Michael Collins
  • Professor
  • Molecular Pharmacology and Therapeutics
Research Keywords
  • Alcohol/Alcoholism
  • Brain
  • Hormones
  • Neurodegenerative Diseases
  • Neurodegenerative Diseases
  • Neuroprotection
  • Neurotoxicology
  • Nutrition/Dietetics
  • Parkinson's Disease
  • Prostaglandins
  • Reactive Oxygen Species
Research Summary

Mediators/mechanisms of neurodegeneration and neuroprotection


Neuroinflammation and Neurodegeneration in Adult Rat Brain from Binge Ethanol Exposure: Abrogation by Docosahexaenoic AcidTajuddin,N.; Moon,K. H.; Marshall,S. A.; Nixon,K.; Neafsey,E. J.; Kim,H. Y.; Collins,M. A.PLoS ONE 2014 ;9(7):e101223

Alcohol, Phospholipase A-associated Neuroinflammation, and omega3 Docosahexaenoic Acid ProtectionCollins,M. A.; Tajuddin,N.; Moon,K. H.; Kim,H. Y.; Nixon,K.; Neafsey,E. J.Molecular neurobiology 2014 ; ( ):

Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice culturesCollins,M. A.; Moon,K. H.; Tajuddin,N.; Neafsey,E. J.; Kim,H. Y.Neurotoxicity Research 2013 ;23(1):105-110

Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activationTajuddin,N. F.; Przybycien-Szymanska,M. M.; Pak,T. R.; Neafsey,E. J.; Collins,M. A.Alcohol (Fayetteville, N.Y.) 2013 ;47(1):39-45

Phospholipase A2, Oxidative Stress, and Neurodegeneration in Binge Ethanol-Treated Organotypic Slice Cultures of Developing Rat BrainMoon,K. H.; Tajuddin,N.; Brown,J.,3rd; Neafsey,E. J.; Kim,H. Y.; Collins,M. A.Alcoholism, Clinical and Experimental Research 2013 ; ( ):

Putative Agmatinase Inhibitor for Hypoxic-Ischemic New Born Brain DamagePiletz,J. E.; Klenotich,S.; Lee,K. S.; Zhu,Q. L.; Valente,E.; Collins,M. A.; Jones,V.; Lee,S. N.; Yangzheng,F.Neurotoxicity Research 2013 ; ( ):

Ethanol and adult CNS neurodamage: oxidative stress, but possibly not excitotoxicity.Collins,M. A.; Neafsey,E. J.Frontiers in Bioscience 2012 ;4( ):1358-1367

Neuroinflammatory pathways in binge alcohol-induced neuronal degeneration: oxidative stress cascade involving aquaporin, brain edema, and phospholipase A2 activationCollins,M. A.; Neafsey,E. J.Neurotoxicity Research 2012 ;21(1):70-78

Moderate alcohol consumption and cognitive riskNeafsey,E. J.; Collins,M. A.NEUROPSYCHIATRIC DISEASE AND TREATMENT 2011 ;7( ):465-484

Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector heat shock proteinsSivaswamy,S.; Neafsey,E. J.; Collins,M. A.The European journal of neuroscience 2010 ;32(11):1800-1812

Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanismsCollins,M. A.; Neafsey,E. J.; Wang,K.; Achille,N. J.; Mitchell,R. M.; Sivaswamy,S.Molecular neurobiology 2010 ;41(2-3):420-425

Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo.Sripathirathan,K.; Brown,J.,3rd; Neafsey,E. J.; Collins,M. A.Journal of neurotrauma 2009 ;26(2):261-273

Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA).Brown,J.,3rd; Achille,N.; Neafsey,E. J.; Collins,M. A.Neurochemical research 2009 ;34(2):260-267

Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro.Mitchell,R. M.; Neafsey,E. J.; Collins,M. A.Journal of neurochemistry 2009 ;111(2):580-588

Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studiesCollins,M. A.; Neafsey,E. J.; Mukamal,K. J.; Gray,M. O.; Parks,D. A.; Das,D. K.; Korthuis,R. J.Alcoholism: Clinical & Experimental Research 2009 ;33(2):206-219

Wine, beer, and spirits metabolismCollins,M.; Wehrmacher,W. H.; Messmore,H. L.Comprehensive therapy 2008 ;34(3-4):177-182

Alcohol consumption: benefit versus perilWehrmacher,W. H.; Messmore,H. L.; Collins,M.Comprehensive therapy 2008 ;34(3-4):166-170

Tetrahydropapaveroline in Parkinson's disease and alcoholism: a look back in honor of Merton Sandler.Collins,M. A.Neurotoxicology 2004 ;25(1-2):117-120

Alcohol-induced neurodegeneration: when, where and why?.Crews,F. T.; Collins,M. A.; Dlugos,C.; Littleton,J.; Wilkins,L.; Neafsey,E. J.; Pentney,R.; Snell,L. D.; Tabakoff,B.; Zou,J.; Noronha,A.Alcoholism: Clinical & Experimental Research 2004 ;28(2):350-364

Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake.Storch,A.; Hwang,Y. I.; Gearhart,D. A.; Beach,J. W.; Neafsey,E. J.; Collins,M. A.; Schwarz,J.Journal of neurochemistry 2004 ;89(3):685-694

Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by moderate ethanol preconditioning.Belmadani,A.; Kumar,S.; Schipma,M.; Collins,M. A.; Neafsey,E. J.Neuroreport 2004 ;15(13):2093-2096

Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations.Belmadani,A.; Neafsey,E. J.; Collins,M. A.Journal of neurovirology 2003 ;9(1):45-54

Alkaloids, alcohol and Parkinson's diseaseCollins,M. A.Parkinsonism & related disorders 2002 ;8(6):417-422

Potential neurotoxic "agents provocateurs" in Parkinson's diseaseCollins,M. A.; Neafsey,E. J.Neurotoxicology and teratology 2002 ;24(5):571-577

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