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April 03, 2013
Loyola Researchers to Determine if Certain Bacteria Cause Overactive Bladder Symptoms
Nationally renowned researchers looking for women to enroll in study
MAYWOOD, Ill. – Thousands of women suffer from overactive bladder (OAB) or the sudden need to urinate, yet many don’t get relief from medication. Researchers at Loyola University Health System believe certain bacteria may be to blame.
Loyola has launched a clinical trial to determine if the bacteria present in the urine of women who respond to treatment for overactive bladder is different than those who do not respond.
“Overactive bladder can be caused by a number of issues, which may explain why medication works for some and not others,” said Linda Brubaker, MD, a urogynecologist at Loyola University Health System and dean of Loyola University Chicago Stritch School of Medicine. “If we can identify differences in the bacteria in women who respond to treatment and those who do not, we can better manage these patients and improve their quality of life."
OAB is a socially debilitating disease that may result from various issues, including cancer or neurological diseases. Urinary tract infections also lead to symptoms of OAB with the difference being bacteria.
“Certain bacteria in the urine may contribute to urinary symptoms,” Dr. Brubaker said. “While further research is needed, women with these bacteria may benefit from antibiotics rather than traditional treatments for OAB."
Loyola researchers are looking to recruit women for this study. Study participants will complete a questionnaire and will undergo a series of screening procedures.
Women involved in the study also will provide urine samples, which researchers will evaluate with traditional cultures and DNA-based detection measures to identify the bacteria present. Women can call (708) 216-2067 to determine if they are eligible to participate in the study.
Loyola University Health System (LUHS) is a member of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. The medical center campus is conveniently located in Maywood, 13 miles west of the Chicago Loop and 8 miles east of Oak Brook, Ill. The heart of the medical center campus is a 559-licensed-bed hospital that houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children's Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as the LUC Stritch School of Medicine, the LUC Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 255-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.