Matthias Majetschak
  • Associate Professor
  • Surgical Research
  • Molecular Pharmacology and Therapeutics
Research Summary

Research Interests: New therapeutic approaches to critical illness

The main goal of research in the Majetschak laboratory is to identify molecular targets for new therapeutic approaches, which are aimed to improve cardiovascular function and reduce secondary organ dysfunction and damage in critical illness. A main focus is the understanding of the mechanisms which contribute to the development of hemodynamic instability, impairment of cardiopulmonary function and development of (multiple) organ dysfunction and failure. Current research is focused 1) on the role of the intracellular ubiquitin proteasome pathway of protein degradation during the local and systemic response to tissue injury and 2) on the role of the SDF-1a (CXCL12)/Ubiquitin-CXCR4/CXCR7 axis during trauma and shock.
Our approach is clinically oriented, integrative and translational in nature. Utilizing initial observations in patients to develop novel hypotheses, we establish cell systems to determine underlying molecular mechanisms, which are then probed for therapeutic applicability in in vivo models to provide proof of concept, followed by rigorous preclinical efficacy testing to enable transition towards clinical applicability.

View a partial list of target=_blank>Dr. Majetschak's publications through the National Library of Medicine's PubMed online database.


Heteromerization of chemokine (C-X-C motif) receptor 4 with alpha1A/B-adrenergic receptors controls alpha1-adrenergic receptor functionTripathi,A.; Vana,P. G.; Chavan,T. S.; Brueggemann,L. I.; Byron,K. L.; Tarasova,N. I.; Volkman,B. F.; Gaponenko,V.; Majetschak,M.Proceedings of the National Academy of Sciences of the United States of America 2015 ; ( ):

Activities of Nonlysosomal Proteolytic Systems in Skeletal and Cardiac Muscle During Burn-Induced HypermetabolismWong,Y. M.; La Porte,H. M.; Szilagyi,A.; Bach,H. H.,4th; Ke-He,L.; Kennedy,R. H.; Gamelli,R. L.; Shankar,R.; Majetschak,M.Journal of burn care & research : official publication of the American Burn Association 2014 ; ( ):

Proteasomes in lungs from organ donors and patients with end-stage pulmonary diseasesBaker,T. A.; Bach,H. H.,4th; Gamelli,R. L.; Love,R. B.; Majetschak,M.Physiological Research / Academia Scientiarum Bohemoslovaca 2014 ;63(3):311-319

Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular alpha(1)-adrenergic receptor functionBach,H. H.,4th; Wong,Y. M.; Tripathi,A.; Nevins,A. M.; Gamelli,R. L.; Volkman,B. F.; Byron,K. L.; Majetschak,M.Molecular medicine (Cambridge, Mass.) 2014 ;20( ):435-447

CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1alpha and ubiquitinTripathi,A.; Davis,J. D.; Staren,D. M.; Volkman,B. F.; Majetschak,M.Cytokine 2013 ; ( ):

Differential Protein Kinase C-Dependent Modulation of Kv7.4 and Kv7.5 Subunits of Vascular Kv7 ChannelsBrueggemann,L. I.; Mackie,A. R.; Cribbs,L. L.; Freda,J.; Tripathi,A.; Majetschak,M.; Byron,K. L.The Journal of biological chemistry 2013 ; ( ):

Modulation of the CXC Chemokine Receptor 4 Agonist Activity of Ubiquitin through C-Terminal Protein ModificationTripathi,A.; Saini,V.; Marchese,A.; Volkman,B. F.; Tang,W. J.; Majetschak,M.Biochemistry 2013 ; ( ):

Proteasome inhibition prolongs survival during lethal hemorrhagic shock in ratsBach,H. H.,4th; Laporte,H. M.; Wong,Y. M.; Gamelli,R. L.; Majetschak,M.The journal of trauma and acute care surgery 2013 ;74(2):499-507

Initial assessment of the role of CXC chemokine receptor 4 after polytraumaBach,H. H.,4th; Saini,V.; Baker,T. A.; Tripathi,A.; Gamelli,R. L.; Majetschak,M.Molecular Medicine 2012 ;18( ):1056-1066

Ubiquitin and stromal cell-derived factor-1alpha in bronchoalveolar lavage fluid after burn and inhalation injury.Baker,T. A.; Davis,C. S.; Bach,H. H.,4th; Romero,J.; Burnham,E. L.; Kovacs,E. J.; Gamelli,R. L.; Majetschak,M.Journal of Burn Care & Research 2012 ;33(1):57-64

Effects of exogenous ubiquitin in a polytrauma model with blunt chest trauma.Baker,T. A.; Romero,J.; Bach,H. H.,4th; Strom,J. A.; Gamelli,R. L.; Majetschak,M.Critical care medicine 2012 ;40(8):2376-2384

Systemic release of cytokines and heat shock proteins in porcine models of polytrauma and hemorrhageBaker,T. A.; Romero,J.; Bach,H. H.,4th; Strom,J. A.; Gamelli,R. L.; Majetschak,M.Critical care medicine 2012 ;40(3):876-885

Extracellular ubiquitin: immune modulator and endogenous opponent of damage-associated molecular pattern moleculesMajetschak,M.Journal of leukocyte biology 2011 ;89(2):205-219

The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1alpha function through distinct receptor interactions.Saini,V.; Staren,D. M.; Ziarek,J. J.; Nashaat,Z. N.; Campbell,E. M.; Volkman,B. F.; Marchese,A.; Majetschak,M.Journal of Biological Chemistry 2011 ;286(38):33466-33477

Structural determinants of ubiquitin-CXC chemokine receptor 4 interactionSaini,V.; Marchese,A.; Tang,W. J.; Majetschak,M.The Journal of biological chemistry 2011 ;286(51):44145-44152

CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin.Saini,V.; Marchese,A.; Majetschak,M.Journal of Biological Chemistry 2010 ;285(20):15566-15576

Ubiquitin receptor binding and signaling in primary human leukocytesSaini,V.; Romero,J.; Marchese,A.; Majetschak,M.Communicative & integrative biology 2010 ;3(6):608-610

Circulating proteasomes after burn injury.Majetschak,M.; Zedler,S.; Romero,J.; Albright,J. M.; Kraft,R.; Kovacs,E. J.; Faist,E.; Gamelli,R. L.Journal of Burn Care & Research 2010 ;31(2):243-250

Prolongation of myocardial viability by proteasome inhibition during hypothermic organ preservationBaker,T. A.; Geng,Q.; Romero,J.; Picken,M. M.; Gamelli,R. L.; Majetschak,M.Biochemical and biophysical research communications 2010 ;401(4):548-553

A subset of 26S proteasomes is activated at critically low ATP concentrations and contributes to myocardial injury during cold ischemia.Geng,Q.; Romero,J.; Saini,V.; Baker,T. A.; Picken,M. M.; Gamelli,R. L.; Majetschak,M.Biochemical & Biophysical Research Communications 2009 ;390(4):1136-1141

Proteasomes in human bronchoalveolar lavage fluid after burn and inhalation injuryAlbright,J. M.; Romero,J.; Saini,V.; Sixt,S. U.; Bird,M. D.; Kovacs,E. J.; Gamelli,R. L.; Peters,J.; Majetschak,M.Journal of Burn Care & Research 2009 ;30(6):948-956

Detection and possible role of proteasomes in the bronchoalveolar space of the injured lung.Majetschak,M.; Sorell,L. T.; Patricelli,T.; Seitz,D. H.; Knoferl,M. W.Physiological Research 2009 ;58(3):363-372

Circulating 20S proteasome levels in patients with mixed connective tissue disease and systemic lupus erythematosus.Majetschak,M.; Perez,M.; Sorell,L. T.; Lam,J.; Maldonado,M. E.; Hoffman,R. W.Clinical & Vaccine Immunology: CVI 2008 ;15(9):1489-1493

Immunological methods to quantify and characterize proteasome complexes: development and application.Majetschak,M.; Sorell,L. T.Journal of immunological methods 2008 ;334(1-2):91-103

Medical School
  • University of Duisburg-Essen
  • University Hospital, Essen, Surgery: General Surgery
  • University Hospital, Essen, Trauma Surgery