Philip Wai
M.D.
Assistant Professor
Intra-Abdominal Transplantation
Molecular Pharmacology and Therapeutics
CONTACT INFORMATION
Specialties
Liver Transplant, Kidney and Pancreas Transplant, Liver Cancer, Bile Duct Disorders
Locations
Board Certifications
Surgery - General Cert: AM Board of Surgery
Publications
Epithelial-Mesenchymal Transition, TGF-[beta], and Osteopontin in Wound Healing and Tissue Remodeling After InjuryWeber,C. E.; Li,N. Y.; Wai,P. Y.; Kuo,P. C.JOURNAL OF BURN CARE & RESEARCH 2012 ;33(3):311-318
Epithelial-mesenchymal transition, TGF-beta, and osteopontin in wound healing and tissue remodeling after injuryWeber,C. E.; Li,N. Y.; Wai,P. Y.; Kuo,P. C.JOURNAL OF BURN CARE & RESEARCH 2012 ;33(3):311-318
Donation after cardiac death: a 29-year experience.Bellingham,J. M.; Santhanakrishnan,C.; Neidlinger,N.; Wai,P.; Kim,J.; Niederhaus,S.; Leverson,G. E.; Fernandez,L. A.; Foley,D. P.; Mezrich,J. D.; Odorico,J. S.; Love,R. B.; De Oliveira,N.; Sollinger,H. W.; D'Alessandro,A. M.SURGERY 2011 ;150(4):692-702
Long-term outcomes after simultaneous pancreas-kidney transplantWai,P. Y.; Sollinger,H. W.CURRENT OPINION IN ORGAN TRANSPLANTATION 2011 ; ( ):128-134
Luminex-based desensitization protocols: the University of Wisconsin initial experience.Niederhaus,S. V.; Muth,B.; Lorentzen,D. F.; Wai,P.; Pirsch,J. D.; Samaniego-Picota,M.; Leverson,G. E.; D'alessandro,A. M.; Sollinger,H. W.; Djamali,A.TRANSPLANTATION 2011 ;92(1):12-17
The significance of donor-specific HLA antibodies in rejection and ductopenia development in ABO compatible liver transplantation.Musat,A. I.; Agni,R. M.; Wai,P. Y.; Pirsch,J. D.; Lorentzen,D. F.; Powell,A.; Leverson,G. E.; Bellingham,J. M.; Fernandez,L. A.; Foley,D. P.; Mezrich,J. D.; D'Alessandro,A. M.; Lucey,M. R.AMERICAN JOURNAL OF TRANSPLANTATION 2011 ;11(3):500-510
Laparoscopic ventral hernia repair during pregnancy.Wai,P. Y.; Ruby,J. A.; Davis,K. A.; Roberts,A. C.; Roberts,K. E.Hernia 2009 ;13(5):559-563
Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis.Guo,H.; Wai,P. Y.; Mi,Z.; Gao,C.; Zhang,J.; Kuo,P. C.SURGERY 2008 ;144(2):182-188
Functional analysis of tumor metastasis: modeling colon cancerWai,P. Y.; Reddy,S. K.; Kuo,P. C.Oncology Reviews 2008 ;2(1):9-20
Osteopontin: regulation in tumor metastasisWai,P. Y.; Kuo,P. C.Cancer & Metastasis Reviews 2008 ;27(1):103-118
Post-operative care
Wai,P. Y.; Kuo,P. C.; Schroeder,R. A. 2007 ; ( ):120-120
Wai,P. Y.; Kuo,P. C.; Schroeder,R. A. 2007 ; ( ):120-120
Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells.Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Kuo,P. C.Carcinogenesis 2006 ;27(6):1134-1145
Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.Guo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.BIOCHEMICAL JOURNAL 2006 ;394(Pt 2):379-387
Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells.Wai,P. Y.; Mi,Z.; Gao,C.; Guo,H.; Marroquin,C.; Kuo,P. C.JOURNAL OF BIOLOGICAL CHEMISTRY 2006 ;281(28):18973-18982
Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation.Wai,P. Y.; Guo,L.; Gao,C.; Mi,Z.; Guo,H.; Kuo,P. C.SURGERY 2006 ;140(2):132-140
Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis.Wai,P. Y.; Mi,Z.; Guo,H.; Sarraf-Yazdi,S.; Gao,C.; Wei,J.; Marroquin,C. E.; Clary,B.; Kuo,P. C.Carcinogenesis 2005 ;26(4):741-751
Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin.Gao,C.; Guo,H.; Mi,Z.; Wai,P. Y.; Kuo,P. C.JOURNAL OF IMMUNOLOGY 2005 ;175(1):523-530
Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages.Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Nitric Oxide 2005 ;12(2):121-126
Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells.Guo,H.; Marroquin,C. E.; Wai,P. Y.; Kuo,P. C.Digestive Diseases & Sciences 2005 ;50(7):1288-1298
Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4.Marroquin,C. E.; Wai,P. Y.; Kuo,P. C.; Guo,H.SURGERY 2005 ;138(1):93-99
Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Wei,J.; Kuo,P. C.JOURNAL OF BIOLOGICAL CHEMISTRY 2004 ;279(45):46659-46667
S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P.; Kuo,P. C.JOURNAL OF BIOLOGICAL CHEMISTRY 2004 ;279(12):11236-11243
A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line.Gao,C.; Mi,Z.; Guo,H.; Wei,J.; Wai,P. Y.; Kuo,P. C.Biochemical & Biophysical Research Communications 2004 ;321(4):1010-1016
The role of Osteopontin in tumor metastasisWai,P. Y.; Kuo,P. C.JOURNAL OF SURGICAL RESEARCH 2004 ;121(2):228-241
Candida fasciitis following renal transplantationWai,P. H.; Ewing,C. A.; Johnson,L. B.; Lu,A. D.; Attinger,C.; Kuo,P. C.TRANSPLANTATION 2001 ;72(3):477-479
Education
Medical School
Georgetown University School of Medicine
Residency
Yale University School of Medicine/New Haven Hospital, General Surgery
Yale University School of Medicine/New Haven Hospital, General Surgery
Fellowship
University of Wisconsin Hospital and Clinics, Transplant Surgery
Languages
Chinese