CONTACT INFORMATION http://www.loyola.org
Elizabeth Kovacs
Ph.D.
  • Professor
  • Director of Research, Burn and Shock Trauma Institute
  • Director, Alcohol Research Program
  • Division Director, Surgical Research
  • Surgical Research
  • Microbiology and Immunology
Research Keywords
  • Alcohol/Alcoholism
  • Burns
  • Cytokines
  • Inflammation
  • Innate Immunity
  • Pulmonary Diseases
Research Summary

Overall focus: The effects of advanced age, radiation, and alcohol exposure on inflammatory responses after traumatic injury.

  1. Binge alcohol exposure and inflammatory/immune responses after injury and/or infection. Systemic and organ-specific inflammatory response after burn injury with or without pulmonary infection. Effects of ethanol on macrophage and neutrophil recruitment, activation and function, including Toll-like receptor (TLR) mediated signal transduction, cytokine and chemokine production, receptor expression, phagocytosis and bacterial killing, apoptosis and chemotaxis.
  2. Inflamm-aging, “macroph-aging” and immunosenescence: Age-dependent effects on pulmonary response after remote injury or infection. Inflammatory and cutaneous wound infection in young vs. aged subjects. Role of TLR activation and mitogen activated protein (MAP) kinases in macrophages. Sex differences and hormone replacement alter inflammatory and immunity after burn injury in the aged.
  3. Combined radiation injury (CRI): Effects of total body irradiation (TBI) combined with scald burn injury on systemic, pulmonary and intestinal inflammation and barrier function. Development of pneumonitis and pulmonary fibrosis. Mitigating agents.
  4. Pulmonary response to smoke inhalation and infection after burn injury. Effect of smoke inhalation on acute lung injury and acute respiratory distress syndrome and systemic complications.
  5. Development of bronchiolitis obliterans in lung transplant recipients. Effects of donor and recipient alcohol exposure on pro-inflammatory and fibrogenic responses after lung transplantation.

View a partial list of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?dispmax=20&db=PubMed&pmfilter_EDatLimit=No+Limit&cmd_current=Limits&orig_db=PubMed&cmd=Search&term=Kovacs+EJ%5BAuthor+Name%5D&doptcmdl=DocSum target=_blank>Dr. Kovacs's publications through the National Library of Medicine's PubMed online database.

Publications

Episodic Binge Ethanol Exposure Impairs Murine Macrophage Infiltration and Delays Wound Closure by Promoting Defects in Early Innate Immune ResponsesCurtis,B. J.; Hlavin,S.; Brubaker,A. L.; Kovacs,E. J.; Radek,K. A.Alcoholism, Clinical and Experimental Research 2014 ; ( ):

Adipose inflammation and macrophage infiltration after binge ethanol and burn injuryQin,Y.; Hamilton,J. L.; Bird,M. D.; Chen,M. M.; Ramirez,L.; Zahs,A.; Kovacs,E. J.; Makowski,L.Alcoholism, Clinical and Experimental Research 2014 ;38(1):204-213

The diagnostic value of gastroesophageal reflux disease (GERD) symptoms and detection of pepsin and bile acids in bronchoalveolar lavage fluid and exhaled breath condensate for identifying lung transplantation patients with GERD-induced aspirationReder,N. P.; Davis,C. S.; Kovacs,E. J.; Fisichella,P. M.Surgical endoscopy 2014 ; ( ):

Usefulness of pH monitoring in predicting the survival status of patients with scleroderma awaiting lung transplantationFisichella,P. M.; Reder,N. P.; Gagermeier,J.; Kovacs,E. J.The Journal of surgical research 2014 ; ( ):

Modulation of inflammation by alcohol exposureLehnert,M.; Kovacs,E. J.; Molina,P. E.; Relja,B.Mediators of inflammation 2014 ;2014( ):283756

Age-related differences in the neutrophil response to pulmonary pseudomonas infectionChen,M. M.; Palmer,J. L.; Plackett,T. P.; Deburghgraeve,C. R.; Kovacs,E. J.Experimental gerontology 2014 ; ( ):

Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking.Burnham,E. L.; Kovacs,E. J.; Davis,C. S.American journal of physiology.Lung cellular and molecular physiology 2013 ;304(12):L873-82

Pepsin concentrations are elevated in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis after lung transplantationDavis,C. S.; Mendez,B. M.; Flint,D. V.; Pelletiere,K.; Lowery,E.; Ramirez,L.; Love,R. B.; Kovacs,E. J.; Fisichella,P. M.The Journal of surgical research 2013 ; ( ):

Intoxication by intraperitoneal injection or oral gavage equally potentiates postburn organ damage and inflammationChen,M. M.; Palmer,J. L.; Ippolito,J. A.; Curtis,B. J.; Choudhry,M. A.; Kovacs,E. J.Mediators of inflammation 2013 ;2013( ):971481

Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6Chen,M. M.; Bird,M. D.; Zahs,A.; Deburghgraeve,C.; Posnik,B.; Davis,C. S.; Kovacs,E. J.Alcohol (Fayetteville, N.Y.) 2013 ;47(3):223-229

Intestinal barrier disruption as a cause of mortality in combined radiation and burn injuryCarter,S. R.; Zahs,A.; Palmer,J. L.; Wang,L.; Ramirez,L.; Gamelli,R. L.; Kovacs,E. J.Shock (Augusta, Ga.) 2013 ;40(4):281-289

Aspiration, Localized Pulmonary Inflammation, and Predictors of Early-Onset Bronchiolitis Obliterans Syndrome after Lung TransplantationFisichella,P. M.; Davis,C. S.; Lowery,E.; Ramirez,L.; Gamelli,R. L.; Kovacs,E. J.Journal of the American College of Surgeons 2013 ;217(1):90-100

G-CSF Enhances Resolution of Staphylococcus aureus Wound Infection in an Age-Dependent MannerBrubaker,A. L.; Kovacs,E. J.Shock (Augusta, Ga.) 2013 ; ( ):

Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced ageBrubaker,A. L.; Rendon,J. L.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Journal of immunology (Baltimore, Md.: 1950) 2013 ;190(4):1746-1757

The Role of Aryl Hydrocarbon Receptor in Interleukin-23-Dependent Restoration of Interleukin-22 Following Ethanol Exposure and Burn InjuryRendon,J. L.; Li,X.; Brubaker,A. L.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.Annals of Surgery 2013 ; ( ):

Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injuryZahs,A.; Bird,M. D.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Shock 2013 ;39(4):373-379

Epigenetic targets for reversing immune defects caused by alcohol exposureCurtis,B. J.; Zahs,A.; Kovacs,E. J.Alcohol research : current reviews 2013 ;35(1):97-113

Alcohol and immunology: Summary of the 2012 Alcohol and Immunology Research Interest Group (AIRIG) meetingIppolito,J. A.; Curtis,B. J.; Choudhry,M. A.; Kovacs,E. J.Alcohol (Fayetteville, N.Y.) 2013 ; ( ):

Implications of alcohol intoxication at the time of burn and smoke inhalation injury: an epidemiologic and clinical analysisDavis,C. S.; Esposito,T. J.; Palladino-Davis,A. G.; Rychlik,K.; Schermer,C. R.; Gamelli,R. L.; Kovacs,E. J.Journal of Burn Care & Research 2013 ;34(1):120-126

Inhalation injury severity and systemic immune perturbations in burned adultsDavis,C. S.; Janus,S. E.; Mosier,M. J.; Carter,S. R.; Gibbs,J. T.; Ramirez,L.; Gamelli,R. L.; Kovacs,E. J.Annals of Surgery 2013 ;257(6):1137-1146

Combined radiation and burn injury results in exaggerated early pulmonary inflammationPalmer,J. L.; Deburghgraeve,C. R.; Bird,M. D.; Hauer-Jensen,M.; Chen,M. M.; Yong,S.; Kovacs,E. J.Radiation research 2013 ;180(3):276-283

The aging lungLowery,E. M.; Brubaker,A. L.; Kuhlmann,E.; Kovacs,E. J.Clinical interventions in aging 2013 ;8( ):1489-1496

Alcohol and inflammation and infection: clinical and experimental systems--summary of the 2010 Alcohol and Immunology Research Interest Group Meeting.Zahs,A.; Cook,R. T.; Waldschimdt,T. J.; Choudhry,M. A.; Kovacs,E. J.; Bird,M. D.Alcohol 2012 ;46(2):147-153

Early pulmonary immune hyporesponsiveness is associated with mortality after burn and smoke inhalation injury.Davis,C. S.; Albright,J. M.; Carter,S. R.; Ramirez,L.; Kim,H.; Gamelli,R. L.; Kovacs,E. J.Journal of Burn Care & Research 2012 ;33(1):26-35

The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury.Albright,J. M.; Davis,C. S.; Bird,M. D.; Ramirez,L.; Kim,H.; Burnham,E. L.; Gamelli,R. L.; Kovacs,E. J.Critical care medicine 2012 ;40(4):1113-1121

Alcohol and epigenetic changes: summary of the 2011 Alcohol and Immunology Research Interest Group (AIRIG) meetingZahs,A.; Curtis,B. J.; Waldschmidt,T. J.; Brown,L. A.; Gauthier,T. W.; Choudhry,M. A.; Kovacs,E. J.; Bird,M. D.Alcohol (Fayetteville, N.Y.) 2012 ;46(8):783-787

Exhaled breath condensate collection in the mechanically ventilated patientCarter,S. R.; Davis,C. S.; Kovacs,E. J.Respiratory medicine 2012 ;106(5):601-613

Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammationNomellini,V.; Brubaker,A. L.; Mahbub,S.; Palmer,J. L.; Gomez,C. R.; Kovacs,E. J.Aging and disease 2012 ;3(3):234-247

Writing a first grant proposalGomez-Cambronero,J.; Allen,L. A.; Cathcart,M. K.; Justement,L. B.; Kovacs,E. J.; McLeish,K. R.; Nauseef,W. M.Nature immunology 2012 ;13(2):105-108

A review of the role of GERD-induced aspiration after lung transplantationFisichella,P. M.; Davis,C. S.; Kovacs,E. J.Surgical endoscopy 2012 ;26(5):1201-1204

Pulmonary immune changes early after laparoscopic antireflux surgery in lung transplant patients with gastroesophageal reflux disease.Fisichella,P. M.; Davis,C. S.; Lowery,E.; Pittman,M.; Gagermeier,J.; Love,R. B.; Kovacs,E. J.Journal of Surgical Research 2012 ;177(2):e65-73

Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in miceBiju,P. G.; Garg,S.; Wang,W.; Choudhry,M. A.; Kovacs,E. J.; Fink,L. M.; Hauer-Jensen,M.Shock (Augusta, Ga.) 2012 ;38(2):170-176

The prevalence and extent of gastroesophageal reflux disease correlates to the type of lung transplantation.Fisichella,P. M.; Davis,C. S.; Shankaran,V.; Gagermeier,J.; Dilling,D.; Alex,C. G.; Kovacs,E. J.; Joehl,R. J.; Love,R. B.Surgical laparoscopy, endoscopy & percutaneous techniques 2012 ;22(1):46-51

Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury.Zahs,A.; Bird,M. D.; Ramirez,L.; Turner,J. R.; Choudhry,M. A.; Kovacs,E. J.American Journal of Physiology - Gastrointestinal & Liver Physiology 2012 ;303(6):G705-12

Ubiquitin and stromal cell-derived factor-1alpha in bronchoalveolar lavage fluid after burn and inhalation injury.Baker,T. A.; Davis,C. S.; Bach,H. H.,4th; Romero,J.; Burnham,E. L.; Kovacs,E. J.; Gamelli,R. L.; Majetschak,M.Journal of Burn Care & Research 2012 ;33(1):57-64

Advanced age impairs macrophage polarization.Mahbub,S.; Deburghgraeve,C. R.; Kovacs,E. J.Journal of Interferon & Cytokine Research 2012 ;32(1):18-26

Ethanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcgammaR-mediated phagocytosis.Karavitis,J.; Murdoch,E. L.; Deburghgraeve,C.; Ramirez,L.; Kovacs,E. J.Cellular immunology 2012 ;274(1-2):61-71

Aging of the Innate Immune System: An UpdateMahbub,S.; Brubaker,A. L.; Kovacs,E. J.Current immunology reviews 2011 ;7(1):104-115

Laparoscopic antireflux surgery for gastroesophageal reflux disease after lung transplantation.Fisichella,P. M.; Davis,C. S.; Gagermeier,J.; Dilling,D.; Alex,C. G.; Dorfmeister,J. A.; Kovacs,E. J.; Love,R. B.; Gamelli,R. L.Journal of Surgical Research 2011 ;170(2):e279-86

Prolonged chemokine expression and excessive neutrophil infiltration in the lungs of burn-injured mice exposed to ethanol and pulmonary infection.Murdoch,E. L.; Karavitis,J.; Deburghgraeve,C.; Ramirez,L.; Kovacs,E. J.Shock 2011 ;35(4):403-410

Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury.Li,X.; Akhtar,S.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.Journal of Burn Care & Research 2011 ;32(4):489-497

Alcohol exposure and mechanisms of tissue injury and repairJung,M. K.; Callaci,J. J.; Lauing,K. L.; Otis,J. S.; Radek,K. A.; Jones,M. K.; Kovacs,E. J.Alcoholism, Clinical and Experimental Research 2011 ;35(3):392-399

Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury.Akhtar,S.; Li,X.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.Molecular Medicine 2011 ;17(1-2):88-94

Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals.Schneider,D. F.; Palmer,J. L.; Tulley,J. M.; Kovacs,E. J.; Gamelli,R. L.; Faunce,D. E.Journal of Surgical Research 2011 ;171(1):361-373

Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent ModelsBrubaker,A. L.; Palmer,J. L.; Kovacs,E. J.Aging and disease 2011 ;2(5):346-360

Neutrophils and natural killer T cells as negative regulators of wound healingBrubaker,A. L.; Schneider,D. F.; Kovacs,E. J.Expert review of dermatology 2011 ;6(1):5-8

An improved cell isolation method for flow cytometric and functional analyses of cutaneous wound leukocytes.Brubaker,A. L.; Schneider,D. F.; Palmer,J. L.; Faunce,D. E.; Kovacs,E. J.Journal of immunological methods 2011 ;373(1-2):161-166

Development of a combined radiation and burn injury modelPalmer,J. L.; Deburghgraeve,C. R.; Bird,M. D.; Hauer-Jensen,M.; Kovacs,E. J.Journal of Burn Care & Research 2011 ;32(2):317-323

Macrophage phagocytosis: effects of environmental pollutants, alcohol, cigarette smoke, and other external factorsKaravitis,J.; Kovacs,E. J.Journal of leukocyte biology 2011 ;90(6):1065-1078

The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation.Fisichella,P. M.; Davis,C. S.; Lundberg,P. W.; Lowery,E.; Burnham,E. L.; Alex,C. G.; Ramirez,L.; Pelletiere,K.; Love,R. B.; Kuo,P. C.; Kovacs,E. J.Surgery 2011 ;150(4):598-606

A novel role for NKT cells in cutaneous wound repairSchneider,D. F.; Palmer,J. L.; Tulley,J. M.; Speicher,J. T.; Kovacs,E. J.; Gamelli,R. L.; Faunce,D. E.The Journal of surgical research 2011 ;168(2):325-333

Circulating proteasomes after burn injury.Majetschak,M.; Zedler,S.; Romero,J.; Albright,J. M.; Kraft,R.; Kovacs,E. J.; Faist,E.; Gamelli,R. L.Journal of Burn Care & Research 2010 ;31(2):243-250

Gastroesophageal reflux disease after lung transplantation: pathophysiology and implications for treatment.Davis,C. S.; Shankaran,V.; Kovacs,E. J.; Gagermeier,J.; Dilling,D.; Alex,C. G.; Love,R. B.; Sinacore,J.; Fisichella,P. M.Surgery 2010 ;148(4):737-744

A review of the potential applications and controversies of non-invasive testing for biomarkers of aspiration in the lung transplant populationDavis,C. S.; Gagermeier,J.; Dilling,D.; Alex,C.; Lowery,E.; Kovacs,E. J.; Love,R. B.; Fisichella,P. M.Clinical transplantation 2010 ;24(3):E54-61

Decreased pulmonary inflammation after ethanol exposure and burn injury in intercellular adhesion molecule-1 knockout mice.Bird,M. D.; Morgan,M. O.; Ramirez,L.; Yong,S.; Kovacs,E. J.Journal of Burn Care & Research 2010 ;31(4):652-660

Gender-based differences in cytokine production after burn injury: a role of interleukin-6.Plackett,T. P.; Gamelli,R. L.; Kovacs,E. J.Journal of the American College of Surgeons 2010 ;210(1):73-78

Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling.Bird,M. D.; Zahs,A.; Deburghgraeve,C.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Alcoholism: Clinical & Experimental Research 2010 ;34(10):1733-1741

Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model.D'Souza El-Guindy,N. B.; Kovacs,E. J.; De Witte,P.; Spies,C.; Littleton,J. M.; de Villiers,W. J.; Lott,A. J.; Plackett,T. P.; Lanzke,N.; Meadows,G. G.Alcoholism: Clinical & Experimental Research 2010 ;34(9):1489-1511

Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.Gomez,C. R.; Karavitis,J.; Palmer,J. L.; Faunce,D. E.; Ramirez,L.; Nomellini,V.; Kovacs,E. J.Mediators of inflammation 2010 ;2010(Article ID):475139

Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration.Gomez,C. R.; Nomellini,V.; Baila,H.; Oshima,K.; Kovacs,E. J.Shock 2009 ;31(2):178-184

Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factorsKovacs,E. J.; Palmer,J. L.; Fortin,C. F.; Fulop,T.,Jr; Goldstein,D. R.; Linton,P. J.Trends in immunology 2009 ;30(7):319-324

Ethanol potentiates the acute fatty infiltration of liver caused by burn injury: prevention by insulin treatment.Emanuele,N. V.; Emanuele,M. A.; Morgan,M. O.; Sulo,D.; Yong,S.; Kovacs,E. J.; Himes,R. D.; Callaci,J. J.Journal of Burn Care & Research 2009 ;30(3):482-488

Alcohol and trauma: a summary of the Satellite Symposium at the 30th Annual Meeting of the Shock Society.Bird,M. D.; Choudhry,M. A.; Molina,P. E.; Kovacs,E. J.Alcohol 2009 ;43(3):247-252

Aging and animal models of systemic insult: trauma, burn, and sepsisNomellini,V.; Gomez,C. R.; Gamelli,R. L.; Kovacs,E. J.Shock 2009 ;31(1):11-20

Implications of formal alcohol screening in burn patients.Albright,J. M.; Kovacs,E. J.; Gamelli,R. L.; Schermer,C. R.Journal of Burn Care & Research 2009 ;30(1):62-69

Proteasomes in human bronchoalveolar lavage fluid after burn and inhalation injuryAlbright,J. M.; Romero,J.; Saini,V.; Sixt,S. U.; Bird,M. D.; Kovacs,E. J.; Gamelli,R. L.; Peters,J.; Majetschak,M.Journal of Burn Care & Research 2009 ;30(6):948-956

Exposure-dependent effects of ethanol on the innate immune systemGoral,J.; Karavitis,J.; Kovacs,E. J.Alcohol 2008 ;42(4):237-247

Innate immunity and agingGomez,C. R.; Nomellini,V.; Faunce,D. E.; Kovacs,E. J.Experimental gerontology 2008 ;43(8):718-728

Effects of ethanol on pulmonary inflammation in postburn intratracheal infection.Murdoch,E. L.; Brown,H. G.; Gamelli,R. L.; Kovacs,E. J.Journal of Burn Care & Research 2008 ;29(2):323-330

Sex differences and estrogen modulation of the cellular immune response after injuryBird,M. D.; Karavitis,J.; Kovacs,E. J.Cellular immunology 2008 ;252(1-2):57-67

Organ-specific inflammation following acute ethanol and burn injuryBird,M. D.; Kovacs,E. J.Journal of leukocyte biology 2008 ;84(3):607-613

An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition.Nomellini,V.; Faunce,D. E.; Gomez,C. R.; Kovacs,E. J.Journal of leukocyte biology 2008 ;83(6):1493-1501

Aging and impairment of innate immunityNomellini,V.; Gomez,C. R.; Kovacs,E. J.Contributions to microbiology 2008 ;15( ):188-205

Alcohol and inflammation and immune responses: summary of the 2006 Alcohol and Immunology Research Interest Group (AIRIG) meeting.Waldschmidt,T. J.; Cook,R. T.; Kovacs,E. J.Alcohol 2008 ;42(2):137-142

Profound Effects of Burn and Ethanol on Proinflammatory Cytokines of the Reproductive Axis in the Male MouseEmanuele,N. V.; LaPaglia,N.; Kovacs,E. J.; Gamelli,R. L.; Emanuele,M. A.Journal of Burn Care & Research 2008 ;29(3):531-540

Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functions.Karavitis,J.; Murdoch,E. L.; Gomez,C. R.; Ramirez,L.; Kovacs,E. J.Journal of Interferon & Cytokine Research 2008 ;28(7):413-422

Adverse clinical outcomes associated with elevated blood alcohol levels at the time of burn injurySilver,G. M.; Albright,J. M.; Schermer,C. R.; Halerz,M.; Conrad,P.; Ackerman,P. D.; Lau,L.; Emanuele,M. A.; Kovacs,E. J.; Gamelli,R. L.Journal of Burn Care & Research 2008 ;29(5):784-789

Acute models of ethanol exposure to mice.Plackett,T. P.; Kovacs,E. J.Methods in Molecular Biology 2008 ;447( ):3-9

Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells.Radek,K. A.; Kovacs,E. J.; Gallo,R. L.; DiPietro,L. A.American Journal of Physiology - Heart & Circulatory Physiology 2008 ;295(1):H174-84

Effects of acute ethanol exposure on the early inflammatory response after excisional injury.Fitzgerald,D. J.; Radek,K. A.; Chaar,M.; Faunce,D. E.; DiPietro,L. A.; Kovacs,E. J.Alcoholism: Clinical & Experimental Research 2007 ;31(2):317-323

Matrix proteolytic activity during wound healing: modulation by acute ethanol exposure.Radek,K. A.; Kovacs,E. J.; DiPietro,L. A.Alcoholism: Clinical & Experimental Research 2007 ;31(6):1045-1052

The early acute phase response after burn injury in mice.Plackett,T. P.; Colantoni,A.; Heinrich,S. A.; Messingham,K. A.; Gamelli,R. L.; Kovacs,E. J.Journal of Burn Care & Research 2007 ;28(1):167-172

Effects of insulin on hepatic inflammation induced by ethanol and burn injury in a murine model of critical illness.Emanuele,M. A.; Emanuele,N. V.; Gamelli,R. L.; Kovacs,E. J.; LaPaglia,N.Journal of Burn Care & Research 2007 ;28(3):490-499

Vitamin E prevents ethanol-induced inflammatory, hormonal, and cytotoxic changes in reproductive tissues.Zhu,Q.; Emanuele,M. A.; LaPaglia,N.; Kovacs,E. J.; Emanuele,N. V.Endocrine 2007 ;32(1):59-68

Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats.Li,X.; Kovacs,E. J.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.American Journal of Physiology - Lung Cellular & Molecular Physiology 2007 ;292(5):1193-1201

Aging and estrogen: modulation of inflammatory responses after injury.Gomez,C. R.; Plackett,T. P.; Kovacs,E. J.Experimental gerontology 2007 ;42(5):451-456

Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.Gomez,C. R.; Hirano,S.; Cutro,B. T.; Birjandi,S.; Baila,H.; Nomellini,V.; Kovacs,E. J.Critical care medicine 2007 ;35(1):246-251

Acute ethanol exposure combined with burn injury enhances IL-6 levels in the murine ileum.Scalfani,M. T.; Chan,D. M.; Murdoch,E. L.; Kovacs,E. J.; White,F. A.Alcoholism: Clinical & Experimental Research 2007 ;31(10):1731-1737

Signal transduction in the aging innate immune systemGomez,C. R.; Boehmer,E. D.; Nomellini,V.; Kovacs,E. J.Current immunology reviews 2007 ;3( ):23-30

Acute and chronic alcohol abuse modulate immunity.Brown,L. A.; Cook,R. T.; Jerrells,T. R.; Kolls,J. K.; Nagy,L. E.; Szabo,G.; Wands,J. R.; Kovacs,E. J.Alcoholism: Clinical & Experimental Research 2006 ;30(9):1624-1631

Aberrant acute-phase response in aged interleukin-6 knockout mice.Gomez,C. R.; Goral,J.; Ramirez,L.; Kopf,M.; Kovacs,E. J.Shock 2006 ;25(6):581-585

Alcohol and inflammation and immune responses: summary of the 2005 Alcohol and Immunology Research Interest Group (AIRIG) meeting.Waldschmidt,T. J.; Cook,R. T.; Kovacs,E. J.Alcohol 2006 ;38(2):121-125

Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells.Palmer,J. L.; Tulley,J. M.; Kovacs,E. J.; Gamelli,R. L.; Taniguchi,M.; Faunce,D. E.Journal of Immunology 2006 ;177(1):92-99

Lack of aromatase improves cell-mediated immune response after burn.Plackett,T. P.; Oz,O. K.; Simpson,E. R.; Kovacs,E. J.Burns 2006 ;32(5):577-582

Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway.Boehmer,E. D.; Meehan,M. J.; Cutro,B. T.; Kovacs,E. J.Mechanisms of Ageing & Development 2005 ;126(12):1305-1313

RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ damageHoek,J.; Thiele,G. M.; Klassen,L. W.; Mandrekar,P.; Zakhari,S.; Cook,R. T.; Ray,N. B.; Happel,K. I.; Kolls,J. K.; Kovacs,E. J.; Szab,G.Alcoholism: Clinical & Experimental Research 2005 ;29(9):1735-1743

CD1d-restricted NKT cells contribute to the age-associated decline of T cell immunity.Faunce,D. E.; Palmer,J. L.; Paskowicz,K. K.; Witte,P. L.; Kovacs,E. J.Journal of Immunology 2005 ;175(5):3102-3109

A low blood ethanol level is associated with improved cytokine production in aged mice after traumatic injury.Plackett,T. P.; Jarrett,J.; Gamelli,R. L.; Kovacs,E. J.Journal of Trauma-Injury Infection & Critical Care 2005 ;59(4):984-989

Aging, traumatic injury, and estrogen treatmentKovacs,E. J.Experimental gerontology 2005 ;40(7):549-555

Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury.Li,X.; Rana,S. N.; Kovacs,E. J.; Gamelli,R. L.; Chaudry,I. H.; Choudhry,M. A.American Journal of Physiology - Regulatory Integrative & Comparative Physiology 2005 ;289(1):R37-44

Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function.Kavanaugh,M. J.; Clark,C.; Goto,M.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.; Choudhry,M. A.Burns 2005 ;31(3):290-296

Effects of chronic ethanol (EtOH) administration on pro-inflammatory cytokines of the hypothalamic-pituitary-gonadal (HPG) axis in female rats.Emanuele,N.; LaPaglia,N.; Kovacs,E. J.; Emanuele,M. A.Endocrine research 2005 ;31(1):9-16

The impact of burn injury and ethanol on the cytokine network of the mouse hypothalamus: reproductive implications.Emanuele,N. V.; LaPaglia,N.; Kovacs,E. J.; Emanuele,M. A.Cytokine 2005 ;30(3):109-115

In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation.Goral,J.; Kovacs,E. J.Journal of Immunology 2005 ;174(1):456-463

The aging innate immune systemGomez,C. R.; Boehmer,E. D.; Kovacs,E. J.Current opinion in immunology 2005 ;17(5):457-462

Acute ethanol exposure impairs angiogenesis and the proliferative phase of wound healing.Radek,K. A.; Matthies,A. M.; Burns,A. L.; Heinrich,S. A.; Kovacs,E. J.; Dipietro,L. A.American Journal of Physiology - Heart & Circulatory Physiology 2005 ;289(3):H1084-90

Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK.Goral,J.; Choudhry,M. A.; Kovacs,E. J.Journal of leukocyte biology 2004 ;75(3):553-559

Impaired intestinal immunity and barrier function: a cause for enhanced bacterial translocation in alcohol intoxication and burn injuryChoudhry,M. A.; Rana,S. N.; Kavanaugh,M. J.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.Alcohol 2004 ;33(3):199-208

Combined alcohol and burn injury differentially regulate P-38 and ERK activation in mesenteric lymph node T cell.Choudhry,M. A.; Ren,X.; Romero,A.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.Journal of Surgical Research 2004 ;121(1):62-68

Immunosuppression after injury in aged mice is associated with a TH1-TH2 shift, which can be restored by estrogen treatment.Kovacs,E. J.; Duffner,L. A.; Plackett,T. P.Mechanisms of Ageing & Development 2004 ;125(2):121-123

Ethanol and burn injury: estrogen modulation of immunityKovacs,E. J.; Faunce,D. E.; Messingham,K. A.Alcohol 2004 ;33(3):209-216

Alcohol and immunology: introduction to and summary of the 2003 Alcohol and Immunology Research Interest Group (AIRIG) meeting.Kovacs,E. J.; Jerrells,T. R.Alcohol 2004 ;33(3):171-174

Estrogen replacement, aging, and cell-mediated immunity after injury.Kovacs,E. J.; Plackett,T. P.; Witte,P. L.Journal of leukocyte biology 2004 ;76(1):36-41

Aging and innate immune cellsPlackett,T. P.; Boehmer,E. D.; Faunce,D. E.; Kovacs,E. J.Journal of leukocyte biology 2004 ;76(2):291-299

Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression.Boehmer,E. D.; Goral,J.; Faunce,D. E.; Kovacs,E. J.Journal of leukocyte biology 2004 ;75(2):342-349

Monocyte chemoattractant protein-1 (MCP-1) and macrophage infiltration into the skin after burn injury in aged mice.Shallo,H.; Plackett,T. P.; Heinrich,S. A.; Kovacs,E. J.Burns 2003 ;29(7):641-647

Advanced age negatively influences mesenteric lymph node T cell responses after burn injury.Choudhry,M. A.; Plackett,T. P.; Schilling,E. M.; Faunce,D. E.; Gamelli,R. L.; Kovacs,E. J.Immunology letters 2003 ;86(2):177-182

Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines.Colantoni,A.; Idilman,R.; De Maria,N.; La Paglia,N.; Belmonte,J.; Wezeman,F.; Emanuele,N.; Van Thiel,D. H.; Kovacs,E. J.; Emanuele,M. A.Alcoholism: Clinical & Experimental Research 2003 ;27(7):1184-1189

A role for CD1d-restricted NKT cells in injury-associated T cell suppression.Faunce,D. E.; Gamelli,R. L.; Choudhry,M. A.; Kovacs,E. J.Journal of leukocyte biology 2003 ;73(6):747-755

Effect of acute ethanol exposure on the dermal inflammatory response after burn injury.Faunce,D. E.; Garner,J. L.; Llanas,J. N.; Patel,P. J.; Gregory,M. S.; Duffner,L. A.; Gamelli,R. L.; Kovacs,E. J.Alcoholism: Clinical & Experimental Research 2003 ;27(7):1199-1206

Elevated monocyte chemoattractant protein-1 levels following thermal injury precede monocyte recruitment to the wound site and are controlled, in part, by tumor necrosis factor-alpha.Heinrich,S. A.; Messingham,K. A.; Gregory,M. S.; Colantoni,A.; Ferreira,A. M.; Dipietro,L. A.; Kovacs,E. J.Wound Repair & Regeneration 2003 ;11(2):110-119

Murine model of peritoneal adhesion formation.Jahoda,A. E.; Olson,M. K.; Kovacs,E. J.Methods in Molecular Medicine 2003 ;78( ):141-148

Aging enhances lymphocyte cytokine defects after injury.Plackett,T. P.; Schilling,E. M.; Faunce,D. E.; Choudhry,M. A.; Witte,P. L.; Kovacs,E. J.FASEB Journal 2003 ;17(6):688-689

Alcohol, injury, and cellular immunityMessingham,K. A.; Faunce,D. E.; Kovacs,E. J.Alcohol 2002 ;28(3):137-149

Interleukin-4 treatment restores cellular immunity after ethanol exposure and burn injury.Messingham,K. A.; Heinrich,S. A.; Schilling,E. M.; Kovacs,E. J.Alcoholism: Clinical & Experimental Research 2002 ;26(4):519-526

Modulation of immunity and viral-host interactions by alcohol.Thiele,G. M.; Szabo,G.; Kovacs,E. J.; Bautista,A. P.; Sosa,L.; Jerrells,T. R.Alcoholism: Clinical & Experimental Research 2002 ;26(12):1897-1908

Hepatic estrogen receptors and alcohol intake.Colantoni,A.; Emanuele,M. A.; Kovacs,E. J.; Villa,E.; Van Thiel,D. H.Molecular & Cellular Endocrinology 2002 ;193(1-2):101-104

Survival and cell-mediated immunity after brun injury in aged mice.Kovacs,E. J.; Grabowski,K. A.; Duffner,L. A.; Plackett,T. P.; Gregory,M. S.Age 2002 ;25(1):3-9

Influence of alcohol and gender on immune responseKovacs,E. J.; Messingham,K. A.Alcohol Research & Health: the Journal of the National Institute on Alcohol Abuse & Alcoholism 2002 ;26(4):257-263

Estrogen regulation of immune responses after injuryKovacs,E. J.; Messingham,K. A.; Gregory,M. S.Molecular & Cellular Endocrinology 2002 ;193(1-2):129-135

Differential neutrophil traffic in gut and lung after scald injury.Dries,D. J.; Lorenz,K.; Kovacs,E. J.Journal of Burn Care & Rehabilitation 2001 ;22(3):203-209

Evidence of oxidative injury during aging of the liver in a mouse modelColantoni,A.; Idilman,R.; de Maria,N.; Duffner,L. A.; Van Thiel,D. H.; Witte,P. L.; Kovacs,E. J.Journal of the American Aging Association 2001 ;24(2):51-57

Wound healing in MIP-1alpha(-/-) and MCP-1(-/-) mice.Low,Q. E.; Drugea,I. A.; Duffner,L. A.; Quinn,D. G.; Cook,D. N.; Rollins,B. J.; Kovacs,E. J.; DiPietro,L. A.American Journal of Pathology 2001 ;159(2):457-463

Testosterone receptor blockade restores cellular immunity in male mice after burn injury.Messingham,K. A.; Shirazi,M.; Duffner,L. A.; Emanuele,M. A.; Kovacs,E. J.Journal of Endocrinology 2001 ;169(2):299-308

Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production.Messingham,K. A.; Heinrich,S. A.; Kovacs,E. J.Journal of leukocyte biology 2001 ;70(6):887-895

Cellular immunity after ethanol exposure and burn injury: dose and time dependence.Messingham,K. A.; Fontanilla,C. V.; Colantoni,A.; Duffner,L. A.; Kovacs,E. J.Alcohol 2000 ;22(1):35-44

Anti-interleukin-6 antibody treatment restores cell-mediated immune function in mice with acute ethanol exposure before burn trauma.Fontanilla,C. V.; Faunce,D. E.; Gregory,M. S.; Messingham,K. A.; Durbin,E. A.; Duffner,L. A.; Kovacs,E. J.Alcoholism: Clinical & Experimental Research 2000 ;24(9):1392-1399

Dose-dependent effect of ethanol on hepatic oxidative stress and interleukin-6 production after burn injury in the mouse.Colantoni,A.; Duffner,L. A.; De Maria,N.; Fontanilla,C. V.; Messingham,K. A.; Van Thiel,D. H.; Kovacs,E. J.Alcoholism: Clinical & Experimental Research 2000 ;24(9):1443-1448

Ethanol exacerbates T cell dysfunction after thermal injury.Choudhry,M. A.; Messingham,K. A.; Namak,S.; Colantoni,A.; Fontanilla,C. V.; Duffner,L. A.; Sayeed,M. M.; Kovacs,E. J.Alcohol 2000 ;21(3):239-243

Estrogen mediates the sex difference in post-burn immunosuppression.Gregory,M. S.; Duffner,L. A.; Faunce,D. E.; Kovacs,E. J.Journal of Endocrinology 2000 ;164(2):129-138

Differential production of prostaglandin E(2) in male and female mice subjected to thermal injury contributes to the gender difference in immune function: possible role for 15-hydroxyprostaglandin dehydrogenase.Gregory,M. S.; Duffner,L. A.; Hahn,E. L.; Tai,H. H.; Faunce,D. E.; Kovacs,E. J.Cellular immunology 2000 ;205(2):94-102

Gender difference in cell-mediated immunity after thermal injury is mediated, in part, by elevated levels of interleukin-6.Gregory,M. S.; Faunce,D. E.; Duffner,L. A.; Kovacs,E. J.Journal of leukocyte biology 2000 ;67(3):319-326

The role of interleukin 6 in interferon-gamma production in thermally injured mice.Durbin,E. A.; Gregory,M. S.; Messingham,K. A.; Fontanilla,C. V.; Duffner,L. A.; Kovacs,E. J.Cytokine 2000 ;12(11):1669-1675

Education
Fellowship
  • National Cancer Institute (NCI), Biological Response Modifiers Program