CONTACT INFORMATION http://www.loyola.org
Mashkoor A. Choudhry
Ph.D.
  • Professor
  • Surgical Research
  • Microbiology and Immunology
Research Keywords
  • Alcohol/Alcoholism
  • Burns
  • Gastrointestinal Diseases
  • Immunopathology
  • Inflammation
Research Summary

Research Interest: Gut immunity and epithelial barrier in response to injury

Intestine is the major reservoir of bacteria within the body and it maintains an effective barrier against these bacteria under healthy conditions. However, this barrier is compromised following alcohol exposure, burn injury and other traumatic insults; a compromised intestinal barrier facilitates the entry of intestinal bacteria and their products to extra intestinal sites. These intestinal-derived bacteria or their products present a major clinical problem to burn/trauma victims as well as in patients with history of alcohol exposure and are implicated in the subsequent development of multiple organ failure. Dr. Choudhry’s laboratory is interested in learning the mechanisms of impaired gut barrier following alcohol exposure and major trauma such as burn.

The focus of his ongoing research is on:
1) T cell mediated immunity against gut-derived bacteria;
2) Neutrophils and their role in tissue damage and defense against bacteria;
3) Epithelial cells and their role in defense against gut bacteria.

Additionally, emerging evidence indicates that gut microflora plays critical roles in maintaining an effective gut barrier. So, another major aspect of ongoing studies in Dr. Choudhry’s laboratory is to determine whether alcohol exposure or traumatic injury influences the gut microflora and whether changes in gut microflora have any relationship with impaired gut mucosal immunity and epithelial barrier function under those conditions.

View a partial list of Dr. Choudhry's publications through the National Library of Medicine's PubMed online database.

Publications

An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in miceChen,M. M.; Zahs,A.; Brown,M. M.; Ramirez,L.; Turner,J. R.; Choudhry,M. A.; Kovacs,E. J.American journal of physiology.Gastrointestinal and liver physiology 2014 ; ( ):

T Cell IFN-gamma Suppression Following Alcohol and Burn Injury Is Independent of miRNA155Li,X.; Rendon,J. L.; Choudhry,M. A.PLoS ONE 2014 ;9(8):e105314

The Role of Aryl Hydrocarbon Receptor in Interleukin-23-Dependent Restoration of Interleukin-22 Following Ethanol Exposure and Burn InjuryRendon,J. L.; Li,X.; Brubaker,A. L.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.Annals of Surgery 2013 ; ( ):

Noninvasive measurement of intestinal inflammation after burn injurySigman,M.; Conrad,P.; Rendon,J. L.; Akhtar,S.; Eberhardt,J.; Gamelli,R. L.; Choudhry,M. A.Journal of burn care & research : official publication of the American Burn Association 2013 ;34(6):633-638

Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced ageBrubaker,A. L.; Rendon,J. L.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Journal of immunology (Baltimore, Md.: 1950) 2013 ;190(4):1746-1757

Intoxication by intraperitoneal injection or oral gavage equally potentiates postburn organ damage and inflammationChen,M. M.; Palmer,J. L.; Ippolito,J. A.; Curtis,B. J.; Choudhry,M. A.; Kovacs,E. J.Mediators of inflammation 2013 ;2013( ):971481

Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injuryZahs,A.; Bird,M. D.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Shock 2013 ;39(4):373-379

Alcohol and immunology: Summary of the 2012 Alcohol and Immunology Research Interest Group (AIRIG) meetingIppolito,J. A.; Curtis,B. J.; Choudhry,M. A.; Kovacs,E. J.Alcohol (Fayetteville, N.Y.) 2013 ; ( ):

Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injuryRendon,J. L.; Li,X.; Akhtar,S.; Choudhry,M. A.Shock (Augusta, Ga.) 2013 ;39(1):11-18

Alcohol and epigenetic changes: summary of the 2011 Alcohol and Immunology Research Interest Group (AIRIG) meetingZahs,A.; Curtis,B. J.; Waldschmidt,T. J.; Brown,L. A.; Gauthier,T. W.; Choudhry,M. A.; Kovacs,E. J.; Bird,M. D.Alcohol (Fayetteville, N.Y.) 2012 ;46(8):783-787

Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury.Zahs,A.; Bird,M. D.; Ramirez,L.; Turner,J. R.; Choudhry,M. A.; Kovacs,E. J.American Journal of Physiology - Gastrointestinal & Liver Physiology 2012 ;303(6):G705-12

Alcohol and inflammation and infection: clinical and experimental systems--summary of the 2010 Alcohol and Immunology Research Interest Group Meeting.Zahs,A.; Cook,R. T.; Waldschimdt,T. J.; Choudhry,M. A.; Kovacs,E. J.; Bird,M. D.Alcohol 2012 ;46(2):147-153

Th17 cells: critical mediators of host responses to burn injury and sepsisRendon,J. L.; Choudhry,M. A.Journal of leukocyte biology 2012 ;92(3):529-538

Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury.Li,X.; Akhtar,S.; Choudhry,M. A.Biochimica et biophysica acta 2012 ;1822(2):196-203

Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in miceBiju,P. G.; Garg,S.; Wang,W.; Choudhry,M. A.; Kovacs,E. J.; Fink,L. M.; Hauer-Jensen,M.Shock (Augusta, Ga.) 2012 ;38(2):170-176

Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury.Akhtar,S.; Li,X.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.Molecular Medicine 2011 ;17(1-2):88-94

Role of PPARgamma in the salutary effects of 17beta-estradiol on Kupffer cell cytokine production following trauma-hemorrhageSuzuki,T.; Kawasaki,T.; Choudhry,M. A.; Chaudry,I. H.Journal of cellular physiology 2011 ;226(1):205-211

Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury.Li,X.; Akhtar,S.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.Journal of Burn Care & Research 2011 ;32(4):489-497

Salutary effects of 17beta-estradiol on Peyer's patch T cell functions following trauma-hemorrhageKawasaki,T.; Suzuki,T.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Cytokine 2010 ;51(2):166-172

Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling.Bird,M. D.; Zahs,A.; Deburghgraeve,C.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Alcoholism: Clinical & Experimental Research 2010 ;34(10):1733-1741

Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury.Akhtar,S.; Li,X.; Chaudry,I. H.; Choudhry,M. A.American Journal of Physiology - Gastrointestinal & Liver Physiology 2009 ;297(2):G340-7

Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activationHsieh,C. H.; Nickel,E. A.; Chen,J.; Schwacha,M. G.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Journal of immunology (Baltimore, Md.: 1950) 2009 ;182(7):4406-4414

Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulationHsu,J. T.; Kan,W. H.; Hsieh,C. H.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Critical care medicine 2009 ;37(8):2338-2344

Role of extracellular signal-regulated protein kinase (ERK) in 17beta-estradiol-mediated attenuation of lung injury after trauma-hemorrhageHsu,J. T.; Kan,W. H.; Hsieh,C. H.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Surgery 2009 ;145(2):226-234

ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury.Li,X.; Chaudry,I. H.; Choudhry,M. A.Journal of Immunology 2009 ;183(6):3955-3962

Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhageKawasaki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Cell physiology 2009 ;296(1):C124-30

Alcohol and trauma: a summary of the Satellite Symposium at the 30th Annual Meeting of the Shock Society.Bird,M. D.; Choudhry,M. A.; Molina,P. E.; Kovacs,E. J.Alcohol 2009 ;43(3):247-252

Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responsesYang,S.; Hu,S.; Chen,J.; Choudhry,M. A.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Journal of leukocyte biology 2009 ;85(6):1015-1026

Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhageSuzuki,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Cytokine 2008 ;42(1):32-38

Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in miceLederer,J. A.; Brownstein,B. H.; Lopez,M. C.; Macmillan,S.; Delisle,A. J.; Macconmara,M. P.; Choudhry,M. A.; Xiao,W.; Lekousi,S.; Cobb,J. P.; Baker,H. V.; Mannick,J. A.; Chaudry,I. H.; Inflammation and the Host Response to Injury Collaborative Research Program ParticipantsPhysiological Genomics 2008 ;32(3):299-310

The role of MIP-1 alpha in the development of systemic inflammatory response and organ injury following trauma hemorrhageHsieh,C. H.; Frink,M.; Hsieh,Y. C.; Kan,W. H.; Hsu,J. T.; Schwacha,M. G.; Choudhry,M. A.; Chaudry,I. H.Journal of immunology (Baltimore, Md.: 1950) 2008 ;181(4):2806-2812

Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levelsHsu,J. T.; Kan,W. H.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Shock (Augusta, Ga.) 2008 ;30(4):372-378

Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injuryLi,X.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Shock (Augusta, Ga.) 2008 ;29(3):377-383

Inhibition of protein tyrosine phosphatases prevents mesenteric lymph node T-cell suppression following alcohol intoxication and burn injuryLi,X.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Journal of burn care & research : official publication of the American Burn Association 2008 ;29(3):519-530

Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2- production in a two-hit model of alcohol intoxication and burn injuryLi,X.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Journal of immunology (Baltimore, Md.: 1950) 2008 ;180(10):6933-6940

The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: direct modulation of CINC-1 production by Kupffer cellsShimizu,T.; Suzuki,T.; Yu,H. P.; Yokoyama,Y.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Cytokine 2008 ;43(1):88-92

17beta-Estradiol: a novel hormone for improving immune and cardiovascular responses following trauma-hemorrhageChoudhry,M. A.; Chaudry,I. H.Journal of leukocyte biology 2008 ;83(3):518-522

Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhageSuzuki,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Journal of cellular physiology 2008 ;214(3):662-672

Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosisKan,W. H.; Hsieh,C. H.; Schwacha,M. G.; Choudhry,M. A.; Raju,R.; Bland,K. I.; Chaudry,I. H.Journal of applied physiology (Bethesda, Md.: 1985) 2008 ;105(2):595-602

p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhageKan,W. H.; Hsu,J. T.; Ba,Z. F.; Schwacha,M. G.; Chen,J.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Heart and circulatory physiology 2008 ;294(6):H2627-36

Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase GKan,W. H.; Hsu,J. T.; Schwacha,M. G.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Annals of Surgery 2008 ;248(2):294-302

Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injuryKan,W. H.; Hsu,J. T.; Schwacha,M. G.; Choudhry,M. A.; Raju,R.; Bland,K. I.; Chaudry,I. H.Journal of applied physiology (Bethesda, Md.: 1985) 2008 ;105(4):1076-1082

Estradiol's salutary effects on keratinocytes following trauma-hemorrhage are mediated by estrogen receptor (ER)-alpha and ER-betaMoeinpour,F.; Choudhry,M. A.; de Figueiredo,L. F.; Bland,K. I.; Chaudry,I. H.Molecular medicine (Cambridge, Mass.) 2008 ;14(11-12):689-696

Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase processKawasaki,T.; Choudhry,M. A.; Schwacha,M. G.; Fujimi,S.; Lederer,J. A.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Cell physiology 2008 ;294(3):C754-64

17beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alphaKawasaki,T.; Choudhry,M. A.; Suzuki,T.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Molecular immunology 2008 ;45(2):376-385

Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged miceMatsutani,T.; Kang,S. C.; Miyashita,M.; Sasajima,K.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Gastrointestinal and liver physiology 2007 ;292(1):G268-74

Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhageMatsutani,T.; Kang,S. C.; Miyashita,M.; Sasajima,K.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.American Journal of Surgery 2007 ;193(1):61-68

Trauma and immune response--effect of gender differencesChoudhry,M. A.; Bland,K. I.; Chaudry,I. H.Injury 2007 ;38(12):1382-1391

Mitochondria play an important role in 17beta-estradiol attenuation of H(2)O(2)-induced rat endothelial cell apoptosisLu,A.; Frink,M.; Choudhry,M. A.; Schwacha,M. G.; Hubbard,W. J.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.American journal of physiology.Endocrinology and metabolism 2007 ;292(2):E585-93

Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhageFrink,M.; Hsieh,Y. C.; Hsieh,C. H.; Pape,H. C.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.Shock (Augusta, Ga.) 2007 ;28(5):576-581

Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: upregulation of estradiol synthesisFrink,M.; Hsieh,Y. C.; Hu,S.; Hsieh,C. H.; Pape,H. C.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Annals of Surgery 2007 ;246(5):836-843

TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhageFrink,M.; Hsieh,Y. C.; Thobe,B. M.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Molecular immunology 2007 ;44(10):2625-2630

Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine productionFrink,M.; Lu,A.; Thobe,B. M.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Kunkel,S. L.; Chaudry,I. H.American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 2007 ;292(3):R1110-6

17beta-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhageFrink,M.; Thobe,B. M.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Lung cellular and molecular physiology 2007 ;292(2):L585-91

Regulation of the postburn wound inflammatory response by gammadelta T-cellsDaniel,T.; Thobe,B. M.; Chaudry,I. H.; Choudhry,M. A.; Hubbard,W. J.; Schwacha,M. G.Shock (Augusta, Ga.) 2007 ;28(3):278-283

Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathwayYu,H. P.; Hsieh,Y. C.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Journal of leukocyte biology 2007 ;82(3):774-780

The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhageYu,H. P.; Hsieh,Y. C.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Annals of Surgery 2007 ;245(6):971-977

Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhageYang,S.; Hu,S.; Choudhry,M. A.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Journal of Molecular and Cellular Cardiology 2007 ;42(3):620-630

Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathwayShimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Suzuki,T.; Bland,K. I.; Chaudry,I. H.Annals of Surgery 2007 ;245(2):297-304

The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhageShimizu,T.; Yu,H. P.; Suzuki,T.; Szalay,L.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Journal of Hepatology 2007 ;46(6):1047-1054

Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats.Li,X.; Kovacs,E. J.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.American Journal of Physiology - Lung Cellular & Molecular Physiology 2007 ;292(5):1193-1201

Metabolic modulators following trauma sepsis: sex hormonesHsieh,Y. C.; Frink,M.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Critical care medicine 2007 ;35(9 Suppl):S621-9

Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhageHsieh,Y. C.; Frink,M.; Hsieh,C. H.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Lung cellular and molecular physiology 2007 ;292(5):L1227-32

Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhageHsieh,Y. C.; Frink,M.; Kawasaki,T.; Thobe,B. M.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Journal of cellular physiology 2007 ;211(2):364-370

17Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhageHsieh,Y. C.; Frink,M.; Thobe,B. M.; Hsu,J. T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Molecular immunology 2007 ;44(9):2165-2172

G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhageHsieh,Y. C.; Yu,H. P.; Frink,M.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.The American journal of pathology 2007 ;170(4):1210-1218

Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulationHsu,J. T.; Kan,W. H.; Hsieh,C. H.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Journal of leukocyte biology 2007 ;82(4):1019-1026

Estrogen receptor-alpha predominantly mediates the salutary effects of 17beta-estradiol on splenic macrophages following trauma-hemorrhageSuzuki,T.; Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Cell physiology 2007 ;293(3):C978-84

Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-alphaSuzuki,T.; Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Chaudry,I. H.American journal of physiology.Cell physiology 2007 ;292(6):C2103-11

Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhageSuzuki,T.; Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.Journal of applied physiology (Bethesda, Md.: 1985) 2007 ;102(1):163-168

Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhageHsu,J. T.; Hsieh,Y. C.; Kan,W. H.; Chen,J. G.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Heart and circulatory physiology 2007 ;292(6):H2982-7

The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhageThobe,B. M.; Frink,M.; Hildebrand,F.; Schwacha,M. G.; Hubbard,W. J.; Choudhry,M. A.; Chaudry,I. H.Journal of cellular physiology 2007 ;210(3):667-675

17 Beta-estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhageMoeinpour,F.; Choudhry,M. A.; Kawasaki,T.; Timares,L.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Molecular immunology 2007 ;44(13):3317-3323

T cells of the gammadelta T-cell receptor lineage play an important role in the postburn wound healing processAlexander,M.; Daniel,T.; Chaudry,I. H.; Choudhry,M. A.; Schwacha,M. G.Journal of burn care & research : official publication of the American Burn Association 2006 ;27(1):18-25

A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhageShimizu,T.; Szalay,L.; Hsieh,Y. C.; Suzuki,T.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Annals of Surgery 2006 ;244(1):131-138

A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injuryLi,X.; Rana,S. N.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Journal of leukocyte biology 2006 ;80(2):367-375

A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injuryLi,X.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Journal of leukocyte biology 2006 ;79(3):453-462

Trauma-hemorrhage induces depressed splenic dendritic cell functions in miceKawasaki,T.; Fujimi,S.; Lederer,J. A.; Hubbard,W. J.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Journal of immunology (Baltimore, Md.: 1950) 2006 ;177(7):4514-4520

Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta?Hildebrand,F.; Hubbard,W. J.; Choudhry,M. A.; Thobe,B. M.; Pape,H. C.; Chaudry,I. H.Journal of leukocyte biology 2006 ;79(6):1173-1180

Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus femalesHildebrand,F.; Hubbard,W. J.; Choudhry,M. A.; Thobe,B. M.; Pape,H. C.; Chaudry,I. H.Journal of leukocyte biology 2006 ;80(4):759-765

Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhageHildebrand,F.; Thobe,B. M.; Hubbard,W. J.; Choudhry,M. A.; Pape,H. C.; Chaudry,I. H.Cytokine 2006 ;36(3-4):107-114

Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhageHsieh,Y. C.; Choudhry,M. A.; Yu,H. P.; Shimizu,T.; Yang,S.; Suzuki,T.; Chen,J.; Bland,K. I.; Chaudry,I. H.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 ;20(8):1109-1117

Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhageHsieh,Y. C.; Yu,H. P.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Journal of Molecular and Cellular Cardiology 2006 ;41(3):511-521

The role of the general transcription factor IIF in androgen receptor-dependent transcriptionChoudhry,M. A.; Ball,A.; McEwan,I. J.Molecular endocrinology (Baltimore, Md.) 2006 ;20(9):2052-2061

Gender and susceptibility to sepsis following traumaChoudhry,M. A.; Bland,K. I.; Chaudry,I. H.Endocrine, metabolic & immune disorders drug targets 2006 ;6(2):127-135

Alcohol intoxication and post-burn complicationsChoudhry,M. A.; Chaudry,I. H.Frontiers in bioscience : a journal and virtual library 2006 ;11( ):998-1005

A role for corticosterone in impaired intestinal immunity and barrier function in a rodent model of acute alcohol intoxication and burn injuryChoudhry,M. A.; Li,X.; Chaudry,I. H.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2006 ;1(4):428-434

Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunctionDaniel,T.; Alexander,M.; Hubbard,W. J.; Chaudry,I. H.; Choudhry,M. A.; Schwacha,M. G.Journal of cellular physiology 2006 ;208(2):418-427

Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: upregulation of heme oxygenase-1Yu,H. P.; Yang,S.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Lung cellular and molecular physiology 2006 ;291(3):L400-6

MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxiaZheng,R.; Pan,G.; Thobe,B. M.; Choudhry,M. A.; Matsutani,T.; Samy,T. S.; Kang,S. C.; Bland,K. I.; Chaudry,I. H.Molecular medicine (Cambridge, Mass.) 2006 ;12(4-6):65-73

Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1Yu,H. P.; Choudhry,M. A.; Shimizu,T.; Hsieh,Y. C.; Schwacha,M. G.; Yang,S.; Chaudry,I. H.Journal of leukocyte biology 2006 ;79(2):277-284

Salutary effects of estrogen receptor-beta agonist on lung injury after trauma-hemorrhageYu,H. P.; Hsieh,Y. C.; Suzuki,T.; Shimizu,T.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.American journal of physiology.Lung cellular and molecular physiology 2006 ;290(5):L1004-9

Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteinsYu,H. P.; Shimizu,T.; Choudhry,M. A.; Hsieh,Y. C.; Suzuki,T.; Bland,K. I.; Chaudry,I. H.Journal of Molecular and Cellular Cardiology 2006 ;40(1):185-194

Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhageYu,H. P.; Shimizu,T.; Hsieh,Y. C.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.Journal of leukocyte biology 2006 ;79(5):963-970

Estrus cycle: influence on cardiac function following trauma-hemorrhageYang,S.; Choudhry,M. A.; Hsieh,Y. C.; Hu,S.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.American journal of physiology.Heart and circulatory physiology 2006 ;291(6):H2807-15

Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhageYang,S.; Hu,S.; Hsieh,Y. C.; Choudhry,M. A.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Journal of Molecular and Cellular Cardiology 2006 ;40(4):570-579

Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsisSzalay,L.; Shimizu,T.; Suzuki,T.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Gastrointestinal and liver physiology 2006 ;291(2):G260-6

Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expressionSzalay,L.; Shimizu,T.; Suzuki,T.; Yu,H. P.; Choudhry,M. A.; Schwacha,M. G.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 2006 ;290(3):R812-8

Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsisSuzuki,T.; Shimizu,T.; Szalay,L.; Choudhry,M. A.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Cytokine 2006 ;34(1-2):76-84

17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alphaSuzuki,T.; Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Surgery 2006 ;140(2):141-148

Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxiaThobe,B. M.; Frink,M.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Cell physiology 2006 ;291(3):C476-82

Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in miceKawasaki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Cell physiology 2006 ;291(5):C1049-55

Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function.Kavanaugh,M. J.; Clark,C.; Goto,M.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.; Choudhry,M. A.Burns 2005 ;31(3):290-296

Mechanism responsible for the salutary effects of flutamide on cardiac performance after trauma-hemorrhagic shock: Upregulation of cardiomyocyte estrogen receptorsYu,H. P.; Yang,S.; Choudhry,M. A.; Hsieh,Y. C.; Bland,K. I.; Chaudry,I. H.Surgery 2005 ;138(1):85-92

Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injuryRana,S. N.; Li,X.; Chaudry,I. H.; Bland,K. I.; Choudhry,M. A.Journal of leukocyte biology 2005 ;77(5):719-728

Salutary effects of androstenediol on hepatic function after trauma-hemorrhage are mediated via peroxisome proliferators-activated receptor gammaShimizu,T.; Szalay,L.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Surgery 2005 ;138(2):204-211

Gender differences in acute response to trauma-hemorrhageChoudhry,M. A.; Schwacha,M. G.; Hubbard,W. J.; Kerby,J. D.; Rue,L. W.; Bland,K. I.; Chaudry,I. H.Shock (Augusta, Ga.) 2005 ;24 Suppl 1( ):101-106

Alcohol ingestion before burn injury decreases splanchnic blood flow and oxygen deliveryChoudhry,M. A.; Ba,Z. F.; Rana,S. N.; Bland,K. I.; Chaudry,I. H.American journal of physiology.Heart and circulatory physiology 2005 ;288(2):H716-21

Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthaseShimizu,T.; Szalay,L.; Choudhry,M. A.; Schwacha,M. G.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.American journal of physiology.Gastrointestinal and liver physiology 2005 ;288(2):G244-50

Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury.Li,X.; Rana,S. N.; Kovacs,E. J.; Gamelli,R. L.; Chaudry,I. H.; Choudhry,M. A.American Journal of Physiology - Regulatory Integrative & Comparative Physiology 2005 ;289(1):R37-44

Inhibition of T cell MAPKs (Erk 1/2, p38) with thermal injury is related to down-regulation of Ca2+ signaling.Fazal,N.; Choudhry,M. A.; Sayeed,M. M.Biochimica et biophysica acta 2005 ;1741(1-2):113-119

Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhageShimizu,T.; Choudhry,M. A.; Szalay,L.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 2004 ;287(2):R386-90

Impaired intestinal immunity and barrier function: a cause for enhanced bacterial translocation in alcohol intoxication and burn injuryChoudhry,M. A.; Rana,S. N.; Kavanaugh,M. J.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.Alcohol 2004 ;33(3):199-208

Combined alcohol and burn injury differentially regulate P-38 and ERK activation in mesenteric lymph node T cell.Choudhry,M. A.; Ren,X.; Romero,A.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.Journal of Surgical Research 2004 ;121(1):62-68

Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK.Goral,J.; Choudhry,M. A.; Kovacs,E. J.Journal of leukocyte biology 2004 ;75(3):553-559

Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage?Kang,S. C.; Matsutani,T.; Choudhry,M. A.; Schwacha,M. G.; Rue,L. W.; Bland,K. I.; Chaudry,I. H.Cytokine 2004 ;26(5):223-230

Advanced age negatively influences mesenteric lymph node T cell responses after burn injury.Choudhry,M. A.; Plackett,T. P.; Schilling,E. M.; Faunce,D. E.; Gamelli,R. L.; Kovacs,E. J.Immunology letters 2003 ;86(2):177-182

T-cell proliferative responses following sepsis in neonatal ratsDallal,O.; Ravindranath,T. M.; Choudhry,M. A.; Kohn,A.; Muraskas,J. K.; Namak,S. Y.; Alattar,M. H.; Sayeed,M. M.Biology of the neonate 2003 ;83(3):201-207

Effects of pentoxyfylline on mesenteric lymph node T-cells in a rat model of thermal injury.Kotadia,B. K.; Ravindranath,T. M.; Choudhry,M. A.; Haque,F.; Al-Ghoul,W.; Sayeed,M. M.Shock 2003 ;20(6):517-520

Aging enhances lymphocyte cytokine defects after injury.Plackett,T. P.; Schilling,E. M.; Faunce,D. E.; Choudhry,M. A.; Witte,P. L.; Kovacs,E. J.FASEB Journal 2003 ;17(6):688-689

Enteral nutritional supplementation prevents mesenteric lymph node T-cell suppression in burn injury.Choudhry,M. A.; Haque,F.; Khan,M.; Fazal,N.; Al-Ghoul,W.; Ravindranath,T.; Gamelli,R. L.; Sayeed,M. M.Critical care medicine 2003 ;31(6):1764-1770

A role for CD1d-restricted NKT cells in injury-associated T cell suppression.Faunce,D. E.; Gamelli,R. L.; Choudhry,M. A.; Kovacs,E. J.Journal of leukocyte biology 2003 ;73(6):747-755

Gut-associated lymphoid T cell suppression enhances bacterial translocation in alcohol and burn injury.Choudhry,M. A.; Fazal,N.; Goto,M.; Gamelli,R. L.; Sayeed,M. M.American Journal of Physiology - Gastrointestinal & Liver Physiology 2002 ;282(6):G937-47

Effects of burn with and without Escherichia coli infection in rats on intestinal vs. splenic T-cell responsesRavindranath,T.; Al-Ghoul,W.; Namak,S.; Fazal,N.; Durazo-Arvizu,R. A.; Choudhry,M. A.; Sayeed,M. M.Critical care medicine 2001 ;29(12):2245-2250

Sepsis-induced alteration in T-cell Ca(2+) signaling in neonatal ratsAlattar,M. H.; Ravindranath,T. M.; Choudhry,M. A.; Muraskas,J. K.; Namak,S. Y.; Dallal,O.; Sayeed,M. M.Biology of the neonate 2001 ;80(4):300-304

Ethanol exacerbates T cell dysfunction after thermal injury.Choudhry,M. A.; Messingham,K. A.; Namak,S.; Colantoni,A.; Fontanilla,C. V.; Duffner,L. A.; Sayeed,M. M.; Kovacs,E. J.Alcohol 2000 ;21(3):239-243

Neutrophil depletion prevents intestinal mucosal permeability alterations in burn-injured rats.Sir,O.; Fazal,N.; Choudhry,M. A.; Gamelli,R. L.; Sayeed,M. M.American Journal of Physiology - Regulatory Integrative & Comparative Physiology 2000 ;278(5):R1224-31

Role of neutrophils in burn-induced microvascular injury in the intestine.Sir,O.; Fazal,N.; Choudhry,M. A.; Goris,R. J.; Gamelli,R. L.; Sayeed,M. M.Shock 2000 ;14(2):113-117