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January 14, 2014
Loyola study provides guidance on drug holidays from popular osteoporosis treatments
Certain patients may be at risk for fractures during break from medication
MAYWOOD, Ill. – Doctors commonly recommend drug holidays, or breaks, from certain osteoporosis drugs due to the risks associated with these treatments. Yet little has been known about the ideal duration of the holidays and how best to manage patients during this time.
This popular class of medications, known as bisphosphonates, has been shown to cause fractures in the thigh bones and tissue decay in the jaw bone. The American Association of Clinical Endocrinologists recommends a drug holiday or break from these treatments after four to five years of bone density stability if osteoporosis is moderate and after 10 years of stability if fracture risk is high.
However, new research from Loyola University Health System reveals that patients should resume treatment if they develop a fracture, have a decline in bone strength or an early rise in signs indicative of increased fracture risk. Researchers also found that elderly patients and those with very low bone strength should be closely followed during a break from treatment. These findings were published in the latest issue of Endocrine Practice.
“This study provides some guidance about what to do during drug holidays and how long they should last,” said Pauline Camacho, MD, study investigator and director of the Loyola University Osteoporosis & Metabolic Bone Disease Center. “The results highlight groups who are at risk for fractures during drug holidays and recommendations on when to resume treatment."
Loyola researchers evaluated 209 patients who started a drug holiday from bisphosphonates. Eleven patients (5.2 percent) developed fractures and all patients had a significant increase in bone-specific alkaline phosphatase at six months. This level was more pronounced in patients who developed a fracture. While there was no significant change in the bone mineral density of the lumbar spine, there was a statistically significant decline in the femoral neck bone mineral density.
“These findings will help us continue to refine the current practice of drug holidays to better manage patients with osteoporosis,” Dr. Camacho said.
Maguy Chiha, MD, Department of Endocrinology and Metabolism, Loyola University Health System; Lauren Myers, medical student, Loyola University Chicago Stritch School of Medicine; Caroline Ball, MD, SSOM; and Jim Sinacore, PhD, Department of Public Health Sciences, SSOM, also were study investigators.
The Loyola University Chicago Health Sciences Division (HSD) advances interprofessional, multidisciplinary, and transformative education and research while promoting service to others through stewardship of scientific knowledge and preparation of tomorrow's leaders. The HSD is located on the Health Sciences Campus in Maywood, Illinois. It includes the Marcella Niehoff School of Nursing, the Stritch School of Medicine, the biomedical research programs of the Graduate School, and several other institutes and centers encouraging new research and interprofessional education opportunities across all of Loyola University Chicago. The faculty and staff of the HSD bring a wealth of knowledge, experience, and a strong commitment to seeing that Loyola's health sciences continue to excel and exceed the standard for academic and research excellence. For more on the HSD, visit LUC.edu/hsd.