Clinical Research Details

Aortic Valve Operative Outcomes in Marfan Patients

The purpose of the study is to: -Evaluate and compare operative outcomes of the aortic valve-sparing (AVS) and aortic valve replacement (AVR) surgical interventions in different categories of patients with Marfan syndrome and estimate predictors of the surgical outcomes; - Compare the outcomes described in above objective in different categories of patients with Marfan syndrome who underwent the AVS or the AVR surgical intervention; - Determine predictors that have prognostic importance for the outcomes of surgical interventions in different categories of patients with Marfan syndrome who underwent the AVS or the AVR surgical intervention; - Evaluate prevalence of different types of AVR and AVS operations in patients with Marfan syndrome who had surgical intervention for correction of aortic valve abnormalities; - Evaluate indications used to perform AVR and AVS operations in patients with Marfan syndrome; - In different categories of patients with Marfan syndrome who underwent the AVS or the AVR surgical intervention, estimate: a) short-term morbidity & mortality in patients with Marfan syndrome undergoing the AVS or the AVR surgical intervention; b) cumulative incidence of selected complications estimated from the 24 month follow-up period; c) freedom from selected complications estimated from the 24 month follow-up period; d) survival rate estimated from the 24 month follow-up period; e) Quality of life score Develop a centralized on-line database for accumulation of data on patients with Marfan syndrome undergoing the AVS or the AVR surgery; - Develop a repository for blood and tissue samples obtained from study participants.

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To be eligible for the study, participants must have documented diagnosis of Marfan syndrome and have planned to repair or replace the aortic valve with or without replacement of the ascending aorta.

There is no treatment given.

Jeffrey Schwartz, M.D.

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