical reviews 2012 ;4(2):93-106

Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro.Govindan,S.; Sarkey,J.; Ji,X.; Sundaresan,N. R.; Gupta,M. P.; de Tombe,P. P.; Sadayappan,S.Journal of Muscle Research & Cell Motility 2012 ;33(1):17-30

Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes.Sarkey,J. P.; Chu,M.; McShane,M.; Bovo,E.; Mou,Y. A.; Zima,A. V.; de Tombe,P. P.; Kartje,G. L.; Martin,J. L.Journal of Molecular & Cellular Cardiology 2011 ;50(6):1044-1055

Myosin head orientation: a structural determinant for the Frank-Starling relationship.Farman,G. P.; Gore,D.; Allen,E.; Schoenfelt,K.; Irving,T. C.; de Tombe,P. P.American Journal of Physiology - Heart & Circulatory Physiology 2011 ;300(6):H2155-60

Equal force recovery in dysferlin-deficient and wild-type muscles following saponin exposure.Zhao,P.; Xu,L.; Ait-Mou,Y.; de Tombe,P. P.; Han,R.Journal of Biomedicine & Biotechnology 2011 ;2011( ):235216

Myofilament length dependent activationde Tombe,P. P.; Mateja,R. D.; Tachampa,K.; Mou,Y. A.; Farman,G. P.; Irving,T. C.Journal of Molecular & Cellular Cardiology 2010 ;48(5):851-858

Glass microneedles for force measurements: a finite-element analysis model.Ayittey,P. N.; Walker,J. S.; Rice,J. J.; de Tombe,P. P.Pflugers Archiv - European Journal of Physiology 2009 ;457(6):1415-1422

Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation.Scruggs,S. B.; Hinken,A. C.; Thawornkaiwong,A.; Robbins,J.; Walker,L. A.; de Tombe,P. P.; Geenen,D. L.; Buttrick,P. M.; Solaro,R. J.Journal of Biological Chemistry 2009 ;284(8):5097-5106

Spatially-compressed cardiac myofilament models generate hysteresis that is not found in real muscle.Rice,J. J.; Tu,Y.; Poggesi,C.; De Tombe,P. P.Pacific Symposium on Biocomputing 2008 ; ( ):366-377

Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations.Rice,J. J.; Wang,F.; Bers,D. M.; de Tombe,P. P.Biophysical journal 2008 ;95(5):2368-2390

Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function.Solaro,R. J.; de Tombe,P. P.Cardiovascular research 2008 ;77(4):616-618

Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle.Tachampa,K.; Kobayashi,T.; Wang,H.; Martin,A. F.; Biesiadecki,B. J.; Solaro,R. J.; de Tombe,P. P.Journal of Biological Chemistry 2008 ;283(22):15114-15121

Some rat: a very special rat with a rather special titin.Cazorla,O.; de Tombe,P. P.Journal of Molecular & Cellular Cardiology 2008 ;44(6):976-978

Cardiac thin filament regulationKobayashi,T.; Jin,L.; de Tombe,P. P.Pflugers Archiv - European Journal of Physiology 2008 ;457(1):37-46

Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes.Koshman,Y. E.; Waters,S. B.; Walker,L. A.; Los,T.; de Tombe,P. P.; Goldspink,P. H.; Russell,B.Journal of Molecular & Cellular Cardiology 2008 ;45(6):853-856

Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?.Marston,S. B.; de Tombe,P. P.Journal of Molecular & Cellular Cardiology 2008 ;45(5):603-607

Blebbistatin: use as inhibitor of muscle contraction.Farman,G. P.; Tachampa,K.; Mateja,R.; Cazorla,O.; Lacampagne,A.; de Tombe,P. P.Pflugers Archiv - European Journal of Physiology 2008 ;455(6):995-1005

Differential contribution of cardiac sarcomeric proteins in the myofibrillar force response to stretch.Ait Mou,Y.; le Guennec,J. Y.; Mosca,E.; de Tombe,P. P.; Cazorla,O.Pflugers Archiv - European Journal of Physiology 2008 ;457(1):25-36

Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae.Farman,G. P.; Allen,E. J.; Gore,D.; Irving,T. C.; de Tombe,P. P.Biophysical journal 2007 ;92(9):73-75

p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.Vahebi,S.; Ota,A.; Li,M.; Warren,C. M.; de Tombe,P. P.; Wang,Y.; Solaro,R. J.Circulation research 2007 ;100(3):408-415

Cardiac troponin I threonine 144: role in myofilament length dependent activation.Tachampa,K.; Wang,H.; Farman,G. P.; de Tombe,P. P.Circulation research 2007 ;101(11):1081-1083

The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation.Biesiadecki,B. J.; Kobayashi,T.; Walker,J. S.; John Solaro,R.; de Tombe,P. P.Circulation research 2007 ;100(10):1486-1493

Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics.de Tombe,P. P.; Belus,A.; Piroddi,N.; Scellini,B.; Walker,J. S.; Martin,A. F.; Tesi,C.; Poggesi,C.American Journal of Physiology - Regulatory Integrative & Comparative Physiology 2007 ;292(3):R1129-36

Impact of temperature on cross-bridge cycling kinetics in rat myocardium.de Tombe,P. P.; Stienen,G. J.Journal of Physiology 2007 ;584(Pt 2):591-600

Development of contractile dysfunction in rat heart failure: hierarchy of cellular events.Daniels,M. C.; Naya,T.; Rundell,V. L.; de Tombe,P. P.American Journal of Physiology - Regulatory Integrative & Comparative Physiology 2007 ;293(1):R284-92

Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein.Boateng,S. Y.; Belin,R. J.; Geenen,D. L.; Margulies,K. B.; Martin,J. L.; Hoshijima,M.; de Tombe,P. P.; Russell,B.American Journal of Physiology - Heart & Circulatory Physiology 2007 ;292(1):H259-69

Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium.Lamberts,R. R.; Hamdani,N.; Soekhoe,T. W.; Boontje,N. M.; Zaremba,R.; Walker,L. A.; de Tombe,P. P.; van der Velden,J.; Stienen,G. J.Journal of Physiology 2007 ;582(Pt 2):695-709

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failureBelin,R. J.; Sumandea,M. P.; Allen,E. J.; Schoenfelt,K.; Wang,H.; Solaro,R. J.; de Tombe,P. P.Circulation research 2007 ;101(2):195-204

Languages
  • Dutch
  • German
Interests
  • Photography
  • Travel