MAYWOOD, Ill. -- Loyola University Health System researchers are reporting on a promising new approach to treating diabetic wounds, bed sores, chronic ulcers and other slow-to-heal wounds.
It may be possible to speed healing by suppressing certain immune cells, researchers wrote in the February 2011 issue of the journal Expert Reviews in Dermatology.
The cells are called neutrophils and natural killer T (NKT) cells. These white blood cells act to kill bacteria and other germs that can infect wounds. NKT cells also recruit other white blood cells to the site of injury. But in some cases, these NKT cells can do more harm than good, said senior author Elizabeth Kovacs, PhD, director of research in Loyola's Burn & Shock Trauma Institute.
Neutrophils can be beneficial to wound healing by gobbling up harmful bacteria and debris such as dead cells. But neutrophils also can do harm -- by producing enzymes that digest healthy surrounding tissue, leading to excessive scar tissue and slower healing.
"It's a balancing act. You need neutrophils but not too many of them," said Aleah Brubaker, first author of the article and an MD/PhD student at Loyola University Chicago Stritch School of Medicine. The third co-author is Dr. David Schneider, a surgical resident at Loyola.
NKT cells respond to wound injuries by producing proteins called cytokines and chemokines that attract neutrophils and other white blood cells to the wound. A previous study at Loyola demonstrated that the presence of activated NKT cells slows down the healing process, while the absence of these cells leads to faster wound closure.
In an editorial, Kovacs and colleagues wrote that since neutrophils and NKT cells are among the earliest immune system responders to injury, "they serve as ideal targets for modulation of the wound-repair process." For example, in experimental models, treatment with antibodies against surface molecules on neutrophils or NKT cells can inactivate the cells or prevent them from entering the wound.
Early treatment in high-risk patients using such therapeutic strategies may be able to "decrease the incidence and prevalence of chronic, non-healing wounds, reduce infectious complications and ameliorate associated health-care costs," Kovacs and her colleagues wrote.
The study is supported by grants from the National Institutes of Health and the Dr. Ralph and Marian C. Falk Medical Research Trust.
Loyola University Health System (LUHS) is a member of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. The medical center campus is conveniently located in Maywood, 13 miles west of the Chicago Loop and 8 miles east of Oak Brook, Ill. The heart of the medical center campus, Loyola University Hospital, is a 569-licensed-bed facility. It houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children’s Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as the LUC Stritch School of Medicine, the LUC Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 264-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.