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Participants must be 18 years or older and have a pathologically proven diagnosis of squamous cell carcinoma, which is HPV positive. Participants must have exams by a radiation and a medical oncologist as well as an ENT or head and neck surgeon, which must include a laryngopharyngoscopy. Other required tests include: CBC,CMP, swallowing evaluation, audiogram, EKG, CT/MRI/PET of neck, a whole-body PET/CT, a dental evaluation, and a possible feeding tube evaluation.
The purpose of this study is to compare the effects, good and/or bad, of two standard treatments for head and neck cancer: radiation therapy and cisplatin or radiation therapy and cetuximab. The two treatments may be comparable in treating your cancer, but radiation and cetuximab may result in less severe side effects.