Maurizio Bocchetta
  • Associate Professor
  • Pathology
  • Molecular Pharmacology and Therapeutics
Research Summary

Our research is focused on studying and fighting hypoxic tumor microenvironment

Primary research interests involve the following: mechanisms of malignant transformation caused by oncogenic DNA viruses, interaction of the major Simian Virus 40 (SV40) oncogenes with cellular proteins, pathogenesis of mesothelioma.


Amyloid Precursor Protein (APP) Affects Global Protein Synthesis in Dividing Human CellsSobol,A.; Galluzzo,P.; Liang,S.; Rambo,B.; Skucha,S.; Weber,M. J.; Alani,S.; Bocchetta,M.Journal of cellular physiology 2014 ; ( ):

Depletion of Amyloid Precursor Protein (APP) causes G0 arrest in nonsmall cell lung cancer (NSCLC) cellsSobol,A.; Galluzzo,P.; Weber,M. J.; Alani,S.; Bocchetta,M.Journal of cellular physiology 2014 ; ( ):

Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary studyPievani,M.; Bocchetta,M.; Boccardi,M.; Cavedo,E.; Bonetti,M.; Thompson,P. M.; Frisoni,G. B.Neurobiology of aging 2013 ;34(7):1728-1739

Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairmentClerx,L.; van Rossum,I. A.; Burns,L.; Knol,D. L.; Scheltens,P.; Verhey,F.; Aalten,P.; Lapuerta,P.; van de Pol,L.; van Schijndel,R.; de Jong,R.; Barkhof,F.; Wolz,R.; Rueckert,D.; Bocchetta,M.; Tsolaki,M.; Nobili,F.; Wahlund,L. O.; Minthon,L.; Frolich,L.; Hampel,H.; Soininen,H.; Visser,P. J.Neurobiology of aging 2013 ;34(8):2003-2013

Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzleBoccardi,M.; Bocchetta,M.; Aronen,H. J.; Repo-Tiihonen,E.; Vaurio,O.; Thompson,P. M.; Tiihonen,J.; Frisoni,G. B.International journal of law and psychiatry 2013 ;36(2):157-167

Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentationBoccardi,M.; Bocchetta,M.; Ganzola,R.; Robitaille,N.; Redolfi,A.; Duchesne,S.; Jack,C. R.,Jr; Frisoni,G. B.; EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging InitiativeAlzheimer's & dementia : the journal of the Alzheimer's Association 2013 ; ( ):

Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) MicroenvironmentLiang,S.; Galluzzo,P.; Sobol,A.; Skucha,S.; Rambo,B.; Bocchetta,M.Genes & cancer 2012 ;3(2):141-151

Notch signaling in lung cancerGalluzzo,P.; Bocchetta,M.Expert Review of Anticancer Therapy 2011 ;11(4):533-540

Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocolBoccardi,M.; Ganzola,R.; Bocchetta,M.; Pievani,M.; Redolfi,A.; Bartzokis,G.; Camicioli,R.; Csernansky,J. G.; de Leon,M. J.; deToledo-Morrell,L.; Killiany,R. J.; Lehericy,S.; Pantel,J.; Pruessner,J. C.; Soininen,H.; Watson,C.; Duchesne,S.; Jack,C. R.,Jr; Frisoni,G. B.Journal of Alzheimer's disease : JAD 2011 ;26 Suppl 3( ):61-75

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.Eliasz,S.; Liang,S.; Chen,Y.; De Marco,M. A.; Machek,O.; Skucha,S.; Miele,L.; Bocchetta,M.Oncogene 2010 ;29(17):2488-2498

Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular OncogenesZhang,L.; Qi,F.; Gaudino,G.; Strianese,O.; Yang,H.; Morris,P.; Pass,H. I.; Nerurkar,V. R.; Bocchetta,M.; Carbone,M.Genes & cancer 2010 ;1(10):1008-1020

SV40 Tag/p53 complexes actively promote malignant cell growth of human mesothelial cells.Bocchetta,M.; Carbone,M.Cellular Oncology 2008 ;30(5):455

The SV40 large T antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth.Bocchetta,M.; Eliasz,S.; De Marco,M. A.; Rudzinski,J.; Zhang,L.; Carbone,M.Cancer research 2008 ;68(4):1022-1029

A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells.Carbone,M.; Pannuti,A.; Zhang,L.; Testa,J. R.; Bocchetta,M.Cancer research 2008 ;68(22):9488-9496

Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway.Graziani,I.; Eliasz,S.; De Marco,M. A.; Chen,Y.; Pass,H. I.; De May,R. M.; Strack,P. R.; Miele,L.; Bocchetta,M.Cancer research 2008 ;68(23):9678-9685

Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung.Chen,Y.; De Marco,M. A.; Graziani,I.; Gazdar,A. F.; Strack,P. R.; Miele,L.; Bocchetta,M.Cancer research 2007 ;67(17):7954-7959

Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters.Kroczynska,B.; Cutrone,R.; Bocchetta,M.; Yang,H.; Elmishad,A. G.; Vacek,P.; Ramos-Nino,M.; Mossman,B. T.; Pass,H. I.; Carbone,M.Proceedings of the National Academy of Sciences of the United States of America 2006 ;103(38):14128-14133

Polio vaccines, SV40 and human tumours, an update on false positive and false negative results.Elmishad,A. G.; Bocchetta,M.; Pass,H. I.; Carbone,M.Developments in biologicals 2006 ;123( ):109-117

TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis.Yang,H.; Bocchetta,M.; Kroczynska,B.; Elmishad,A. G.; Chen,Y.; Liu,Z.; Bubici,C.; Mossman,B. T.; Pass,H. I.; Testa,J. R.; Franzoso,G.; Carbone,M.Proceedings of the National Academy of Sciences of the United States of America 2006 ;103(27):10397-10402

Cellular and molecular parameters of mesotheliomaRamos-Nino,M. E.; Testa,J. R.; Altomare,D. A.; Pass,H. I.; Carbone,M.; Bocchetta,M.; Mossman,B. T.Journal of cellular biochemistry 2006 ;98(4):723-734

Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961.Cutrone,R.; Lednicky,J.; Dunn,G.; Rizzo,P.; Bocchetta,M.; Chumakov,K.; Minor,P.; Carbone,M.Cancer research 2005 ;65(22):10273-10279

SV40 detection in human tumor specimensCarbone,M.; Rdzanek,M. A.; Rudzinski,J. J.; De Marco,M. A.; Bocchetta,M.; Ramos Nino,M.; Mossman,B.; Pass,H. I.Cancer research 2005 ;65(21):10120-10121

Evidence of an important role for SV40 in mesotheliomaPass,H. I.; Bocchetta,M.; Carbone,M.Thoracic Surgery Clinics 2004 ;14(4):489-495

Genetically distant American Canine distemper virus lineages have recently caused epizootics with somewhat different characteristics in raccoons living around a large suburban zoo in the USA.Lednicky,J. A.; Dubach,J.; Kinsel,M. J.; Meehan,T. P.; Bocchetta,M.; Hungerford,L. L.; Sarich,N. A.; Witecki,K. E.; Braid,M. D.; Pedrak,C.; Houde,C. M.Virology Journal 2004 ;1( ):2

SV40 and Notch-I: multi-functionality meets pleiotropyCarbone,M.; Bocchetta,M.Progress in Molecular & Subcellular Biology 2004 ;36( ):289-305

Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformationBocchetta,M.; Carbone,M.Oncogene 2004 ;23(38):6484-6491

Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells.Bocchetta,M.; Miele,L.; Pass,H. I.; Carbone,M.Oncogene 2003 ;22(1):81-89

SV40 and human brain tumorsCarbone,M.; Bocchetta,M.; Cristaudo,A.; Emri,S.; Gazdar,A.; Jasani,B.; Lednicky,J.; Miele,L.; Mutti,L.; Pass,H. I.; Ramael,M.; Rizzo,P.; Testa,J. R.; Weggen,S.; Yeung,A.International journal of cancer.Journal international du cancer 2003 ;106(1):140-2; author reply 143-5

Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation.Carbone,M.; Burck,C.; Rdzanek,M.; Rudzinski,J.; Cutrone,R.; Bocchetta,M.Cancer research 2003 ;63(19):6125-6129

New developments about the association of SV40 with human mesotheliomaCarbone,M.; Pass,H. I.; Miele,L.; Bocchetta,M.Oncogene 2003 ;22(33):5173-5180

High throughput testing of the SV40 Large T antigen binding to cellular p53 identifies putative drugs for the treatment of SV40-related cancers.Carbone,M.; Rudzinski,J.; Bocchetta,M.Virology 2003 ;315(2):409-414

Advances in prophylactic cancer vaccine researchLe Poole,I. C.; Bommiasamy,H.; Bocchetta,M.; Kast,W. M.Expert Review of Anticancer Therapy 2003 ;3(4):537-545

Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cellsToyooka,S.; Carbone,M.; Toyooka,K. O.; Bocchetta,M.; Shivapurkar,N.; Minna,J. D.; Gazdar,A. F.Oncogene 2002 ;21(27):4340-4344

SV40 infection induces telomerase activity in human mesothelial cellsFoddis,R.; De Rienzo,A.; Broccoli,D.; Bocchetta,M.; Stekala,E.; Rizzo,P.; Tosolini,A.; Grobelny,J. V.; Jhanwar,S. C.; Pass,H. I.; Testa,J. R.; Carbone,M.Oncogene 2002 ;21(9):1434-1442

Molecular analyses, morphology and immunohistochemistry together differentiate pleural synovial sarcomas from mesotheliomas: clinical implicationsCarbone,M.; Rizzo,P.; Powers,A.; Bocchetta,M.; Fresco,R.; Krausz,T.Anticancer Research 2002 ;22(6B):3443-3448

Interactions between 23S rRNA and tRNA in the ribosomal E siteBocchetta,M.; Xiong,L.; Shah,S.; Mankin,A. S.RNA (New York, N.Y.) 2001 ;7(1):54-63

SV40 and the pathogenesis of mesotheliomaRizzo,P.; Bocchetta,M.; Powers,A.; Foddis,R.; Stekala,E.; Pass,H. I.; Carbone,M.Seminars in cancer biology 2001 ;11(1):63-71

Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicityBocchetta,M.; Di Resta,I.; Powers,A.; Fresco,R.; Tosolini,A.; Testa,J. R.; Pass,H. I.; Rizzo,P.; Carbone,M.Proceedings of the National Academy of Sciences of the United States of America 2000 ;97(18):10214-10219

Phylogenetic depth of the bacterial genera Aquifex and Thermotoga inferred from analysis of ribosomal protein, elongation factor, and RNA polymerase subunit sequencesBocchetta,M.; Gribaldo,S.; Sanangelantoni,A.; Cammarano,P.Journal of Molecular Evolution 2000 ;50(4):366-380

  • University of Illinois at Chicago Medical Center, Research