Cancer Clinical Research
This is a listing of Loyola University Health System Cancer clinical research that is open and actively recruiting patients. Please click on the name of the research for a brief description, eligibility requirements and contact information. All research listed below have been approved by Loyola's Institutional Review Board chairman for promotion on our Web site.
Lung Transplant: Does Cyclosporine Inhaled Solution Help Prevent the Rejection?The purpose of this study is to determine whether inhaled cyclosporine (CIS), in addition to other medications that put down the immune system, helps prevent a new lung(s) transplant from being rejected by the body?s natural defense system.
Brain tumor
A Phase III trial comparing the standard dose of temozolomide with a more increased, longer lasting dose of temozlomide in patients with newly diagnosed glioblastomaThe purpose of this study is to determine whether increasing the duration of temozolomide treatment after radiation from five days out of 28 days (standard-dose schedule) to 21 days out of 28 days (dose-dense schedule) will further improve results.
Breast cancer
A randomized phase III study of whole breast radiation versus partial breast radiation for women with breast cancerThe purpose of this study is to see if partial breast irradiation is as good as or better than whole breast irradiation in keeping cancer from coming back in the breast.
SOFT TrialThe purpose of this study is to see if shutting down a woman's ovaries plus giving tamoxifen is better at preventing the return of breast cancer than just giving tamoxifen alone in premenopausal women. It also will test whether a newer hormone drug called exemestane plus suppression of the ovaries is better than tamoxifen plus suppression of the ovaries. The side effects of these different treatments will be studied.
Anastrozole with or without fulvestrant as first-line therapy in treating postmenopausal women with metastatic breast cancerThe purpose of this study is to determine how effective combining anastronzole with fulvestrant is compared to anastrozole alone in treating postmenopausal women with metastatic breast cancer.
Administration of hormone therapy to suppress ovary function during chemotherapy after surgical removal of breast cancer.The research is being done to determine if supressing ovary function during chemotherapy can reduce the incidence of premature menopause, which is often caused during adjuvant chemotherapy for breast cancer.
Breast Radiation Using Mammosite Brachytherapy (after breast conserving surgery)The purpose is to test whether radiation to part of the breast using brachytherapy after the removal of cancer gives similar results to those obtained when the whole breast receives radiation therapy. The study seeks to assess safety of the mammosite device in this setting, including the quality of life.
Cancer, Cervical or Endometrial
A phase II study of radiation therapy to the pelvis with or without chemotherapy for patients diagnosed with endometrial or cervical cancerThe purpose of the study is to test whether the use of an advanced radiation therapy delivery technique called intensity-modulated radiation therapy (IMRT) can spare normal tissue, including small bowel and large bowel, from radiation. The research is being done to try to reduce radiation side effects (especially diarrhea) that occur with the standard radiation methods.
Head and neck cancer
A study to treat surgically removed cancer of the head and neck using a chemotherapy drug in combination with radiation therapyThe purpose of the study is to find the best dose of the chemotherapy agent Docetaxel when given with radiation therapy after surgical removal of all visible head and neck cancer and to see how effective the treatment is on overall patient survival rates.
Melanoma
Vaccine Trial for Melanoma Patients Whose Disease Has Metastasized (Stage IV).The main purpose of the study is to determine the safety of the trial's experimental procedure and the maximum dose of the vaccine that a human can tolerate. A secondary purpose is to see if the experimental procedure causes the melanoma cancer to shrink.