Charles Hemenway
Charles Hemenway
Ronald McDonald House Charities Endowed Professor in Pediatric Oncology
Director, M.D./Ph.D. Program
Division Director, Pediatric Hematology/Oncology
Pediatric Hematology/Oncology
Cancer in children and adolescents
Bleeding disorders in children and adolescents
Anemia in children and adolescents
Loyola Center for Health at Homer Glen
Ronald McDonald <sup>®</sup> Children's Hospital
Loyola Outpatient Center
Board Certifications
Pediatric Hematology-Oncology - Subspecialty Cert: AM Board of Pediatrics
Malik,B.; Hemenway,C. S.CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3 FEBS letters 2013 ; :
Lin,J. J.; Hemenway,C. S.Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. Journal of Biological Chemistry 2010 ;285(16):11966-11973
Chang,M. J.; Wu,H.; Achille,N. J.; Reisenauer,M. R.; Chou,C. W.; Zeleznik-Le,N. J.; Hemenway,C. S.; Zhang,W.Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes Cancer research 2010 ;70(24):10234-10242
Bennett,C. A.; Winters,A. C.; Barretto,N. N.; Hemenway,C. S.Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents. Leukemia research 2009 ;33(7):937-947
Palermo,C. M.; Bennett,C. A.; Winters,A. C.; Hemenway,C. S.The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells. Leukemia research 2008 ;32(4):633-642
Karras,N. A.; Hemenway,C. S.Hurricane Katrina's impact on pediatric and adult patients with sickle cell disease. Journal of Health Care for the Poor & Underserved 2007 ;18(2):382-393
Zhang,W.; Xia,X.; Reisenauer,M. R.; Hemenway,C. S.; Kone,B. C.Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. Journal of Biological Chemistry 2006 ;281(26):18059-18068
Reiser,J.; Zhang,X. Y.; Hemenway,C. S.; Mondal,D.; Pradhan,L.; La Russa,V. F.Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases Expert Opinion on Biological Therapy 2005 ;5(12):1571-1584
Erfurth,F.; Hemenway,C. S.; de Erkenez,A. C.; Domer,P. H.MLL fusion partners AF4 and AF9 interact at subnuclear foci Leukemia 2004 ;18(1):92-102
Srinivasan,R. S.; Nesbit,J. B.; Marrero,L.; Erfurth,F.; LaRussa,V. F.; Hemenway,C. S.The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells Leukemia 2004 ;18(8):1364-1372
Srinivasan,R. S.; de Erkenez,A. C.; Hemenway,C. S.The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor Oncogene 2003 ;22(22):3395-3406
Hemenway,C. S.; de Erkenez,A. C.; Gould,G. C.The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias Oncogene 2001 ;20(29):3798-3805
Hemenway,C. S.; Halligan,B. W.; Gould,G. C.; Levy,L. S.Identification and analysis of a third mouse Polycomb gene, MPc3 Gene 2000 ;242(1-2):31-40
Medical School
University of Massachusetts Medical School
University of Florida, Internal Medicine & Pediatrics
Duke University Medical Center, Pediatrics: Pediatric Hematology-Oncology
Interests & Hobbies
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